Research Achievements - Original paper -
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Sudo K.
Anticancer Research ( Anticancer Research ) 37 ( 10 ) 5565 - 5571 2017.10 [Refereed]
Research paper (journal) Domestic Co-author
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Acute aortic regurgitation in a bicuspid aortic valve due to the rupture of an anomalous cord
Watanabe H.
Anatolian Journal of Cardiology ( Anatolian Journal of Cardiology ) 17 ( 6 ) 2017.06 [Refereed]
Research paper (journal) Domestic Co-author
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Sato T.
Cardiovascular Research ( Cardiovascular Research ) 113 ( 7 ) 760 - 769 2017.06 [Refereed]
Research paper (journal) Domestic Co-author
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Okuda Y.
Cancer Chemotherapy and Pharmacology ( Cancer Chemotherapy and Pharmacology ) 79 ( 5 ) 1013 - 1020 2017.05 [Refereed]
Research paper (journal) Domestic Co-author
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Rapidly growing intraventricular mass in a patient with hereditary haemorrhagic telangiectasia
Shimbo M.
European Heart Journal Cardiovascular Imaging ( European Heart Journal Cardiovascular Imaging ) 18 ( 4 ) 2017.04 [Refereed]
Research paper (journal) Domestic Co-author
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Iwakawa H.
Intensive Care Medicine ( Intensive Care Medicine ) 43 ( 1 ) 135 - 136 2017.01 [Refereed]
Research paper (journal) Domestic Co-author
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Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
Kimura H.
JCI Insight ( JCI Insight ) 2 ( 1 ) 2017.01 [Refereed]
Research paper (journal) Domestic Co-author
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Blunt traumatic rupture of the right ventricle: visualization of spurting blood using transthoracic echocardiography.
Mai Shimbo, Hiroyuki Watanabe, Kumiko Watanabe, Genbu Yamaura, Hiroshi Ito
European heart journal. Cardiovascular Imaging 17 ( 11 ) 1258 - 1258 2016.11 [Refereed]
Research paper (journal)
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An unusual cause of superior vena cava syndrome after pacemaker implantation.
Hiroyuki Watanabe, Takako Iino, Hiroshi Ito
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 18 ( 5 ) 657 - 657 2016.05 [Refereed]
Research paper (journal)
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The association of circulating inflammatory and oxidative stress biomarker levels with diagonal earlobe crease in patients with atherosclerotic diseases.
Takashi Koyama, Hiroyuki Watanabe, Hiroshi Ito
Journal of cardiology 67 ( 4 ) 347 - 51 2016.04 [Refereed]
Research paper (journal)
BACKGROUND: Earlobe creases (ELC) are frequently observed in patients with atherosclerosis. Atherosclerosis is considered to be a systemic vascular inflammatory disease, and oxidative stress is known to be a contributor to vascular inflammation. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes. This study was designed to test the hypothesis that biomarkers of inflammation and oxidative stress are increased in patients with ELC. METHODS: A total of 223 consecutive patients with atherosclerotic risk factors were enrolled and divided into two groups. One group consisted of patients with ELC (ELC group, n=134) and the other was without ELC (non-ELC group, n=89). Medical information and biomarker levels related to atherosclerosis were acquired from these patients. RESULTS: The male ratio, prevalence of hypertension, diabetes mellitus, and MDA-LDL, hs-CRP, and PTX3 levels were found to be higher in the ELC group, compared with the non-ELC group. A multiple logistic regression analysis showed that PTX3 levels, rather than hs-CRP, constituted the strongest predictive factor for the appearance of ELC. CONCLUSIONS: Vascular inflammation and oxidative stress are associated with the presence of ELC.
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Tricuspid valve chordae tendineae as protective filter to prevent massive pulmonary embolism.
Hiroyuki Watanabe, Mai Shimbo, Mai Terada, Hironori Kiso, Seiya Shimizu, Yasunori Oguma, Kenji Iino, Hiroshi Ito
Journal of thoracic disease 8 ( 3 ) E225-8 2016.03 [Refereed] [Invited]
Research paper (journal)
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Isolated Atrial Septal Defect Complicated by Tricuspid Valve Infective Endocarditis.
