研究等業績 - その他 - 成田　伸太郎

POLYMORPHISMS IN THE XRCC1 AND MDM2 GENES MAY BE ASSOCIATED WITH RECURRENCE IN NON-MUSCLE INVASIVE BLADDER CANCER

Yohei Horikawa, Takamitsu Inoue, Shintaro Narita, Takashi Obara, Mitsuru Saito, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E306 - E306   2010年04月

研究発表要旨（国際会議）  

TWEAK-FN14 SIGNALING REGULATES ANDROGEN-INDEPENDENT PROSTATE CANCER CELL INVASIVENESS AND CORRELATES WITH POOR PATIENT OUTCOME

Huang Mingguo, Shintaro Narita, Ma Zhiyong, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Mitsuru Saito, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E213 - E213   2010年04月

研究発表要旨（国際会議）  

画像解析による移植腎線維組織の定量的測定と線維増生に関連する因子の解析

三浦 喜子, 齋藤 満, 沼倉 一幸, 鶴田 大, 小原 崇, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 羽渕 友則, 加賀谷 英彰, 三浦 昌朋, 佐藤 滋

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 )  101 ( 2 ) 220 - 220   2010年02月

AVP-010 秋田大学におけるドナー腎摘術の変遷から : 最良の術式は存在するか?(副腎・腎・尿管,総会賞応募ビデオ,第98回日本泌尿器科学総会)

土谷 龍彦, 成田 伸太郎, 井上 高光, 齋藤 満, 鶴田 大, 小原 崇, 沼倉 一幸, 堀川 洋平, 佐藤 滋, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  101 ( 2 ) 169 - 169   2010年

DOI

The novel tumor-suppressor Mel-18 in prostate cancer: its functional polymorphism, expression and clinical significance.

Wei Wang, Takeshi Yuasa, Norihiko Tsuchiya, Zhiyong Ma, Shinya Maita, Shintaro Narita, Teruaki Kumazawa, Takamitsu Inoue, Hiroshi Tsuruta, Yohei Horikawa, Mitsuru Saito, Weilie Hu, Osamu Ogawa, Tomonori Habuchi

International journal of cancer   125 ( 12 ) 2836 - 43   2009年12月

Mel-18 is a member of the polycomb group (PcG) proteins, which are chromatin regulatory factors and play important roles in development and oncogenesis. This study was designed to investigate the clinical and prognostic significance of Mel-18 in patients with prostate cancer. A total of 539 native Japanese subjects consisting of 393 prostate cancer patients and 146 controls were enrolled in this study. Mel-18 genotyping was analyzed using a PCR-RFLP method and an automated sequencer using the GENESCAN software. Immunohistochemistry revealed that Mel-18 expression was diminished in high grade and high stage prostate cancers. Moreover, patients with positive Mel-18 expression had significantly longer PSA recurrence-free survival than patients negative for Mel-18 expression (p=0.038). A Mel-18 1805A/G SNP was located in the 3' untranslated region and was predicted to alter the secondary structure of the mRNA. Mel-18 mRNA expression of the 1805A allele was clearly higher than expression of the 1805G allele by allele specific quantitative RT-PCR. In multivariate analysis, a homozygous G allele genotype and negative Mel-18 expression were independent risk factors predicting high PSA recurrence after radical prostatectomy, with HRs of 2.757 (p=0.022) and 2.271 (p=0.045), respectively. Moreover, the G allele was also an independent predictor of poor cancer-specific survival with an HR of 4.658 (p=0.019) for patients with stage D2 prostate cancer. This is the first study to provide important evidence demonstrating that Mel-18 is a tumor suppressor and possible therapeutic target, as well as a diagnostic marker for poor prognosis in prostate cancer patients.

DOI PubMed

Laparoscopic nephrectomy in patients with renal vein and/or inferior vena cava anomalies: Video presentation.

