研究者詳細 - 大田　秀隆

BACKGROUND: Interleukin-6 (IL-6) is an inflammatory cytokine. Whether systemic IL-6 affects atrogene expression and disuse-induced skeletal muscle atrophy is unclear. METHODS: Tail-suspended mice were used as a disuse-induced muscle atrophy model. We administered anti-mouse IL-6 receptor antibody, beta-hydroxy-beta-methylbutyrate (HMB) and vitamin D to the mice and examined the effects on atrogene expression and muscle atrophy. RESULTS: Serum IL-6 levels were elevated in the mice. Inhibition of IL-6 receptor suppressed muscle RING finger 1 (MuRF1) expression and prevented muscle atrophy. HMB and vitamin D inhibited the serum IL-6 surge, downregulated the expression of MuRF1 and atrogin-1 in the soleus muscle, and ameliorated atrophy in the mice. CONCLUSION: Systemic IL-6 affects MuRF1 expression and disuse-induced muscle atrophy.

DOI リポジトリ PubMed

わが国および世界の認知症対策

大田秀隆

Dementia Japan ( (一社)日本認知症学会 ) 31 ( 4 ) 485 - 485 2017年10月

J-GLOBAL

専門医として認知症をどう診るか認知症施策の立場から

大田秀隆

老年精神医学雑誌 ( (株)ワールドプランニング ) 28 ( 増刊II ) 122 - 122 2017年06月

J-GLOBAL

新オレンジプランにおける「認知症の容態に応じた適切な医療・介護の提供」「若年性認知症施策の強化」に関する精神科医療の関わり—Providing health care and long-term care services in a timely and appropriate manner as the stages of dementia progress/Strengthening the measures for early onset dementia in new orange plan—特集初期・認知症への精神科医療の関わり

大田秀隆

日本精神科病院協会雑誌 = Journal of Japanese Association of Psychiatric Hospitals ( 日本精神科病院協会 ) 36 ( 5 ) 418 - 423 2017年05月