研究等業績 - 原著論文 - 渡邊 博之
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Simultaneous appearance of intracardiac masses following chemotherapy in a patient with lung cancer
Shimbo M.
European Heart Journal Cardiovascular Imaging ( European Heart Journal Cardiovascular Imaging ) 19 ( 1 ) 2018年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Watanabe H.
Internal Medicine ( Internal Medicine ) 56 ( 22 ) 2967 - 2968 2017年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Sato W.
Journal of Vascular Surgery ( Journal of Vascular Surgery ) 66 ( 5 ) 1574 - 1575 2017年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Stromal interaction molecule 1 haploinsufficiency causes maladaptive response to pressure overload
Ohba T.
PLoS ONE ( PLoS ONE ) 12 ( 11 ) 2017年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Sudo K.
Anticancer Research ( Anticancer Research ) 37 ( 10 ) 5565 - 5571 2017年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Acute aortic regurgitation in a bicuspid aortic valve due to the rupture of an anomalous cord
Watanabe H.
Anatolian Journal of Cardiology ( Anatolian Journal of Cardiology ) 17 ( 6 ) 2017年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Sato T.
Cardiovascular Research ( Cardiovascular Research ) 113 ( 7 ) 760 - 769 2017年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Okuda Y.
Cancer Chemotherapy and Pharmacology ( Cancer Chemotherapy and Pharmacology ) 79 ( 5 ) 1013 - 1020 2017年05月 [査読有り]
研究論文（学術雑誌） 国内共著
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Rapidly growing intraventricular mass in a patient with hereditary haemorrhagic telangiectasia
Shimbo M.
European Heart Journal Cardiovascular Imaging ( European Heart Journal Cardiovascular Imaging ) 18 ( 4 ) 2017年04月 [査読有り]
研究論文（学術雑誌） 国内共著
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Iwakawa H.
Intensive Care Medicine ( Intensive Care Medicine ) 43 ( 1 ) 135 - 136 2017年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Vps34 regulates myofibril proteostasis to prevent hypertrophic cardiomyopathy
Kimura H.
JCI Insight ( JCI Insight ) 2 ( 1 ) 2017年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Blunt traumatic rupture of the right ventricle: visualization of spurting blood using transthoracic echocardiography.
Mai Shimbo, Hiroyuki Watanabe, Kumiko Watanabe, Genbu Yamaura, Hiroshi Ito
European heart journal. Cardiovascular Imaging 17 ( 11 ) 1258 - 1258 2016年11月 [査読有り]
研究論文（学術雑誌）
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An unusual cause of superior vena cava syndrome after pacemaker implantation.
Hiroyuki Watanabe, Takako Iino, Hiroshi Ito
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 18 ( 5 ) 657 - 657 2016年05月 [査読有り]
研究論文（学術雑誌）
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The association of circulating inflammatory and oxidative stress biomarker levels with diagonal earlobe crease in patients with atherosclerotic diseases.
Takashi Koyama, Hiroyuki Watanabe, Hiroshi Ito
Journal of cardiology 67 ( 4 ) 347 - 51 2016年04月 [査読有り]
研究論文（学術雑誌）
BACKGROUND: Earlobe creases (ELC) are frequently observed in patients with atherosclerosis. Atherosclerosis is considered to be a systemic vascular inflammatory disease, and oxidative stress is known to be a contributor to vascular inflammation. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes. This study was designed to test the hypothesis that biomarkers of inflammation and oxidative stress are increased in patients with ELC. METHODS: A total of 223 consecutive patients with atherosclerotic risk factors were enrolled and divided into two groups. One group consisted of patients with ELC (ELC group, n=134) and the other was without ELC (non-ELC group, n=89). Medical information and biomarker levels related to atherosclerosis were acquired from these patients. RESULTS: The male ratio, prevalence of hypertension, diabetes mellitus, and MDA-LDL, hs-CRP, and PTX3 levels were found to be higher in the ELC group, compared with the non-ELC group. A multiple logistic regression analysis showed that PTX3 levels, rather than hs-CRP, constituted the strongest predictive factor for the appearance of ELC. CONCLUSIONS: Vascular inflammation and oxidative stress are associated with the presence of ELC.
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Isolated Atrial Septal Defect Complicated by Tricuspid Valve Infective Endocarditis.
