WATANABE Hiroyuki

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Organ Function-Oriented Medicine  Department of Cardiovascular Medicine

Research Interests 【 display / non-display

  • イオンチャネル学

  • Cardiology

  • 循環器学

Graduating School 【 display / non-display

  • 1985.04
    -
    1991.03

    Akita University   Faculty of Medicine   Graduated

Graduate School 【 display / non-display

  • 1992.04
    -
    1996.03

    Akita University  Graduate School,Division of Medicine  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2018.03
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Professor  

  • 2009.04
    -
    2018.02

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Organ Function-Oriented Medicine   Associate Professor  

Research Areas 【 display / non-display

  • Life Science / Cardiology

 

Thesis for a degree 【 display / non-display

  • L-type Ca channel block by highly hydrophilic dihydropyridines in single ventricular cells of guinea-pig hearts

    Watanabe H, Nishio M, Miura M, Iijima T 

    J Mol Cell Cardiol.  27 ( 6 ) 1271 - 1279   1996.03  [Refereed]

    Domestic Co-author

    DOI

Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • Coconut Atrium Causing Restrictive Physiology in the Right Ventricle

    Wakaki Tomitaka, Sato Wakana, Suzuki Mayu, Watanabe Hiroyuki

    Internal Medicine ( 一般社団法人 日本内科学会 )  advpub ( 0 )   2023.12  [Refereed]

    Research paper (journal)   Domestic Co-author

    <p>We herein report a 61-year-old woman with a history of mitral valve replacement for rheumatic fever who presented with crural edema and ascites. Computed tomography showed massive left atrial (LA) calcification involving the interatrial septum, termed "coconut atrium." Catheterization revealed not only pulmonary artery hypertension but also a large V-wave in the pulmonary artery wedge pressure waveform and a dip-and-plateau pattern of right ventricular pressure. Three-dimensional transthoracic echocardiography confirmed the early attainment of peak LA volume and a decreased LA expansion index. Stiff LA syndrome due to coconut LA results in the development of restrictive right ventricular physiology. </p>

    DOI PubMed CiNii Research

  • Pathological Analysis of Medial and Intimal Calcification in Lower Extremity Artery Disease: Impact of Hemodialysis

    Tsukasa Kato, Sho Torii, Norihito Nakamura, Kazuki Aihara, Yuta Terabe, Osamu Iida, Takahiro Tokuda, Tatsuya Nakama, Yo Kawahara, Junichi Miyamoto, Takafumi Saito, Norihiko Kamioka, Tsutomu Murakami, Takeshi Ijichi, Makoto Natsumeda, Shigemitsu Tanaka, Yohei Ohno, Gaku Nakazawa, Hiroyuki Watanabe, and Yuji Ikari

    JACC: Advances ( JACC: Advances )  2 ( 9 )   2023.11  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Superiority of the Combination of Input and Output Parameters to the Single Parameter for Lesion Size Estimation

    Hidehiro Iwakawa, Masateru Takigawa, Junji Yamaguchi, Claire A Martin, Masahiko Goya, Tasuku Yamamoto, Miki Amemiya, Takashi Ikenouchi, Miho Negishi, Iwanari Kawamura, Kentaro Goto, Takatoshi Shigeta, Takuro Nishimura, Tomomasa Takamiya, Susumu Tao, Shinsuke Miyazaki , Hiroyuki Watanabe, Tetsuo Sasano

    Circulation Journal ( Circulation Journal )  87 ( 12 ) 1757 - 1764   2023.10  [Refereed]

    Research paper (journal)   Domestic Co-author

    <b><i>Background:</i></b> For lesion size prediction, each input parameter, including ablation energy (AE), and output parameter, such as impedance, is individually used. We hypothesize that using both parameters simultaneously may be more optimal.

    <b><i>Methods and Results:</i></b> Radiofrequency applications at a range of power (30–50 W), contact force (10 g and 20 g), duration (10–60 s), and catheter orientation with normal saline (NS)- or half-normal saline (HNS)-irrigation were performed in excised porcine hearts. The correlations, with lesion size of AE, absolute impedance drop (∆Imp-drop), relative impedance drop (%Imp-drop), and AE*%Imp-drop were examined. Lesion size was analyzed in 283 of 288 lesions (NS-irrigation, n=142; HNS-irrigation, n=141) without steam pops. AE*%Imp-drop consistently showed the strongest correlations with lesion maximum depth (NS-irrigation, ρ=0.91; HNS-irrigation, ρ=0.94), surface area (NS-irrigation, ρ=0.87; HNS-irrigation, ρ=0.86), and volume (NS-irrigation, ρ=0.94; HNS-irrigation, ρ=0.94) compared with the other parameters. Moreover, compared with AE alone, AE*%Imp-drop significantly improved the strength of correlation with lesion maximum depth (AE vs. AE*%Imp-drop, ρ=0.83 vs. 0.91, P<0.01), surface area (ρ=0.73 vs. 0.87, P<0.01), and volume (ρ=0.84 vs. 0.94, P<0.01) with NS-irrigation. This tendency was also observed with HNS-irrigation. Parallel catheter orientation showed a better correlation with lesion depth and volume using ∆Imp-drop, %Imp-drop, and AE*%Imp-drop than perpendicular orientation.

