Research Achievements - Original paper -
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Characterization of a qnrB-like Genes in Citrobacter species of the American Type Culture Collection (ATCC).
Saga T(corresponding), Sabtcheva S, Mitsutake K, Ishii Y, Tateda K, Yamaguchi K, Kaku M
Antimicrobial Agents and Chemotherapy 57 ( 6 ) 2863 - 2866 2013.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2013 Mar 25.
PMID:23529729 -
First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan.
Saga T (Corresponding), Akasaka T, Takase H, Tanaka M, Sato K, Kaku M.
International Journal of Antimicrobial Agents 29 ( 6 ) 738 - 739 2007.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2007 Mar 19.
PMID:17374476 -
Vibrio parahaemolyticus chromosomal qnr homologue VPA0095: demonstration by transformation with a mutated gene of its potential to reduce quinolone susceptibility in Escherichia coli.
Saga T, Kaku M, Onodera Y, Yamachika S, Sato K, Takase H.
Antimicrobial agents and chemotherapy 49 ( 5 ) 2144 - 2145 2005.05 [Refereed]
Research paper (journal) Domestic Co-author
PMID:15855551
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Cholinergic urticaria improved by daily hot bath : The analysis of its etiology
55 ( 1 ) 9 - 12 2001.01 [Refereed]
Research paper (journal) Domestic Co-author
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Molecular Characterization of Extraintestinal Escherichia coli Isolates in Japan: Relationship between Sequence Types and Mutation Patterns of Quinolone Resistance-Determining Regions Analyzed by Pyrosequencing.
Aoike N, Saga T(corresponding), Sakata R, Yoshizumi A, Kimura S, Iwata M, Yoshizawa S, Sugasawa Y, Ishii Y, Yamaguchi K, Tateda K.
Jorunal of Clinical Microbiology 51 ( 6 ) 1692 - 1698 2013.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2013 Mar 20.
PMID:23515543 -
Worldwide Lineages of Clinical Pneumococci in a Japanese Teaching Hospital Identified by DiversiLab System.
Kashiwaya K, Saga T(corresponding author), Ishii Y, Sakata R, Iwata M, Yoshizawa S, Chang B, Ohnishi M, Tateda K
Journal of Infection and Chemotherapy 22 ( 6 ) 407 - 413 2016.06 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2016 Apr 22.
PMID: 27107736 -
Genotyping of Skin and Soft tissue infection (SSTI)-associated Methicillin-resistant Staphylococcus aureus (MRSA) Strains among Outpatients in a Teaching Hospital in Japan: Application of a Phage-open Reading Frame Typing (POT) kit.
Maeda T, Saga T (Corresponding), Miyazaki T, Kouyama Y, Harada S, Iwata M, Yoshizawa S, Kimura S, Ishii Y, Urita Y, Sugimoto M, Yamaguchi K, Tatada K.
Journal of Infection and Chemotherapy 18 ( 6 ) 906 - 914 2012.12 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2012 Nov 13.
PMID:23150115 -
Use of culture-independent analysis to reveal alteration of intestinal microflora by heat-killed Lactobacillus pentosus in a mouse model of endogenous sepsis.
Sugasawa Y, Saga T, Kimura S, Ishii Y, Yamaguchi K, Tateda K.
Journal of Infection and Chemotherapy 19 ( 4 ) 673 - 676 2013.08
Research paper (journal) Domestic Co-author
Epub 2013 Jan 1.
PMID:23277389 -
Molecular analysis of the integrons of metallo-β-lactamase-producing Pseudomonas aeruginosa isolates collected by nationwide surveillance programs across Japan.
Mano Y, Saga T, Ishii Y, Yoshizumi A, Bonomo RA, Yamaguchi K, Tateda K.
BMC Microbiology 15 41 2015.02 [Refereed]
Research paper (journal) Domestic Co-author
PMID: 25881168
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Nosocomial spread of ArmA-mediated high-level aminoglycoside resistance in Enterobacteriaceae isoltes producing CTX-M-3 beta-lactamase in a cancer hospital in Bulgaria.
Sabtcheva S, Saga T, Kantardjiev T, Ivanova M, Ishii Y, Kaku M.
Journal of Chemotherapy (Florence, Italy) 20 ( 5 ) 593 - 599 2008.10 [Refereed]
Research paper (journal) Domestic Co-author
PMID:19028622
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A fatal infection caused by sequence type 398 methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin gene: A case report in Japan.
Koyama H, Sanui M, Saga T, Harada S, Ishii Y, Tateda K, Lefor AK.
Journal of Infection and Chemotherapy 21 ( 7 ) 541 - 543 2015.07 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2015 Apr 9.
