MINAMIYA Yoshihiro



Graduate School of Medicine  Doctorial Course in Medicine  Oncoregulatory Medicine  Department of Thoracis Surgery

Graduating School 【 display / non-display

  • 1980.04

    Akita University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display


    Akita University  Graduate School,Division of Medicine  Doctor's Course  Completed

Studying abroad experiences 【 display / non-display

  • 1992.07

    Clumbia University  

Campus Career 【 display / non-display

  • 2015.04

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Professor  

Research Field (grants-in-aid-for-scientific-research classification) 【 display / non-display

  • Respiratory surgery


Published Papers 【 display / non-display

  • Successful Osimertinib Rechallenge After Osimertinib-induced Interstitial Lung Disease in a Patient with Postoperative Recurrence of Lung Cancer

    Matsuo Tsubasa, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Watanabe Shin-nosuke, Minamiya Yoshihiro

    Haigan ( The Japan Lung Cancer Society )  59 ( 7 ) 1184 - 1189   2019.12

    <p><b><i>Introduction. </i></b>Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown significant efficacy and prolongation of the overall survival in patients with EGFR mutation-positive non-small cell lung cancer. However, drug-induced lung injury is recognized as one of the most severe adverse events. <b><i>Case. </i></b>A 58-year-old woman was diagnosed with pulmonary adenocarcinoma harboring an EGFR exon 19 deletion. After receiving her informed consent, left upper lobectomy and systemic lymph node dissection were performed. Three years after the surgery, the patient received gefitinib for multiple pulmonary metastases, and she experienced a partial response (PR); however, the disease progressed further. A computed tomography (CT)-guided percutaneous needle biopsy for pulmonary metastasis revealed an EGFR T790M mutation. The patient received osimertinib. A light cough without sputum appeared a year after osimertinib initiation, and CT showed a ground-glass shadow localized in the right middle lobe. Based on these findings, we diagnosed the patient with drug-induced lung injury. The patient discontinued osimertinib and started treatment with prednisolone immediately, but her pulmonary metastasis was re-enhanced. Although the patient switched to platinum-doublet chemotherapy, she was unable to maintain a PR. Eventually, we attempted rechallenge with osimertinib with 5 mg prednisolone daily. The patient is now receiving osimertinib treatment without disease progression or recurrence of drug-induced lung injury. <b><i>Conclusion. </i></b>This is a successful osimertinib rechallenge in a case with a history of steroid therapy osimertinib-induced lung injury.</p>

    DOI CiNii

  • Current Status of Sentinel Node Navigation Surgery in Lung Cancer

    Minamiya Y., Imai K., Konno H., Kurihara N., Atari M.

    Nihon Kikan Shokudoka Gakkai Kaiho ( The Japan Broncho-esophagological Society )  70 ( 2 ) 85 - 86   2019

    DOI CiNii

  • Development of equipment and reagent kit for applying electric field mixing to clinical test using enzyme-linked immunosorbent assay.

    HAYASHI Hidehiro, NAKAMURA Ryuta, HOSHINO Iku, NANJO Hiroshi, MINAMIYA Yoshihiro, AKAGAMI Yoichi

    The Proceedings of Mechanical Engineering Congress, Japan ( The Japan Society of Mechanical Engineers )  2019 ( 0 )   2019

    DOI CiNii

  • Investigation of the Mechanism for Rapid Antigen-Antibody Reaction Using Electric Field Mixing (EFM)

    NAKAMURA Ryuta, KUSUMI Takayuki, OKUBO Yoshinobu, NANJO Hiroshi, MINAMIYA Yoshihiro, AKAGAMI Yoichi

    Journal of the Japan Society for Precision Engineering ( The Japan Society for Precision Engineering )  85 ( 2 ) 208 - 212   2019

    <p>By applied electric field mixing (EFM) showed antigen-antibody reaction time in an immunohistochemical staining can be shortened from 90 minutes of conventional method to 10 minutes. In this study, EFM examined the mechanism which makes antigen-antibody reaction of an immunohistochemical staining quicken. As a result, we obtained that it has the mechanism which a reaction time of an immunohistochemical staining is shorten because antigen and antibody improve to increase the frequencies of contact under EFM compared with conventional method. Further, we investigated the effect of AC electric field is applied on antibody. As a result, it found that by applied AC electric field to antibody liquid, antibody dispersed and stabilized, therefore, staining quality is improved.</p>

    DOI CiNii

  • Development of rapid technology for enzyme linked immunosorbent assay using electric field mixing (EFM) (Part .4):Investigation of optimal method of applied electric field for homogenization of electric field mixing between micro well plates

    Nakamura Ryuta, Okubo Yoshinobu, Kusumi Takayuki, Nanjo Hiroshi, Minamiya Yoshihiro, Akagami Yoichi

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )  2019 ( 0 ) 327 - 328   2019

    DOI CiNii

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