Mai Shimbo, Hiroyuki Watanabe, Tatsumi Abe, Teruki Sato, Takashi Koyama, Hiroshi Yamamoto, Hiroshi Ito
Internal medicine (Tokyo, Japan) 54 ( 19 ) 2463 - 5 2015.10 [Refereed]
Research paper (journal)
Infective endocarditis (IE) associated with atrial septal defect (ASD) is extremely rare. However, tricuspid regurgitation (TR) secondary to right ventricular overload is a potential cause of IE, and once it occurs, the development of a paradoxical embolism may lead to fatal complications. We herein report the case of a 50-year-old woman who was admitted due to a persistent fever resistant to antibiotics. Echocardiography showed secundum ASD, moderate TR and a mobile vegetation measuring 15×10 mm attached to the tricuspid valve. Given the risk of developing a paradoxical embolism, urgent surgery was successfully performed.
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Quality of life and heart rate variability following acute myocardial infarction
SHIMBO Mai,KOSAKA Toshimitsu,FUSHIMI Etsuko,KOYAMA Takashi,IINO Kenji,WATANABE Hiroyuki,ITO Hiroshi
秋田医学 42 ( 1 ) 29 - 36 2015.06 [Refereed]
Research paper (journal)
Objective : The aim of this study was to investigate whether cardiac autonomic function measured
by heart rate variability (HRV) indices are related to quality of life (QOL) improvements in
patients with acute myocardial infarction (AMI) treated by percutaneous coronary intervention.
Methods : We enrolled 20 consecutive patients with AMI. Measures of HRV, obtained from
both frequency and time domain analyses using 24-h Holter monitoring before discharge, were as
follows : low and high frequency (HF) domain measures, the square root of the mean squared differences
of successive R-R intervals (rMSSD), and the percentage of differences between adjacent
normal R-R intervals >50 ms for the whole analysis (pNN50). QOL was determined by
physical and mental component summary (PCS and MCS, respectively) scores derived from the
Japanese Medical Outcomes Study 36-item Short Form Health Survey before and 6 months after
discharge.
Results : The subjects showed significant improvement in the MCS, but not the PCS score.
There were also positive correlations between the parasympathetic parameters of HF, rMSSD,
and pNN50 and the change in MCS score. In a multivariate analysis, rMSSD was found to be
independently associated with the change in MCS score.
Conclusions : Parasympathetic tone, as measured by HRV, is independently associated with
QOL, which emphasizes the role of cardiac autonomic function on QOL in patients with AMI. -
Involvement of the orexin system in sympathetic nerve regulation.
Manabu Murakami, Takayoshi Ohba, Testuya Kushikata, Hidetoshi Niwa, Akira Kurose, Tadaatsu Imaizumi, Hiroyuki Watanabe, Teruyuki Yanagisawa, Shigeyuki Nakaji, Kyoichi Ono, Kazuyoshi Hirota
Biochemical and biophysical research communications 460 ( 4 ) 1076 - 81 2015.05 [Refereed]
Research paper (journal)
Orexin, also known as hypocretin, is a secreted neuropeptide implicated in the regulation of sleep and food intake. In the present study, we examined the importance of orexin in regulation of the sympathetic nervous system using an orexin/ataxin-3 transgenic (OXTg) rat, which has a minimal number of orexin neurons. RT-PCR analysis identified expression of prepro-orexin and orexin receptor-1 (OX1R) in the superior cervical ganglion (SCG), and expression of another receptor (OX2R) was marginal in the wild-type rat. The orexin/ataxin-3 transgenic rat showed increased expression of OX1R and OX2R, whereas expression of prepro-orexin was undetectable, suggesting a compensatory increase in both receptors. In the ECG recording (R-R interval), orexin/ataxin-3 transgenic rats showed decreased responsiveness to the β-adrenergic blocker propranolol. Furthermore, OXTg rats had deteriorated R-R interval regulation, indicating involvement of the orexin system in sympathetic nerve regulation. This was accompanied by decreased baroreflex and responsiveness to β-adrenergic blocker in blood pressure recording, also suggesting involvement of the orexin system in sympathetic nerve regulation. Histological examination revealed hypotrophic changes in the transgenic heart, suggesting involvement of the orexin system in cardiac development. Taken together, our present results indicate involvement of the orexin system in sympathetic nerve control.
