Details of a Researcher

NAKAE Hajime

写真a

Affiliation

Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Emergency and Critical Care Medicine

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Research Interests 【 display / non-display 】

general surgery
orthopaedics
救急医学
Critical Care Medicine
Critical Care and Emergency Medicine

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Graduating School 【 display / non-display 】

　

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1989.03

Nara Medical University Faculty of Medicine Graduated

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Campus Career 【 display / non-display 】

2022.04

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Now

Akita University Research Center for Regional Disaster Prevention and Mitigation Professor
2015.07

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Now

Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of Critical Care and Emergency Medicine Professor

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Research Areas 【 display / non-display 】

Life Science / Emergency medicine

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Qualification acquired 【 display / non-display 】

Doctor

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Thesis for a degree 【 display / non-display 】

Bound and soluble adhesion molecule and cytokine levels in patients with severe burns

Endo S, Inada K, Yamada Y

Burns 26 139 - 144 1999.09 [Refereed]

Domestic Co-author

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Research Achievements 【 display / non-display 】

◆Original paper【 display / non-display 】

Conventional and Kampo Medicine Treatment for Mild-to-moderate COVID-19: A Multicenter, Retrospective, Observational Study by the Integrative Management in Japan for Epidemic Disease (IMJEDI study-Observation)

Takayama Shin, Yoshino Tetsuhiro, Koizumi Sayaka, Irie Yasuhito, Suzuki Tomoko, Fujii Susumu, Katori Rie, Kainuma Mosaburo, Kobayashi Seiichi, Nogami Tatsuya, Yokota Kenichi, Yamazaki Mayuko, Minakawa Satoko, Chiba Shigeki, Suda Norio, Nakada Yoshinobu, Ishige Tatsuya, Maehara Hirofumi, Tanaka Yutaka, Nagase Mahiko, Kashio Akihiko, Komatsu Kazuhisa, Nojiri Makoto, Shimooki Osamu, Nakamoto Kayo, Arita Ryutaro, Ono Rie, Saito Natsumi, Kikuchi Akiko, Ohsawa Minoru, Nakae Hajime, Mitsuma Tadamichi, Mimura Masaru, Ishii Tadashi, Nochioka Kotaro, Chiu Shih-Wei, Yamaguchi Takuhiro, Namiki Takao, Hisanaga Akito, Mitani Kazuo, Ito Takashi

Japanese Journal of Medicine ( 一般社団法人日本内科学会 ) advpub ( 0 ) 187 - 199 2023 [Refereed]

Research paper (journal) Domestic Co-author

Objective Patients in whom coronavirus disease 2019 (COVID-19) was suspected or confirmed between January 1, 2020, and October 31, 2021, were enrolled from Japanese hospitals in this multicenter, retrospective, observational study. Methods Data on the treatment administered (including conventional and Kampo medicine) and changes in common cold-like symptoms (such as fever, cough, sputum, dyspnea, fatigue, and diarrhea) were collected from their medical records. The primary outcome was the number of days without a fever (with a body temperature <37 °C). The secondary outcomes were symptomatic relief and the worsening of illness, defined as the presence of a condition requiring oxygen inhalation. The outcomes of patients treated with and without Kampo medicine were compared. Patients We enrolled 962 patients, among whom 528 received conventional and Kampo treatment (Kampo group) and 434 received conventional treatment (non-Kampo group). Results Overall, after adjusting for the staging of COVID-19 and risk factors, there were no significant between-group differences in the symptoms or number of days being afebrile. After performing propensity score matching and restricting the included cases to those with confirmed COVID-19 who did not receive steroid administration and initiated treatment within 4 days from the onset, the risk of illness worsening was significantly lower in the Kampo group than in the non-Kampo group (odds ratio=0.113, 95% confidence interval: 0.014-0.928, p=0.0424). Conclusion Early Kampo treatment may suppress illness worsening risk in COVID-19 cases without steroid use. Further randomized controlled studies are needed to confirm the clinical benefit of Kampo medicine for COVID-19.

DOI PubMed CiNii Research

A case of adverse skin reactions to coronavirus disease 2019 vaccine successfully treated with eppikajutsuto

Kameyama Koumei, Nakae Hajime, Irie Yasuhito

Personalized Medicine Universe ( 一般社団法人国際個別化医療学会 ) 11 ( 0 ) 20 - 22 2022.11 [Refereed]

Research paper (journal) Domestic Co-author

Adverse skin reactions to coronavirus disease 2019 (COVID-19) vaccines have been rare. Because eppikajutsuto (EPTJ), which can alleviate inflammatory swelling, has heatTraditional Medicine module 1 (TM1)-clearing and fluidTM1-regulating potentials, we used it in a case of adverse skin reactions to COVID-19 vaccine. A 35-year-old woman received the second COVID-19 vaccine and presented with hacking, headache, and red glow on the face soon after receiving the vaccine. Symptoms such as flushing and wheal on the upper body improved after treatment with EPTJ. EPTJ can be used to alleviate the symptoms of adverse skin reactions to COVID-19 vaccines.