PMID: 25922086 -
Molecular Characterization of Carbapenem-non-susceptible acinetobacter spp. in Japan: Predominance of Multidrug-resistant Acinetobacter baumannii Clonal Complex 92 and IMP-type Metallo-beta-lactamase-producing Non-baumannii Acinetobacter species.
Kouyama Y, Harada S, Ishii Y, Saga T, Yoshizumi A, Tateda K, Yamaguchi K.
Journal of Infection and Chemotherapy 18 ( 4 ) 522 - 528 2012.08 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2012 Feb 14.
PMID:22327516 -
Virulence-suppressing effects of linezolid on methicillin-resistant Staphylococcus aureus: possible contribution to early defervescence.
Yoshizawa S, Tateda K, Saga T, Ishii Y, Yamaguchi K.
Antimicrobial Agents and Chemotherapy 56 ( 4 ) 1744 - 1748 2012.04 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2012 Jan 30.
PMID:22290944 -
Chromosomal Integration and Location on incT Plasmids of the blaCTX-M-2 Gene in Proteus mirabilis Clinical Isolates.
Harada S, Ishii Y, Saga T, Kouyama Y, Tateda K, Yamaguchi K.
Antimicrobial Agents and Chemotherapy 56 ( 2 ) 1093 - 1096 2012.02 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2011 Nov 21.
PMID:22106217 -
Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative Element in a Proteus mirabilis clinical isolate.
Harada S, Ishii Y, Saga T, Tateda K, Yamaguchi K.
Antimicrobial Agents and Chemotherapy 54 ( 9 ) 3545 - 3550 2010.09 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2010 Jun 21.
PMID:20566768 -
High prevalence of the aac(6')-Ib-cr gene and its dissemination among Enterobacteriaceae isolates by CTX-M-15 plasmids in Bulgaria.
Sabtcheva S, Kaku M, Saga T, Ishii Y, Kantardjiev T.
Antimicrobial Agents and Chemotherapy 53 ( 1 ) 335 - 336 2009.01 [Refereed]
Research paper (journal) Domestic Co-author
Epub 2008 Nov 10.
PMID:19001110 -
Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surface.
Kobayashi H, Aiba S, Yamagishi T, Tanita M, Hara M, Saito H, Tagami H.
Dermatology (Basel, Switzerland) 204 ( 3 ) 173 - 178 2002.05 [Refereed]
Research paper (journal) Domestic Co-author
PMID:12037443
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Diagnostic challenges in pulmonary embolism in young adults: thrombosis associated with cytomegalovirus and Mycoplasma pneumoniae
Haruka Hikichi, Ryo Hasegawa, Akiko Saga, Tomoo Saga, Shigeharu Ueki
Cureus 14 ( 12 ) e32757 2022.12 [Refereed]
Research paper (journal) Domestic Co-author
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Neutrophil and eosinophil ETosis-mediated extracellular trap formation in a patient with chronic granulomatous disease.
Yui Miyabe, Michihiro Yano, Mineyo Fukuchi, Ken Watanabe, Yuki Moritoki, Tomoo Saga, TsutomuTakahashi, Shigeharu Ueki
Allergology International 2022.08 [Refereed]
Research paper (journal) Domestic Co-author
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How to detect eosinophil ETosis (EETosis) and extracellular traps
Fukuchi M, Miyabe Y, Furutani C, Saga T, Moritoki Y, Yamada T, Weller PF, Ueki S
Allergology International ( Allergology International ) 70 ( 1 ) 19 - 29 2021.01 [Refereed]
Research paper (journal) International Co-author
<p>Eosinophils are short-lived and comprise only a small population of circulating leukocytes; however, they play surprisingly multifunctional roles in homeostasis and various diseases including allergy and infection. Recent research has shed light on active cytolytic eosinophil cell death that releases eosinophil extracellular traps (EETs) and total cellular contents, namely eosinophil extracellular trap cell death (EETosis). The pathological contribution of EETosis was made more cogent by recent findings that a classical pathological finding of eosinophilic inflammation, that of Charcot-Leyden crystals, is closely associated with EETosis. Currently no gold standard methods to identify EETosis exist, but "an active eosinophil lysis that releases cell-free granules and net-like chromatin structure" appears to be a common feature of EETosis. In this review, we describe several approaches that visualize EETs/EETosis in clinical samples and <i>in vitro</i> studies using isolated human eosinophils. EETs/EETosis can be observed using simple chemical or fluorescence staining, immunostaining, and electron microscopy, although it is noteworthy that visualization of EETs is greatly changed by sample preparation including the extracellular space of EETotic cells and shear flow. Considering the multiple aspects of biological significance, further study into EETs/EETosis is warranted to give a detailed understanding of the roles played in homeostasis and disease pathogenesis.</p>