研究等業績 - その他 - 成田　伸太郎

What is the most preferred wound site for laparoscopic donor nephrectomy?: a questionnaire assessment.

Mitsuru Saito, Norihiko Tsuchiya, Shinya Maita, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Teruaki Kumazawa, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Takeshi Yuasa, Shigeru Satoh, Tomonori Habuchi

Journal of laparoendoscopic & advanced surgical techniques. Part A   21 ( 6 ) 511 - 5   2011年

INTRODUCTION: Although specimen extraction site selection for laparoscopic donor nephrectomy (LDN) is relatively flexible and is mostly selected by surgeons from the patient's standpoint, the patient's request may differ from the medical worker's recommendation. The cosmetic aspect may also differ with age, gender, and the extent of medical knowledge. We performed an unsigned questionnaire assessment of individual preferences for LDN wound sites. MATERIALS AND METHODS: Between August 2007 and October 2008, we surveyed LDN wound site preferences among 148 physicians, 263 nurses, and 266 outpatients of urology at Akita University Hospital. They were questioned for their age, gender, occupation (medical worker or not), and for the most preferred surgical wound site among the following: A, lower vertical midline: B, upper vertical midline: C, anterior subcostal: D, Pfannenstiel: E, Gibson: and F, subcostal flank. The valid response rate was 93.5% (677/724). RESULTS: Wound sites preferred (ranked in descending order) were F (48.3%), D (25.6%), E (10.5%), A (9.0%), C (5.2%), and B (1.4%). The subcostal flank incision was the most preferred in almost all the categories. Second preferences were Pfannenstiel incisions in women and incisions on the lower abdomen in men. Overall, flank and lower abdominal incisions tended to be preferred, and mid and upper abdominal incisions tended to be avoided. Medical workers selected the subcostal flank and Pfannenstiel incisions more frequently than outpatients. With increasing age, the selection rates of the Gibson and the lower vertical midline incisions increased, whereas the subcostal flank and the Pfannenstiel incisions decreased. CONCLUSIONS: The subcostal flank was the most preferred LDN sites. Age, gender, and the extent of medical knowledge may influence the individual preferences for LDN wound sites.

DOI PubMed

AL-5 サイトカインシグナルを介した高脂肪食摂取下の前立腺癌進展機序の解明(第4回ヤングリサーチグラント受賞者記念講演,第99回日本泌尿器科学会総会)

成田 伸太郎, 黄 明国, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 279 - 279   2011年

DOI

OP-001 食事による前立腺癌xenograft増殖とMCP-1/CCR2の関与(前立腺腫瘍/基礎,一般演題口演,第99回日本泌尿器科学会総会)

黄 明国, 成田 伸太郎, 鶴田 大, 井上 高光, 堀川 洋平, 土谷 順彦, 佐藤 滋, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 341 - 341   2011年

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OP-073 腎盂尿管癌に対する腎尿管全摘除術の予後因子の検討(腎盂・尿管腫瘍,一般演題口演,第99回日本泌尿器科学会総会)

堀川 洋平, 千葉 修司, 米田 真也, 高橋 誠, 沼倉 一幸, 鶴田 大, 小原 崇, 井上 高光, 成田 伸太郎, 土谷 順彦, 佐藤 滋, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 353 - 353   2011年

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PP-206 国際前立腺症状スコア(IPSS)はPSAグレーゾーン症例の前立腺生検癌検出率と逆相関する(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

小原 崇, 小峰 直樹, 高橋 誠, 米田 真也, 沼倉 一幸, 鶴田 大, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 佐藤 滋, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 438 - 438   2011年

DOI

PP-474 BCG(Connaught株)膀注療法におけるレボフロキサシンの効果の検討(一般演題ポスター発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

沼倉 一幸, 米田 真也, 小原 崇, 鶴田 大, 齋藤 満, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 佐藤 滋, 石田 俊哉, 松尾 重樹, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 482 - 482   2011年

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PP-816 SNPアレイを用いた転移性前立腺癌の生存期間に関与する癌関連遺伝子の探索(発表・討論,一般演題ポスター,第99回日本泌尿器科学会総会)

土谷 順彦, 成田 伸太郎, 井上 高光, 鶴田 大, 沼倉 一幸, 堀川 洋平, 畠山 真吾, 大山 力, 荒井 陽一, 小川 修, 斎藤 誠一, 松井 茂之, 羽渕 友則

日本泌尿器科学会雑誌 ( 一般社団法人 日本泌尿器科学会 )  102 ( 2 ) 540 - 540   2011年

DOI

移植後1ヵ月までのグラセプタ薬物動態におよぼすCYP3A5遺伝子多型の影響

佐藤 滋, 齋藤 満, 沼倉 一幸, 小峰 直樹, 高橋 誠, 小原 崇, 鶴田 大, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 羽渕 友則, 加賀谷 英彰, 三浦 昌朋

