研究者詳細 - 永澤　博幸

研究等業績 - その他 - 永澤　博幸

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膝関節周囲骨切り術後のインプラント抜去困難に関する検討

斉藤公男, 齊藤英知, 野坂光司, 木島泰明, 藤井昌, 永澤博幸, 土江博幸, 宮腰尚久, 島田洋一

日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 93 ( 3 ) S835 - S835 2019年03月

超高齢者軟部肉腫の臨床像

土江博幸, 江森誠人, 永澤博幸, 宮腰尚久, 山下敏彦, 島田洋一

日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 93 ( 3 ) S795 - S795 2019年03月

軟部肉腫に対するアクリジンオレンジを用いた辺縁切除手術の治療成績

土江博幸, 江森誠人, 永澤博幸, 宮腰尚久, 山下敏彦, 島田洋一

日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 93 ( 3 ) S793 - S793 2019年03月

論説大腿骨近位部骨折例における術前移動能力と骨粗鬆症関連パラメータの関連性

湯浅悠介, 宮腰尚久, 粕川雄司, 木村善明, 柏倉剛, 永澤博幸, 若林育子, 野坂光司, 土江博幸, 島田洋一

整形外科 ( 南江堂 ) 70 ( 1 ) 1 - 3 2019年01月

DOI CiNii Research

BCG接種後に生じた肋骨骨髄炎の1例

若林玲奈, 宮腰尚久, 土江博幸, 永澤博幸, 島田洋一

東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 31 ( 4 ) 483 - 486 2019年

<p>BCG接種後の副反応に関してはさまざまな報告がある．今回BCG接種後に右肋骨骨髄炎を生じた症例を報告する．症例は1歳9ヵ月，男児．生後5ヵ月でBCGを接種し，1歳8ヵ月で右前胸部の腫瘤を触知した．切開生検による病理組織学的検査にて，乾酪壊死と多核巨細胞の出現を伴う類上皮細胞肉芽腫を認め，BCG接種後骨髄炎と診断した．イソニアジドとリファンピシンを内服することにより治癒している．</p>

DOI

Impact of acridine orange in patients with soft tissue sarcoma treated with marginal resection

Tsuchie H.

Anticancer Research ( Anticancer Research ) 39 ( 11 ) 6365 - 6372 2019年

DOI PubMed

Micro-CT imaging analysis for the effects of ibandronate and eldecalcitol osecondary osteoporosis and arthritis in adjuvant-induced arthritis rats

Ono Y.

Biomedical Research (Japan) ( Biomedical Research (Japan) ) 40 ( 5 ) 197 - 205 2019年

We investigated the effects of ibandronate, a bisphosphonate; eldecalcitol, an active vitamin D3 analogue; and combination treatment with both agents on secondary osteoporosis and arthritis using rats with adjuvant-induced arthritis. Arthritis was induced in 8-week-old male Lewis rats. Rats were randomized into four treatment groups and an untreated normal control group: ibandronate, eldecalcitol, ibandronate + eldecalcitol, vehicle, and control. Paw thickness was measured to evaluate arthritis. Joint destruction was evaluated histomorphometrically by the ankle joint stained with Fast Green and safranin O. The femur and lumbar spine were scanned using dual-energy X-ray absorptiometry, and the distal femur was scanned using micro-computed tomography for bone mineral density (BMD) and trabecular microstructural evaluations. Ibandronate and/or eldecalcitol increased BMD in both the lumbar vertebrae and femur and improved several microstructural parameters (bone volume/total volume, structure model index, trabecular number, and trabecular separation of the distal femur). In addition, there was an additive effect of combination treatment compared with single treatments for most trabecular parameters, including BMD and bone volume. However, ibandronate and/or eldecalcitol did not inhibit arthritis and joint destruction. Combination treatment with ibandronate and eldecalcitol may be effective for secondary osteoporosis associated with arthritis.

DOI PubMed

エルデカルシトールが血清カルシウム動態および腎機能に与える影響 : 2年間の血清カルシウム値,eGFRの変動と血管石灰化および併用薬との関連について

田村康樹, 宮腰尚久, 粕川雄司, 永澤博幸, 島田洋一

日本骨粗鬆症学会雑誌 = The journal of Japan Osteoporosis Society ( 日本骨粗鬆症学会 ) 5 ( 3 ) 445 - 453 2019年 [査読有り]

研究発表要旨（全国大会，その他学術会議）国内共著

Effects of eldecalcitol and ibandronate on secondary osteoporosis and muscle wasting in rats with adjuvant-induced arthritis.

Ono Y, Miyakoshi N, Kasukawa Y, Nagasawa H, Tsuchie H, Akagawa M, Nagahata I, Yuasa Y, Sato C, Shimada Y

Osteoporosis and sarcopenia 4 ( 4 ) 128 - 133 2018年12月

Objectives: Rheumatoid arthritis (RA) is characterized by chronic inflammation of the synovium, progressive erosion of the articular cartilage, and joint destruction. RA also causes secondary osteoporosis and muscle wasting. We investigated the effects of ibandronate (IBN), a bisphosphonate; eldecalcitol (ELD), an active vitamin D3 derivative; and combination treatment with both agents on secondary osteoporosis and muscle wasting using adjuvant-induced arthritis rats. Methods: Arthritis was induced in 8-week-old male Lewis rats. Rats were randomized into 4 treatment groups and an untreated normal control group: IBN (subcutaneously, once every 2 weeks, 10 μg/kg), ELD (orally, once daily, 30 ng/kg/day), IBN + ELD, vehicle, and control. Paw thickness measurements were performed for evaluation of arthritis. The femur was scanned using dual-energy X-ray absorptiometry. Cross-sectional areas of left tibialis and anterior muscle fibers and the expression of MuRF1, atrogin-1, MyoD, and myogenin in the gastrocnemius muscle were measured to evaluate muscle wasting. Results: IBN and/or ELD increased bone mineral density (BMD) in the femur. In addition, there was an additive effect of combination treatment compared with single treatments for BMD. However, IBN and/or ELD did not inhibit muscle wasting in adjuvant-induced arthritis rats. Conclusions: Combination treatment with IBN and ELD may be effective for secondary osteoporosis associated with RA. Other treatments are necessary for muscle wasting associated with RA. Studies in humans are needed to confirm these findings.

