Research Achievements - Original paper -

Characterization of a qnrB-like Genes in Citrobacter species of the American Type Culture Collection (ATCC).

Saga T(corresponding), Sabtcheva S, Mitsutake K, Ishii Y, Tateda K, Yamaguchi K, Kaku M

Antimicrobial Agents and Chemotherapy   57 ( 6 ) 2863 - 2866   2013.06  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 Mar 25.
PMID:23529729

DOI

First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan.

Saga T (Corresponding), Akasaka T, Takase H, Tanaka M, Sato K, Kaku M.

International Journal of Antimicrobial Agents   29 ( 6 ) 738 - 739   2007.06  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2007 Mar 19.
PMID:17374476

DOI

Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.

Saga T, Kaku M, Onodera Y, Yamachika S, Sato K, Takase H.

Antimicrobial agents and chemotherapy   49 ( 5 ) 2144 - 2145   2005.05  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:15855551

DOI

Cholinergic urticaria improved by daily hot bath : The analysis of its etiology

  55 ( 1 ) 9 - 12   2001.01  [Refereed]

Research paper (journal)   Domestic Co-author

Molecular Characterization of Extraintestinal Escherichia coli Isolates in Japan: Relationship between Sequence Types and Mutation Patterns of Quinolone Resistance-Determining Regions Analyzed by Pyrosequencing.

Aoike N, Saga T(corresponding), Sakata R, Yoshizumi A, Kimura S, Iwata M, Yoshizawa S, Sugasawa Y, Ishii Y, Yamaguchi K, Tateda K.

Jorunal of Clinical Microbiology   51 ( 6 ) 1692 - 1698   2013.06  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 Mar 20.
PMID:23515543

DOI

Worldwide Lineages of Clinical Pneumococci in a Japanese Teaching Hospital Identified by DiversiLab System.

Kashiwaya K, Saga T(corresponding author), Ishii Y, Sakata R, Iwata M, Yoshizawa S, Chang B, Ohnishi M, Tateda K

Journal of Infection and Chemotherapy   22 ( 6 ) 407 - 413   2016.06  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2016 Apr 22.
PMID: 27107736

DOI

Genotyping of Skin and Soft tissue infection (SSTI)-associated Methicillin-resistant Staphylococcus aureus (MRSA) Strains among Outpatients in a Teaching Hospital in Japan: Application of a Phage-open Reading Frame Typing (POT) kit.

Maeda T, Saga T (Corresponding), Miyazaki T, Kouyama Y, Harada S, Iwata M, Yoshizawa S, Kimura S, Ishii Y, Urita Y, Sugimoto M, Yamaguchi K, Tatada K.

Journal of Infection and Chemotherapy   18 ( 6 ) 906 - 914   2012.12  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2012 Nov 13.
PMID:23150115

DOI

Use of culture-independent analysis to reveal alteration of intestinal microflora by heat-killed Lactobacillus pentosus in a mouse model of endogenous sepsis.

Sugasawa Y, Saga T, Kimura S, Ishii Y, Yamaguchi K, Tateda K.

Journal of Infection and Chemotherapy   19 ( 4 ) 673 - 676   2013.08

Research paper (journal)   Domestic Co-author

Epub 2013 Jan 1.
PMID:23277389

DOI

Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.

Mano Y, Saga T, Ishii Y, Yoshizumi A, Bonomo RA, Yamaguchi K, Tateda K.

BMC Microbiology   15   41   2015.02  [Refereed]

Research paper (journal)   Domestic Co-author

PMID: 25881168

DOI

Nosocomial spread of ArmA-mediated high-level aminoglycoside resistance in Enterobacteriaceae isoltes producing CTX-M-3 beta-lactamase in a cancer hospital in Bulgaria.

Sabtcheva S, Saga T, Kantardjiev T, Ivanova M, Ishii Y, Kaku M.

Journal of Chemotherapy (Florence, Italy)   20 ( 5 ) 593 - 599   2008.10  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:19028622

DOI

A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan.

Koyama H, Sanui M, Saga T, Harada S, Ishii Y, Tateda K, Lefor AK.

