Research Achievements - Original paper -

High-throughput sequencing of IgG B-cell receptors reveals frequent usage of the rearranged IGHV4–28/IGHJ4 gene in primary immune thrombocytopenia

Hirokawa M, Fujishima N, Togashi M, Saga A, Omokawa A, Saga T, Moritoki Y, Ueki S, Takahashi N, Kitaura K, Suzuki R

Scientific Reports ( Scientific Reports )  9 ( 1 )   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Harada S, Aoki K, Okamoto K, Kinoshita O, Nawata K, Ishii Y, Tateda K, Sasaki M, Saga, T, Doi Y, Yotsuyanagi H, Moriya K, Ono M

International Journal of Infectious Diseases ( International Journal of Infectious Diseases )  84   44 - 47   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community

Matsukawa M, Igarashi M, Watanabe H, Qin L, Ohnishi M, Terajima J, Iyoda S, Morita-Ishihara T, Tateda K, Ishii Y, Saga T, Aoki K, Bonomo RA

Epidemiology and Infection ( Epidemiology and Infection )  147   2019  [Refereed]

Research paper (journal)   International Co-author

DOI

Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice

Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian Z-X, Zhang W, Yang G-X, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Yl, Leung PSC, Tanaka A, Eric Gershwin M, Hirokawa M

Frontiers in Immunology ( Frontiers in Immunology )  9 ( NOV )   2018.11  [Refereed]

Research paper (journal)   International Co-author

DOI

Urine Xanthine Crystals in Tumor Lysis Syndrome

Omokawa A, Oguma M, Ueki S, Saga T, Hirokawa M

Urology ( Urology )  120   e9 - e10   2018.10  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan

Harada S, Ishii Y, Saga T, Aoki K, Tateda K

Diagnostic Microbiology and Infectious Disease ( Diagnostic Microbiology and Infectious Disease )  91 ( 4 ) 354 - 359   2018.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Metronidazole-Induced Encephalopathy in Treatment for a Thoracic Aortic Aneurysm Infected by <i>Bacteroides fragilis</i>

Takagi Daichi, Hirokawa Makoto, Kadohama Takayuki, Yamaura Gembu, Tanaka Fuminobu, Kiriu Kentaro, Itagaki Yoshinori, Yamazaki Yuya, Yamamoto Hiroshi, Saga Tomoo

Japanese Journal of Cardiovascular Surgery ( The Japanese Society for Cardiovascular Surgery )  47 ( 3 ) 142 - 147   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

<p>A 77-year-old man presented with fever and back pain. Computed tomography revealed a distal arch aneurysm. <i>Bacteroides fragilis </i>was found in a blood culture, and we diagnosed a thoracic infected aneurysm. Because of the rapid enlargement of the aneurysm and his frailty, a TEVAR procedure was urgently performed. He left the hospital after antibiotic treatment with meropenem. However, he was re-hospitalized due to recurrence of the infection. The infection was well-controlled by treatment with intravenous meropenem, and the subsequent oral administration of metronidazole (MNZ). He was re-hospitalized again 7 weeks after discharge due to unsteady gait and articulatory disorder. MNZ-induced encephalopathy (MIE) was diagnosed because FLAIR brain magnetic resonance imaging revealed an area of high signal intensity in the bilateral basal dentate nuclei. These symptoms improved after MNZ was changed to AMPC/CVA. Fifteen months later, the patient was doing well and had no recurrence of the infection. We performed TEVAR for a patient with a thoracic aneurysm infected by <i>B. fragilis</i>. The recurrence of the infection was controlled by adequate antibiotic therapy, which included the administration of MNZ. However, patients who are treated with MNZ should be carefully observed to detect the development of neurological signs, as MNZ may induce encephalopathy. The early detection and withdrawal of metronidazole is important for the improvement of MIE.</p>

DOI

ICAM-1 upregulation is not required for retinoic acid-induced human eosinophil survival

Ueki S, Nishikawa J, Fukuchi M, Konno Y, Takeda M, Moritoki Y, Chihara J, Omokawa A, Saga T, Hirokawa M

Immunology Letters ( Immunology Letters )  196   68 - 73   2018.04  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

The effect of hepatocyte growth factor on secretory functions in human eosinophils.

Yamauchi Y, Ueki S, Konno Y, Ito W, Takeda M, Nakamura Y, Nishikawa J, Moritoki Y, Omokawa A, Saga T, Hirokawa M.

