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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Molecular Pathology and Tumor Pathology |
OMORI Yasufumi
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Research Interests 【 display / non-display 】
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E-cadherin
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E-カドヘリン
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gap junction
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p120catenin
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p120カテニン
Graduating School 【 display / non-display 】
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-1992
Tohoku University Graduated
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-1992
Tohoku University Graduated
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1982.04-1988.03
Tohoku University Faculty of Medicine School of Medicine Graduated
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-1988
Tohoku University Faculty of Medicine Graduated
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-1988
Tohoku University Faculty of Medicine School of Medicine Graduated
Graduate School 【 display / non-display 】
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1988.04-1992.03
Tohoku University Graduate School,Division of Medicine Pathology Doctor's Course Completed
Degree 【 display / non-display 】
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Tohoku University - Doctor of Medical Science
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Tohoku University - Bachelor (Medicine)
Campus Career 【 display / non-display 】
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2014.04-2016.03
Akita University Hospital Division of Clinical Pathology Professor
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2013.05-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Professor
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2010.01-2013.04
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Associate Professor
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2007.04-2009.12
Akita University Graduate School of Medicine Lecturer
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2002.01-2007.03
Akita University School of Medicine School of Medicine Lecturer
External Career 【 display / non-display 】
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2013.05
Akita University Graduate School of Medicine Department of Molecular and Tumour Pathology Professor and Chaiman
Research Areas 【 display / non-display 】
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Life Science / Experimental pathology
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Life Science / Cell biology
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Life Science / Molecular biology
Research Achievements 【 display / non-display 】
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Yohei Kawasaki, Yasufumi Omori, Shinsuke Suzuki, Takechiyo Yamada
Archives of Medical Science ( Termedia Sp. z.o.o. ) 19 ( 6 ) 1859 - 1868 2023.12 [Refereed]
Research paper (journal) Domestic Co-author
<jats:sec><jats:title>Introduction</jats:title><jats:p>The prognosis of head and neck squamous cell carcinoma (HNSCC) is generally good in cases of high radiation sensitivity but poor in cases exhibiting radiation resistance; this resistance has been attributed to the presence of cancer stem cells. In recent years, CD98hc overexpression has been associated with poor prognosis in various types of cancers. CD98 is a heterodimer of heavy and light chains and is strongly involved in cell proliferation, survival, migration, and adhesion. We investigated whether CD98hc can be used as a cancer stem cell marker for HNSCC.</jats:p></jats:sec><jats:sec><jats:title>Material and methods</jats:title><jats:p>We exposed five HNSCC cell lines to a total radiation dose of 60 Gy administered in 2 Gy fractions on consecutive days to investigate changes in CD98hc expression. Furthermore, we separated CD98-positive and CD98-negative cell populations to comparatively investigate the properties of each.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Radiation resistance was observed in all five cell lines, and resistant cells exhibited CD98hc overexpression, with enhanced spheroid formation, migratory, and invasive abilities. Radiation-resistant cell lines were separated into CD98-positive and CD98-negative populations. CD98hc-positive radiation-resistant cell lines exhibited enhanced spheroid formation, invasion, and plating efficiency as well as strong tumorigenicity in nude mice.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>CD98hc-positive cells exhibited cancer stem cell-like properties in all cell lines. Thus, CD98hc is a potential marker of radiation sensitivity as well as a potential therapeutic target for improved survival rates of patients with HNSCC.</jats:p></jats:sec>
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Endocytic trafficking of connexins in cancer pathogenesis
Totland M.Z.
Biochimica et Biophysica Acta - Molecular Basis of Disease ( Biochimica et Biophysica Acta - Molecular Basis of Disease ) 1869 ( 7 ) 2023.10 [Refereed]
Research paper (journal) International Co-author
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LAT1 is associated with poor prognosis and radioresistance in head and neck squamous cell carcinoma
Kawasaki Y.
Oncology Letters ( Oncology Letters ) 25 ( 4 ) 171 2023.04 [Refereed]
Research paper (journal) Domestic Co-author
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Suzuki M.
FEBS Open Bio ( FEBS Open Bio ) 13 ( 3 ) 434 - 446 2023.03 [Refereed]
Research paper (journal) Domestic Co-author
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Suzuki H.
Polish Journal of Pathology ( Polish Journal of Pathology ) 74 ( 2 ) 122 - 130 2023 [Refereed]
Research paper (journal) Domestic Co-author
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Ichikawa Dai, Yanagisawa Toshiharu, Omori Yasufumi, Kamada Sachiko
Japanese Journal of Stroke ( The Japan Stroke Society ) advpub ( 0 ) 2023
<p>A 70-year-old woman visited our hospital with a chief complaint of headache. T2-weighted and fluid-attenuated inversion-recovery magnetic resonance imaging (MRI) showed a leptomeningeal lesion in the right temporal lobe and many enlarged perivascular spaces in the centrum semiovale. Follow-up MRI performed 6 months later revealed cortical microbleeds and cortical superficial siderosis. Three years later, the patient presented with right lower quadrant homonymous hemianopsia and disturbance of consciousness. MRI showed diffuse leptomeningeal and significantly increased hemorrhagic lesions. A brain biopsy confirmed diagnosis of amyloid β-related angiitis. Disturbance of consciousness persisted despite steroid treatment. We concluded that vasculitis-induced inflammation preceded bleeding secondary to vascular fragility in our patient. Inflammatory cerebral amyloid angiopathy should be included in the differential diagnosis in patients with early-onset leptomeningeal lesions and enlarged perivascular spaces without hemorrhagic lesions.</p>
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Omae Tomoya, Yanagisawa Toshiharu, Omori Yasufumi
NEUROSURGICAL EMERGENCY ( Japan Society of Neurosurgical Emergency ) 27 ( 2 ) 153 - 158 2022
<p> We describe a case in which a cardiogenic thrombus at the cervical internal carotid artery migrated to the middle cerebral artery. The patient was a 69‒year‒old female who had mild neurological symptoms. At her first visit, magnetic resonance diffusion‒weighted imaging indicated no acute ischemic lesion. Magnetic resonance angiography revealed occlusion of the right internal carotid artery and a patent middle cerebral artery supplied via the posterior communicating artery. The next day, the patient exhibited left hemiparesis and occlusion of both the internal carotid artery and middle cerebral artery. A mechanical thrombectomy was performed. Complete recanalization was achieved, and the patient's neurological deficits were resolved. The mechanical thrombectomy was effective for this emergency state of thrombus migration from the cervical internal carotid artery to the terminus of the internal carotid artery. The present case demonstrates that it is possible for a thrombus of the cervical internal carotid artery to migrate to a distal intracranial artery and result in severe symptoms. In the event of such an emergency, a system for rapid treatment by mechanical thrombectomy is needed.</p>
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好酸球増多疾患・好酸球性肺炎 著明な組織内シャルコー・ライデン結晶を認めた好酸球増多症候群患者
福地 峰世, 植木 重治, 山本 洋平, 奈良 美保, 今野 泰典, 面川 歩, 嵯峨 知生, 守時 由起, 大森 泰文, 高橋 直人, 廣川 誠
アレルギー ( (一社)日本アレルギー学会 ) 68 ( 4-5 ) 529 - 529 2019.05
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2022.04 - 2025.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03