DOI CiNii Research

Application of Traditional Japanese Drug Jidabokuippo in a Modern Society

Nakae H.

Frontiers in Pharmacology ( Frontiers in Pharmacology ) 13 2022.05 [Refereed]

Research paper (journal) Domestic Co-author

DOI

Baclofen Withdrawal With Reversible Posterior Leukoencephalopathy Syndrome: Bacterial Meningitis Mimicker

Satoh K.

Journal of Emergency Medicine ( Journal of Emergency Medicine ) 62 ( 5 ) e98 - e100 2022 [Refereed]

Research paper (journal)

DOI

Blood purification therapy for severe sepsis: a multicenter, observational cohort study in northern Japan

Satoh K.

Renal Replacement Therapy ( Renal Replacement Therapy ) 7 ( 1 ) 2021.12 [Refereed]

Research paper (journal) Domestic Co-author

DOI

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◆Introduction and explanation【 display / non-display 】

Editorial: Potentials of Kampo Medicine in Modern Society

Nakae H.

Frontiers in Nutrition ( Frontiers in Nutrition ) 9 2022.06 [Refereed]

Introduction and explanation (scientific journal) Domestic Co-author

DOI

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◆University bulletin, Research institution【 display / non-display 】

Effectiveness of triple lumen catheter in blood purification

Nakae H

Akita Medical Journal 50 ( 3 ) 40547 2000.01 [Refereed]

Research paper (university bulletin, research institution) Domestic Co-author

Chemical mediators of burns.

Nakae H

Akita J Med 24 ( 40606 ) 163 - 179 1997.01 [Refereed]

Research paper (university bulletin, research institution) Domestic Co-author

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◆Other【 display / non-display 】

Student independent volunteer activities in university hospital disaster training

Tanioka Tomonori, Okuyama Manabu, Nagai Hisako, Moro Takahiro, Matsumoto Tomohiro, Nakae Hajime

Japanese Journal of Disaster Medicine ( Japanese Association for Disaster Medicine ) 27 ( 2 ) 136 - 141 2022.07

For disasters in which medical resources are scarce, the means to secure and utilize medical resources become a challenge. The students have been assisting with disaster recovery in addition to receiving training for disasters under the instruction of respective schools and hospitals. If students are able to carry out activities on their own, then the human resources in health care that were allocated to support students can be allocated to provide restoration assistance. In order to verify whether students are capable of independently providing disaster recovery assistance, a student volunteer office was set up for disaster training at a university hospital in order to provide a training in which the students themselves lead and direct volunteer activities. As a result, under the instruction of the student volunteer office, the student volunteers transported and guided the patients, carried medical materials, and searched the hospital for the families of the patients. It was found that medical students who are engaged in clinical practice at the hospital can carry out adequate support activities in disaster training without advance preparation. It is believed that the implementation of medical students engaged in clinical practice who are independently carrying out volunteer activities in the hospital will lead to the effective use of limited medical resources.

DOI CiNii Research

A structured summary of a study protocol for a multi-center, randomized controlled trial (RCT) of COVID-19 prevention with Kampo medicines (Integrative Management in Japan for Epidemic Disease by prophylactic study: IMJEDI P1 study)

Namiki T.

Trials ( Trials ) 22 ( 1 ) 2021.12 [Refereed]

DOI

Plasma adiponectin levels in acute liver failure patients treated with plasma exchange with dialysis

Nakae H.

Therapeutic Apheresis and Dialysis ( Therapeutic Apheresis and Dialysis ) 26 ( 3 ) 671 - 672 2021 [Refereed]

Prompt report, short report, and research note, etc. (scientific journal) Domestic Co-author

DOI

Continuous plasma exchange with dialysis in patients with acute liver failure

Nakae Hajime, Furuya Tomoki, Satoh Kasumi, Okuyama Manabu

Journal of Japan Society for Blood Purification in Critical Care ( Japan Society for Blood Purification in Critical Care ) 9 ( 1 ) 39 - 43 2018.06

Selective plasma exchange with dialysis (PED) is a type of apheresis in which simple plasma exchange is performed using a selective membrane plasma separator (Evacure EC-2A) while the dialysate flows out of hollow fibers. We developed continuous PED (cPED), which is performed in a single 48-hour session. To evaluate the effect of cPED, biochemical testing was performed in patients with acute liver failure (ALF). We examined 8 patients with ALF who received therapy (22 times in total). Creatinine levels and the international normalized ratio decreased significantly, while total protein and fibrinogen levels increased significantly after treatment. Continuous PED may be useful as blood purification therapy for removal of toxic substances and preservation of coagulation factors in patients with ALF.

DOI CiNii Research

Incidence and outcome of ventilator-associated events

Igarashi Toshiko, Sato Tomoko, Harata Maki, Inagaki Ayumu, Nakae Hajime, Tajimi Kimitaka

Journal of the Japanese Society of Intensive Care Medicine ( The Japanese Society of Intensive Care Medicine ) 25 ( 2 ) 149 - 150 2018

DOI

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