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大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 分子病態学・腫瘍病態学講座 |
職務経歴（学内） 【 表示 ／ 非表示 】
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2014年04月-2016年03月
秋田大学 附属病院 病理部 教授
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2013年05月-継続中
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 教授
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2010年01月-2013年04月
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 准教授
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2007年04月-2009年12月
秋田大学 大学院医学系研究科（医学専攻等） 講師
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2002年01月-2007年03月
秋田大学 医学部 医学科 講師
研究等業績 【 表示 ／ 非表示 】
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LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma
Yohei Kawasaki, Hitomi Suzuki, Masahito Miura, Haruka Hatakeyama, Shinsuke Suzuki, Takchiyo Yamada, Maya Suzuki, Ayumi Ito, Yasufumi Omori
Oncology Letters ( SPANDIDOS PUBLICATIONS UK LTD ) 2023年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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A curcumin analogue GO-Y030 diminishes cancer stem cell population by inhibiting interaction of HSP70/HSP40 complex with its substrates
Maya Suzuki, Yohei Yamamoto, Aki Nishijima-Matsunobu, Yohei Kawasaki, Hiroyuki Shibata, Yasufumi Omori
FEBS Open Bio ( Wiley ) 2023年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Kawasaki Y.
Pathology and Oncology Research ( Pathology and Oncology Research ) 28 2022年08月 [査読有り]
研究論文（学術雑誌） 国内共著
Objective: Despite the use of surgical and chemoradiation therapies, head and neck squamous cell carcinoma (HNSCC) still has a poor prognosis. Immune checkpoint inhibitors have been shown to prolong life expectancy but have limited efficacy. Glycoprotein nonmetastatic melanoma protein B (GPNMB) has received significant attention in breast cancer treatment, in which it has been associated with cancer stem cells (CSCs) and epithelial-mesenchymal transition (EMT); however, the function of GPNMB in HNSCC is completely unknown. This study aimed to clarify the characteristics of GPNMB-positive cells in vitro and their association with the prognosis by immunostaining clinical specimens. Methods: We examined the sphere formation, invasion, and migration ability of GPNMB-positive cells in four HNSCC cell lines in vitro. We also immunostained biopsy specimens with GPNMB from 174 patients with HNSCC diagnosed, treated, and followed-up in our institution to evaluate overall survival and progression-free survival. Results: GPNMB-positive cells showed enhanced sphere formation, invasion, and migration, suggesting that they could have CSC characteristics and the ability to induce EMT, as reported for breast cancer. Clinical specimens showed that overall survival was 39.4% and 57.8% (p = 0.045) and that progression-free survival was 27.6% and 51.6% (p = 0.013) for the high-expression and the low-expression groups, respectively, indicating poor prognosis for the high GPNMB group. The high GPNMB group was also more resistant to chemoradiation and bioradiotherapy. GPNMB was more highly expressed in metastatic lymph nodes than in the primary tumor. Conclusion: GPNMB-positive cells might have CSC characteristics and induce EMT. Detailed functional analyses of GPNMB in HNSCC and the establishment of therapies targeting GPNMB will lead to improved prognoses.
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Suzuki H.
Asian Pacific Journal of Cancer Prevention ( Asian Pacific Journal of Cancer Prevention ) 23 ( 4 ) 1271 - 1278 2022年 [査読有り]
研究論文（学術雑誌）
Background: Tumor-infiltrating lymphocytes (TILs) are assessed by the ratio of the area of lymphocytes infiltrating the stroma. TILs are important in breast cancer and malignant melanoma and are being established as a marker of prognosis and sensitivity to chemotherapy. This has resulted in various therapies being developed in fields such as breast cancer. However, the evaluation of TILs in head and neck squamous cell carcinoma (HNSCC) is not progressing, and the prognosis is still poor. Thus, investigating whether or not the evaluation of TILs is also effective in HNSCC and prognoses can be predicted with just biopsy samples alone is required. Methods: This study included 153 patients who were diagnosed with HNSCC between January 2010 and December 2019, underwent treatment, and could be followed up thereafter at our institution. Results: TILs, overall survival (OS), and progression-free survival (PFS) were evaluated in all patients, the chemoradiotherapy arm, and the surgery arm. The cut-off value for TILs was 50%. In all patients, OS was 69.8% and 40.2% (P = 0.01) and PFS was 58.4% and 31.6% (P = 0.003) in the high and low TIL groups, respectively. Multivariate analyses revealed that TILs independently predicted prognosis. In the chemoradiotherapy arm, OS was 70.8% and 31.6% (P = 0.012) and PFS was 63.4% and 20.3% (P = 0.001) in the high and low TIL groups, respectively. No significant differences were noted in the surgery arm. Conclusions: In HNSCC, TILs can be used as a prognosis predictor and chemoradiotherapy biomarker. Assessments can be performed just with hematoxylin–eosin staining and is very simple. This will greatly contribute to report personalized therapy progress. Further evaluations and, thus, prospective clinical multicenter trials are needed to use TILs in clinical practice for HNSCC
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Two autopsy cases of desmoplastic small round cell tumor
Yamamoto Y.
Pathology International ( Pathology International ) 70 ( 3 ) 171 - 178 2020年03月 [査読有り]
研究論文（学術雑誌） 国内共著
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頚部内頚動脈内血栓に起因した急性頭蓋内主幹動脈閉塞に対する血管内治療の１例
大前 智也, 柳澤 俊晴, 大森 泰文
NEUROSURGICAL EMERGENCY ( 特定非営利活動法人 日本脳神経外科救急学会 Neurosurgical Emergency ) 27 ( 2 ) 153 - 158 2022年
<p> 頭蓋外内頚動脈閉塞症は中大脳動脈が代償性に還流され，初診時軽微な症状だが，経過中に血栓が移動し頭蓋内主幹動脈閉塞を生じ，重篤な神経学的症状を呈する場合がある．</p><p> 症例は69才女性，左上肢のしびれを自覚し，Magnetic Resonance Imaging‒diffusion weight imagingで新鮮梗塞は認められず．Magnetic Resonance angiographyで右内頚動脈閉塞症を指摘された．右中大脳動脈は後交通動脈を介して代償性に還流されていた．翌日朝，左片麻痺，構語障害がみられ，当院に搬送された．Magnetic Resonance Imaging‒diffusion weight imagingで右基底核に新鮮梗塞がみられ，MRAで右内頚動脈から右中大脳動脈の描出がなく，carotid T閉塞と診断され，機械的血栓回収術が行われた．first passでTICI3の再開通が得られた．術後，経過良好で２週間後に自宅退院した．内頚動脈閉塞症は血栓の移動により急激な症状増悪を生じる可能性があり，予め病状の把握を行い，機械的血栓回収術で即時対応できる体制をとるべきと考えられた．</p>
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好酸球増多疾患・好酸球性肺炎 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者
福地 峰世, 植木 重治, 山本 洋平, 奈良 美保, 今野 泰典, 面川 歩, 嵯峨 知生, 守時 由起, 大森 泰文, 高橋 直人, 廣川 誠
アレルギー ( (一社)日本アレルギー学会 ) 68 ( 4-5 ) 529 - 529 2019年05月