Mai Shimbo, Hiroyuki Watanabe, Tatsumi Abe, Teruki Sato, Takashi Koyama, Hiroshi Yamamoto, Hiroshi Ito
Internal medicine (Tokyo, Japan) 54 ( 19 ) 2463 - 5 2015年10月 [査読有り]
研究論文（学術雑誌）
Infective endocarditis (IE) associated with atrial septal defect (ASD) is extremely rare. However, tricuspid regurgitation (TR) secondary to right ventricular overload is a potential cause of IE, and once it occurs, the development of a paradoxical embolism may lead to fatal complications. We herein report the case of a 50-year-old woman who was admitted due to a persistent fever resistant to antibiotics. Echocardiography showed secundum ASD, moderate TR and a mobile vegetation measuring 15×10 mm attached to the tricuspid valve. Given the risk of developing a paradoxical embolism, urgent surgery was successfully performed.
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Quality of life and heart rate variability following acute myocardial infarction
SHIMBO Mai,KOSAKA Toshimitsu,FUSHIMI Etsuko,KOYAMA Takashi,IINO Kenji,WATANABE Hiroyuki,ITO Hiroshi
秋田医学 42 ( 1 ) 29 - 36 2015年06月 [査読有り]
研究論文（学術雑誌）
Objective : The aim of this study was to investigate whether cardiac autonomic function measured
by heart rate variability (HRV) indices are related to quality of life (QOL) improvements in
patients with acute myocardial infarction (AMI) treated by percutaneous coronary intervention.
Methods : We enrolled 20 consecutive patients with AMI. Measures of HRV, obtained from
both frequency and time domain analyses using 24-h Holter monitoring before discharge, were as
follows : low and high frequency (HF) domain measures, the square root of the mean squared differences
of successive R-R intervals (rMSSD), and the percentage of differences between adjacent
normal R-R intervals >50 ms for the whole analysis (pNN50). QOL was determined by
physical and mental component summary (PCS and MCS, respectively) scores derived from the
Japanese Medical Outcomes Study 36-item Short Form Health Survey before and 6 months after
discharge.
Results : The subjects showed significant improvement in the MCS, but not the PCS score.
There were also positive correlations between the parasympathetic parameters of HF, rMSSD,
and pNN50 and the change in MCS score. In a multivariate analysis, rMSSD was found to be
independently associated with the change in MCS score.
Conclusions : Parasympathetic tone, as measured by HRV, is independently associated with
QOL, which emphasizes the role of cardiac autonomic function on QOL in patients with AMI. -
Involvement of the orexin system in sympathetic nerve regulation.
Manabu Murakami, Takayoshi Ohba, Testuya Kushikata, Hidetoshi Niwa, Akira Kurose, Tadaatsu Imaizumi, Hiroyuki Watanabe, Teruyuki Yanagisawa, Shigeyuki Nakaji, Kyoichi Ono, Kazuyoshi Hirota
Biochemical and biophysical research communications 460 ( 4 ) 1076 - 81 2015年05月 [査読有り]
研究論文（学術雑誌）
Orexin, also known as hypocretin, is a secreted neuropeptide implicated in the regulation of sleep and food intake. In the present study, we examined the importance of orexin in regulation of the sympathetic nervous system using an orexin/ataxin-3 transgenic (OXTg) rat, which has a minimal number of orexin neurons. RT-PCR analysis identified expression of prepro-orexin and orexin receptor-1 (OX1R) in the superior cervical ganglion (SCG), and expression of another receptor (OX2R) was marginal in the wild-type rat. The orexin/ataxin-3 transgenic rat showed increased expression of OX1R and OX2R, whereas expression of prepro-orexin was undetectable, suggesting a compensatory increase in both receptors. In the ECG recording (R-R interval), orexin/ataxin-3 transgenic rats showed decreased responsiveness to the β-adrenergic blocker propranolol. Furthermore, OXTg rats had deteriorated R-R interval regulation, indicating involvement of the orexin system in sympathetic nerve regulation. This was accompanied by decreased baroreflex and responsiveness to β-adrenergic blocker in blood pressure recording, also suggesting involvement of the orexin system in sympathetic nerve regulation. Histological examination revealed hypotrophic changes in the transgenic heart, suggesting involvement of the orexin system in cardiac development. Taken together, our present results indicate involvement of the orexin system in sympathetic nerve control.