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Affiliation |
Hospital Orthopedic Surgery |
Graduating School 【 display / non-display 】
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-1994.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-1999.03
Akita University Graduate School,Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2005.04-Now
Akita University Hospital Orthopedic Surgery Assistant Professor
External Career 【 display / non-display 】
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2010.01
Akita University
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2007.04
Akita University University Hospital, Orthopedic Surgery Assistant Professor
Academic Society Affiliations 【 display / non-display 】
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1994-Now
Japan
THE JAPANESE ORTHOPAEDIC ASSOCIATION
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2016-2021
Japan
THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE
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1996-Now
Japan
JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH
Research Areas 【 display / non-display 】
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Life Science / Orthopedics
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Life Science / Orthopedics / 骨軟部腫瘍
Thesis for a degree 【 display / non-display 】
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Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells
Nagasawa H, Takahashi S, Kobayashi A, Tazawa H, Tashima Y, Sato K
Journal of Nutritional Science and Vitaminology 51 311 - 318 1999.03 [Refereed]
Domestic Co-author
Research Achievements 【 display / non-display 】
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Prognostic value of CAF marker expression in the intratumoral and marginal areas of soft tissue sarcoma.
Michinobu Umakoshi, Yukitsugu Kudo-Asabe, Hiroyuki Tsuchie, Zhuo Li, Kei Koyama, Ken Miyabe, Makoto Yoshida, Hiroyuki Nagasawa, Hiroshi Nanjo, Kyoji Okada, Daichi Maeda, Naohisa Miyakoshi, Masamitsu Tanaka, Akiteru Goto
Pathobiology : journal of immunopathology, molecular and cellular biology 2024.07 [Refereed]
Research paper (journal) Domestic Co-author
INTRODUCTION: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphologically or immunohistochemically. METHODS: We scored expression of individual CAF markers (fibroblast activating protein (FAP), CD10, and podoplanin) in the intratumoral and marginal areas of 133 sarcomas. We also examined the association between these markers, as well as the number of CD163-positive macrophages (i.e., tumor-associated macrophages), and clinical outcome. RESULTS: In all cases, the log-rank test revealed that those with high marker scores and macrophage counts (except for marginal CD10+ CAFs) showed significantly worse disease-free survival (DFS). Grade 2/3 cases with high CAF scores (excluding the marginal FAP and CD10 scores) showed significantly worse DFS, whereas those with high intratumoral FAP/CD10 and marginal podoplanin scores showed significantly worse metastasis-free survival (MFS), and those with a high intratumoral CD10 score showed significantly worse local recurrence-free survival (LFS). Multivariate analysis identified intratumoral CD10/podoplanin scores and marginal FAP/podoplanin scores as independent prognostic factors for DFS, intratumoral FAP/CD10 and marginal FAP/podoplanin/CD163-positive macrophage scores as independent prognostic factors for MFS, and the intratumoral podoplanin score as an independent prognostic factor for LFS. There was a weak-to-moderate correlation between each score and CD163-positive macrophage counts. CONCLUSION: Patients with high CAF marker expression in the intratumoral and marginal areas have a poorer outcome.
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Effect of Acridine Orange and Zoledronic Acid on Bone Metastasis in Renal Cell Carcinoma
Oya K.
Anticancer research ( Anticancer research ) 44 ( 6 ) 2487 - 2495 2024.06 [Refereed]
Research paper (journal) Domestic Co-author
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Development of a New Focal Mouse Model of Bone Metastasis in Renal Cell Carcinoma
Oya K.
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 38 ( 3 ) 1074 - 1078 2024.05 [Refereed]
Research paper (journal) Domestic Co-author
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Development of a New Focal Mouse Model of Bone Metastasis in Renal Cell Carcinoma
OYA KEITA, TSUCHIE HIROYUKI, NAGASAWA HIROYUKI, HONGO MICHIO, KASUKAWA YUJI, KUDO DAISUKE, SHOJI RYO, KASAMA FUMIHITO, KAWARAGI TAKASHI, WATANABE MANABU, TOMINAGA KENTA, MIYAKOSHI NAOHISA
In Vivo ( International Institute of Anticancer Research ) 38 ( 3 ) 1074 - 1078 2024
Research paper (journal) Domestic Co-author
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Effects of Soft Tissue Sarcoma and Doxorubicin on Bone Metabolism in Mice
Kasama F.
In vivo (Athens, Greece) ( In vivo (Athens, Greece) ) 37 ( 4 ) 1532 - 1539 2023.07 [Refereed]
Research paper (journal) Domestic Co-author
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70 ( 1 ) 1 - 3 2019.01 [Refereed]
Introduction and explanation (commerce magazine) Domestic Co-author
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Yuasa Y, Miyakoshi N, Kasukawa Y, Nagahata I, Akagawa M, Ono Y, Sato C, Tsuchie H, Nozaka K, Nagasawa H, Hongo M, Shimada Y
Journal of bone and mineral metabolism 38 ( 2 ) 179 - 187 2020.03
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Treatment outcome of chest wall soft tissue sarcomas: Analysis of prognostic factors.
Nakahashi N, Emori M, Tsuchie H, Nagasawa H, Sonoda T, Takada K, Miyajima M, Watanabe A, Shimada Y, Yamashita T
Journal of surgical oncology 120 ( 7 ) 1235 - 1240 2019.12
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Tsuchie H, Emori M, Nagasawa H, Miyakoshi N, Murahashi Y, Shimizu J, Mizushima E, Yamashita T, Shimada Y
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 28 ( 5 ) 425 - 431 2019.09
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Costal osteomyelitis as a side reaction of Bacillus Calmette-Guérin vaccination: A case report
WAKABAYASHI Rena, MIYAKOSHI Naohisa, TSUCHIE Hiroyuki, NAGASAWA Hiroyuki, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 4 ) 483 - 486 2019
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Impact of Acridine Orange in Patients With Soft Tissue Sarcoma Treated With Marginal Resection.
Tsuchie H, Emori M, Miyakoshi N, Nagasawa H, Okada K, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Shimada Y
Anticancer research 39 ( 11 ) 6365 - 6372 2019
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki
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The effect of intravascular administration of acridine orange on multiple metastases of carcinoma
Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03
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Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki
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Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03