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Affiliation |
Hospital Division of Clinical Pathology |
Graduating School 【 display / non-display 】
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-1988.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-1993.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2003.04-Now
Akita University Hospital Division of Clinical Pathology Associate Professor
Research Achievements 【 display / non-display 】
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4times in situ transient one-hour flow decrease can induce intimal thickening and medial remodeling of flow-remodeled artery
Nanjo， H.， Komatsu， M.， Masuda， H， et al
Microcirculation annual 19 45 - 46 2003.01
Research paper (journal) Domestic Co-author
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Ultrastructure of endothelial cells under flow alteration
Masuda， H.， Kawamura， K.， Nanjo， H.， et al
Microsc Res Tech 60 2 - 12 2003.01
Research paper (journal) Domestic Co-author
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High flow derives vascular endothelial cell proliferation during flow-inducued arterial remodeling associated with the expression of vascular endothelial growth factors
Sho， E.， Komatsu， M.， Nanjo， H.， et al
Experimental and Molecular Pathology 75 1 - 11 2003.01 [Refereed]
Research paper (journal) Domestic Co-author
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Efficacy of continuous infusion of prostaglandin E1 through the superior mesenteric artery against ischemic liver cell necrosis after hepatic artery occlusion
Kato， T.， Sato， T.， Kurokawa， T.， Nanjo， H.， et al:
Transplantation 76 1340 - 1345 2003.01 [Refereed]
Research paper (journal) Domestic Co-author
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Suzuki Shinsuke, Taguchi Yukie, Kaya Haruka, Kitabayashi Takuro, Asano Riko, Miyabe Yui, Sato Nobuko, Kawasaki Yohei, Nanjo Hiroshi, Yamada Takechiyo
JMA Journal ( 公益社団法人 日本医師会 / 日本医学会 ) 9 ( 1 ) 180 - 188 2026.01
<p><b>Introduction:</b> Near-infrared photoimmunotherapy (NIR-PIT) has emerged as a promising treatment for unresectable locally advanced or recurrent head and neck cancer. This study aimed to identify potential predictors of NIR-PIT efficacy before treatment by focusing on blood biomarkers in addition to pathological findings, including epidermal growth factor receptor (EGFR) expression in tumors.</p><p><b>Methods:</b> A retrospective analysis of the medical records of 10 patients with head and neck cancer, who exhibited confirmed EGFR expression and underwent NIR-PIT treatment at Akita University Hospital from December 2021 to April 2024, was conducted (13 cycles of NIR-PIT). EGFR expression, cluster of differentiation (CD) 4/CD8 ratio, regulatory T cell (Treg) frequency, serum albumin, neutrophil-to-lymphocyte ratio (NLR), and neutrophil-to-eosinophil ratio (NER) were calculated from the tumor tissue and blood collected immediately before treatment. Correlations of these factors with tumor response to NIR-PIT were determined.</p><p><b>Results:</b> The objective response rate (ORR) was 61.5% and the disease control rate (DCR) was 100%. A statistically significant association was observed between the EGFR index and tumor response. No statistically significant correlation was found between other biomarkers (CD4/CD8 ratio, Treg frequency, serum albumin, NLR, NER) and tumor response.</p><p><b>Conclusions:</b> These findings underscore the important role of EGFR expression in predicting the efficacy of NIR-PIT in the management of head and neck cancer, and highlight the significance of incorporating EGFR assessment in patient selection and optimized treatment strategies. Further studies are needed to elucidate the role that these other potential predictors, including tumor immune response markers, play in NIR-PIT outcomes.</p>
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Kimura Kazuya, Watanabe Kenta, Kobayashi Mizuki, Okubo Keisuke, Sato Hiromi, Narita Shintaro, Wada Yuki, Kumagai Satoshi, Sato Kimihiko, Fukuda Sho, Yoshida Tatsuki, Kodama So, Saruta Yohei, Abe Ryo, Shimodaira Yosuke, Matsuhashi Tamotsu, Arita Junichi, Mori Naoko, Nanjo Hiroshi, Habuchi Tomonori, Iijima Katsunori
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2026
<p>Hydrogel spacers are commonly used to reduce rectal toxicity during radiation therapy for prostate cancer. Although generally safe, rare, serious complications may occur. We report the case of a man with diabetes and renal failure who developed a refractory rectal ulcer and fistula five months after spacer placement, followed by Fournier's gangrene. The patient recovered following surgical drainage and antibiotic therapy. This is the first reported case of Fournier's gangrene following hydrogel spacer insertion. Spacer-related rectal wall infiltration might have contributed to this finding. Clinicians should recognize such adverse events and consider early intervention in high-risk patients presenting with hematochezia or perineal symptoms. </p>
