研究等業績 - その他 - 永澤 博幸
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Tsuchie H.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre ( Medical principles and practice : international journal of the Kuwait University, Health Science Centre ) 33 ( 5 ) 424 - 430 2024年
OBJECTIVES: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although surgical treatment of elderly patients with STS has been reported to improve their prognosis, most of these studies included patients with STS aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in elderly patients aged ≥90 years. SUBJECT AND METHODS: We retrospectively identified patients aged ≥90 years with STS who were treated at our two hospitals between 1994 and 2022. Data on clinical information and detailed assessments were collected. We evaluated the features and factors affecting the prognosis of patients with older-extremity STS. In addition, we compared the clinical courses and results of patients treated with surgery and radiotherapy for primary tumors. RESULTS: Among 454 patients with STS, 16 were aged ≥90 years. Kaplan-Meier curves for overall survival showed a significantly poorer prognosis in patients who did not receive surgical treatment (p = 0.0348) and those who received radiotherapy (p = 0.0070). Moreover, we investigated the difference in prognosis between surgical treatment and radiotherapy, excluding two cases with distant metastasis at initial diagnosis and one case with no treatment. Kaplan-Meier curves for overall survival showed a significantly better prognosis in patients who underwent surgical treatment (p = 0.0161). Univariate analysis revealed that only primary tumor size was a significant predictor of poor prognosis (p = 0.0426). CONCLUSION: In patients with STS aged ≥90 years old, aggressive surgical treatment may improve the prognosis more than radiotherapy.
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腹壁発生のround cell sarcoma with EWSR1-non-ETS fusion(EWSR1-NFATC2 sarcoma)の1例
土江 博幸, 馬越 通信, 永澤 博幸, 長谷川 匡, 岡田 恭司, 南條 博, 後藤 明輝, 宮腰 尚久
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 96 ( 6 ) S1479 - S1479 2022年06月 [査読有り]
研究論文（その他学術会議資料等）
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清水 淳也, 江森 誠人, 高島 弘幸, 村橋 靖崇, 土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一, 山下 敏彦
東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 33 ( 3 ) 381 - 381 2021年08月
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診断に難渋した大腿部aggressive angiomyxomaの1例
土江 博幸, 永澤 博幸, 南條 博, 宮腰 尚久, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1378 - S1378 2021年06月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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軟部肉腫の局所再発に対するアクリジンオレンジを用いた辺縁切除手術の治療成績
土江 博幸, 江森 誠人, 永澤 博幸, 宮腰 尚久, 岡田 恭司, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1423 - S1423 2021年06月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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土江 博幸, 江森 誠人, 永澤 博幸, 宮腰 尚久, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1343 - S1343 2021年06月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1394 - S1394 2021年06月 [査読有り]
研究発表要旨（全国大会，その他学術会議） 国内共著
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軟部肉腫の局所再発に対するアクリジンオレンジを用いた辺縁切除手術の治療成績
土江 博幸, 江森 誠人, 宮腰 尚久, 永澤 博幸, 岡田 恭司, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 3 ) S894 - S894 2021年03月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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遠隔転移を有する軟部肉腫における組織型の違いによる予後への影響
土江 博幸, 江森 誠人, 宮腰 尚久, 永澤 博幸, 岡田 恭司, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 3 ) S896 - S896 2021年03月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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Deep Angiomyxoma of the Thigh That Is Difficult to Diagnose: A Case Report and Literature Review
Tsuchie H.
Acta Medica Okayama ( Acta Medica Okayama ) 75 ( 5 ) 653 - 657 2021年
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銭谷 俊毅, 江森 誠人, 射場 浩介, 清水 淳也, 村橋 靖崇, 寺本 篤史, 山下 敏彦, 土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一, 水島 衣美
北海道整形災害外科学会雑誌 ( 北海道整形災害外科学会 ) 63 ( 139th suppl ) 73 - 73 2021年 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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Prognostic significance of histological subtype in soft tissue sarcoma with distant metastasis
Tsuchie H.
In Vivo ( In Vivo ) 34 ( 4 ) 1975 - 1980 2020年08月
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De Novo Granulocytic Sarcoma of the Humerus in an 82-Year-Old Woman: A Case Report.
Hiroyuki Nagasawa, Kyoji Okada, Naohisa Miyakoshi, Hiroyuki Tsuchie, Hiroshi Nanjo, Yoichi Shimada
Journal of medical cases ( Journal of Medical Cases ) 11 ( 8 ) 249 - 252 2020年08月
Granulocytic sarcoma is a rare solid malignant tumor that occurs in patients with acute myeloid leukemia. As such, granulocytic sarcoma without leukemia occurring in long bones is quite rare. This case report describes an isolated granulocytic sarcoma of the right humerus in an 82-year-old woman in the absence of acute myeloid leukemia. The patient was admitted to our hospital with a pathological fracture of the right humerus. An incisional biopsy was performed, and the pathological diagnosis was granulocytic sarcoma. Radiotherapy (45 Gy) to the humerus resulted in a good clinical outcome with no evidence of myeloid leukemia at 9.5 years of follow-up. Radiotherapy was effective for pain relief and maintenance of good quality of life in this patient. Although laboratory evaluation has not revealed any abnormalities 9.5 years after radiotherapy, periodic observation is required.
