研究者詳細 - 南條　博

十二指腸球部に60mm大の有茎性の粘膜下病変を認められた．Brunner腺過形成が疑われたが，病変の大きさから切除を検討された．しかし，本人に切除の希望がなかったため，経過観察をされた．診断から11年後，心窩部痛をきたし，CTで同病変の十二指腸水平部への嵌頓を認めた．そこで，病変をESDで切除した上で，開腹で切除検体を回収した．最終的に75mm大のBrunner腺過形成と診断された．Brunner腺過形成は，十二指腸の粘膜下病変として発見されることが多いが，確定診断は容易ではない．したがって，増大傾向がある場合や通過障害の原因となる場合には，腫瘍との鑑別のためにも切除の対象となることがある．今回，経過観察中に増大し，嵌頓をきたした十二指腸Brunner腺過形成を内視鏡的に切除しえたが，病変の体外への回収には開腹手術を要した症例を経験した．

DOI CiNii Research

The usefulness of combining narrow-band imaging with magnifying endoscopy and 18F-fluorodeoxyglucose positron emission tomography for predicting the depth of invasion in superficial esophageal squamous cell carcinoma

Kodama S.

Esophagus ( Esophagus ) 22 ( 3 ) 437 - 443 2025年

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Multiplex Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Distinguishing the Histologic Phenotype of Lung Cancer

Kuriyama S.

Pathobiology ( Pathobiology ) 91 ( 6 ) 383 - 392 2024年12月

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特集1 動脈解離再考! 今こそ全身の動脈解離を網羅する動脈解離の病理所見

畠山遥, 廣嶋優子, 南條博

臨床画像 ( メジカルビュー社 ) 40 ( 9 ) 1046 - 1053 2024年09月

DOI CiNii Research

Clinical Course after Carmustine Wafer Implantation for Newly Diagnosed Adult-type Diffuse Gliomas; A controlled propensity matched analysis of a single center cohort

Ono T.

Journal of Neuro-Oncology ( Journal of Neuro-Oncology ) 168 ( 3 ) 393 - 404 2024年07月

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Epithelial granuloma occurring on the staple-stump after segmentectomy for ovarian cancer lung metastasis

Kuriyama S.

Thoracic Cancer ( Thoracic Cancer ) 15 ( 21 ) 1681 - 1684 2024年07月

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Durability Test of Microtome Blades with the High-Precision Tissue-Sectioning Machine

Satoh H.

International Journal of Automation Technology ( International Journal of Automation Technology ) 18 ( 3 ) 390 - 399 2024年05月

In this study, the durability of microtome blades, used for sectioning paraffin blocks, was evaluated with the goal of improving the quality of sections in pathology tests. First, for the durability test of microtome blades, a sectioning test device that realizes stable sectioning operations was developed. This device comprised precise stages supported by cross-roller guides, achieving sufficient rigidness. This device allowed automated repetitive sectioning and simultaneously measured the principal and thrust cutting forces. Samples embedding porcine kidney and rib tissues were used for the durability test. Two types of blades with different blade edge angles were used. Additionally, the rake face and cross-section of blades, as well as H&E-stained sections, were observed. In the durability test with porcine kidney tissue, good quality sections were obtained even after 100 times of sectioning with both microtome blades, showing sufficient durability. However, in sectioning porcine rib tissue, the microtome blade with a large blade edge angle produced good-quality sections in the initial phase of the durability test; however, defects such as overlapping of folds were observed after 100 times of sectioning. Meanwhile, the microtome blade with a small blade edge angle experienced blade damage from the early phase of the durability test, resulting in the production of unsuitable preparations for pathology tests. These results indicated that the microtome blade with a small blade edge angle lacked durability against hard tissues such as porcine ribs.

DOI CiNii Research

Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity

Ishikawa Y.

Journal of Steroid Biochemistry and Molecular Biology ( Journal of Steroid Biochemistry and Molecular Biology ) 238 2024年04月

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豚肋骨の脱灰試料の薄切におけるミクロトーム刃の耐久性試験

佐々木雄大, 佐藤寛恭, 中前圭人, 南條博, 赤上陽一, 中村竜太, 久住孝幸, 吉野雅彦

精密工学会学術講演会講演論文集 ( 公益社団法人精密工学会 ) 2024S ( 0 ) 383 - 384 2024年02月

本報では、病理診断試料の薄切に用いられるミクロトーム刃の耐久性に影響を及ぼす諸因子についての検討結果を報告する。独自に開発した薄切実験装置を用いて、豚肋骨の脱灰試料を一定切取厚さで繰返し薄切する実験を実施した。繰返し薄切による切削力の変化、刃先の損傷、さらに薄切片の品質の変化を測定し、ミクロトーム刃の硬さや刃先先端角、さらに試験片の特性がミクロトーム刃の耐久性に与える影響を検討した。

DOI CiNii Research

Association between NLRP3 Inflammasome and Tumor-NodeMetastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens

Miyauchi T.

Tohoku Journal of Experimental Medicine ( Tohoku Journal of Experimental Medicine ) 264 ( 4 ) 203 - 213 2024年

The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3–4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3–4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.

DOI PubMed CiNii Research

Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing

Imai K.

General Thoracic and Cardiovascular Surgery ( General Thoracic and Cardiovascular Surgery ) 73 ( 7 ) 506 - 513 2024年

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10年生存が得られている乳腺原発腺様囊胞癌・肺転移の1例

山口歩子, 寺田かおり, 南條博, 森菜緒子, 高橋絵梨子, 今野ひかり, 陰地真晃, 今井一博

日本臨床外科学会雑誌 ( 日本臨床外科学会 ) 85 ( 12 ) 1661 - 1665 2024年

乳腺原発腺様囊胞癌は全乳癌の0.1％程度とされ，リンパ節転移や遠隔転移は非常に稀な組織型である．極めて予後良好とされながら，転移・再発例の報告も散見される．今回，術後5年で肺転移を切除，術後10年で新たな肺結節が出現するも，経過観察のみで長期生存が得られている乳腺原発腺様囊胞癌の1例を経験したため，若干の文献的考察を加えて報告する．症例は69歳，女性．右乳房腫瘤を主訴に前医を受診．精査の結果，右乳癌（腺様囊胞癌），cT2N0M0 cStage IIA，トリプルネガティブと診断した．乳房全切除術+腋窩リンパ節郭清（level I）ののち，術後補助化学療法を行った．術後5年で右肺上葉に結節が出現し，当院呼吸器外科を紹介受診．診断と治療を兼ね肺区域切除を施行，乳腺腺様囊胞癌・肺転移と診断された．当科で無治療経過観察中，術後10年に新規肺結節が出現したが，経過観察のみで増大なく，他臓器転移も認めていない．

DOI CiNii Research

Macrophage numbers in the marginal area of sarcomas predict clinical prognosis

Umakoshi M.

Scientific Reports ( Scientific Reports ) 13 ( 1 ) 2023年12月

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Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report

Sasagawa H.

Journal of Cancer Research and Clinical Oncology ( Journal of Cancer Research and Clinical Oncology ) 149 ( 16 ) 15091 - 15094 2023年11月

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Preoperative neoadjuvant chemoradiotherapy provides borderline resectable thoracic esophageal cancer with equivalent treatment results as clinically T3 thoracic esophageal cancer

Wakita A.

Annals of Gastroenterological Surgery ( Annals of Gastroenterological Surgery ) 7 ( 6 ) 904 - 912 2023年11月