Journal of Infection and Chemotherapy   21 ( 7 ) 541 - 543   2015.07  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2015 Apr 9.
PMID: 25922086

DOI

Molecular Characterization of Carbapenem-non-susceptible acinetobacter spp. in Japan: Predominance of Multidrug-resistant Acinetobacter baumannii Clonal Complex 92 and IMP-type Metallo-beta-lactamase-producing Non-baumannii Acinetobacter species.

Kouyama Y, Harada S, Ishii Y, Saga T, Yoshizumi A, Tateda K, Yamaguchi K.

Journal of Infection and Chemotherapy   18 ( 4 ) 522 - 528   2012.08  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2012 Feb 14.
PMID:22327516

DOI

Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence.

Yoshizawa S, Tateda K, Saga T, Ishii Y, Yamaguchi K.

Antimicrobial Agents and Chemotherapy   56 ( 4 ) 1744 - 1748   2012.04  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2012 Jan 30.
PMID:22290944

DOI

Chromosomal Integration and Location on incT Plasmids of the blaCTX-M-2 Gene in Proteus mirabilis Clinical Isolates.

Harada S, Ishii Y, Saga T, Kouyama Y, Tateda K, Yamaguchi K.

Antimicrobial Agents and Chemotherapy   56 ( 2 ) 1093 - 1096   2012.02  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2011 Nov 21.
PMID:22106217

DOI

Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative Element in a Proteus mirabilis clinical isolate.

Harada S, Ishii Y, Saga T, Tateda K, Yamaguchi K.

Antimicrobial Agents and Chemotherapy   54 ( 9 ) 3545 - 3550   2010.09  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2010 Jun 21.
PMID:20566768

DOI

High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria.

Sabtcheva S, Kaku M, Saga T, Ishii Y, Kantardjiev T.

Antimicrobial Agents and Chemotherapy   53 ( 1 ) 335 - 336   2009.01  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2008 Nov 10.
PMID:19001110

DOI

Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface.

Kobayashi H, Aiba S, Yamagishi T, Tanita M, Hara M, Saito H, Tagami H.

Dermatology (Basel, Switzerland)   204 ( 3 ) 173 - 178   2002.05  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:12037443

DOI

Diagnostic challenges in pulmonary embolism in young adults: thrombosis associated with cytomegalovirus and Mycoplasma pneumoniae

Haruka Hikichi, Ryo Hasegawa, Akiko Saga, Tomoo Saga, Shigeharu Ueki

Cureus   14 ( 12 ) e32757   2022.12  [Refereed]

Research paper (journal)   Domestic Co-author

Neutrophil and eosinophil ETosis-mediated extracellular trap formation in a patient with chronic granulomatous disease.

Yui Miyabe, Michihiro Yano, Mineyo Fukuchi, Ken Watanabe, Yuki Moritoki, Tomoo Saga, TsutomuTakahashi, Shigeharu Ueki

Allergology International     2022.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

How to detect eosinophil ETosis (EETosis) and extracellular traps

Fukuchi M, Miyabe Y, Furutani C, Saga T, Moritoki Y, Yamada T, Weller PF, Ueki S

Allergology International ( Allergology International )  70 ( 1 ) 19 - 29   2021.01  [Refereed]

Research paper (journal)   International Co-author

<p>Eosinophils are short-lived and comprise only a small population of circulating leukocytes; however, they play surprisingly multifunctional roles in homeostasis and various diseases including allergy and infection. Recent research has shed light on active cytolytic eosinophil cell death that releases eosinophil extracellular traps (EETs) and total cellular contents, namely eosinophil extracellular trap cell death (EETosis). The pathological contribution of EETosis was made more cogent by recent findings that a classical pathological finding of eosinophilic inflammation, that of Charcot-Leyden crystals, is closely associated with EETosis. Currently no gold standard methods to identify EETosis exist, but "an active eosinophil lysis that releases cell-free granules and net-like chromatin structure" appears to be a common feature of EETosis. In this review, we describe several approaches that visualize EETs/EETosis in clinical samples and <i>in vitro</i> studies using isolated human eosinophils. EETs/EETosis can be observed using simple chemical or fluorescence staining, immunostaining, and electron microscopy, although it is noteworthy that visualization of EETs is greatly changed by sample preparation including the extracellular space of EETotic cells and shear flow. Considering the multiple aspects of biological significance, further study into EETs/EETosis is warranted to give a detailed understanding of the roles played in homeostasis and disease pathogenesis.</p>