Tomonori Habuchi, Shintaro Narita, Norihiko Tsuchiya, Teruaki Kumazawa, Yohei Horikawa, Shigeru Sato

International journal of urology : official journal of the Japanese Urological Association   16 ( 11 ) 854 - 854   2009年11月

Laparoscopic nephrectomy is a standard surgery for the treatment of many types of renal tumor, renal pelvic tumor, and benign disease. Renal vein and inferior vena cava anomalies are not uncommon, having been detected at an incidence of 2-17%. With the increasing number of patients undergoing laparoscopic nephrectomy, surgeons have more opportunities to encounter major anomalies of the renal vein and inferior vena cava. This video presents images of the management of the renal pedicle in laparoscopic nephrectomy in cases where there were anomalies of the renal vein and inferior vena cava. Patient 1 had left renal tumor with the left inferior vena cava, patient 2 had left ureteral tumor with double inferior vena cava, patient 3 had left renal tumor with double inferior vena cava and a circumaortic renal vein, patient 4 had left renal tumor with a retro-aortic renal vein, and patient 5 had left renal tumor with a circumaortic renal vein. Multiple renal arteries were present in patients 3, 4, and 5. In laparoscopic nephrectomy complicated by anomalies of the renal vein and inferior vena cava, (i) surgical staff should be alert for the potential presence of aberrant veins and multiple renal arteries that may not be visualized in preoperative imaging. (ii) An anterior transperitoneal approach is well-suited in the understanding of positional relationships of vessels and anatomical landmarks in cases of vascular anomalies. (iii) With recent advances in diagnostic imaging modalities, such as multislice computed tomography (CT) and 3-D CT, it has become easier to identify the major arterial and venous anomalies. However, intraoperative observation and assessment remain important and mandatory in the management of smaller anomalous vessels accompanied by major anomalies.

DOI PubMed

Clinical significance of a single nucleotide polymorphism and allelic imbalance of matrix metalloproteinase-1 promoter region in prostate cancer.

Norihiko Tsuchiya, Shintaro Narita, Teruaki Kumazawa, Takamitsu Inoue, Zhiyong Ma, Hiroshi Tsuruta, Mitsuru Saito, Yohei Horikawa, Takeshi Yuasa, Shigeru Satoh, Osamu Ogawa, Tomonori Habuchi

Oncology reports   22 ( 3 ) 493 - 9   2009年09月

Matrix metalloproteinase-1 (MMP-1) is associated with cancer invasion and metastasis. The 2G allele of the polymorphic site in the MMP-1 promoter was demonstrated to have a higher transcription activity than the 1G allele. Allelic imbalance (AI) at 11q22 harboring the MMP-1 is frequently observed in various cancers and may be associated with an advanced disease. We conducted a case-control study to determine the association of the MMP-1 genotype with susceptibility to prostate cancer involving 283 prostate cancer patients and 251 controls. Furthermore, AI, retention allele of the MMP-1 promoter, and MMP-1 protein expression were analyzed in 77 prostate cancer specimens. The MMP-1 promoter polymorphism was associated with neither susceptibility nor progression of prostate cancer. Tumors with 1G/2G and 2G/2G genotypes had a significantly higher MMP-1 expression level compared to those with 1G/1G genotype (P=0.006 and 0.013, respectively). AI at 11q22 was observed in 13 (40.6%) of 32 informative cases. Retention of the 1G and 2G alleles were observed in 4 and 9 cases, respectively. AI was significantly associated with the Gleason score (P=0.003) and pathological stage (P=0.022). In addition, retention of the 2G allele showed a significant association with the pathological stage (P=0.026). AI at 11q22 region, retention of the 2G allele, specifically appeared to be involved in the progression of prostate cancer. However, the presence of the 2G allele of the MMP-1 promoter polymorphism itself seems to influence neither the susceptibility nor the progression of prostate cancer.

