研究等業績 - その他 - 成田 伸太郎
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CLINICAL CHARACTERISTICS OF XP11.2 TRANSLOCATION RENAL CELL CARCINOMA IN ADULT JAPANESE PATIENTS
Kazuyuki Numakura, Norihiko Tsuchiya, Takeshi Yuasa, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Shingo Hatakeyama, Chikara Ohyama, Toru Inoue, Hiromitsu Mimata, Hideo Saito, Yoichi Arai, Toru Kanno, Tomomi Kamba, Osamu Ogawa, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E706 - E706 2011年04月
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BASILIXIMAB INDUCTION THERAPY COMBINED WITH A LOWER TARGET TROUGH LEVEL OF TACROLIMUS AND LOW DOSE OF MYCOPHENOLATE MOFETIL DECREASED INTERSTITIAL FIBROSIS AT 1-YEAR POSTTRANSPLANTATION AND IMPROVED THE 5-YEAR GRAFT SURVIVAL
Shigeru Satoh, Kazuyuki Numakura, Mitsuru Saito, Yoshiko Miura, Takashi Obara, Hiroshi Tsuruta, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi, Hideaki Kagaya, Masatomo Miura
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E905 - E905 2011年04月
研究発表要旨(国際会議)
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ELEVATED URINE LEVELS OF RANTES AND HIGH EXPRESSION LEVELS OF THE RANTES RECEPTOR (CCR5) IN BLADDER CANCER
Hiroshi Tsuruta, Yohei Horikawa, Shintaro Narita, Takamitsu Inoue, Takashi Obara, Kazuyuki Numakura, Shinya Maita, Shigeru Sato, Norihiko Tsuchiya, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E496 - E496 2011年04月
研究発表要旨(国際会議)
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EXTRACELLULAR MATRIX METALLOPROTEINASE INDUCER (EMMPRIN/CD147) IS ASSOCIATED WITH MALIGNANT PHENOTYPES OF HUMAN BLADDER CANCER
Kiyofumi Satoyoshi, Noriko Yamaguchi, Shintaro Narita, Norihiko Tsuchiya, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E349 - E349 2011年04月
研究発表要旨(国際会議)
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FACTORS ASSOCIATED WITH QUANTITATIVE INTERSTITIAL FIBROSIS AT 0-HOUR (DONOR) BIOPSY BY COMPUTERIZED IMAGE ANALYSIS IN LIVING DONORS
Yoshiko Miura, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Hiroshi Tsuruta, Takashi Obara, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habichi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E903 - E903 2011年04月
研究発表要旨(国際会議)
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IMPACT OF CLINICAL CHARACTERISTICS AND PRETRANSPLANT URINARY BLADDER CAPACITY ON URODYNAMICS ONE YEAR POSTTRANSPLANTATION IN 54 ADULT RECIPIENTS
Takashi Obara, Shigeru Satoh, Kazuyuki Numakura, Hiroshi Tsuruta, Shintaro Narita, Horikawa Yohei, Norihiko Tsuchiya, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E830 - E830 2011年04月
研究発表要旨(国際会議)
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POSTTRANSPLANT HYPERURICEMIA IN THE EARLY STAGE OF RENAL TRANSPLANT RECIPIENTS: INCIDENCE, CLINICAL CHARACTERISTICS, TACROLIMUS PARMACOKINETICS, AND RELATED GENOMIC POLYMORPHISMS
Kazuyuki Numakura, Shigeru Satoh, Norihiko Tsuchiya, Mitsuru Saito, Takamitsu Inoue, Takashi Obara, Hiroshi Tsuruta, Shintaro Narita, Yohei Horikawa, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E906 - E906 2011年04月
研究発表要旨(国際会議)
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PREDICTION OF SURVIVAL IN METASTATIC PROSTATE CANCER PATIENTS BY SNP ARRAY ANALYSIS OF CANCER-ASSOCIATED GENES
Norihiko Tsuchiya, Shigeyuki Matsui, Shintaro Narita, Takamitsu Inoue, Kazuyuki Numakura, Yohei Horikawa, Shingo Hatakeyama, Chikara Ohyama, Youichi Arai, Seiichi Saito, Osamu Ogawa, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E917 - E917 2011年04月
研究発表要旨(国際会議)
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PREOPERATIVE SERUM LEVELS OF INTERLEUKIN-6 AND INTERLEUKIN-12 PREDICT BIOCHEMICAL RECURRENCE IN PATIENTS WITH PROSTATE CANCER TREATED USING RADICAL PROSTATECTOMY
Shintaro Narita, Norihiko Tsuchiya, Shinya Maita, Takashi Obara, Kazuyuki Numakura, Hiroshi Tsuruta, Takamitsu Inoue, Yohei Horikawa, Shigeru Satoh, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E937 - E937 2011年04月
研究発表要旨(国際会議)
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PROSTATE CANCER PROGRESSION UNDER HIGH-FAT DIET IS ENHANCED BY MCP-1/CCR2 SIGNALING
Mingguo Huang, Shintaro Narita, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Takamitsu Inoue, Yohei Horikawa, Norihiko Tsuchiya, Shigeru Satoh, Tomonori Habuchi
JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC ) 185 ( 4 ) E115 - E115 2011年04月
研究発表要旨(国際会議)
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A case of ureteral malignant lymphoma diagnosed by laparoscopic needle biopsy.