DOI

High-throughput sequencing of IgG B-cell receptors reveals frequent usage of the rearranged IGHV4–28/IGHJ4 gene in primary immune thrombocytopenia

Hirokawa M, Fujishima N, Togashi M, Saga A, Omokawa A, Saga T, Moritoki Y, Ueki S, Takahashi N, Kitaura K, Suzuki R

Scientific Reports ( Scientific Reports )  9 ( 1 )   2019.12  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Left ventricular assist device-associated endocarditis involving multiple clones of Staphylococcus aureus with distinct antimicrobial susceptibility patterns

Harada S, Aoki K, Okamoto K, Kinoshita O, Nawata K, Ishii Y, Tateda K, Sasaki M, Saga, T, Doi Y, Yotsuyanagi H, Moriya K, Ono M

International Journal of Infectious Diseases ( International Journal of Infectious Diseases )  84   44 - 47   2019.07  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Epidemiology and genotypic characterisation of dissemination patterns of uropathogenic Escherichia coli in a community

Matsukawa M, Igarashi M, Watanabe H, Qin L, Ohnishi M, Terajima J, Iyoda S, Morita-Ishihara T, Tateda K, Ishii Y, Saga T, Aoki K, Bonomo RA

Epidemiology and Infection ( Epidemiology and Infection )  147   2019  [Refereed]

Research paper (journal)   International Co-author

DOI

Anti-drug antibodies against a novel humanized anti-CD20 antibody impair its therapeutic effect on primary biliary cholangitis in human CD20- and FcγR-expressing mice

Moritoki Y, Tsuneyama K, Nakamura Y, Kikuchi K, Shiota A, Ohsugi Y, Lian Z-X, Zhang W, Yang G-X, Ueki S, Takeda M, Omokawa A, Saga T, Saga A, Watanabe D, Miura M, Ueno Yl, Leung PSC, Tanaka A, Eric Gershwin M, Hirokawa M

Frontiers in Immunology ( Frontiers in Immunology )  9 ( NOV )   2018.11  [Refereed]

Research paper (journal)   International Co-author

DOI

Urine Xanthine Crystals in Tumor Lysis Syndrome

Omokawa A, Oguma M, Ueki S, Saga T, Hirokawa M

Urology ( Urology )  120   e9 - e10   2018.10  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Molecular epidemiology of Klebsiella pneumoniae K1 and K2 isolates in Japan

Harada S, Ishii Y, Saga T, Aoki K, Tateda K

Diagnostic Microbiology and Infectious Disease ( Diagnostic Microbiology and Infectious Disease )  91 ( 4 ) 354 - 359   2018.08  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

Metronidazole-Induced Encephalopathy in Treatment for a Thoracic Aortic Aneurysm Infected by <i>Bacteroides fragilis</i>

Takagi Daichi, Hirokawa Makoto, Kadohama Takayuki, Yamaura Gembu, Tanaka Fuminobu, Kiriu Kentaro, Itagaki Yoshinori, Yamazaki Yuya, Yamamoto Hiroshi, Saga Tomoo

Japanese Journal of Cardiovascular Surgery ( The Japanese Society for Cardiovascular Surgery )  47 ( 3 ) 142 - 147   2018.05  [Refereed]