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Pigmented Villonodular Synovitis Around the Elbow Joint That Required Upper Arm Amputation.
Yuichi Ono, Naohisa Miyakoshi, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Hiroshi Nanjo, Yoichi Shimada
Journal of medical cases ( Journal of Medical Cases ) 11 ( 7 ) 201 - 203 2020年07月
Pigmented villonodular synovitis (PVNS) is a relatively rare benign proliferative disorder of the synovium, and it commonly occurs in the knee joint. A unique case of huge PVNS originating around the elbow joint that required upper arm amputation is reported. A 74-year-old woman had a 5-month history of right elbow pain and noticed a mass measuring 8 × 5 cm on the olecranon side. She had a past history of undergoing tumor resection and flap surgery 9 years earlier, diagnosed as a giant cell tumor involving the right elbow region. She had chronic renal failure, with a shunt on the right forearm. On magnetic resonance imaging, the tumor around the elbow joint showed low signal intensity on T1-weighted images and low to high intensity on T2-weighted images. It was thought that it was difficult to preserve the limb because of the size of the tumor and the shunt blood vessel. Therefore, upper arm amputation was performed. The histological diagnosis was PVNS. There was no recurrence of PVNS postoperatively. In the treatment of PVNS, initial surgery with complete resection of the synovial membrane and careful postoperative follow-up are considered important.
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銭谷 俊毅, 江森 誠人, 土江 博幸, 清水 淳也, 村橋 靖崇, 永澤 博幸, 宮腰 尚久, 島田 洋一, 山下 敏彦
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 94 ( 6 ) S1432 - S1432 2020年07月
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超高齢者軟部肉腫症例に対する手術治療の有効性
土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一
The Japanese Journal of Rehabilitation Medicine ( (公社)日本リハビリテーション医学会 ) 57 ( 特別号 ) 3 - 4 2020年07月
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遠隔転移を有する軟部肉腫における組織型の違いによる予後への影響
土江 博幸, 江森 誠人, 宮腰 尚久, 永澤 博幸, 岡田 恭司, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 94 ( 6 ) S1402 - S1402 2020年07月
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デスモイド腫瘍における新たな予後予測 T1強調画像におけるdark fiber signの有用性
村橋 靖崇, 江森 誠人, 清水 淳也, 水島 衣美, 田中 太晶, 中 紀文, 土江 博幸, 永澤 博幸, 島田 洋一, 山下 敏彦
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 94 ( 6 ) S1479 - S1479 2020年07月 [査読有り]
研究発表要旨（全国大会，その他学術会議） 国内共著
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Yuasa Y.
Journal of Bone and Mineral Metabolism ( Journal of Bone and Mineral Metabolism ) 38 ( 2 ) 179 - 187 2020年03月
INTRODUCTION: Postmenopausal osteoporosis and dyslipidemia are well-known skeletal and metabolic changes in middle-aged women. We investigated the effects of combined treatments with a selective estrogen receptor modulator (SERM) and exercise on bone and fat parameters in ovariectomized (OVX) rats. MATERIALS AND METHODS: Sixteen-week-old female Sprague-Dawley rats underwent bilateral ovariectomy, and rats were randomized to BZA (bazedoxifene at 0.3 mg/kg/day), Exe (treadmill exercise at 12-15 m/min, 60 min/day, 5 days/week), Comb (BZA and Exe), and Cont (control treated with vehicle and no exercise) groups 8 weeks after ovariectomy. After 4 or 8 weeks of treatment, bone mineral density (BMD) of the total femur and lumbar spine and whole-body percentage fat mass were determined by dual-energy X-ray absorptiometry, and mechanical testing of the femoral shaft, and bone and fat histomorphometric analyses of the proximal tibia were performed. RESULTS: Treadmill exercise had decreased bone marrow adipocytes from 4 weeks of treatment and whole-body percentage fat mass at 8 weeks. BZA increased BMD at the lumbar spine and decreased the whole-body percentage fat mass from 4 weeks and bone marrow adipocytes at 8 weeks. Combination therapy increased BMD for the lumbar spine and decreased bone marrow adipocytes and whole-body percentage fat mass from 4 weeks. CONCLUSION: Combination therapy with BZA and exercise appears effective to improve bone and fat parameters in OVX rats.
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Double level osteotomyが膝蓋大腿関節に及ぼす影響
斉藤 公男, 齊藤 英知, 野坂 光司, 木島 泰明, 藤井 昌, 河野 哲也, 永澤 博幸, 土江 博幸, 村田 昇平, 宮腰 尚久, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 94 ( 3 ) S565 - S565 2020年03月 [査読有り]
国内共著