研究者詳細 - 白澤　弘光

研究等業績 - その他 - 白澤　弘光

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Nationwide survey on the transition of treatment protocols after the introduction of insurance coverage for assisted reproductive technology in Japan: The IZANAMI project

Keiji Kuroda, Seung Chik Jwa, Hiromitsu Shirasawa, Miyuki Harada, Yutaka Osuga, Mitsutoshi Yamada

J Obstet Gynaecol Res . 51 ( 2 ) e16234 2025年02月 [査読有り]

Nationwide survey on the transition of treatment protocols after the introduction of insurance coverage for assisted reproductive technology in Japan: The IZANAMI project

Kuroda K.

Journal of Obstetrics and Gynaecology Research ( Journal of Obstetrics and Gynaecology Research ) 51 ( 2 ) 2025年02月

DOI

第1土曜特集生殖医学--基礎研究と実地診療の進歩ヒト第一体細胞分裂(1st cleavage)に対する時空間的解析

白澤弘光, 小野有紀, 寺田幸弘

医学のあゆみ ( 医歯薬出版 ) 291 ( 10 ) 931 - 936 2024年12月

DOI CiNii Research

【生殖医学-基礎研究と実地診療の進歩】ヒト第一体細胞分裂(1st cleavage)に対する時空間的解析

白澤弘光, 小野有紀, 寺田幸弘

医学のあゆみ ( 医歯薬出版(株) ) 291 ( 10 ) 931 - 936 2024年12月

＜文献概要＞ヒト第一体細胞分裂(1st cleavage)は,ヒト胚盤胞を形作る最初の体細胞分裂であり,重要な過程である.しかし,ヒト胚を用いた第一体細胞分裂過程の研究には倫理的ハードルがあり,マウス胚,ウシ胚などの非ヒト胚における同分野の知見の蓄積とは対照的に研究が不十分であった.不妊治療では,タイムラプスイメージングなどの非侵襲的な動的解析を用いて,ヒト第一体細胞分裂の検討も進められている.しかし,ヒトとマウスにおける中心体,中心体小体,微小管形成中心(MTOCs)などの細胞骨格の種差を考慮すると,ヒト胚を用いた細胞生物学的検討は不可欠である.近年,提供ヒト卵子,ヒト接合子を用いたライブセルイメージングによるヒト第一体細胞分裂過程の時間的・空間的な解析により,明視野画像による解析では得られなかった知見が多く報告されている.不妊治療の臨床にも重要である第一体細胞分裂における染色体分配機構の解析について,近年の新たな知見を紹介する.

診療報酬改定を踏まえた保険診療の現状と今後の課題

白澤弘光

日本産科婦人科学会雑誌 76 ( 12 ) 1815 - 1818 2024年12月

生殖補助医療におけるadd-ons導入と社会医学的課題に関する包括的研究

白澤弘光

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 ) 76 ( 10 ) 1029 - 1037 2024年10月

J-GLOBAL

ヒト配偶子・胚を用いたARTの細胞生物学的な解析 add-ons医療の本質の究明

白澤弘光

日本産科婦人科学会雑誌 ( (公社)日本産科婦人科学会 ) 76 ( 9 ) 979 - 988 2024年09月

特集産婦人科医が知っておきたい　プレコンセプションケアの最前線Ⅱ 5.卵巣機能とプレコンセプションケア

岩澤卓也, 藤嶋明子, 白澤弘光, 寺田幸弘

産婦人科の実際 ( 金原出版 ) 73 ( 6 ) 557 - 562 2024年06月

DOI CiNii Research

子宮筋層内に迷入したIUDを腹腔鏡手術で摘出した１例

岩澤卓也, 坂口太一, 白澤弘光, 熊澤由紀代, 寺田幸弘

日本産科婦人科内視鏡学会雑誌 ( 日本産科婦人科内視鏡学会 ) 40 ( 1 ) 100 - 104 2024年

<p>　An intrauterine device (IUD) is a commonly used, reversible contraception. Reports of IUD-related complications have increased, and one of these is uterine perforation at IUD insertion with subsequent migration into the intraperitoneal cavity. This is a rare complication, occurring in approximately 0.2-3.6 per 1000 cases. We report a case of laparoscopic surgery for removal of an IUD that had migrated into the uterine myometrium. A 39-year-old nulliparous woman underwent IUD insertion to prevent intrauterine adhesions after laparoscopic myomectomy (LM). Three months after LM, the IUD could not be removed by pulling the IUD strings. CT and MRI revealed that the IUD had migrated into the uterine myometrium. We removed the IUD by laparoscopic surgery. Insertion of an IUD after myomectomy, especially under anesthesia, carries a risk of uterine perforation. Multiple cross-sectional images on CT and MRI are useful for diagnosing IUD migration into the uterine myometrium.</p>