Research paper (journal)   Domestic Co-author

<p>A 77-year-old man presented with fever and back pain. Computed tomography revealed a distal arch aneurysm. <i>Bacteroides fragilis </i>was found in a blood culture, and we diagnosed a thoracic infected aneurysm. Because of the rapid enlargement of the aneurysm and his frailty, a TEVAR procedure was urgently performed. He left the hospital after antibiotic treatment with meropenem. However, he was re-hospitalized due to recurrence of the infection. The infection was well-controlled by treatment with intravenous meropenem, and the subsequent oral administration of metronidazole (MNZ). He was re-hospitalized again 7 weeks after discharge due to unsteady gait and articulatory disorder. MNZ-induced encephalopathy (MIE) was diagnosed because FLAIR brain magnetic resonance imaging revealed an area of high signal intensity in the bilateral basal dentate nuclei. These symptoms improved after MNZ was changed to AMPC/CVA. Fifteen months later, the patient was doing well and had no recurrence of the infection. We performed TEVAR for a patient with a thoracic aneurysm infected by <i>B. fragilis</i>. The recurrence of the infection was controlled by adequate antibiotic therapy, which included the administration of MNZ. However, patients who are treated with MNZ should be carefully observed to detect the development of neurological signs, as MNZ may induce encephalopathy. The early detection and withdrawal of metronidazole is important for the improvement of MIE.</p>

DOI

ICAM-1 upregulation is not required for retinoic acid-induced human eosinophil survival

Ueki S, Nishikawa J, Fukuchi M, Konno Y, Takeda M, Moritoki Y, Chihara J, Omokawa A, Saga T, Hirokawa M

Immunology Letters ( Immunology Letters )  196   68 - 73   2018.04  [Refereed]

Research paper (journal)   Domestic Co-author

DOI

The effect of hepatocyte growth factor on secretory functions in human eosinophils.

Yamauchi Y, Ueki S, Konno Y, Ito W, Takeda M, Nakamura Y, Nishikawa J, Moritoki Y, Omokawa A, Saga T, Hirokawa M.

Cytokine   88   45 - 50   2016.12  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2016 Aug 20.
PMID: 27552115

DOI

Molecular epidemiologic analysis of a Pneumocystis pneumonia outbreak among renal transplant patients.

Urabe N, Ishii Y, Hyodo Y, Aoki K, Yoshizawa S, Saga T, Murayama SY, Sakai K, Homma S, Tateda K.

Clinical Microbiology and Infection   22 ( 4 ) 365 - 371   2016.04  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2015 Dec 25.
PMID:26724988

DOI

Neurosyphilis Mimicking Ramsay Hunt Syndrome.

Maeda T, Yoshizawa S, Hirayama T, Saga T, Tateda K, Urita Y.

Journal of Nippon Medical School   82 ( 5 ) 254 - 256   2015.11  [Refereed]

Research paper (journal)   Domestic Co-author

PMID: 26568393

DOI

Incorrect diagnosis of Clostridium difficile infection in a university hospital in Japan.

Mori N, Yoshizawa S, Saga T, Ishii Y, Murakami H, Iwata M, Collins DA, Riley TV, Tateda K.

Journal of Infection and Chemotherapy   21 ( 10 ) 718 - 722   2015.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2015 Jul 6.
PMID: 26238001

DOI

ESBL-producing Enterobacteriaceae in environmental water in Dhaka, Bangladesh.

Haque A, Yoshizumi A, Saga T, Ishii Y, Tateda K

Journal of Infection and Chemotherapy   20 ( 11 ) 735 - 737   2014.11  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2014 Aug 5.
PMID: 25103169

DOI

Antibiotic susceptibility and molecular epidemiology of Panton-Valentine leukocidin-positive meticillin-resistant Staphylococcus aureus: An international survey.

Macedo-Viñas M, Conly J, Francois P, Aschbacher R, Blanc DS, Coombs G, Daikos G, Dhawan B, Empel J, Etienne J, Figueiredo AMS, Golding and CNISP G, Han L, Kim HB, Köck R, Larsen A, Layer F, Lo J, Maeda T, Mulvey M, Pantosti A, Saga T, Schrenzel J, Simor A, Skov R, Van Rijen M, Wang H, Zakaria Z, Harbarth, S

Journal of Global Antimicrobial Resistance   2 ( 1 ) 43 - 47   2014.03  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 Sep 3.
PMID:27873637

DOI

Protective effect of procysteine on acinetobacter pneumonia in hyperoxic conditions.