DOI PubMed

Effects of activated Vitamin D, alfacalcidol, and low-intensity aerobic exercise on osteopenia and muscle atrophy in type 2 diabetes mellitus model rats

Akagawa M.

PLoS ONE ( PLoS ONE ) 13 ( 10 ) e0204857 2018年10月

Diabetes mellitus causes secondary osteoporosis and muscle atrophy. The ability of alfacalcidol (ALF) and exercise (Exe) to inhibit osteoporosis and muscle atrophy in type 2 diabetes mellitus (T2DM) model rats was examined. Twenty-week-old Otsuka Long-Evans Tokushima Fatty rats were randomized to ALF (orally 0.1 μg/kg/day), Exe (treadmill exercise at 10 m/min, 60 min/day, 5 days/week), Comb (ALF and Exe), and Cont (T2DM control treated with vehicle and no exercise) groups (n = 8-10 per group). Sedentary Long-Evans Tokushima Otsuka rats were used as a non-hyperphagic control. After treatment for 2 or 6 weeks, blood glucose (BG) levels, cross-sectional area (CSA) of tibialis anterior muscle fibers, femoral bone mineral density (BMD), and relative quantities of muscle anabolic markers (Pax7, MyoD, and myogenin) and catabolic markers (Atrogin-1, MuRF1, and REDD1) of the soleus muscle assessed by real-time polymerase chain reaction assays were measured. Exe and Comb treatments for 6 weeks decreased BG levels compared with those of the Cont group. ALF, Exe, and Comb treatments for 2 and 6 weeks recovered the CSA compared with that of the Cont group. ALF and Comb treatments for 6 weeks increased femoral BMDs compared with those of the Cont group. After 2 weeks of treatment, Comb treatment increased MyoD expression and decreased MuRF1 expression. ALF or Exe monotherapy significantly decreased Atrogin-1 or MuRF1 expression after 2 weeks of treatment, respectively. After 6 weeks of treatment, ALF and Comb treatments decreased Atrogin-1 and REDD1. These results demonstrate that a combination of ALF and Exe improved CSA from the early phase of treatment by stimulating skeletal muscle differentiation and suppressing muscle catabolic genes. Improvements in BG, BMD, and CSA were observed as long-term effects of the combination therapy. Continued suppression of muscle catabolic genes was observed as a background to these effects.

DOI PubMed

The prognostic significance of surgical treatment for excessive elderly patients with soft tissue sarcoma

Tsuchie H.

International Journal of Clinical Oncology ( International Journal of Clinical Oncology ) 23 ( 4 ) 775 - 782 2018年08月

Background: Soft tissue sarcoma (STS) mainly occurs in middle-aged and senior citizens. Although a poorer prognosis has been reported for older patients, few studies have examined advanced elderly excessive older patients. We evaluated the clinical features of advanced elderly patients with STS. Methods: One hundred and forty-four patients were included in this retrospective study, and we divided them into two groups based on a cut-off age of 85 (older and younger groups). The patients’ information, including age, tumor type, location, size, presence of metastasis, AJCC stage, FNCLCC classification, treatment-related factors, local and distant relapse, and outcome, was collected. We compared the clinical courses between the 2 groups. Results: In all patients, the frequency of chemotherapy in the older group was significantly lower than in the younger group (P &lt
0.01), and the follow-up period in the older group was significantly shorter than in the younger group (P &lt
0.01). Surgical treatment was refused more frequently in the older group (P = 0.01). The older group showed a significantly poorer prognosis (P &lt
0.05). However, in patients with localized disease at presentation treated with surgery, there was no significant difference in prognosis between the 2 groups. Only surgical treatment affected the prognosis in older patients (P &lt
0.01). Conclusion: Although the prognosis of advanced elderly STS patients is generally poor, that of STS patients with surgical treatment is not poor. Only surgical treatment intervention strongly influences the prognosis, and so the prognosis may be improved with aggressive surgical treatment.

DOI PubMed

Charcot足関節におけるリング型創外固定とLIPUS併用の有用性

野坂光司, 宮腰尚久, 松永俊樹, 本郷道生, 永澤博幸, 粕川雄司, 齊藤英知, 木島泰明, 土江博幸, 斉藤公男, 藤井昌, 島田洋一

東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 30 ( 3 ) 473 - 473 2018年08月

国内共著

外傷:難治性外傷の治療超高齢者脆弱性骨折におけるIlizarov創外固定の有用性

野坂光司, 宮腰尚久, 本郷道生, 永澤博幸, 粕川雄司, 齊藤英知, 木島泰明, 土江博幸, 斉藤公男, 藤井昌, 湯浅悠介, 島田洋一

東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 30 ( 3 ) 274 - 274 2018年08月

多発性骨軟骨腫症患者に発生した膝窩部MRSA蜂窩織炎の1例

若林玲奈, 土江博幸, 永澤博幸, 宮腰尚久, 島田洋一

東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 30 ( 3 ) 453 - 453 2018年08月

超高齢者軟部肉腫の臨床像