Kazuyuki Numakura, Norihiko Tsuchiya, Takashi Obara, Hiroshi Tsuruta, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Yohei Horikawa, Shigeru Satoh, Tomonori Habuchi
Japanese journal of clinical oncology 41 ( 3 ) 440 - 2 2011年03月
A pathological diagnosis of a lesion in the ureteral wall is often attended with a difficulty. We report a case of a 54-year-old man who presented a thickening of the ureteral wall and diffuse swelling of paraaortic lymph nodes diagnosed as a non-Hodgkin lymphoma by a laparoscopic needle biopsy. This is a safe and useful technique by which target tissues can be surely obtained.
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Factors increasing quantitative interstitial fibrosis from 0 hr to 1 year in living kidney transplant patients receiving tacrolimus.
Yoshiko Miura, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Takamitsu Inoue, Takashi Obara, Hiroshi Tsuruta, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Atsushi Komatsuda, Hideaki Kagaya, Masatomo Miura, Tomonori Habuchi
Transplantation 91 ( 1 ) 78 - 85 2011年01月
BACKGROUND: This study investigated the increase in interstitial fibrosis (IF) from 0 hr to 1 month and 1 year posttransplantation in biopsy sections and assessed the risk of developing IF in 118 living kidney recipients. METHODS: A quantitative analysis of IF was performed using computer-assisted imaging. The percent IF (%IF) in the cortical region at 0 hr was defined as the baseline, and the increases in %IF at 1 month and 1 year were calculated. Demographics, higher (regimen 1) and lower (regimen 2) target trough concentrations of tacrolimus, and the cytochrome P450 (CYP) 3A5 polymorphism were tested as risk factors. RESULTS: The mean %IF at 0 hr, 1 month, and 1 year was 10.3%+/-4.2%, 15.0%+/-5.8%, and 19.0%+/-7.7%, respectively. %IF increased 1.7- and 2.2-fold from 0 hr to 1 month and 1 year posttransplantation, respectively. At 1 year, the increase was higher in patients with the CYP3A5*3/*3 genotype (nonexpressers), those treated with regimen 1, and those with a lower estimated glomerular filtration rate and higher body mass index. In a multivariate analysis, CYP3A5 nonexpression correlated with the development of IF (odds ratio 2.63, P=0.018). Tacrolimus blood levels in the early stage posttransplantation were higher in nonexpressers than CYP3A5 expressers in both regimens 1 and 2, despite therapeutic drug monitoring. CONCLUSIONS: The higher concentrations of tacrolimus, especially in the nonexpressers treated with regimen 1, might influence the development of IF. This study suggested that a new regimen with lower and narrow target trough levels of tacrolimus or a dosing strategy based on the CYP3A5 genotype is needed to reduce the risk of developing IF.
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What is the most preferred wound site for laparoscopic donor nephrectomy?: a questionnaire assessment.