移植 ( (一社)日本移植学会 )  45 ( 総会臨時 ) 186 - 186   2010年10月

腎移植長期生着のために何が必要か 画像解析装置による定量的線維増生に及ぼす因子からの検討

三浦 喜子, 齋藤 満, 沼倉 一幸, 小原 崇, 鶴田 大, 井上 高光, 成田 伸太郎, 堀川 洋平, 土谷 順彦, 羽渕 友則, 小松田 敦, 加賀谷 英彰, 三浦 昌朋, 佐藤 滋

移植 ( (一社)日本移植学会 )  45 ( 総会臨時 ) 158 - 158   2010年10月

Clinical significance of polymorphism and expression of chromogranin a and endothelin-1 in prostate cancer.

Zhiyong Ma, Norihiko Tsuchiya, Takeshi Yuasa, Mingguo Huang, Takashi Obara, Shintaro Narita, Yohei Horikawa, Hiroshi Tsuruta, Mitsuru Saito, Shigeru Satoh, Osamu Ogawa, Tomonori Habuchi

The Journal of urology   184 ( 3 ) 1182 - 8   2010年09月

PURPOSE: We investigated the clinical significance of chromogranin A and endothelin-1 polymorphism and expression in prostate cancer. MATERIALS AND METHODS: We analyzed 2 CHGA polymorphisms by polymerase chain reaction-restriction fragment length polymorphism in DNA samples of 435 patients with prostate cancer and 316 age matched male controls. Chromogranin A and endothelin-1 expression was evaluated by immunohistochemistry in prostate specimens of 114 men with prostate cancer who underwent radical retropubic prostatectomy and in 27 with bladder cancer who underwent radical cystectomy and served as controls. RESULTS: For the CHGA Glu264Asp polymorphism men with the GG genotype were at 2.05 times higher risk for prostate cancer than men with the CC genotype (p = 0.014). In men with prostate cancer higher chromogranin A immunohistochemistry grade was associated with higher stage and higher Gleason score (p = 0.011 and 0.044, respectively). Multivariate analysis showed that chromogranin A immunohistochemistry grade was an independent variable for predicting biochemical failure after radical prostatectomy (p = 0.023). Higher endothelin-1 expression was observed in prostate cancers (p = 0.011), especially those with a higher Gleason score (p = 0.042). There was no significant relationship between chromogranin A polymorphisms, and chromogranin A and endothelin-1 expression. CONCLUSIONS: Polymorphism and expression of chromogranin A and endothelin-1 have clinical significance in prostate cancer. Chromogranin A expression was an independent predictor of biochemical failure after prostatectomy in patients with localized prostate cancer.

DOI PubMed

Relationship between bone mineral density and androgen-deprivation therapy in Japanese prostate cancer patients.

Takeshi Yuasa, Shinya Maita, Norihiko Tsuchiya, Zhiyong Ma, Shintaro Narita, Yohei Horikawa, Shinya Yamamoto, Junji Yonese, Iwao Fukui, Shunji Takahashi, Kiyohiko Hatake, Tomonori Habuchi

Urology   75 ( 5 ) 1131 - 7   2010年05月

OBJECTIVES: To examine Japanese patients who had received androgen-deprivation therapy (ADT) for longer periods, as it is known that ADT of patients with prostate cancer reduces their bone mineral density (BMD). However, our previous cross-sectional study revealed that short-term ADT (average, 23.5 months) does not significantly increase the prevalence of osteoporosis in Japanese patients. METHODS: The subjects consisted of 201 native Japanese patients with prostate cancer. They comprised 113 ADT-treated and 88 hormone-naive patients. Lumbar spine, total hip, and femoral neck BMDs were measured by dual-energy x-ray absorptiometry and expressed in standard deviation units relative to the scores of young adult men (T-score) or age-matched men (Z-score). Serum levels of bone metabolism markers were also measured. RESULTS: The ADT-treated patients had significantly lower BMD values, T-scores, and even Z-scores than the hormone-naive patients (P <.001). For patients who were hormone-naive, ADT-treated for less than 2 years, and ADT-treated for more than 2 years, the osteoporosis prevalence was 4.5% (4/88), 12.1% (4/33), and 10.8% (4/37), respectively. The ADT-treated patients had significantly higher serum amino-terminal telopeptide levels than the hormone-naive patients (P = .014), but significantly lower serum carboxy-terminal telopeptide of type-I collagen levels than the ADT-treated patients with bone metastasis (P <.001). CONCLUSIONS: Our cross-sectional study confirmed that both ADT-treated and hormone-naive Japanese patients with prostate cancer have low rates of osteoporosis. These findings are different from those of studies in western countries. Genetic and hormonal or other environmental factors may result in population differences in the characteristics of prostate cancer and BMD.