Saito K, Kimura S, Saga T, Misonoo Y, Yoshizawa S, Akasaka Y, Ishii T, Kuwano K, Yamaguchi K, Tateda K.

The Journal of Antimicrobial Chemotherapy   68 ( 10 ) 2305 - 2310   2013.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2013 May 16.
PMID:23681269

DOI

Efficacies of calcium-EDTA in combination with imipenem in a murine model of sepsis caused by Escherichia coli with NDM-1 beta-lactamase.

Yoshizumi A, Ishii Y, Livermore DM, Woodford N, Kimura S, Saga T, Harada S, Yamaguchi K, Tateda K.

Journal of Infection and Chemotherapy   19 ( 5 ) 992 - 995   2013.10  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2012 Dec 12.
PMID:23233082

DOI

Paravastatin Inhibits Farnesol Production in Candica albicans and Improves Survival in a Mouse Model of Systemic Candidiasis.

Tashiro M, Kimura S, Tateda K, Saga T, Ohno A, Ishii Y, Izumikawa K, Tashiro T, Kohno S, Yamaguchi K.

Medical Mycology   50 ( 4 ) 353 - 360   2012.05  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2011 Sep 28.
PMID:21954955

DOI

Roles of IL-17 in an Experimental legionella Pneumonia Model.

Kimizuka Y, Kimura S, Saga T, Ishii M, Hasegawa N, Betsuyaku T, Iwakura Y, Tateda K, Yamaguchi K.

Infection and Immunity   80 ( 3 ) 1121 - 1127   2012.03  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2011 Dec 5.
PMID:22144493

DOI

Efficacy of calcium-EDTA as an inhibitor for metallo-beta-lactamase in a mouse model of Pseudomonas aeruginosa pneumonia.

Aoki N, Ishii Y, Tateda K, Saga T, Kimura S, Kikuchi Y, Kobayashi Y, Tanabe Y, Tsukuda H, Gejyo F, Yamaguchi K.

Antimicrobial Agents and Chemotherapy   54 ( 11 ) 4582 - 4588   2010.11  [Refereed]

Research paper (journal)   Domestic Co-author

Epub 2010 Aug 16.
PMID:20713659

DOI

Sequential changes of legionella antigens and bacterial load in the lungs and urines of a mouse model of pneumonia.

Chen Y, Tateda K, Fujita K, Ishii T, Ishii Y, Kimura S, Saga T, Annaka T, Yamada S, Zhao L, Li S, Azuma A, Gemma A, Kudoh S, Yamaguchi K.

Diagnostic Microbiology and Infectious Disease   66 ( 3 ) 253 - 260   2010.03  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:20159373

DOI

Evaluation of a fully automated system (RAISUS) for rapid identification and antimicrobial susceptibility testing of staphylococci.

Kanemitsu K, Kunishima H, Hatta M, Inden K, Saga T, Ouchi H, Ishizawa K, Harigae H, Takemura H, Kaku M.

Journal of Clinical Microbiology   43 ( 11 ) 5808 - 5810   2005.11  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:16272527

DOI

Assessment of RAISUS, a novel system for identification and antimicrobial susceptibility testing for enterococci.

Kanemitsu K, Kunishima H, Inden K, Hatta M, Saga T, Ueno K, Harigae H, Ishizawa K, Kaku M.

Diagnostic Microbiology and Infectious Disease   53 ( 1 ) 23 - 27   2005.09  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:15994047

DOI

Residual formaldehyde on plastic materials and medical equipment following low-temperature steam and formaldehyde sterilization.

Kanemitsu K, Kunishima H, Saga T, Harigae H, Imasaka T, Hirayama Y, Kaku M.

The Journal of Hospital Infection   59 ( 4 ) 361 - 364   2005.04  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:15749325

DOI

Efficacy of amikacin combinations for nocardiosis.

Kanemitsu K, Kunishima H, Saga T, Harigae H, Ishikawa S, Takemura H, Kaku M.

The Tohoku Journal of Experimental Medicine   201 ( 3 ) 157 - 163   2003.11  [Refereed]

Research paper (journal)   Domestic Co-author

PMID:14649737