研究等業績 - その他 - 南條　博

Decision tree models combining Bi-parametric vesical imaging reporting and data system and apparent diffusion coefficient metrics for predicting muscle-invasive bladder cancer

Sugawara D.

Abdominal Radiology ( Abdominal Radiology )    2026年

DOI

Fournier's Gangrene Following Hydrogel Spacer-Related Rectal Ulcer and Fistula in a Patient Undergoing Radiation Therapy for Prostate Cancer: A Case Report

Kimura Kazuya, Watanabe Kenta, Kobayashi Mizuki, Okubo Keisuke, Sato Hiromi, Narita Shintaro, Wada Yuki, Kumagai Satoshi, Sato Kimihiko, Fukuda Sho, Yoshida Tatsuki, Kodama So, Saruta Yohei, Abe Ryo, Shimodaira Yosuke, Matsuhashi Tamotsu, Arita Junichi, Mori Naoko, Nanjo Hiroshi, Habuchi Tomonori, Iijima Katsunori

Internal Medicine ( 一般社団法人 日本内科学会 )  advpub ( 0 )   2026年

<p>Hydrogel spacers are commonly used to reduce rectal toxicity during radiation therapy for prostate cancer. Although generally safe, rare, serious complications may occur. We report the case of a man with diabetes and renal failure who developed a refractory rectal ulcer and fistula five months after spacer placement, followed by Fournier's gangrene. The patient recovered following surgical drainage and antibiotic therapy. This is the first reported case of Fournier's gangrene following hydrogel spacer insertion. Spacer-related rectal wall infiltration might have contributed to this finding. Clinicians should recognize such adverse events and consider early intervention in high-risk patients presenting with hematochezia or perineal symptoms. </p>

DOI PubMed CiNii Research

Prognostic Impact of Clinical Diagnosis-based Treatment in Glioblastoma Patients Aged ≥80 Years: A Single-center Cohort Study Focused on Performance Status Maintenance

ONO Takahiro, SAITO Ayana, ABE Masamichi, NANJO Hiroshi, SHIMIZU Hiroaki

Neurologia medico-chirurgica ( 一般社団法人 日本脳神経外科学会 )  advpub ( 0 )   2026年

<p>In aging societies such as Japan, the number of patients aged ≥80 years with glioblastoma who are unsuited for surgery is rapidly increasing. At our institution, we adopted a therapeutic strategy based on clinical diagnosis without histological confirmation when surgery was not feasible. This study aimed to retrospectively evaluate the short-term outcomes and clinical value of surgical intervention and histological confirmation in this population. Patients aged ≥80 years diagnosed with glioblastoma between 2011 and 2025 were reviewed. Clinical diagnosis was applied when patients were unfit for surgery. Patient data, including age, sex, Karnofsky performance status, extent of resection, treatment options, and complications, were analyzed for associations with overall survival, Karnofsky performance status improvement, and discharge home. Among 203 cases, 31 patients (15.3%) were included. Their mean age was 84 years; the median Karnofsky performance status scores at admission and discharge were 50 and 60, respectively. Six patients underwent resection, 14 biopsy, and 11 clinical diagnosis. The clinical diagnosis group showed better functional outcomes, including improved Karnofsky performance status, shorter hospitalization, and higher discharge home rates than the biopsy group. Bevacizumab contributed significantly to these outcomes. Perioperative complications occurred in 4 patients; none recovered functionally or were discharged home. Low Karnofsky performance status at discharge was the only independent predictor of poor overall survival. Surgical intervention did not significantly affect the functional and survival outcomes. In conclusion, clinical diagnosis-based treatment, particularly with bevacizumab, could help preserve function and facilitate discharge in very elderly patients with glioblastoma. Biopsies might negatively impact the outcomes in the present cohort.</p>

DOI PubMed CiNii Research

A case of successful pembrolizumab plus FP neoadjuvant chemotherapy for a tumor preoperatively diagnosed as gastric squamous cell carcinoma

Fukuda S.