    <b><i>Conclusions:</i></b> The combination of input and output parameters is more optimal than each single parameter for lesion prediction.

    DOI PubMed CiNii Research

  • Successful treatment of lead-related superior vena cava syndrome in combination with transvenous lead extraction and venous stenting

    Hidehiro Iwakawa, Tomohito Suzuki, Ken Terata, Hiroyuki Watanabe

    Journal of Arrhythmia ( Journal of Arrhythmia )  39 ( 5 ) 813 - 815   2023.09  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Asymmetric remodeling between the left and right atria in patients with advanced interatrial block and atrial fibrillation

    Ryota Kaimori, Hidehiro Iwakawa, Nobuhiro Suzuki, Mako Aokawa, Haruwo Tashiro, Ken Terata, Hiroyuki Watanabe

    Journal of Electrocardiology ( Journal of Electrocardiology )  80   63 - 68   2023.05  [Refereed]

    Research paper (journal)   Domestic Co-author

    BACKGROUND: Advanced interatrial block (A-IAB) on electrocardiography (ECG) represents the conduction delay between the left and right atria. We investigated the association of A-IAB with left and right atrial (LA/RA) remodeling in patients with atrial fibrillation (AF). METHODS: We enrolled 74 patients who underwent ECG, cardiac computed tomography (CCT), and echocardiography during sinus rhythm before catheter ablation of AF. A-IAB was defined as P-wave duration ≥120 ms with a biphasic morphology in leads III and aVF or notched morphology in lead II. We compared the maximum and minimum LA/RA volume indices (max and min LAV/RAVI), LA/RA expansion index (LAEI/RAEI), and total, passive, and active LA/RA emptying fraction (LAEF/RAEF) between patients with and without A-IAB. RESULTS: Of the 74 patients (mean age, 64.3 ± 9.6 years), 35 (47%) showed A-IAB. Patients with A-IAB had a significantly higher likelihood of hypertension and left ventricular diastolic dysfunction than those without. Patients with A-IAB had significantly larger max (69.2 [60.7-79.7]mL/m2 vs. 60.9 [50.4-68.3]mL/m2, P < 0.01) and min (44.0 [37.2-52.1]mL/m2 vs. 34.1 [29.2-43.5]mL/m2, P < 0.01) LAVI than those without. The max and min RAVI were not significantly different between groups. LAEI (55.1 [48.2-78.5]% vs. 72.1 [57.8-84.8]%, P < 0.05), total LAEF (35.5 [32.5-44.0]% vs. 41.9 [36.6-45.9]%, P < 0.05), and passive LAEF (12.2 [10.0-14.4]% vs. 15.5 [11.2-19.6]%, P < 0.05) were significantly lower in patients with A-IAB than without. CONCLUSIONS: A-IAB was associated with LA, but not RA enlargement, in patients with AF. A-IAB may indicate LA functional remodeling in the reservoir and conduit phases.

    DOI PubMed

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Books 【 display / non-display

  • SOCE and TRPC/Stim/Orai Signaling in Cardiac Myocytes. In: Store-operated Ca entry (SOCE) pathways : eds by Groschner K

    Hiroyuki Watanabe, Takayoshi Ohba,Hiroshi Ito

    Springer – Verlag  2012.09

  • Sublethal ischemia delays the Q-wave development and promotes blunted electrical response to subsequent sustained ischemia. in Building Bridges in Electrocardiology. eds by A. van Oosterom, T.F. Oostendrorp, G.J.H.Uijen

    Fujiwara T, Saito T, Kimura Y, Miura H, Watanabe H, Iwaya M, Nakagomi A, Tamura Y and Miura M

    University Press Nijmegen  1995.10

  • Involvement of potassium channel activation in stretch-induced and rate-dependented changes in epicardial bipolar potential and monophasic action potential in isolated perfused rabbit heart. in Building Bridges in Electrocardiology. eds by A. van Oosterom, T.F. Oostendrorp, G.J.H.Uijen

    Saito T, Takahashi K, Abe T, Kimura Y, Fujiwara T, Miura H, Watanabe H, Nakagomi A, Miura M

    University Press Nijmegen  1995.08