研究等業績 - 原著論文 - 渡邊 博之
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Wakaki T.
IJC Heart and Vasculature ( IJC Heart and Vasculature ) 56 2025年02月 [査読有り]
研究論文（学術雑誌）
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Tashiro H.
Journal of Arrhythmia ( Journal of Arrhythmia ) 40 ( 4 ) 991 - 997 2024年08月 [査読有り]
研究論文（学術雑誌）
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Iwakawa H.
Journal of Cardiovascular Electrophysiology ( Journal of Cardiovascular Electrophysiology ) 2024年 [査読有り]
研究論文（学術雑誌）
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Coconut Atrium Causing Restrictive Physiology in the Right Ventricle
Wakaki Tomitaka, Sato Wakana, Suzuki Mayu, Watanabe Hiroyuki
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2023年12月 [査読有り]
研究論文（学術雑誌） 国内共著
<p>We herein report a 61-year-old woman with a history of mitral valve replacement for rheumatic fever who presented with crural edema and ascites. Computed tomography showed massive left atrial (LA) calcification involving the interatrial septum, termed "coconut atrium." Catheterization revealed not only pulmonary artery hypertension but also a large V-wave in the pulmonary artery wedge pressure waveform and a dip-and-plateau pattern of right ventricular pressure. Three-dimensional transthoracic echocardiography confirmed the early attainment of peak LA volume and a decreased LA expansion index. Stiff LA syndrome due to coconut LA results in the development of restrictive right ventricular physiology. </p>
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Tsukasa Kato, Sho Torii, Norihito Nakamura, Kazuki Aihara, Yuta Terabe, Osamu Iida, Takahiro Tokuda, Tatsuya Nakama, Yo Kawahara, Junichi Miyamoto, Takafumi Saito, Norihiko Kamioka, Tsutomu Murakami, Takeshi Ijichi, Makoto Natsumeda, Shigemitsu Tanaka, Yohei Ohno, Gaku Nakazawa, Hiroyuki Watanabe, and Yuji Ikari
JACC: Advances ( JACC: Advances ) 2 ( 9 ) 2023年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Hidehiro Iwakawa, Masateru Takigawa, Junji Yamaguchi, Claire A Martin, Masahiko Goya, Tasuku Yamamoto, Miki Amemiya, Takashi Ikenouchi, Miho Negishi, Iwanari Kawamura, Kentaro Goto, Takatoshi Shigeta, Takuro Nishimura, Tomomasa Takamiya, Susumu Tao, Shinsuke Miyazaki , Hiroyuki Watanabe, Tetsuo Sasano
Circulation Journal ( Circulation Journal ) 87 ( 12 ) 1757 - 1764 2023年10月 [査読有り]
研究論文（学術雑誌） 国内共著
<b><i>Background:</i></b> For lesion size prediction, each input parameter, including ablation energy (AE), and output parameter, such as impedance, is individually used. We hypothesize that using both parameters simultaneously may be more optimal.
<b><i>Methods and Results:</i></b> Radiofrequency applications at a range of power (30–50 W), contact force (10 g and 20 g), duration (10–60 s), and catheter orientation with normal saline (NS)- or half-normal saline (HNS)-irrigation were performed in excised porcine hearts. The correlations, with lesion size of AE, absolute impedance drop (∆Imp-drop), relative impedance drop (%Imp-drop), and AE*%Imp-drop were examined. Lesion size was analyzed in 283 of 288 lesions (NS-irrigation, n=142; HNS-irrigation, n=141) without steam pops. AE*%Imp-drop consistently showed the strongest correlations with lesion maximum depth (NS-irrigation, ρ=0.91; HNS-irrigation, ρ=0.94), surface area (NS-irrigation, ρ=0.87; HNS-irrigation, ρ=0.86), and volume (NS-irrigation, ρ=0.94; HNS-irrigation, ρ=0.94) compared with the other parameters. Moreover, compared with AE alone, AE*%Imp-drop significantly improved the strength of correlation with lesion maximum depth (AE vs. AE*%Imp-drop, ρ=0.83 vs. 0.91, P<0.01), surface area (ρ=0.73 vs. 0.87, P<0.01), and volume (ρ=0.84 vs. 0.94, P<0.01) with NS-irrigation. This tendency was also observed with HNS-irrigation. Parallel catheter orientation showed a better correlation with lesion depth and volume using ∆Imp-drop, %Imp-drop, and AE*%Imp-drop than perpendicular orientation.