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ONO Takahiro, SAITO Ayana, ABE Masamichi, NANJO Hiroshi, SHIMIZU Hiroaki
Neurologia medico-chirurgica ( 一般社団法人 日本脳神経外科学会 ) advpub ( 0 ) 116 - 126 2026
<p>In aging societies such as Japan, the number of patients aged ≥80 years with glioblastoma who are unsuited for surgery is rapidly increasing. At our institution, we adopted a therapeutic strategy based on clinical diagnosis without histological confirmation when surgery was not feasible. This study aimed to retrospectively evaluate the short-term outcomes and clinical value of surgical intervention and histological confirmation in this population. Patients aged ≥80 years diagnosed with glioblastoma between 2011 and 2025 were reviewed. Clinical diagnosis was applied when patients were unfit for surgery. Patient data, including age, sex, Karnofsky performance status, extent of resection, treatment options, and complications, were analyzed for associations with overall survival, Karnofsky performance status improvement, and discharge home. Among 203 cases, 31 patients (15.3%) were included. Their mean age was 84 years; the median Karnofsky performance status scores at admission and discharge were 50 and 60, respectively. Six patients underwent resection, 14 biopsy, and 11 clinical diagnosis. The clinical diagnosis group showed better functional outcomes, including improved Karnofsky performance status, shorter hospitalization, and higher discharge home rates than the biopsy group. Bevacizumab contributed significantly to these outcomes. Perioperative complications occurred in 4 patients; none recovered functionally or were discharged home. Low Karnofsky performance status at discharge was the only independent predictor of poor overall survival. Surgical intervention did not significantly affect the functional and survival outcomes. In conclusion, clinical diagnosis-based treatment, particularly with bevacizumab, could help preserve function and facilitate discharge in very elderly patients with glioblastoma. Biopsies might negatively impact the outcomes in the present cohort.</p>
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Multiple Pulmonary Cavernous Hemangioma: A Case Report
Takashima Shinogu, Nanjo Hiroshi, Matsuo Tsubasa, Kuriyama Shoji, Iwai Hidenobu, Suzuki Haruka, Kobayashi Mirai, Fujibayashi Tatsuki, Shibano Sumire, Minamiya Yoshihiro, Imai Kazuhiro
Surgical Case Reports ( 一般社団法人 日本外科学会 ) 11 ( 1 ) n/a 2025
<p><b>INTRODUCTION:</b> Pulmonary cavernous hemangioma (PCH) is extremely rare and, due to the lack of specific radiological characteristics, is often misdiagnosed as other pulmonary diseases, including metastatic tumors. Here, we report a case of multiple PCH lesions with concomitant hepatic cavernous hemangioma (HCH), emphasizing the diagnostic implications of imaging findings.</p><p><b>CASE PRESENTATION:</b> A 57-year-old man presented with fever. CT revealed numerous well-circumscribed pulmonary nodules and multiple low-density hepatic lesions. Dynamic contrast-enhanced CT demonstrated mild, nonspecific enhancement of the pulmonary nodules, whereas the hepatic lesions showed enhancement from the center to the periphery. Serum tumor markers were within normal limits, and PET-CT revealed no abnormal fluorodeoxyglucose uptake in any of the lesions. Although the hepatic lesions appeared suggestive of hemangioma on imaging, the possibility of malignancy, such as hepatic angiosarcoma and its pulmonary metastases, could not be completely ruled out. Therefore, both hepatic and pulmonary biopsies were performed, and histopathological examination confirmed cavernous hemangioma in both organs.</p><p><b>CONCLUSIONS:</b> PCH is a rare benign tumor lacking distinctive imaging characteristics; therefore, differentiation from metastatic pulmonary tumors is often challenging and represents a key diagnostic issue. Although definitive diagnosis currently relies on surgical biopsy, combining suggestive imaging findings—such as the presence of microcalcifications within nodules and the absence of fluorodeoxyglucose uptake on PET-CT—may help avoid unnecessary invasive procedures.</p>
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Development of an Automated Sectioning Device for Paraffin-Embedded Specimens in Pathological Diagnosis
YOSHINO Masahiko, SASAKI takahiro, NANJO Hiroshi, NAKAMURA Ryuta, KUSUMI Takayuki, AKAKAMI Youichi
The Proceedings of Mechanical Engineering Congress, Japan ( The Japan Society of Mechanical Engineers ) 2025 ( 0 ) J241-02 2025