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Modified autonomic regulation in mice mutated in the β4 subunit of the lh/lh calcium channel.
Manabu Murakami, Takashi Suzuki, Tsai-Wen Wu, Kenji Kuwasako, Eiki Takahashi, Hiroyuki Watanabe, Agnieszka M Murakami, Ichiro Miyoshi, Teruyuki Yanagisawa, Hironobu Sasano, Kyoichi Ono, Takayoshi Ohba
Biochemical and biophysical research communications 461 ( 2 ) 200 - 5 2015.05 [Refereed]
Research paper (journal)
Genetic analyses have revealed an important association between P/Q-type calcium channel activities and hereditary neurological disorders. The P/Q-type channels are composed principally of heterologous multimeric subunits including CaV2.1 and CaVβ4. Of these, the β4 subunit is thought to play a significant role in channel physiology, because a mouse line mutant in that subunit (the lethargic mouse: lh) exhibits a severe ataxic phenotype. The aim of the present study was to elucidate the physiological importance of the β4 subunit. ECG analysis showed that the T wave was high in 8-week-old lh mutants; this may be associated with hyperkalemia. Upon pharmacological ECG analysis, 2-3-week-old lh mutants exhibited reduced responses to a β-blocker and a muscarinic receptor antagonist. Analysis of heart rate variability revealed that the R-R interval was unstable in lh mutants and that both the low- and high-frequency components had increased in extent, indicating that the tonus of both the sympathetic and parasympathetic nervous systems was modified. Thus, our present study revealed that the β4 subunit played a significant role in regulation of sympathetic and parasympathetic nerve activities.
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Serial Changes in Hamman's Sign Secondary to the Evolution of a Shallow Left-Sided Spontaneous Pneumothorax.
Katsuhito Seki, Hiroyuki Watanabe, Ryo Morita, Kazuhiro Sato, Mariko Asano, Takako Iino, Kenji Iino, Hiroshi Ito
Respiratory care 60 ( 5 ) e110-2 2015.05 [Refereed]
Research paper (journal)
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Beneficial effects of adaptive servo-ventilation therapy on albuminuria in patients with heart failure.
Yoshikazu Tamura, Takashi Koyama, Hiroyuki Watanabe, Tomoki Hosoya, Hiroshi Ito
Journal of cardiology 65 ( 5 ) 412 - 7 2015.05 [Refereed]
Research paper (journal)
BACKGROUND: Short-duration adaptive servo-ventilation (ASV) therapy can be effective for heart failure (HF) patients. Albuminuria is recognized as a prognostic marker for HF. We investigated whether short-duration and short-term ASV therapy reduced albuminuria in HF patients. METHODS AND RESULTS: Twenty-one consecutive HF patients were divided into two groups: those who tolerated ASV therapy (ASV group, n=14) and those who did not (non-ASV group, n=7). ASV therapy was administered to enrolled patients for 1 week for 2h per day (1h in the morning and 1h in the afternoon). The urinary albumin to creatinine ratio (UACR), urinary 24h norepinephrine (NE) excretion, high-sensitivity C-reactive protein (hs-CRP), and plasma brain natriuretic peptide (BNP) levels were measured before and 1 week after ASV therapy. In the ASV group, but not the non-ASV group, the UACR significantly decreased, together with a decrease in urinary NE and hs-CRP levels. There were significant correlations between the changes in UACR and hs-CRP and between the changes in urinary NE and hs-CRP. Multiple linear regression analyses indicated that ASV use was the strongest predictor of decreased UACR. CONCLUSION: Albuminuria, urinary NE, and hs-CRP levels reduced in HF patients who could receive short-duration and short-term ASV therapy. Anti-inflammatory effects of ASV therapy may partly mediate the reduction of albuminuria.