研究等業績 - その他 - 南條　博

Familial adenomatous polyposis family with clustering of psychiatric disorders

Funaki M.

Japanese Journal of Clinical Oncology ( Japanese Journal of Clinical Oncology )  55 ( 4 ) 435 - 439   2025年04月

DOI

Evaluation of Grading Estrogen Receptors in Breast Cancer Using Fully Automated Rapid Immunohistochemistry Based on Alternating-Current Electric Field Technology

Kudo C.

Cancers ( Cancers )  17 ( 3 )   2025年02月

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Prognostic Value of Cancer-Associated Fibroblast Marker Expression in the Intratumoral and Marginal Areas of Soft Tissue Sarcoma

Umakoshi M.

Pathobiology ( Pathobiology )  92 ( 1 )   2025年02月

DOI

嵌頓をきたした十二指腸のBrunner腺過形成を内視鏡的に切除しえた１例（動画付き）

佐藤 真生, 吉田 樹, 松橋 保, 高橋 壮, 福田 翔, 南條 博, 廣嶋 優子, 飯島 克則

日本消化器内視鏡学会雑誌 ( 一般社団法人 日本消化器内視鏡学会 )  67 ( 2 ) 140 - 148   2025年

<p>十二指腸球部に60mm大の有茎性の粘膜下病変を認められた．Brunner腺過形成が疑われたが，病変の大きさから切除を検討された．しかし，本人に切除の希望がなかったため，経過観察をされた．診断から11年後，心窩部痛をきたし，CTで同病変の十二指腸水平部への嵌頓を認めた．そこで，病変をESDで切除した上で，開腹で切除検体を回収した．最終的に75mm大のBrunner腺過形成と診断された．Brunner腺過形成は，十二指腸の粘膜下病変として発見されることが多いが，確定診断は容易ではない．したがって，増大傾向がある場合や通過障害の原因となる場合には，腫瘍との鑑別のためにも切除の対象となることがある．今回，経過観察中に増大し，嵌頓をきたした十二指腸Brunner腺過形成を内視鏡的に切除しえたが，病変の体外への回収には開腹手術を要した症例を経験した．</p>

DOI CiNii Research

The usefulness of combining narrow-band imaging with magnifying endoscopy and 18F-fluorodeoxyglucose positron emission tomography for predicting the depth of invasion in superficial esophageal squamous cell carcinoma

Kodama S.

Esophagus ( Esophagus )    2025年

DOI

Multiplex Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Distinguishing the Histologic Phenotype of Lung Cancer

Kuriyama S.

Pathobiology ( Pathobiology )  91 ( 6 ) 383 - 392   2024年12月

DOI

特集1 動脈解離再考! 今こそ全身の動脈解離を網羅する 動脈解離の病理所見

畠山 遥, 廣嶋 優子, 南條 博

臨床画像 ( メジカルビュー社 )  40 ( 9 ) 1046 - 1053   2024年09月

DOI CiNii Research

Clinical Course after Carmustine Wafer Implantation for Newly Diagnosed Adult-type Diffuse Gliomas; A controlled propensity matched analysis of a single center cohort

Ono T.

Journal of Neuro-Oncology ( Journal of Neuro-Oncology )  168 ( 3 ) 393 - 404   2024年07月

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Epithelial granuloma occurring on the staple-stump after segmentectomy for ovarian cancer lung metastasis

Kuriyama S.

Thoracic Cancer ( Thoracic Cancer )  15 ( 21 ) 1681 - 1684   2024年07月

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Durability Test of Microtome Blades with the High-Precision Tissue-Sectioning Machine

Satoh H.

International Journal of Automation Technology ( International Journal of Automation Technology )  18 ( 3 ) 390 - 399   2024年05月

<p>In this study, the durability of microtome blades, used for sectioning paraffin blocks, was evaluated with the goal of improving the quality of sections in pathology tests. First, for the durability test of microtome blades, a sectioning test device that realizes stable sectioning operations was developed. This device comprised precise stages supported by cross-roller guides, achieving sufficient rigidness. This device allowed automated repetitive sectioning and simultaneously measured the principal and thrust cutting forces. Samples embedding porcine kidney and rib tissues were used for the durability test. Two types of blades with different blade edge angles were used. Additionally, the rake face and cross-section of blades, as well as H&E-stained sections, were observed. In the durability test with porcine kidney tissue, good quality sections were obtained even after 100 times of sectioning with both microtome blades, showing sufficient durability. However, in sectioning porcine rib tissue, the microtome blade with a large blade edge angle produced good-quality sections in the initial phase of the durability test; however, defects such as overlapping of folds were observed after 100 times of sectioning. Meanwhile, the microtome blade with a small blade edge angle experienced blade damage from the early phase of the durability test, resulting in the production of unsuitable preparations for pathology tests. These results indicated that the microtome blade with a small blade edge angle lacked durability against hard tissues such as porcine ribs.</p>

DOI CiNii Research

Histopathological analysis of tumor microenvironment in adrenocortical carcinoma: Possible effects of in situ disorganized glucocorticoid production on tumor immunity

Ishikawa Y.

