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所属 |
附属病院 整形外科 |
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研究室住所 |
秋田市本道１－１－１ |
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研究室電話 |
018-884-6148 |
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研究室FAX |
018-836-2617 |
永澤 博幸 (ナガサワ ヒロユキ)
NAGASAWA Hiroyuki
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職務経歴（学外） 【 表示 ／ 非表示 】
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2010年01月-継続中
秋田大学医学部 School of Medicine 医学部講師
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2007年04月-継続中
秋田大学医学部附属病院 整形外科 助教
学会（学術団体）・委員会 【 表示 ／ 非表示 】
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1994年-継続中
日本国
日本整形外科学会
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2016年-2021年
日本国
日本リハビリテーション医学会
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2000年-継続中
日本国
日本骨粗鬆症学会
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1996年-継続中
日本国
日本骨代謝学会
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1995年-2021年03月
日本国
日本小児整形外科学会
学位論文 【 表示 ／ 非表示 】
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Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells
Nagasawa H, Takahashi S, Kobayashi A, Tazawa H, Tashima Y, Sato K
Journal of Nutritional Science and Vitaminology 51 311 - 318 1999年03月 [査読有り]
国内共著
研究等業績 【 表示 ／ 非表示 】
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Surgical Treatment and Prognosis of Soft Tissue Sarcoma in Patients Aged 85 Years and Older
Tsuchie H.
In Vivo ( In Vivo ) 39 ( 3 ) 1661 - 1668 2025年05月 [査読有り]
研究論文（学術雑誌） 国内共著
BACKGROUND/AIM: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although it has been reported that surgical treatment of elderly patients with STS improves prognosis, most of these studies included patients aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in excessively elderly patients aged ≥85 or ≥90 years. PATIENTS AND METHODS: We retrospectively identified 398 patients with STS who were treated at our two hospitals between 1994 and 2022. Only histological types that existed in ≥20 cases were included. Data on clinical information and detailed assessments were collected. We divided the patients into two subgroups according to 85 or 90 years of age and compared the groups within each subgroup. Furthermore, we examined the factors affecting the prognosis of all and older patients. RESULTS: Patients ≥85 or ≥90 years old comprised 12.1% and 4.0% of the study population, respectively. In all patients, Kaplan-Meier curves for overall survival demonstrated a significantly poorer prognosis in elderly patients with STS aged ≥85 years (p=0.0476) and ≥90 years (p=0.0164). However, no significant differences were observed when analyzing only patients who underwent surgical treatment without distant metastasis at diagnosis. In the multivariate analyses, surgical treatment for the primary tumor improved prognosis exclusively in patients ≥85 years old (p =0.0300). CONCLUSION: Surgical treatment improves the prognosis in elderly STS patients aged ≥85 years and possibly among those aged ≥90 years.
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Isolated Talar Metastasis of Renal Cell Carcinoma Treated With Tibiocalcaneal Arthrodesis Using an Ilizarov External Fixation.
Shuichi Chida, Koji Nozaka, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Naohisa Miyakoshi
Cureus 17 ( 1 ) e77275 2025年01月 [査読有り]
研究論文（学術雑誌） 国内共著
Acrometastases to the feet are exceedingly rare. We report a case of isolated talar metastasis from renal cell carcinoma successfully managed through surgical excision and reconstruction with Ilizarov external fixation. A 65-year-old male presented with a six-month history of right ankle pain. Radiographs revealed an osteolytic lesion in the talus. An incisional biopsy confirmed the diagnosis of metastatic renal cell carcinoma. Systemic evaluation showed no recurrence in the right kidney or metastases beyond the right talus. En bloc resection of the talus was performed via an anterior approach, followed by tibiocalcaneal arthrodesis using Ilizarov external fixation. At the four-year follow-up, the patient remained pain-free while walking and showed no evidence of recurrence or additional metastases.
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Zeniya T.
Acta Orthopaedica Belgica ( Acta Orthopaedica Belgica ) 90 ( 4 ) 731 - 737 2024年12月 [査読有り]
研究論文（学術雑誌） 国内共著
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A Case of Subungual Exostosis With Early Postoperative Recurrence and Rapid Growth.