Clinical Journal of Gastroenterology ( Clinical Journal of Gastroenterology )  18 ( 6 ) 1108 - 1113   2025年12月

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Contribution of laparoscopic surgery to the diagnosis of ovarian metastasis from thymoma: A rare case and review of the literature

Sejimo Y.

Gynecologic Oncology Reports ( Gynecologic Oncology Reports )  62   2025年12月

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IGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation

Huang M.

Cell Communication and Signaling ( Cell Communication and Signaling )  23 ( 1 )   2025年12月

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Inhibition of Fatty Acid-Binding Protein 4 Limits High-Fat-Diet-Associated Prostate Tumorigenesis and Progression in TRAMP Mice

Huang M.

International Journal of Molecular Sciences ( International Journal of Molecular Sciences )  26 ( 21 )   2025年11月

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Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both in vitro and in vivo models

Terasawa A.

World Journal of Experimental Medicine ( World Journal of Experimental Medicine )  15 ( 2 )   2025年06月

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Prognostic significance of cancer-associated fibroblasts and tumor-associated macrophages in the tongue squamous cell carcinoma and their correlation with tumor budding

Oikawa Y.

Oral Oncology ( Oral Oncology )  165   2025年06月

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Familial adenomatous polyposis family with clustering of psychiatric disorders

Funaki M.

Japanese Journal of Clinical Oncology ( Japanese Journal of Clinical Oncology )  55 ( 4 ) 435 - 439   2025年04月

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Evaluation of Grading Estrogen Receptors in Breast Cancer Using Fully Automated Rapid Immunohistochemistry Based on Alternating-Current Electric Field Technology

Kudo C.

Cancers ( Cancers )  17 ( 3 )   2025年02月

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Prognostic Value of Cancer-Associated Fibroblast Marker Expression in the Intratumoral and Marginal Areas of Soft Tissue Sarcoma

Umakoshi M.

Pathobiology ( Pathobiology )  92 ( 1 )   2025年02月

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Multiple Pulmonary Cavernous Hemangioma: A Case Report

Takashima Shinogu, Nanjo Hiroshi, Matsuo Tsubasa, Kuriyama Shoji, Iwai Hidenobu, Suzuki Haruka, Kobayashi Mirai, Fujibayashi Tatsuki, Shibano Sumire, Minamiya Yoshihiro, Imai Kazuhiro

Surgical Case Reports ( 一般社団法人 日本外科学会 )  11 ( 1 ) n/a   2025年

<p><b>INTRODUCTION:</b> Pulmonary cavernous hemangioma (PCH) is extremely rare and, due to the lack of specific radiological characteristics, is often misdiagnosed as other pulmonary diseases, including metastatic tumors. Here, we report a case of multiple PCH lesions with concomitant hepatic cavernous hemangioma (HCH), emphasizing the diagnostic implications of imaging findings.</p><p><b>CASE PRESENTATION:</b> A 57-year-old man presented with fever. CT revealed numerous well-circumscribed pulmonary nodules and multiple low-density hepatic lesions. Dynamic contrast-enhanced CT demonstrated mild, nonspecific enhancement of the pulmonary nodules, whereas the hepatic lesions showed enhancement from the center to the periphery. Serum tumor markers were within normal limits, and PET-CT revealed no abnormal fluorodeoxyglucose uptake in any of the lesions. Although the hepatic lesions appeared suggestive of hemangioma on imaging, the possibility of malignancy, such as hepatic angiosarcoma and its pulmonary metastases, could not be completely ruled out. Therefore, both hepatic and pulmonary biopsies were performed, and histopathological examination confirmed cavernous hemangioma in both organs.</p><p><b>CONCLUSIONS:</b> PCH is a rare benign tumor lacking distinctive imaging characteristics; therefore, differentiation from metastatic pulmonary tumors is often challenging and represents a key diagnostic issue. Although definitive diagnosis currently relies on surgical biopsy, combining suggestive imaging findings—such as the presence of microcalcifications within nodules and the absence of fluorodeoxyglucose uptake on PET-CT—may help avoid unnecessary invasive procedures.</p>