Journal of Steroid Biochemistry and Molecular Biology ( Journal of Steroid Biochemistry and Molecular Biology )  238   2024年04月

DOI

豚肋骨の脱灰試料の薄切におけるミクロトーム刃の耐久性試験

佐々木 雄大, 佐藤 寛恭, 中前 圭人, 南條 博, 赤上 陽一, 中村 竜太, 久住 孝幸, 吉野 雅彦

精密工学会学術講演会講演論文集 ( 公益社団法人 精密工学会 )  2024S ( 0 ) 383 - 384   2024年02月

<p>本報では、病理診断試料の薄切に用いられるミクロトーム刃の耐久性に影響を及ぼす諸因子についての検討結果を報告する。独自に開発した薄切実験装置を用いて、豚肋骨の脱灰試料を一定切取厚さで繰返し薄切する実験を実施した。繰返し薄切による切削力の変化、刃先の損傷、さらに薄切片の品質の変化を測定し、ミクロトーム刃の硬さや刃先先端角、さらに試験片の特性がミクロトーム刃の耐久性に与える影響を検討した。</p>

DOI CiNii Research

Association between NLRP3 Inflammasome and Tumor-NodeMetastasis Staging in Prostate Cancer: Immunohistochemical Studies of Prostate Needle Biopsy and Radical Prostatectomy Specimens

Miyauchi T.

Tohoku Journal of Experimental Medicine ( Tohoku Journal of Experimental Medicine )  264 ( 4 ) 203 - 213   2024年

<p>The pathological role of NLRP3 inflammasome in prostate cancer (PCa) remains unclear. This study aimed to elucidate the expression of its major components in PCa by immunohistochemistry and its clinicopathological significance. An immunohistochemical analysis of 184 prostate needle biopsy and 38 radical prostatectomy specimens from PCa revealed the expression status of NLRP3, PYCARD, and caspase-1, which form NLRP3 inflammasome. Furthermore, the association between the expression of these 3 proteins and the clinical parameters at diagnosis and operation was analyzed. In biopsy specimens, the Cochran-Armitage test demonstrated that the proportion of the high expression of NLRP3 (P < 0.001) and PYCARD (P < 0.001) in cancerous tissue tended to increase as the value of the Gleason Grade Group increased, and immunohistochemistry of NLRP3 and PYCARD helped to distinguish cancerous tissue from adjacent noncancerous tissue in some cases. Furthermore, a univariable logistic regression analysis revealed the high expression of NLRP3 to be associated with clinical T3–4 (P = 0.0056) and distant metastasis at diagnosis (P = 0.011), while the high expression of PYCARD was associated with clinical T3–4 (P < 0.001), regional lymph node metastasis (P < 0.001), and distant metastasis at diagnosis (P < 0.001). However, a multivariable logistic regression analysis showed no significant association. In prostatectomy specimens, no significant association existed between the expression of NLRP3 inflammasome and the clinical parameters at operation, partly due to the influence of neoadjuvant chemohormonal or hormone therapy. In conclusion, these results suggest that NLRP3 inflammasome may promote disease progression and metastasis in PCa, therefore immunohistochemistry of NLRP3 and PYCARD could be useful for diagnosing PCa accurately.</p>

DOI PubMed CiNii Research

Intraoperative rapid immunohistochemistry of microsatellite instability using non-contact alternating current electric field mixing

Imai K.

General Thoracic and Cardiovascular Surgery ( General Thoracic and Cardiovascular Surgery )    2024年

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Macrophage numbers in the marginal area of sarcomas predict clinical prognosis

Umakoshi M.

Scientific Reports ( Scientific Reports )  13 ( 1 )   2023年12月

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Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report

Sasagawa H.

Journal of Cancer Research and Clinical Oncology ( Journal of Cancer Research and Clinical Oncology )  149 ( 16 ) 15091 - 15094   2023年11月

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Preoperative neoadjuvant chemoradiotherapy provides borderline resectable thoracic esophageal cancer with equivalent treatment results as clinically T3 thoracic esophageal cancer

Wakita A.

Annals of Gastroenterological Surgery ( Annals of Gastroenterological Surgery )  7 ( 6 ) 904 - 912   2023年11月

DOI

骨組織包埋試料の薄切におけるミクロトーム刃の耐久性試験

佐藤 寛恭, 中前 圭人, 佐々木 雄大, 南條 博, 赤上 陽一, 中村 竜太, 久住 孝幸, 吉野 雅彦

精密工学会学術講演会講演論文集 ( 公益社団法人 精密工学会 )  2023A ( 0 ) 762 - 763   2023年08月

<p>本報では病理診断試料の薄切に用いられるミクロトーム刃の耐久性について調査した結果を報告する。豚肋骨組織を包埋したパラフィンブロックを試料として用い、独自に開発した自動薄切実験装置により、一定切取厚さで繰返し薄切実験を行った。繰返しに伴う切削力の変化、刃先の損傷を測定し、薄切片の組織の品質に与える影響を検討した。</p>

DOI CiNii Research

High TLR6 Expression Status Predicts a More Favorable Prognosis after Esophagectomy for Locally Advanced Thoracic Esophageal Squamous Cell Carcinoma

Sato Y.

Current Oncology ( Current Oncology )  30 ( 5 ) 4724 - 4735   2023年05月

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特集 GERDを極める [各論　病態と診断] GERDの合併症-Barrett食道を含めて-

松橋 保, 南條 博, 飯島 克則

消化器内視鏡 ( 東京医学社 )  35 ( 5 ) 644 - 650   2023年05月

DOI CiNii Research