PubMed

高齢生体腎移植レシピエントの臨床成績と薬物動態

佐藤 滋, 齋藤 満, 三浦 嘉子, 沼倉 一幸, 小原 崇, 鶴田 大, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 羽渕 友則, 三浦 昌朋

移植 ( (一社)日本移植学会 )  44 ( 総会臨時 ) 287 - 287   2009年09月

A GENETIC POLYMORPHISM OF THE OSTEOPROTEGERIN GENE IS ASSOCIATED WITH AN INCREASED RISK OF ADVANCED PROSTATE CANCER

Naofumi Narita, Takeshi Yuasa, Norihiko Tsuchiya, Teruaki Kumazawa, Shintaro Narita, Takamitsu Inoue, Zhiyong Ma, Mitsuru Saito, Yohei Horikawa, Shigeru Satoh, Osamu Ogawa, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 168 - 168   2009年04月

研究発表要旨（国際会議）  

EVALUATION OF OUTCOMES AND GENETIC PREDICTIVE FACTORS FOR PROGNOSIS AND TOXICITY IN HORMONE-REFRACTORY PROSTATE CANCER PATIENTS FOLLOWING COMBINATION THERAPY WITH DOCETAXEL, ESTRAMUSTINE, AND CARBOPLATIN

Shintaro Narita, Hiroshi Tsuruta, Mitsuru Saito, Teruaki Kumazawa, Yohei Horikawa, Takeshi Yuasa, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 293 - 293   2009年04月

研究発表要旨（国際会議）  

INFLUENCE OF POLYMORPHISMS AND EXPRESSION OF CHROMOGRANIN A AND ENDOTHELIN-1 ON THE DEVELOPMENT AND PROGRESSION OF PROSTATE CANCER

Zhiyong Ma, Norihiko Tsuchiya, Takeshi Yuasa, Shintaro Narita, Yohei Horikawa, Teruaki Kumazawa, Mitsuru Saito, Takashi Obara, Hiroshi Tsuruta, Naoko Kawata, Shigeru Satoh, Osamu Ogawa, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 49 - 50   2009年04月

研究発表要旨（国際会議）  

MICROVASCULAR TUMOR INVASION AS A PROGNOSTIC FACTOR FOR TUMOR RECURRENCE AFTER RADICAL NEPHRECTOMY IN PATIENTS WITH RENAL CELL CARCINOMA

Norihiko Tsuchiya, Takashi Obara, Kojiro Nishio, Teruaki Kumazawa, Shintaro Narita, Yohei Horikawa, Takamitsu Inoue, Mitsuru Saito, Takeshi Yuasa, Shigeru Satoh, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 213 - 214   2009年04月

研究発表要旨（国際会議）  

OVEREXPRESSION OF BCL-2 SEEN IN RESIDUAL PROSTATE CANCER AFTER NEOADJUVANT CHEMOHORMONAL THERAPY WITH DOCETAXEL FOR LOCALLY ADVANCED PROSTATE CANCER

Teruaki Kumazawa, Hiroshi Tsuruta, Mitsuru Saito, Shintaro Narita, Yohei Horikawa, Takeshi Yuasa, Norihiko Tsuchiya, Shigeru Satoh, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 97 - 97   2009年04月

研究発表要旨（国際会議）  

POLYMORPHISMS OF FIBROBLAST GROWTH FACTOR RECEPTOR 4 HAVE ASSOCIATION WITH THE DEVELOPMENT OF PROSTATE CANCER AND BENIGN PROSTATIC HYPERPLASIA AND THE PROGRESSION OF PROSTATE CANCER IN A JAPANESE POPULATION

Zhiyong Ma, Norihiko Tsuchiya, Takeshi Yuasa, Shintaro Narita, Yohei Horikawa, Teruaki Kumazawa, Mitsuru Saito, Takashi Obara, Hiroshi Tsuruta, Naoko Kawata, Shigeru Satoh, Osamu Ogawa, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 48 - 49   2009年04月

研究発表要旨（国際会議）  

SIMULTANEOUS LAPAROSCOPIC TREATMENT FOR URETEROPELVIC JUNCTION OBSTRUCTION ACCOMPANIED BY NEPHROLITHIASIS

Norihiko Tsuchiya, Takamitsu Inoue, Takeshi Yuasa, Sohei Kanda, Teruaki Kumazawa, Shintaro Narita, Mitsuru Saito, Hiroshi Tsuruta, Shigeru Satoh, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 736 - 736   2009年04月

