研究等業績 - その他 - 成田 伸太郎
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Hand assisted retroperitoneoscopic living donor nephrectomy in elderly donors.
Norihiko Tsuchiya, Shigeru Satoh, Kazunari Sato, Masahiro Iinuma, Shintaro Narita, Takamitsu Inoue, Shinobu Matsuura, Tomonori Habuchi
The Journal of urology 175 ( 1 ) 230 - 4 2006年01月
PURPOSE: We assessed the influence of HARDN on residual donor kidney and allograft function, invasiveness and morbidity in elderly living donors. MATERIALS AND METHODS: A total of 89 living donors underwent nephrectomy before September 2004 at our institution. The 18 donors who were 65 years or older included 4 of 27 with ODN and 14 of 62 with HARDN. RESULTS: In older (65 years or older) donors mean operative time, mean blood loss and warm ischemia time in the HARDN group did not differ from those in the ODN group. None of the donors had major complications. Older donors with HARDN had a tendency toward a shorter hospital stay than those with ODN. Postoperative serum creatinine in older donors with HARDN was higher than that in younger donors with HARDN, while there was no difference in postoperative serum creatinine between older donors with HARDN and those with ODN. The frequency of allograft losses tended to be higher in older than in younger kidneys (4 of 18 vs 5 of 71, p = 0.054). However, most allograft losses did not seem to be related to surgical technique. CONCLUSIONS: Although further studies, especially with long-term followup, are necessary, HARDN is suggested to be safe and minimally invasive surgery even in elderly donors and to be comparable to open surgery in terms of morbidity, the residual donor kidney and allograft function.
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MP-712 MVACによる副作用発現の個人差における遺伝子多型の意義(一般演題ポスター,第94回日本泌尿器科学会総会)
土谷 順彦, 井上 高光, 成田 伸太郎, 熊澤 光明, 齋藤 満, 堀川 洋平, 柿沼 秀秋, 湯浅 健, 松浦 忍, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 97 ( 2 ) 544 - 544 2006年
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OP-074 長期移植腎機能におよぼすインターロイキン2遺伝子多型の影響(一般演題口演,第94回日本泌尿器科学会総会)
佐藤 滋, 沼倉 一幸, 斎藤 満, 井上 高光, 熊澤 光明, 成田 伸太郎, 堀川 洋平, 柿沼 秀秋, 湯浅 健, 松浦 忍, 土谷 順彦, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 97 ( 2 ) 299 - 299 2006年
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Successful renal transplantation in the right iliac fossa 2 years after serious deep venous thrombosis in a patient with systemic lupus erythematosus.
Norihiko Tsuchiya, Shigeru Satoh, Shintaro Narita, Naotake Shimoda, Shinobu Matsuura, Chikara Ohyama, Kazunari Sato, Tetsuro Kato, Hiroshi Ohtani, Atsushi Komatsuda, Tomonori Habuchi
International journal of urology : official journal of the Japanese Urological Association 12 ( 10 ) 912 - 6 2005年10月
Deep venous thrombosis (DVT) possibly occurs in the perioperative period, and induces serious complications such as a pulmonary embolism. On the other hand, allograft renal vein thrombosis leads to a high incidence of graft loss. We experienced a case in which a serious DVT occurred prior to renal transplantation; however, a successful renal transplantation in the right iliac fossa was performed after 2 years of anticoagulant therapy. It is suggested that the external iliac vein even after suffering from DVT can be anastomosed to an allograft vein successfully, when enough blood fl ow or a lower venous pressure is confirmed. However, one should be aware of the risk factors and the adequate management of thrombosis in renal transplantation because of the serious complications of DVT and the poor prognosis of allograft vein thrombosis.
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CYP3A5 gene polymorphism and risk of prostate cancer in a Japanese population.
Li Zhenhua, Norihiko Tsuchiya, Shintaro Narita, Takamitsu Inoue, Yohei Horikawa, Hideaki Kakinuma, Tetsuro Kato, Osamu Ogawa, Tomonori Habuchi
Cancer letters 225 ( 2 ) 237 - 43 2005年07月
The CYP3A5 gene (CYP3A5) encodes the cytochrome P450 3A5, which catalyzes the 6beta-hydroxylation of testosterone. We explored association between the CYP3A5 A6986G polymorphism and a risk of prostate cancer in 260 prostate cancer patients, 199 BPH patients and 212 male controls. The CYP3A5 gene polymorphism did not influence significantly a risk of developing of prostate cancer in general. However, compared with males with the GG genotype, those with the AA genotype had a 0.23-fold decreased risk of developing low-grade prostate cancer (P=0.023), and a 0.31-fold decreased risk of developing localized (stages A-C) prostate cancer (P=0.044). The CYP3A5 A6986G polymorphism may be specifically associated with a decreased risk of low-grade or early stage prostate cancer.
