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2024年04月-継続中
秋田大学 附属病院 附属病院長
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2018年03月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 機能展開医学系 教授
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2009年04月-2018年02月
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 機能展開医学系 准教授
学位論文 【 表示 ／ 非表示 】
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L-type Ca channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts
Watanabe H, Nishio M, Miura M, Iijima T
J Mol Cell Cardiol. 27 ( 6 ) 1271 - 1279 1996年03月 [査読有り]
国内共著
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Coconut Atrium Causing Restrictive Physiology in the Right Ventricle
Wakaki Tomitaka, Sato Wakana, Suzuki Mayu, Watanabe Hiroyuki
Internal Medicine ( 一般社団法人 日本内科学会 ) advpub ( 0 ) 2023年12月 [査読有り]
研究論文（学術雑誌） 国内共著
<p>We herein report a 61-year-old woman with a history of mitral valve replacement for rheumatic fever who presented with crural edema and ascites. Computed tomography showed massive left atrial (LA) calcification involving the interatrial septum, termed "coconut atrium." Catheterization revealed not only pulmonary artery hypertension but also a large V-wave in the pulmonary artery wedge pressure waveform and a dip-and-plateau pattern of right ventricular pressure. Three-dimensional transthoracic echocardiography confirmed the early attainment of peak LA volume and a decreased LA expansion index. Stiff LA syndrome due to coconut LA results in the development of restrictive right ventricular physiology. </p>
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Tsukasa Kato, Sho Torii, Norihito Nakamura, Kazuki Aihara, Yuta Terabe, Osamu Iida, Takahiro Tokuda, Tatsuya Nakama, Yo Kawahara, Junichi Miyamoto, Takafumi Saito, Norihiko Kamioka, Tsutomu Murakami, Takeshi Ijichi, Makoto Natsumeda, Shigemitsu Tanaka, Yohei Ohno, Gaku Nakazawa, Hiroyuki Watanabe, and Yuji Ikari
JACC: Advances ( JACC: Advances ) 2 ( 9 ) 2023年11月 [査読有り]
研究論文（学術雑誌） 国内共著
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Hidehiro Iwakawa, Masateru Takigawa, Junji Yamaguchi, Claire A Martin, Masahiko Goya, Tasuku Yamamoto, Miki Amemiya, Takashi Ikenouchi, Miho Negishi, Iwanari Kawamura, Kentaro Goto, Takatoshi Shigeta, Takuro Nishimura, Tomomasa Takamiya, Susumu Tao, Shinsuke Miyazaki , Hiroyuki Watanabe, Tetsuo Sasano
Circulation Journal ( Circulation Journal ) 87 ( 12 ) 1757 - 1764 2023年10月 [査読有り]
研究論文（学術雑誌） 国内共著
<b><i>Background:</i></b> For lesion size prediction, each input parameter, including ablation energy (AE), and output parameter, such as impedance, is individually used. We hypothesize that using both parameters simultaneously may be more optimal.
<b><i>Methods and Results:</i></b> Radiofrequency applications at a range of power (30–50 W), contact force (10 g and 20 g), duration (10–60 s), and catheter orientation with normal saline (NS)- or half-normal saline (HNS)-irrigation were performed in excised porcine hearts. The correlations, with lesion size of AE, absolute impedance drop (∆Imp-drop), relative impedance drop (%Imp-drop), and AE*%Imp-drop were examined. Lesion size was analyzed in 283 of 288 lesions (NS-irrigation, n=142; HNS-irrigation, n=141) without steam pops. AE*%Imp-drop consistently showed the strongest correlations with lesion maximum depth (NS-irrigation, ρ=0.91; HNS-irrigation, ρ=0.94), surface area (NS-irrigation, ρ=0.87; HNS-irrigation, ρ=0.86), and volume (NS-irrigation, ρ=0.94; HNS-irrigation, ρ=0.94) compared with the other parameters. Moreover, compared with AE alone, AE*%Imp-drop significantly improved the strength of correlation with lesion maximum depth (AE vs. AE*%Imp-drop, ρ=0.83 vs. 0.91, P<0.01), surface area (ρ=0.73 vs. 0.87, P<0.01), and volume (ρ=0.84 vs. 0.94, P<0.01) with NS-irrigation. This tendency was also observed with HNS-irrigation. Parallel catheter orientation showed a better correlation with lesion depth and volume using ∆Imp-drop, %Imp-drop, and AE*%Imp-drop than perpendicular orientation.