Cytokine   88   45 - 50   2016.12  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2016 Aug 20.
PMID: 27552115

DOI

Molecular epidemiologic analysis of a Pneumocystis pneumonia outbreak among renal transplant patients.

Urabe N, Ishii Y, Hyodo Y, Aoki K, Yoshizawa S, Saga T, Murayama SY, Sakai K, Homma S, Tateda K.

Clinical Microbiology and Infection   22 ( 4 ) 365 - 371   2016.04  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2015 Dec 25.
PMID:26724988

DOI

Neurosyphilis Mimicking Ramsay Hunt Syndrome.

Maeda T, Yoshizawa S, Hirayama T, Saga T, Tateda K, Urita Y.

Journal of Nippon Medical School   82 ( 5 ) 254 - 256   2015.11  [Refereed]

Research paper (journal)   Domestic Co-author

PMID: 26568393

DOI

Incorrect diagnosis of Clostridium difficile infection in a university hospital in Japan.

Mori N, Yoshizawa S, Saga T, Ishii Y, Murakami H, Iwata M, Collins DA, Riley TV, Tateda K.

Journal of Infection and Chemotherapy   21 ( 10 ) 718 - 722   2015.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2015 Jul 6.
PMID: 26238001

DOI

ESBL-producing Enterobacteriaceae in environmental water in Dhaka, Bangladesh.

Haque A, Yoshizumi A, Saga T, Ishii Y, Tateda K

Journal of Infection and Chemotherapy   20 ( 11 ) 735 - 737   2014.11  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2014 Aug 5.
PMID: 25103169

DOI

Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey.

Macedo-Viñas M, Conly J, Francois P, Aschbacher R, Blanc DS, Coombs G, Daikos G, Dhawan B, Empel J, Etienne J, Figueiredo AMS, Golding and CNISP G, Han L, Kim HB, Köck R, Larsen A, Layer F, Lo J, Maeda T, Mulvey M, Pantosti A, Saga T, Schrenzel J, Simor A, Skov R, Van Rijen M, Wang H, Zakaria Z, Harbarth, S

Journal of Global Antimicrobial Resistance   2 ( 1 ) 43 - 47   2014.03  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 Sep 3.
PMID:27873637

DOI

Protective effect of procysteine on acinetobacter pneumonia in hyperoxic conditions.

Saito K, Kimura S, Saga T, Misonoo Y, Yoshizawa S, Akasaka Y, Ishii T, Kuwano K, Yamaguchi K, Tateda K.

The Journal of Antimicrobial Chemotherapy   68 ( 10 ) 2305 - 2310   2013.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 May 16.
PMID:23681269

DOI

Efficacies of calcium-EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coli with NDM-1 beta-lactamase.

Yoshizumi A, Ishii Y, Livermore DM, Woodford N, Kimura S, Saga T, Harada S, Yamaguchi K, Tateda K.

Journal of Infection and Chemotherapy   19 ( 5 ) 992 - 995   2013.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2012 Dec 12.
PMID:23233082

DOI

Paravastatin Inhibits Farnesol Production in Candica albicans and Improves Survival in a Mouse Model of Systemic Candidiasis.

Tashiro M, Kimura S, Tateda K, Saga T, Ohno A, Ishii Y, Izumikawa K, Tashiro T, Kohno S, Yamaguchi K.

Medical Mycology   50 ( 4 ) 353 - 360   2012.05  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2011 Sep 28.
PMID:21954955

DOI

Roles of IL-17 in an Experimental legionella Pneumonia Model.

Kimizuka Y, Kimura S, Saga T, Ishii M, Hasegawa N, Betsuyaku T, Iwakura Y, Tateda K, Yamaguchi K.

Infection and Immunity   80 ( 3 ) 1121 - 1127   2012.03  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2011 Dec 5.
PMID:22144493

DOI

Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.

Aoki N, Ishii Y, Tateda K, Saga T, Kimura S, Kikuchi Y, Kobayashi Y, Tanabe Y, Tsukuda H, Gejyo F, Yamaguchi K.

Antimicrobial Agents and Chemotherapy   54 ( 11 ) 4582 - 4588   2010.11  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2010 Aug 16.
PMID:20713659

DOI

Sequential changes of legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia.

Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S, Yamaguchi K.

Diagnostic Microbiology and Infectious Disease   66 ( 3 ) 253 - 260   2010.03  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:20159373

DOI