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An A/G polymorphism of core 2 branching enzyme gene is associated with prostate cancer.
Lizhong Wang, Junya Mitoma, Norihiko Tsuchiya, Shintaro Narita, Yohei Horikawa, Tomonori Habuchi, Atsushi Imai, Hirofumi Ishimura, Chikara Ohyama, Minoru Fukuda
Biochemical and biophysical research communications 331 ( 4 ) 958 - 63 2005年06月
The expression of core 2 beta1,6-N-acetylglucosaminyltransferase-1 (C2GnT) is associated with development and progression of malignancy. Sequence analysis showed that the codon 152 of C2GnT has a polymorphism having GTT encoding valine or ATT encoding isoleucine. By examining the polymorphism in prostate cancer and benign prostatic hyperplasia patients, we found that the C2GnT G allele was more frequently observed in the prostate cancer group (p=0.015) than the control group. Men with the GG genotype had a 3.60-fold increased risk of prostate cancer, and men with the AG genotype had a 1.58-fold increased risk of prostate cancer compared with those with the AA genotype. The G allele was found to have a gene dosage effect for prostate cancer risk. No such risk was associated for benign prostatic hyperplasia. These results demonstrate that C2GnT A/G polymorphism is associated with the susceptibility to prostate cancer in a Japanese population.
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[Outcome of treatment with surgical resection of the remaining tumor after modified M-VAC treatment for advanced urothelial carcinoma].
Shintaro Narita, Masahiro Nakano, Masato Matsuzaki, Jyunichi Watanabe, Hiroshi Morikawa, Hirokatsu Murata, Hiroyuki Oda, Hideki Komatsu
Hinyokika kiyo. Acta urologica Japonica 51 ( 3 ) 155 - 8 2005年03月
We retrospectively evaluated the effect of the surgical resection of the remaining tumor after modified M-VAC (methotrexate, vinblastine, doxorubicin and cisplatin) (m-M-VAC) treatment for locally advanced or metastatic urothelial carcinoma. In m-M-VAC therapy, methotrexate and vinblastine on 15 and 22 days were omitted from the classical M-VAC to avoid the discontinuation and the dose reduction, and duration of 1 course was shortened to 21 days from 28 days of the classical M-VAC. Seven patients with locally invasive or metastatic carcinoma of the renal pelvis, ureter, and bladder, 6 males and 1 female, with a median age 64.1 years, ranging from 49 to 77 years received m-M-VAC chemotherapy without severe side effects. In all patients, the residual viable carcinoma was completely resected and they achieved complete remission. The median survival time was 20 months (range, 7 to 61). Five of these 7 patients were still alive. Two patients had no recurrence and achieved long-term survival (survival duration; 61 and 39 months). Although further studies and long-term follow up are required, these results suggest that patients who present with locally advanced or metastatic urothelial carcinoma may benefit from surgical resection after m-M-VAC.
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[Comparison of radical retropubic prostatectomy under combined lumbar spinal and epidural anesthesia with that under combined general and epidural anesthesia].
Masahiro Nakano, Masato Matsuzaki, Shintaro Narita, Junichi Watanabe, Hirofumi Morikawa, Hirokatsu Murata, Hiroyuki Oda, Komatsu Hideki
Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 96 ( 1 ) 11 - 6 2005年01月
PURPOSE: To evaluate the efficacy of combined lumbar spinal and epidural (CLSE) anesthesia in retropubic radical prostatectomy. MATERIALS AND METHODS: Twenty consecutive patients who underwent radical retropubic prostatectomy by a single surgeon (H.K.) under CLSE anesthesia from July of 2003 to February of 2004 were selected as subjects. They were compared with 20 consecutive patients who underwent radical retropubic prostatectomy performed by the same surgeon under combined general and epidural (CGE) anesthesia from April to December of 2002. Both periods were carefully selected to exclude radical prostatectomies with intraoperative complications to evaluate genuine effects of anesthesia. For lumbar spinal anesthesia, 0.5% hyperbaric bupivacaine hydrochloride or 0.5% hyperbaric tetracaine hydrochloride (dissolved in a 10% glucose solution) was used. An epidural tube was inserted for both lumbar spinal anesthesia and general anesthesia mainly for the purpose of controlling a pain after operation. RESULTS: Intraoperative blood loss was significantly less in the CLSE anesthesia group compared with CGE anesthesia group (p = 0.024). Postoperative water drinking was started at 0.4 days (average) for CLSE anesthesia and at 1.1 days (average) for CGE anesthesia (p < 0.0001). Postoperative diet was begun at 0.7 days (average) for CLSE anesthesia and at 1.5 days (average) for CGE anesthesia (p < 0.0001). Compared with the CLSE anesthesia group, the mean of the highest intraoperative mean blood pressure was significantly higher in the CGE anesthesia group (p = 0.002). CONCLUSION: Intraoperative blood loss was less, intraoperative change in blood pressure was less and recovery of postoperative intestinal peristalsis was earlier in patients who underwent prostatectomy under CLSE anesthesia than in patients who underwent prostatectomy under CGE anesthesia. We believe that prostatectomy under CLSE anesthesia is more advantageous than prostatectomy under CGE anesthesia.