Shohei Murata, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Toshihito Ebina, Naohisa Miyakoshi
Cureus 16 ( 11 ) e73933 2024年11月 [査読有り]
研究論文（学術雑誌） 国内共著
Subungual exostosis is a relatively rare benign bone tumor that occurs near the distal phalanges of the fingers and toes. Though it is similar to osteochondroma, it can be distinguished by its specific location and lack of communication with the medullary cavity. Although recurrence after surgical excision has been reported, no studies have examined the timing or progression of recurrence, nor have there been reports detailing the chronological imaging findings of recurrent cases. A case of subungual exostosis that recurred rapidly with significant growth shortly after surgical excision is reported. The patient was a 13-year-old boy with subungual exostosis of the fourth toe. Tumor recurrence was observed four weeks after the initial excision, and it gradually enlarged, growing to several times the size of the original tumor three months after surgery. A second procedure was performed approximately four months after the initial procedure, and no recurrence has been observed since. This case represents the first report of the chronological radiographic progression of recurrent subungual exostosis, highlighting the importance of careful follow-up and consideration of early recurrence after excision.
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Michinobu Umakoshi, Yukitsugu Kudo-Asabe, Hiroyuki Tsuchie, Zhuo Li, Kei Koyama, Ken Miyabe, Makoto Yoshida, Hiroyuki Nagasawa, Hiroshi Nanjo, Kyoji Okada, Daichi Maeda, Naohisa Miyakoshi, Masamitsu Tanaka, Akiteru Goto
Pathobiology : journal of immunopathology, molecular and cellular biology ( Pathobiology ) 92 ( 1 ) 2024年07月 [査読有り]
研究論文（学術雑誌） 国内共著
INTRODUCTION: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphologically or immunohistochemically. METHODS: We scored expression of individual CAF markers (fibroblast activating protein (FAP), CD10, and podoplanin) in the intratumoral and marginal areas of 133 sarcomas. We also examined the association between these markers, as well as the number of CD163-positive macrophages (i.e., tumor-associated macrophages), and clinical outcome. RESULTS: In all cases, the log-rank test revealed that those with high marker scores and macrophage counts (except for marginal CD10+ CAFs) showed significantly worse disease-free survival (DFS). Grade 2/3 cases with high CAF scores (excluding the marginal FAP and CD10 scores) showed significantly worse DFS, whereas those with high intratumoral FAP/CD10 and marginal podoplanin scores showed significantly worse metastasis-free survival (MFS), and those with a high intratumoral CD10 score showed significantly worse local recurrence-free survival (LFS). Multivariate analysis identified intratumoral CD10/podoplanin scores and marginal FAP/podoplanin scores as independent prognostic factors for DFS, intratumoral FAP/CD10 and marginal FAP/podoplanin/CD163-positive macrophage scores as independent prognostic factors for MFS, and the intratumoral podoplanin score as an independent prognostic factor for LFS. There was a weak-to-moderate correlation between each score and CD163-positive macrophage counts. CONCLUSION: Patients with high CAF marker expression in the intratumoral and marginal areas have a poorer outcome.