DOI CiNii Research

ヒト6日目胎盤胞の直径は,栄養外胚葉成分の遺伝的均一性を反映する

HASEGAWA Hisataka, HASEGAWA Hisataka, TAKAHASHI Kazumasa, KOBAYASHI Tatsuya, KOBAYASHI Tatsuya, KOBAYASHI Tatsuya, IWASAWA Takuya, FUJISHIMA Akiko, TOGASHI Kazue, MAKINO Kenichi, SHIRASAWA Hiromitsu, MIURA Hiroshi, SATO Wataru, KUMAZAWA Yukiyo, KOBAYASHI Junichi, TERADA Yukihiro

秋田医学 50 ( 2 ) 2023年

J-GLOBAL

生殖・内分泌委員会

寺田幸弘, 岩瀬明, 大須賀穣, 岡田英孝, 小野政徳, 折坂誠, 河村和弘, 柴原浩章, 高井泰, 高橋俊文, 浜谷敏生, 平池修, 白澤弘光

日本産科婦人科学会雑誌 75 ( 6 ) 2023年

J-GLOBAL

施設背景を考慮したメディカル・ノンメディカル卵子凍結コストの公開ウェブサイト記載情報を用いた比較検討

白澤弘光, 熊澤由紀代, 佐藤亘, 岩澤卓也, 高橋和政, 寺田幸弘

日本生殖医学会雑誌 ( (一社)日本生殖医学会 ) 67 ( 4 ) 332 - 332 2022年10月

Na+/K+ ATPase ?1 and ?3 subunits are localized to the basolateral membrane of trophectoderm cells in human blastocysts

Hirakawa T.

Human Reproduction ( Human Reproduction ) 37 ( 7 ) 1423 - 1430 2022年07月

DOI

First comparison of the egg freezing and storage cost between medical adaptation and social adaptation of Japan fertility hospitals and clinics based on institution's websites

H Shirasawa, Y Kumazawa, W Sato, K Togashi, N Ono, A Fujishima, Y Terada

Human Reproduction ( Oxford University Press (OUP) ) 37 ( Supplement_1 ) 2022年06月

Abstract

Study question

In Japan, how much of freezing cost and the yearly storage cost of medical and social egg freezing for fertility preservation is clearly disclosed on the institution's website?

Summary answer

Of the 621 infertility treatment institutions, 146 listed egg freezing on their websites, 46 specified the freezing cost, and 71 specified the yearly storage cost.

What is known already

In Japan, from April 2022, standard assisted reproductive technology will be covered by insurance, but medical and social egg freezing will continue to be privately funded. Therefore, it is unclear how many facilities in Japan perform egg freezing. Furthermore, while the cost of freezing and yearly storage varies significantly from facility to facility, there has been no data comparing egg freezing among facilities in Japan or other countries. Therefore, we extracted data about freezing and storage cost from each institution's website and compared them for the first time.

Study design, size, duration

This study is a web-based survey in which a single board-certified specialist by Japan Society for Reproductive Medicine exhaustively browsed the websites of all 621 fertility treatment institutions in Japan in October 2021 and analyzed the implementation of egg freezing, freezing costs, and yearly storage costs of egg are clearly stated on the websites. The costs of drugs used for egg retrieval and ovarian stimulation were excluded.

Participants/materials, setting, methods

Of the 621 institutions, 88 institutions that clearly stated on their websites that they offer egg freezing for medical reasons were divided into a medical group, and 58 institutions that clearly stated that they offer egg freezing for only social reasons were divided into social group for statistical analysis. We compared the freezing and the yearly storage cost, respectively, whether it varies depending on the number of eggs or whether it is a fixed cost.

Main results and the role of chance

Of the 621 institutions, 146 (23.5%), 88 in the medical group and 58 in the social group, specified that they offer egg freezing. The percentages of clarification for freezing cost and yearly storage cost on the website were 27.3% and 30.7% in the medical group, 72.4%, and 75.9% in the social group, so the social group was higher in both cases (p &lt; 0.01). The percentage of fixed costs for egg freezing was significantly lower in the social group (6/42, 14.3%) than in the medical group (9/24, 37.5%) (p &lt; 0.05). The percentage of fixed costs for yearly storage cost was samely significantly lower in the social group (30/44, 68.2%) than in the medical group (25/27, 92.6%) (p &lt; 0.05). The mean freezing cost/yearly storage cost was as follows for 1, 5, and 10 eggs. The medical group was (JPY45,527/JPY22,327, JPY65,179/JPY22,530, JPY90,311/JPY22,770), and the social group was (JPY56,822/JPY40,178, JPY88,429/JPY56,502, JPY136,550/JPY79,090), so the social group had the significantly highest amount of costs in each case. Note that JPY 10,000 is about EUR77.7. The most expensive clinic to store ten eggs was JPY500,000 (EUR3,883) per year, and the least university hospital was JPY 4,600 (EUR35.7) per year.

Limitations, reasons for caution

This survey was conducted by carefully browsing the facility's website, but since we did not confirm the information through questionnaires or e-mail, there is the possibility that the information may have been updated. Another limitation is that less than half of the medical groups list cost details on their websites.

Wider implications of the findings

This is the first report to analyze the cost of egg freezing in Japan using the institution's website. The rate of cost disclosure on the website is still low. Moreover, the costs of social freezing are significantly higher than medical reasons, but this may change with the insurance of ART.

Trial registration number

not applicable