研究発表要旨（国際会議）  

THE NOVEL TUMOR-SUPPRESSOR MEL-18 IN PROSTATE CANCER: ITS FUNCTIONAL POLYMORPHISM, EXPRESSION, AND CLINICAL SIGNIFICANCE

Wei Wang, Takeshi Yuasa, Norihiko Tsuchiya, Zhiyong Ma, Shinya Maita, Teruaki Kumazawa, Shintaro Narita, Takamitsu Inoue, Mitsuru Saito, Hiroshi Tsuruta, Yohei Horikawa, Jian Huang, Shigeru Satoh, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  181 ( 4 ) 50 - 50   2009年04月

研究発表要旨（国際会議）  

移植早期の高齢者レシピエントにおけるタクロリムス(TAC)、セルセプト(MMF)、プレドニゾロン(PDS)の薬物動態

佐藤 滋, 齋藤 満, 鶴田 大, 熊澤 光明, 成田 伸太郎, 堀川 洋平, 湯浅 健, 土谷 順彦, 三浦 昌朋, 加賀谷 英彰, 鈴木 敏夫, 羽渕 友則

日本泌尿器科学会雑誌 ( (一社)日本泌尿器科学会 )  100 ( 2 ) 257 - 257   2009年02月

Cystoprostatectomy as a treatment of prostate cancer involving the bladder neck.

Teruaki Kumazawa, Norihiko Tsuchiya, Mitsuru Saito, Takamitsu Inoue, Shintaro Narita, Youhei Horikawa, Takeshi Yuasa, Shigeru Satoh, Tetsuro Kato, Hiroshi Nanjyo, Tomonori Habuchi

Urologia internationalis   83 ( 2 ) 141 - 5   2009年

OBJECTIVE: We evaluated the clinicopathological findings and short- and long-term outcomes of prostate cancer (PCa) patients with bladder neck invasion who underwent cystoprostatectomy. PATIENTS AND METHODS: Between 1989 and 2005, we performed 17 cystoprostatectomies for PCa patients having bladder neck invasion without distant visceral or distant lymph node metastasis. Of the 17 patients, 11 were treated with neoadjuvant hormone therapy and all patients were treated with adjuvant hormone therapy immediately after surgery. RESULTS: All 7 patients in whom pelvic lymph node swelling was identified by preoperative imaging studies had pathological lymph node metastasis. Of the 10 patients judged as cN0 preoperatively, 7 (70.0%) had lymph node metastasis. Although local recurrence was found in 2 (11.8%) patients, no additional urinary diversion or inconvenient urinary symptoms due to PCa progression were observed in any patients. The 5-year prostate-specific antigen recurrence-free survival rate was 62.2%. Cause-specific survival at 5 years after surgery was 87.1%. The 5-year cause-specific survival rate of node-positive patients was 92.3%. CONCLUSION: Cystoprostatectomy followed by immediate hormone therapy may be a feasible treatment option to achieve excellent local control for patients with previously untreated PCa, even in the presence of pelvic lymph node metastasis.

DOI PubMed

APP-029-AM Survivin遺伝子多型が膀胱癌の発症リスクと予後に及ぼす影響についての検討(総会賞応募ポスター,第97回日本泌尿器科学会総会)

河田 真子, 堀川 洋平, 三浦 喜子, 米田 真也, 鶴田 大, 齋藤 満, 井上 高光, 成田 伸太郎, 熊澤 光明, 湯浅 健, 佐藤 滋, 土谷 順彦, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  100 ( 2 ) 139 - 139   2009年

DOI

APP-050-AM 前立腺癌におけるchromogranin Aならびにendothelin-1の臨床的意義(総会賞応募ポスター,第97回日本泌尿器科学会総会)

馬 智勇, 土谷 順彦, 湯浅 健, 成田 伸太郎, 堀川 洋平, 熊澤 光明, 鶴田 大, 齋藤 満, 河田 真子, 井上 高光, 佐藤 滋, 小川 修, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  100 ( 2 ) 149 - 149   2009年

DOI