<b><i>Conclusions:</i></b> The combination of input and output parameters is more optimal than each single parameter for lesion prediction. -
Hidehiro Iwakawa, Tomohito Suzuki, Ken Terata, Hiroyuki Watanabe
Journal of Arrhythmia ( Journal of Arrhythmia ) 39 ( 5 ) 813 - 815 2023年09月 [査読有り]
研究論文（学術雑誌） 国内共著
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Ryota Kaimori, Hidehiro Iwakawa, Nobuhiro Suzuki, Mako Aokawa, Haruwo Tashiro, Ken Terata, Hiroyuki Watanabe
Journal of Electrocardiology ( Journal of Electrocardiology ) 80 63 - 68 2023年05月 [査読有り]
研究論文（学術雑誌） 国内共著
BACKGROUND: Advanced interatrial block (A-IAB) on electrocardiography (ECG) represents the conduction delay between the left and right atria. We investigated the association of A-IAB with left and right atrial (LA/RA) remodeling in patients with atrial fibrillation (AF). METHODS: We enrolled 74 patients who underwent ECG, cardiac computed tomography (CCT), and echocardiography during sinus rhythm before catheter ablation of AF. A-IAB was defined as P-wave duration ≥120 ms with a biphasic morphology in leads III and aVF or notched morphology in lead II. We compared the maximum and minimum LA/RA volume indices (max and min LAV/RAVI), LA/RA expansion index (LAEI/RAEI), and total, passive, and active LA/RA emptying fraction (LAEF/RAEF) between patients with and without A-IAB. RESULTS: Of the 74 patients (mean age, 64.3 ± 9.6 years), 35 (47%) showed A-IAB. Patients with A-IAB had a significantly higher likelihood of hypertension and left ventricular diastolic dysfunction than those without. Patients with A-IAB had significantly larger max (69.2 [60.7-79.7]mL/m2 vs. 60.9 [50.4-68.3]mL/m2, P < 0.01) and min (44.0 [37.2-52.1]mL/m2 vs. 34.1 [29.2-43.5]mL/m2, P < 0.01) LAVI than those without. The max and min RAVI were not significantly different between groups. LAEI (55.1 [48.2-78.5]% vs. 72.1 [57.8-84.8]%, P < 0.05), total LAEF (35.5 [32.5-44.0]% vs. 41.9 [36.6-45.9]%, P < 0.05), and passive LAEF (12.2 [10.0-14.4]% vs. 15.5 [11.2-19.6]%, P < 0.05) were significantly lower in patients with A-IAB than without. CONCLUSIONS: A-IAB was associated with LA, but not RA enlargement, in patients with AF. A-IAB may indicate LA functional remodeling in the reservoir and conduit phases.
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Yao A.
Journal of Cardiology ( Journal of Cardiology ) 80 ( 6 ) 525 - 531 2022年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Utility of P-wave abnormalities for distinguishing embolic stroke from non-embolic stroke
Iwakawa H.
International Journal of Cardiology ( International Journal of Cardiology ) 368 72 - 77 2022年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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Terata K.
Internal Medicine ( Internal Medicine ) 61 ( 22 ) 3315 - 3322 2022年11月 [査読有り]
研究論文（学術雑誌） 国内共著
<p><b>Objective </b>Early recurrence (ER) after pulmonary vein isolation (PVI) for atrial fibrillation (AF) is expected to resolve within the recommended 3-month blanking period, irrespective of the ablation device used. To compare the occurrence and relationship of AF within the blanking period and subsequent late recurrence (LR) with radiofrequency (RF) and cryoballoon (CB) ablation. </p><p><b>Methods </b>A retrospective analysis of 294 patients (mean age=62±9, 70.0% male) undergoing PVI for drug-refractory paroxysmal AF was done. After categorizing the patients into the RF group (n=152) and the CB group (n=142), a group-wise comparison was done to investigate the impact of ER on LR throughout a 2-year follow-up. </p><p><b>Results </b>The groups were similar regarding the occurrence of ER (RF=22.4%, CB=24.6%, p=0.62), while LR was significantly higher in the RF group (p=0.003). ER was associated with LR in the RF group (p<0.01) but not in the CB group (p=0.08), while a significant independent association with an increased LR risk was observed [hazard ratio (HR) 6.12; 95% confidence interval (CI) 3.56-10.51, p<0.01]. RF ablation also significantly increased the risk of LR (HR=2.93; 95% CI=1.64-5.23, p<0.01). </p><p><b>Conclusion </b>A recurrence of atrial arrhythmia is more frequent with RF-PVI than with CB-PVI for patients with paroxysmal AF. ER and RF-ablation are strong predictors for LR after the 3-month blanking period. </p>
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Suto Y.
Diagnostics ( Diagnostics ) 12 ( 11 ) 2022年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Narrow QRS complex tachycardia with and without ventriculoatrial block: What is the mechanism?
Iwakawa H.