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Clinical evaluation of random biopsy in superficial bladder cancer
堀川 洋平, 灘岡 純一, 成田 伸太郎, 井上 高光, 柿沼 秀秋, 冨樫 寿文, 松浦 忍, 土谷 順彦, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 96 ( 2 ) 322 - 322 2005年
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Hand-Assisted Retroperitoneoscopic Donor Nephrectomy(Endoscopic Live Donor Nephrectomy)
Satoh Shigeru, Tsuchiya Norihiko, Matsuura Shinobu, Narita Shintaro, Inoue Takamitsu, Horikawa Yohei, Kakinuma Hideaki, Togashi Hisafumi, Iinuma Masahiro, Ohyama Chikara, Sato Kazunari, Habuchi Tomonori
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 96 ( 2 ) 123 - 123 2005年
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XRCC1遺伝子多型と精巣腫瘍の発症・進展ならびにヘテロ接合性消失との関連に対する検討(第93回日本泌尿器科学会総会)
成田 伸太郎, 土谷 順彦, 三品 睦輝, 井上 高光, 堀川 洋平, 柿沼 秀秋, 冨樫 寿文, 松浦 忍, 佐藤 滋, 小川 修, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 96 ( 2 ) 223 - 223 2005年
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前立腺腫瘍細胞に対するHDAC阻害薬 (FK228) の抗腫瘍効果と抗癌剤増強作用(第93回日本泌尿器科学会総会)
神崎 正俊, 柿沼 秀秋, 畠山 真吾, 井上 高光, 成田 伸太郎, 堀川 洋平, 冨樫 寿文, 松浦 忍, 土谷 順彦, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 96 ( 2 ) 160 - 160 2005年
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Association of lipoprotein lipase gene polymorphism with risk of prostate cancer in a Japanese population.
Shintaro Narita, Norihiko Tsuchiya, Lizhong Wang, Shinobu Matsuura, Chikara Ohyama, Shigeru Satoh, Kazunari Sato, Osamu Ogawa, Tomonori Habuchi, Tetsuro Kato
International journal of cancer 112 ( 5 ) 872 - 6 2004年12月
A high fat intake has been associated with prostate cancer risk, and gene polymorphisms of lipoprotein lipase (LPL) play an important role in plasma lipoprotein metabolism. We herein analyzed the association of LPL gene polymorphisms with the risk of prostate cancer in a Japanese population. Three single nucleotide polymorphisms (SNPs) of LPL designated as Ser447stop, HindIII and PvuII were genotyped by the polymerase chain reaction-restriction fragment length polymorphism method in 273 prostate cancer patients, 205 benign prostatic hyperplasia (BPH) patients and 230 male controls. The men with the CG + GG genotypes of the Ser447stop polymorphism had an increased risk of prostate cancer compared to those with the CC genotype [age-adjusted odds ratio (aOR) = 1.625; 95% CI = 1.068-2.471; p = 0.023]. Furthermore, the increased risk associated with the CG + GG genotypes was more strongly observed in patients with high-grade cancers (aOR = 2.843; 95% CI = 1.252-6.458; p = 0.039) or metastatic diseases (aOR = 2.300; 95% CI = 1.042-5.074; p = 0.013), whereas the risk was not significant in those with low- to intermediate-grade cancers or nonmetastatic diseases. In the HindIII and PvuII polymorphisms, there was no significant difference between the prostate cancer patients and the controls, and no significant results as for tumor grade and stage. None of the 3 polymorphisms showed any association with the risk of BPH. Our results suggest that the LPL Ser447stop polymorphism is a common genetic modifier for the development of prostate cancer, particularly that of high-grade and/or high-stage, in a Japanese population.
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Transitional cell carcinoma in an ectopic ureter.
Shintaro Narita, Toshiya Akao, Norihiko Tsuchiya, Teruaki Kumazawa, Hideaki Kakinuma, Shigeru Satoh, Kazunari Sato, Tomonori Habuchi, Tetsuro Kato
International journal of urology : official journal of the Japanese Urological Association 10 ( 5 ) 276 - 7 2003年05月
We experienced an 82-year-old man with transitional cell carcinoma in an ectopic ureter draining into the prostatic urethra. Carcinoma arising from an ectopic ureter is very rare and a differential diagnosis is difficult. To our knowledge, our case is the third male case reported in the literature.