MINAMIYA Yoshihiro



Graduate School of Medicine  Doctorial Course in Medicine  Oncoregulatory Medicine  Department of Thoracis Surgery

Graduating School 【 display / non-display

  • 1980.04

    Akita University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display


    Akita University  Graduate School,Division of Medicine  Doctor's Course  Completed

Studying abroad experiences 【 display / non-display

  • 1992.07

    Clumbia University  

Campus Career 【 display / non-display

  • 2015.04

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Oncoregulatory Medicine   Professor  

Research Field (grants-in-aid-for-scientific-research classification) 【 display / non-display

  • Respiratory surgery


Published Papers 【 display / non-display

  • Successful Osimertinib Rechallenge After Osimertinib-induced Interstitial Lung Disease in a Patient with Postoperative Recurrence of Lung Cancer

    Matsuo Tsubasa, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Watanabe Shin-nosuke, Minamiya Yoshihiro

    Haigan ( The Japan Lung Cancer Society )  59 ( 7 ) 1184 - 1189   2019.12

    <p><b><i>Introduction. </i></b>Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown significant efficacy and prolongation of the overall survival in patients with EGFR mutation-positive non-small cell lung cancer. However, drug-induced lung injury is recognized as one of the most severe adverse events. <b><i>Case. </i></b>A 58-year-old woman was diagnosed with pulmonary adenocarcinoma harboring an EGFR exon 19 deletion. After receiving her informed consent, left upper lobectomy and systemic lymph node dissection were performed. Three years after the surgery, the patient received gefitinib for multiple pulmonary metastases, and she experienced a partial response (PR); however, the disease progressed further. A computed tomography (CT)-guided percutaneous needle biopsy for pulmonary metastasis revealed an EGFR T790M mutation. The patient received osimertinib. A light cough without sputum appeared a year after osimertinib initiation, and CT showed a ground-glass shadow localized in the right middle lobe. Based on these findings, we diagnosed the patient with drug-induced lung injury. The patient discontinued osimertinib and started treatment with prednisolone immediately, but her pulmonary metastasis was re-enhanced. Although the patient switched to platinum-doublet chemotherapy, she was unable to maintain a PR. Eventually, we attempted rechallenge with osimertinib with 5 mg prednisolone daily. The patient is now receiving osimertinib treatment without disease progression or recurrence of drug-induced lung injury. <b><i>Conclusion. </i></b>This is a successful osimertinib rechallenge in a case with a history of steroid therapy osimertinib-induced lung injury.</p>


  • Development of rapid technology for enzyme linked immunosorbent assay using electric field mixing (EFM) (Part .4):Investigation of optimal method of applied electric field for homogenization of electric field mixing between micro well plates

    Nakamura Ryuta, Okubo Yoshinobu, Kusumi Takayuki, Nanjo Hiroshi, Minamiya Yoshihiro, Akagami Yoichi

    Proceedings of JSPE Semestrial Meeting ( The Japan Society for Precision Engineering )  2019 ( 0 ) 327 - 328   2019


  • Intraoperative diagnosis with novel rapid-immunohistochemistry (R-IHC)

    NANJO Hiroshi, AKAGAMI Yoichi, NAKAMURA Rhuta, HIROSHIMA Yuko, TERADA Kaori, IMAI Kazuhiro, Minamiya Yoshihiro

    The Proceedings of Mechanical Engineering Congress, Japan ( The Japan Society of Mechanical Engineers )  2019 ( 0 )   2019

    <p>Immunohistochemistry (IHC) is the most common application of immunostaining. It is widely used in the disgnosis of abnormal cells such as those found in cancerous tumors. Intraoperative pathological diagnosis is also important in selecting suitable surgery for cancer patients. We performed intraoperative diagnosis of 830 cases in Akita University Hospital., with a novel method of rapid-immunohistochemistory (R-IHC) using an alternating current electric field. The results were very good, R-IHC detected an objective evidence that were undetected using conventional HE staining. So we can diagnose degree of malignancy, histological type of cancer, and lymph node metastasis more accurately.</p>


  • Current Status of Sentinel Node Navigation Surgery in Lung Cancer

    Minamiya Y., Imai K., Konno H., Kurihara N., Atari M.

    Nihon Kikan Shokudoka Gakkai Kaiho ( The Japan Broncho-esophagological Society )  70 ( 2 ) 85 - 86   2019


  • Development of electric field mixing (EFM) to realize rapid intraoperative immunohistochemical staining

    NAKAMURA Ryuta, OKUBO Yoshinobu, NANJO Hiroshi, MINAMIYA Yoshihiro, KUSUMI Takayuki, AKAGAMI Yoichi

    The Proceedings of Mechanical Engineering Congress, Japan ( The Japan Society of Mechanical Engineers )  2019 ( 0 )   2019

    <p>We aim to develop innovative stirring technology (electric field mixing (EFM)) applied abrasive control technique with AC electric field. This technique allows for stirring without contact by applying AC electric field to droplets. This technique was applied to intraoperative immunohistochemical staining. Under EFM showed antigen-antibody reaction time in immunohistochemical staining can be shortened from 90 minutes of conventional method to 10 minutes. In this study, EFM examined the mechanism which makes antigen-antibody reaction of an immunohistochemical staining quicken. As a result, we obtained that it has the mechanism which a reaction time of an immunohistochemical staining is shorten because antigens and antibodies improve to increase the frequencies of contact, and further antibodies disperse and becomes easy to react to antigens under EFM. compared with conventional method.</p>


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