Mitsuru Saito, Norihiko Tsuchiya, Shinya Maita, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Teruaki Kumazawa, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Takeshi Yuasa, Shigeru Satoh, Tomonori Habuchi
Journal of laparoendoscopic & advanced surgical techniques. Part A 21 ( 6 ) 511 - 5 2011年
INTRODUCTION: Although specimen extraction site selection for laparoscopic donor nephrectomy (LDN) is relatively flexible and is mostly selected by surgeons from the patient's standpoint, the patient's request may differ from the medical worker's recommendation. The cosmetic aspect may also differ with age, gender, and the extent of medical knowledge. We performed an unsigned questionnaire assessment of individual preferences for LDN wound sites. MATERIALS AND METHODS: Between August 2007 and October 2008, we surveyed LDN wound site preferences among 148 physicians, 263 nurses, and 266 outpatients of urology at Akita University Hospital. They were questioned for their age, gender, occupation (medical worker or not), and for the most preferred surgical wound site among the following: A, lower vertical midline: B, upper vertical midline: C, anterior subcostal: D, Pfannenstiel: E, Gibson: and F, subcostal flank. The valid response rate was 93.5% (677/724). RESULTS: Wound sites preferred (ranked in descending order) were F (48.3%), D (25.6%), E (10.5%), A (9.0%), C (5.2%), and B (1.4%). The subcostal flank incision was the most preferred in almost all the categories. Second preferences were Pfannenstiel incisions in women and incisions on the lower abdomen in men. Overall, flank and lower abdominal incisions tended to be preferred, and mid and upper abdominal incisions tended to be avoided. Medical workers selected the subcostal flank and Pfannenstiel incisions more frequently than outpatients. With increasing age, the selection rates of the Gibson and the lower vertical midline incisions increased, whereas the subcostal flank and the Pfannenstiel incisions decreased. CONCLUSIONS: The subcostal flank was the most preferred LDN sites. Age, gender, and the extent of medical knowledge may influence the individual preferences for LDN wound sites.
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AL-5 サイトカインシグナルを介した高脂肪食摂取下の前立腺癌進展機序の解明(第4回ヤングリサーチグラント受賞者記念講演,第99回日本泌尿器科学会総会)
成田 伸太郎, 黄 明国, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 279 - 279 2011年
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OP-001 食事による前立腺癌xenograft増殖とMCP-1/CCR2の関与(前立腺腫瘍/基礎,一般演題口演,第99回日本泌尿器科学会総会)
黄 明国, 成田 伸太郎, 鶴田 大, 井上 高光, 堀川 洋平, 土谷 順彦, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 341 - 341 2011年
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OP-073 腎盂尿管癌に対する腎尿管全摘除術の予後因子の検討(腎盂・尿管腫瘍,一般演題口演,第99回日本泌尿器科学会総会)
堀川 洋平, 千葉 修司, 米田 真也, 高橋 誠, 沼倉 一幸, 鶴田 大, 小原 崇, 井上 高光, 成田 伸太郎, 土谷 順彦, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 353 - 353 2011年
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PP-206 国際前立腺症状スコア(IPSS)はPSAグレーゾーン症例の前立腺生検癌検出率と逆相関する(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
小原 崇, 小峰 直樹, 高橋 誠, 米田 真也, 沼倉 一幸, 鶴田 大, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 佐藤 滋, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 438 - 438 2011年
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PP-474 BCG(Connaught株)膀注療法におけるレボフロキサシンの効果の検討(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
沼倉 一幸, 米田 真也, 小原 崇, 鶴田 大, 齋藤 満, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 佐藤 滋, 石田 俊哉, 松尾 重樹, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 482 - 482 2011年
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PP-816 SNPアレイを用いた転移性前立腺癌の生存期間に関与する癌関連遺伝子の探索(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)
土谷 順彦, 成田 伸太郎, 井上 高光, 鶴田 大, 沼倉 一幸, 堀川 洋平, 畠山 真吾, 大山 力, 荒井 陽一, 小川 修, 斎藤 誠一, 松井 茂之, 羽渕 友則
日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 ) 102 ( 2 ) 540 - 540 2011年
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移植後1ヵ月までのグラセプタ薬物動態におよぼすCYP3A5遺伝子多型の影響
佐藤 滋, 齋藤 満, 沼倉 一幸, 小峰 直樹, 高橋 誠, 小原 崇, 鶴田 大, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 羽渕 友則, 加賀谷 英彰, 三浦 昌朋
移植 ( (一社)日本移植学会 ) 45 ( 総会臨時 ) 186 - 186 2010年10月