DOI PubMed

AN ORAL SMALL-MOLECULE MULTITARGETED RECEPTOR TYROSINE KINASE INHIBITOR, SUNITINIB, DEMONSTRATES GROWTH INHIBITION IN BONE METASTASIS OF RENAL CELL CANCER IN VIVO

Shinya Maita, Takeshi Yuasa, Norihiko Tsuchiya, Yoko Mitobe, Shintaro Narita, Yohei Horikawa, Iwao Fukui, Kiyohiko Hatake, Shinya Kimura, Taira Maekawa, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E30 - E30   2010年04月

研究発表要旨（国際会議）  

CLINICAL RISK FACTORS FOR INCREASED INTERSTITIAL FIBROSIS BY COMPUTERIZED IMAGE ANALYSIS AFTER RENAL TRANSPLANTATION

Yoshiko Miura, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Hiroshi Tsuruta, Takashi Obara, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E802 - E802   2010年04月

研究発表要旨（国際会議）  

Clinical Risk Factors for Increased Interstitial Fibrosis by Computerized Image Analysis after Renal Transplantation

Yoshiko Miura, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Shintaro Narita, Yohei Horika, Norihiko Tsuchiya, Tomonori Habuchi

AMERICAN JOURNAL OF TRANSPLANTATION ( WILEY-BLACKWELL PUBLISHING, INC )  10   408 - 408   2010年04月

研究発表要旨（国際会議）  

COMBINATION THERAPY CONSISTING OF GEMCITABINE, CARBOPLATIN, AND DOCETAXEL (GCD) AS AN ACTIVE TREATMENT FOR ADVANCED UROTHELIAL CELL CARCINOMA

Hiroshi Tsuruta, Yohei Horikawa, Shintaro Narita, Mitsuru Saito, Takashi Obara, Kazuyuki Numakura, Shigeru Sato, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E659 - E659   2010年04月

研究発表要旨（国際会議）  

GENETIC POLYMORPHISM INFLUENCES INDIVIDUAL VARIATIONS IN SERUM TESTOSTERONE LEVELS IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY

Shintaro Narita, Kazuyuki Numakura, Takashi Obara, Hiroshi Tsuruta, Mitsuru Saito, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E801 - E801   2010年04月

研究発表要旨（国際会議）  

Impact of Clinical Characteristics and Pretransplant Urinary Bladder Capacity on Urodynamics One Year Posttransplantation in Adult Recipients

Takashi Obara, Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Hiroshi Tsuruta, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi

AMERICAN JOURNAL OF TRANSPLANTATION ( WILEY-BLACKWELL PUBLISHING, INC )  10   254 - 254   2010年04月

研究発表要旨（国際会議）  

Incidence, Clinical Risk Factors, Tacrolimus Pharmacokinetics, and Genomic Polymorphisms in Post Transplant Hyperuricemia in Early Stage Renal Transplant Recipients

Kazuyuki Numakura, Shigeru Satoh, Mitsuru Saito, Norihiko Tsuchiya, Yoshiko Miura, Takashi Obara, Hiroshi Tsuruta, Shintaro Narita, Yohei Horikawa, Tomonori Habuchi

AMERICAN JOURNAL OF TRANSPLANTATION ( WILEY-BLACKWELL PUBLISHING, INC )  10   528 - 528   2010年04月

研究発表要旨（国際会議）  

INSULIN-LIKE GROWTH FACTOR-I (IGF-I) POLYMORPHISMS PREDICT THE SURVIVAL OF PROSTATE CANCER PATIENTS WITH BONE METASTASIS AT INITIAL PRESENTATION

Norihiko Tsuchiya, Shintaro Narita, Zhiyong Ma, Yohei Horikawa, Hiroshi Tsuruta, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Takamitsu Inoue, Osamu Ogawa, Tomonori Habuchi

JOURNAL OF UROLOGY ( ELSEVIER SCIENCE INC )  183 ( 4 ) E797 - E798   2010年04月

研究発表要旨（国際会議）  

No Impact of Age on Dose-Adjusted Pharmacokinetics of Tacrolimus, Mycophenolic Acid and Prednisolone One Month after Renal Transplantation

Shigeru Satoh, Mitsuru Saito, Kazuyuki Numakura, Hiroshi Tsuruta, Takashi Obara, Takamitsu Inoue, Shintaro Narita, Yohei Horikawa, Norihiko Tsuchiya, Tomonori Habuchi, Hideaki Kagaya, Masatomo Miura

AMERICAN JOURNAL OF TRANSPLANTATION ( WILEY-BLACKWELL PUBLISHING, INC )  10   322 - 322   2010年04月

研究発表要旨（国際会議）