DOI CiNii Research

嵌頓をきたした十二指腸のBrunner腺過形成を内視鏡的に切除しえた１例（動画付き）

佐藤 真生, 吉田 樹, 松橋 保, 高橋 壮, 福田 翔, 南條 博, 廣嶋 優子, 飯島 克則

日本消化器内視鏡学会雑誌 ( 一般社団法人 日本消化器内視鏡学会 )  67 ( 2 ) 140 - 148   2025年

<p>十二指腸球部に60mm大の有茎性の粘膜下病変を認められた．Brunner腺過形成が疑われたが，病変の大きさから切除を検討された．しかし，本人に切除の希望がなかったため，経過観察をされた．診断から11年後，心窩部痛をきたし，CTで同病変の十二指腸水平部への嵌頓を認めた．そこで，病変をESDで切除した上で，開腹で切除検体を回収した．最終的に75mm大のBrunner腺過形成と診断された．Brunner腺過形成は，十二指腸の粘膜下病変として発見されることが多いが，確定診断は容易ではない．したがって，増大傾向がある場合や通過障害の原因となる場合には，腫瘍との鑑別のためにも切除の対象となることがある．今回，経過観察中に増大し，嵌頓をきたした十二指腸Brunner腺過形成を内視鏡的に切除しえたが，病変の体外への回収には開腹手術を要した症例を経験した．</p>

DOI CiNii Research

The usefulness of combining narrow-band imaging with magnifying endoscopy and 18F-fluorodeoxyglucose positron emission tomography for predicting the depth of invasion in superficial esophageal squamous cell carcinoma

Kodama S.

Esophagus ( Esophagus )  22 ( 3 ) 437 - 443   2025年

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Multiplex Intraoperative Rapid Immunohistochemistry with Noncontact Antibody Mixing for Distinguishing the Histologic Phenotype of Lung Cancer

Kuriyama S.

Pathobiology ( Pathobiology )  91 ( 6 ) 383 - 392   2024年12月

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特集1 動脈解離再考! 今こそ全身の動脈解離を網羅する 動脈解離の病理所見

畠山 遥, 廣嶋 優子, 南條 博

臨床画像 ( メジカルビュー社 )  40 ( 9 ) 1046 - 1053   2024年09月

DOI CiNii Research

Clinical Course after Carmustine Wafer Implantation for Newly Diagnosed Adult-type Diffuse Gliomas; A controlled propensity matched analysis of a single center cohort

Ono T.

Journal of Neuro-Oncology ( Journal of Neuro-Oncology )  168 ( 3 ) 393 - 404   2024年07月

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Epithelial granuloma occurring on the staple-stump after segmentectomy for ovarian cancer lung metastasis

Kuriyama S.

Thoracic Cancer ( Thoracic Cancer )  15 ( 21 ) 1681 - 1684   2024年07月

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Durability Test of Microtome Blades with the High-Precision Tissue-Sectioning Machine

Satoh H.

International Journal of Automation Technology ( International Journal of Automation Technology )  18 ( 3 ) 390 - 399   2024年05月

<p>In this study, the durability of microtome blades, used for sectioning paraffin blocks, was evaluated with the goal of improving the quality of sections in pathology tests. First, for the durability test of microtome blades, a sectioning test device that realizes stable sectioning operations was developed. This device comprised precise stages supported by cross-roller guides, achieving sufficient rigidness. This device allowed automated repetitive sectioning and simultaneously measured the principal and thrust cutting forces. Samples embedding porcine kidney and rib tissues were used for the durability test. Two types of blades with different blade edge angles were used. Additionally, the rake face and cross-section of blades, as well as H&E-stained sections, were observed. In the durability test with porcine kidney tissue, good quality sections were obtained even after 100 times of sectioning with both microtome blades, showing sufficient durability. However, in sectioning porcine rib tissue, the microtome blade with a large blade edge angle produced good-quality sections in the initial phase of the durability test; however, defects such as overlapping of folds were observed after 100 times of sectioning. Meanwhile, the microtome blade with a small blade edge angle experienced blade damage from the early phase of the durability test, resulting in the production of unsuitable preparations for pathology tests. These results indicated that the microtome blade with a small blade edge angle lacked durability against hard tissues such as porcine ribs.</p>

DOI CiNii Research