<b><i>Conclusions:</i></b> The combination of input and output parameters is more optimal than each single parameter for lesion prediction. -
Hidehiro Iwakawa, Tomohito Suzuki, Ken Terata, Hiroyuki Watanabe
Journal of Arrhythmia ( Journal of Arrhythmia ) 39 ( 5 ) 813 - 815 2023年09月 [査読有り]
研究論文（学術雑誌） 国内共著
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Ryota Kaimori, Hidehiro Iwakawa, Nobuhiro Suzuki, Mako Aokawa, Haruwo Tashiro, Ken Terata, Hiroyuki Watanabe
Journal of Electrocardiology ( Journal of Electrocardiology ) 80 63 - 68 2023年05月 [査読有り]
研究論文（学術雑誌） 国内共著
BACKGROUND: Advanced interatrial block (A-IAB) on electrocardiography (ECG) represents the conduction delay between the left and right atria. We investigated the association of A-IAB with left and right atrial (LA/RA) remodeling in patients with atrial fibrillation (AF). METHODS: We enrolled 74 patients who underwent ECG, cardiac computed tomography (CCT), and echocardiography during sinus rhythm before catheter ablation of AF. A-IAB was defined as P-wave duration ≥120 ms with a biphasic morphology in leads III and aVF or notched morphology in lead II. We compared the maximum and minimum LA/RA volume indices (max and min LAV/RAVI), LA/RA expansion index (LAEI/RAEI), and total, passive, and active LA/RA emptying fraction (LAEF/RAEF) between patients with and without A-IAB. RESULTS: Of the 74 patients (mean age, 64.3 ± 9.6 years), 35 (47%) showed A-IAB. Patients with A-IAB had a significantly higher likelihood of hypertension and left ventricular diastolic dysfunction than those without. Patients with A-IAB had significantly larger max (69.2 [60.7-79.7]mL/m2 vs. 60.9 [50.4-68.3]mL/m2, P < 0.01) and min (44.0 [37.2-52.1]mL/m2 vs. 34.1 [29.2-43.5]mL/m2, P < 0.01) LAVI than those without. The max and min RAVI were not significantly different between groups. LAEI (55.1 [48.2-78.5]% vs. 72.1 [57.8-84.8]%, P < 0.05), total LAEF (35.5 [32.5-44.0]% vs. 41.9 [36.6-45.9]%, P < 0.05), and passive LAEF (12.2 [10.0-14.4]% vs. 15.5 [11.2-19.6]%, P < 0.05) were significantly lower in patients with A-IAB than without. CONCLUSIONS: A-IAB was associated with LA, but not RA enlargement, in patients with AF. A-IAB may indicate LA functional remodeling in the reservoir and conduit phases.
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SOCE and TRPC/Stim/Orai Signaling in Cardiac Myocytes. In: Store-operated Ca entry (SOCE) pathways : eds by Groschner K
Hiroyuki Watanabe, Takayoshi Ohba,Hiroshi Ito ( 担当： 共著 )
Springer – Verlag 2012年09月
学術書
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Sublethal ischemia delays the Q-wave development and promotes blunted electrical response to subsequent sustained ischemia. in Building Bridges in Electrocardiology. eds by A. van Oosterom, T.F. Oostendrorp, G.J.H.Uijen
Fujiwara T, Saito T, Kimura Y, Miura H, Watanabe H, Iwaya M, Nakagomi A, Tamura Y and Miura M ( 担当： 共著 )
University Press Nijmegen 1995年10月
学術書
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Involvement of potassium channel activation in stretch-induced and rate-dependented changes in epicardial bipolar potential and monophasic action potential in isolated perfused rabbit heart. in Building Bridges in Electrocardiology. eds by A. van Oosterom, T.F. Oostendrorp, G.J.H.Uijen
Saito T, Takahashi K, Abe T, Kimura Y, Fujiwara T, Miura H, Watanabe H, Nakagomi A, Miura M ( 担当： 共著 )
University Press Nijmegen 1995年08月
学術書