Heart Rhythm ( Heart Rhythm ) 19 ( 11 ) 1907 - 1909 2022年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Sato Wakana, Nomura Kyoko, Satoh Michihiro, Hara Azusa, Tsubota-Utsugi Megumi, Murakami Takahisa, Asayama Kei, Tatsumi Yukako, Kobayashi Yuki, Hirose Takuo, Inoue Ryusuke, Totsune Tomoko, Kikuya Masahiro, Hozawa Atsushi, Metoki Hirohito, Imai Yutaka, Watanabe Hiroyuki, Ohkubo Takayoshi
Ｊｏｕｒｎａｌ ｏｆ Ａｔｈｅｒｏｓｃｌｅｒｏｓｉｓ ａｎｄ Ｔｈｒｏｍｂｏｓｉｓ ( 一般社団法人 日本動脈硬化学会 ) advpub ( 0 ) 2022年10月 [査読有り]
研究論文（学術雑誌） 国内共著
<p><b>Aims: </b>Few studies have investigated the subclinical atherosclerotic changes in the brain and carotid artery, and in East Asian populations. We sought to investigate whether gravidity, delivery, the age at menarche and menopause and estrogen exposure period are associated with subclinical atherosclerosis of the brain and carotid arteriopathy.<b> </b></p><p><b>Methods: </b>This cross-sectional study formed part of a cohort study of Ohasama residents initiated in 1986. Brain atherosclerosis and carotid arteriopathy were diagnosed as white matter hyperintensity (WMH) and lacunae evident on brain magnetic resonance imaging (MRI) and carotid intimal media thickness (IMT) or plaque revealed by ultrasound, respectively. The effect of the reproductive events on brain atherosclerosis and carotid arteriopathy was investigated using logistic regression and general linear regression models after adjusting for covariates.<b> </b></p><p><b>Results: </b>Among 966 women aged ≥ 55 years in 1998, we identified 622 and 711 women (mean age: 69.2 and 69.7 years, respectively) who underwent either MRI or carotid ultrasound between 1992–2008 or 1993–2018, respectively. The highest quartile of gravidity (≥ 5 vs. 3) and delivery (≥ 4 vs. 2), and the highest and second highest (3 vs. 2) quartiles of delivery were associated with an increased risk of WMH and carotid artery plaque, respectively. Neither of age at menarche, menopause, and estrogen exposure period estimated by subtracting age at menarche from age at menopause was associated with atherosclerotic changes of brain and carotid arteries.<b> </b></p><p><b>Conclusions: </b>Higher gravidity and delivery are associated with subclinical atherosclerosis of the brain and carotid plaque.</p>
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Kato T.
Cardiology Research ( Cardiology Research ) 13 ( 5 ) 289 - 296 2022年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Asymptomatic Coarctation of the Aorta in Adults with Preserved Exercise Capacity: A Case Report
Tashiro Haruwo, Sato Wakana, Seki Katsuhito, Ono Yuto, Kato Tsukasa, Sato Teruki, Watanabe Hiroyuki
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2022年09月 [査読有り]
研究論文（学術雑誌） 国内共著
<p>We herein report a case of coarctation of the aorta (CoA) in an asymptomatic adult who had a preserved exercise capacity. A 56-year-old man with mild hypertension exhibited left ventricular hypertrophy on an electrocardiogram during an annual medical checkup. Echocardiography showed a bicuspid aortic valve and cor triatriatum sinister, and subsequent computed tomography revealed CoA with developed collaterals. Cardiopulmonary exercise testing showed a good exercise capacity. He refused surgical repair and has been asymptomatic for five years. This case is of special interest, as CoA is usually rarely noticed during adulthood if there are no severe congenital anomalies, and in addition, this patient had good exercise capacity. </p>
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Wide QRS complex tachycardia and alternating bundle branch block aberration: What is the mechanism?
Iwakawa H.
Journal of Arrhythmia ( Journal of Arrhythmia ) 38 ( 3 ) 478 - 481 2022年06月 [査読有り]
研究論文（学術雑誌）
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Kato T.
Journal of Echocardiography ( Journal of Echocardiography ) 2022年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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飯野 貴子, 渡邊 博之
超音波医学 ( 公益社団法人 日本超音波医学会 ) 49 ( 2 ) 97 - 104 2022年03月 [査読有り] [招待有り]
研究論文（学術雑誌） 国内共著
<p>左室拡張機能は，様々な心疾患において予後に影響する重要な因子の一つである．心臓超音波検査によって，非侵襲的に左室弛緩能，左室充満圧上昇の有無について評価することができる．心臓超音波検査による左室拡張機能評価は，循環器疾患の診断，予後予測に有用なだけでなく，特に心不全症例においては治療方針をも左右する．そのため，個々の病態に適した複数の指標を用いて，左室拡張機能を的確に判定することが求められる．左室拡張機能は様々な指標を用いて評価される．代表的指標の一つである左室流入血流速波形は，左室弛緩能，左室充満圧だけでなく，その他様々な要素の影響を受け，変化する．それぞれの指標の特徴と限界を理解したうえで，適切に用い，解釈することが必要である．本稿では，2016年米国心エコー図学会（ASE）/欧州心血管画像協会（EACVI）より提唱されたガイドラインを用いた左室拡張機能評価と代表的な拡張機能指標の特徴と限界について概説する．</p>
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Sudden and severe cardiotoxicity induced with pembrolizumab, its clinical course, therapeutic intervention, and outcome
Matsumoto.T
International Cancer Conference Journal 11 ( 1 ) 81 - 86 2022年01月 [査読有り]
研究論文（学術雑誌） 国内共著