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大腿骨近位部骨折例における術前移動能力と骨粗鬆症関連パラメータの関連性
湯浅 悠介, 宮腰 尚久, 粕川 雄司, 木村 善明, 柏倉 剛, 永澤 博幸, 若林 育子, 野坂 光司, 土江 博幸, 島田 洋一
整形外科 = Orthopedic surgery ( 南江堂 ) 70 ( 1 ) 1 - 3 2019年01月 [査読有り]
総説・解説（商業誌） 国内共著
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Tsuchie H.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre ( Medical principles and practice : international journal of the Kuwait University, Health Science Centre ) 33 ( 5 ) 424 - 430 2024年
OBJECTIVES: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although surgical treatment of elderly patients with STS has been reported to improve their prognosis, most of these studies included patients with STS aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in elderly patients aged ≥90 years. SUBJECT AND METHODS: We retrospectively identified patients aged ≥90 years with STS who were treated at our two hospitals between 1994 and 2022. Data on clinical information and detailed assessments were collected. We evaluated the features and factors affecting the prognosis of patients with older-extremity STS. In addition, we compared the clinical courses and results of patients treated with surgery and radiotherapy for primary tumors. RESULTS: Among 454 patients with STS, 16 were aged ≥90 years. Kaplan-Meier curves for overall survival showed a significantly poorer prognosis in patients who did not receive surgical treatment (p = 0.0348) and those who received radiotherapy (p = 0.0070). Moreover, we investigated the difference in prognosis between surgical treatment and radiotherapy, excluding two cases with distant metastasis at initial diagnosis and one case with no treatment. Kaplan-Meier curves for overall survival showed a significantly better prognosis in patients who underwent surgical treatment (p = 0.0161). Univariate analysis revealed that only primary tumor size was a significant predictor of poor prognosis (p = 0.0426). CONCLUSION: In patients with STS aged ≥90 years old, aggressive surgical treatment may improve the prognosis more than radiotherapy.
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腹壁発生のround cell sarcoma with EWSR1-non-ETS fusion(EWSR1-NFATC2 sarcoma)の1例
土江 博幸, 馬越 通信, 永澤 博幸, 長谷川 匡, 岡田 恭司, 南條 博, 後藤 明輝, 宮腰 尚久
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 96 ( 6 ) S1479 - S1479 2022年06月 [査読有り]
研究論文（その他学術会議資料等）
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清水 淳也, 江森 誠人, 高島 弘幸, 村橋 靖崇, 土江 博幸, 永澤 博幸, 宮腰 尚久, 島田 洋一, 山下 敏彦
東日本整形災害外科学会雑誌 ( 東日本整形災害外科学会 ) 33 ( 3 ) 381 - 381 2021年08月
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診断に難渋した大腿部aggressive angiomyxomaの1例
土江 博幸, 永澤 博幸, 南條 博, 宮腰 尚久, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1378 - S1378 2021年06月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
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軟部肉腫の局所再発に対するアクリジンオレンジを用いた辺縁切除手術の治療成績
土江 博幸, 江森 誠人, 永澤 博幸, 宮腰 尚久, 岡田 恭司, 村橋 靖崇, 水島 衣美, 清水 淳也, 山下 敏彦, 島田 洋一
日本整形外科学会雑誌 ( (公社)日本整形外科学会 ) 95 ( 6 ) S1423 - S1423 2021年06月 [査読有り]
研究論文（その他学術会議資料等） 国内共著
◆原著論文【 表示 ／ 非表示 】
◆総説・解説【 表示 ／ 非表示 】
◆その他【 表示 ／ 非表示 】
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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転移性骨腫瘍に対するアクリジンオレンジ血管内投与の効果の検討
基盤研究(C)
研究期間: 2019年04月 - 2022年03月 代表者: 土江 博幸
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癌腫多発転移に対するアクリジンオレンジ血管内投与の効果の検討
基盤研究(C)
研究期間: 2024年04月 - 2027年03月 代表者: 土江 博幸, 永澤 博幸, 粕川 雄司, 宮腰 尚久
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転移性骨腫瘍に対するアクリジンオレンジ血管内投与の効果の検討
基盤研究(C)
研究期間: 2019年04月 - 2022年03月 代表者: 土江 博幸
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転移性骨腫瘍に対するアクリジンオレンジ血管内投与の効果の検討
基盤研究(C)
研究期間: 2019年04月 - 2022年03月 代表者: 土江 博幸
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転移性骨腫瘍に対するアクリジンオレンジ血管内投与の効果の検討
基盤研究(C)
研究期間: 2019年04月 - 2022年03月 代表者: 土江 博幸
担当経験のある授業科目(学外) 【 表示 ／ 非表示 】
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悪性骨腫瘍
秋田大学医学部
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末梢神経障害
秋田大学医学部
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良性骨腫瘍
秋田大学医学部
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転移性骨腫瘍の外科的治療
秋田大学大学院医学系研究科
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転移性骨腫瘍・軟部腫瘍
秋田大学医学部