|
Affiliation |
Hospital Orthopedic Surgery |
Graduating School 【 display / non-display 】
-
-1994.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
-
-1999.03
Akita University Graduate School,Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
-
2005.04-Now
Akita University Hospital Orthopedic Surgery Assistant Professor
External Career 【 display / non-display 】
-
2010.01
Akita University
-
2007.04
Akita University University Hospital, Orthopedic Surgery Assistant Professor
Academic Society Affiliations 【 display / non-display 】
-
1994-Now
Japan
THE JAPANESE ORTHOPAEDIC ASSOCIATION
-
2016-2021
Japan
THE JAPANESE ASSOCIATION OF REHABILITATION MEDICINE
-
1996-Now
Japan
JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH
Research Areas 【 display / non-display 】
-
Life Science / Orthopedics
-
Life Science / Orthopedics / 骨軟部腫瘍
Thesis for a degree 【 display / non-display 】
-
Effect of retinoic acid on murine preosteoblastic MC3T3-E1 cells
Nagasawa H, Takahashi S, Kobayashi A, Tazawa H, Tashima Y, Sato K
Journal of Nutritional Science and Vitaminology 51 311 - 318 1999.03 [Refereed]
Domestic Co-author
Research Achievements 【 display / non-display 】
-
Surgical Treatment and Prognosis of Soft Tissue Sarcoma in Patients Aged 85 Years and Older
Tsuchie H.
In Vivo ( In Vivo ) 39 ( 3 ) 1661 - 1668 2025.05 [Refereed]
Research paper (journal) Domestic Co-author
BACKGROUND/AIM: The incidence of soft tissue sarcomas (STSs) among older patients is increasing. Although it has been reported that surgical treatment of elderly patients with STS improves prognosis, most of these studies included patients aged <85 years. This study aimed to analyze the clinical features and prognostic factors of STS in excessively elderly patients aged ≥85 or ≥90 years. PATIENTS AND METHODS: We retrospectively identified 398 patients with STS who were treated at our two hospitals between 1994 and 2022. Only histological types that existed in ≥20 cases were included. Data on clinical information and detailed assessments were collected. We divided the patients into two subgroups according to 85 or 90 years of age and compared the groups within each subgroup. Furthermore, we examined the factors affecting the prognosis of all and older patients. RESULTS: Patients ≥85 or ≥90 years old comprised 12.1% and 4.0% of the study population, respectively. In all patients, Kaplan-Meier curves for overall survival demonstrated a significantly poorer prognosis in elderly patients with STS aged ≥85 years (p=0.0476) and ≥90 years (p=0.0164). However, no significant differences were observed when analyzing only patients who underwent surgical treatment without distant metastasis at diagnosis. In the multivariate analyses, surgical treatment for the primary tumor improved prognosis exclusively in patients ≥85 years old (p =0.0300). CONCLUSION: Surgical treatment improves the prognosis in elderly STS patients aged ≥85 years and possibly among those aged ≥90 years.
-
Isolated Talar Metastasis of Renal Cell Carcinoma Treated With Tibiocalcaneal Arthrodesis Using an Ilizarov External Fixation.
Shuichi Chida, Koji Nozaka, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Naohisa Miyakoshi
Cureus 17 ( 1 ) e77275 2025.01 [Refereed]
Research paper (journal) Domestic Co-author
Acrometastases to the feet are exceedingly rare. We report a case of isolated talar metastasis from renal cell carcinoma successfully managed through surgical excision and reconstruction with Ilizarov external fixation. A 65-year-old male presented with a six-month history of right ankle pain. Radiographs revealed an osteolytic lesion in the talus. An incisional biopsy confirmed the diagnosis of metastatic renal cell carcinoma. Systemic evaluation showed no recurrence in the right kidney or metastases beyond the right talus. En bloc resection of the talus was performed via an anterior approach, followed by tibiocalcaneal arthrodesis using Ilizarov external fixation. At the four-year follow-up, the patient remained pain-free while walking and showed no evidence of recurrence or additional metastases.
-
Zeniya T.
Acta Orthopaedica Belgica ( Acta Orthopaedica Belgica ) 90 ( 4 ) 731 - 737 2024.12 [Refereed]
Research paper (journal) Domestic Co-author
-
A Case of Subungual Exostosis With Early Postoperative Recurrence and Rapid Growth.
Shohei Murata, Hiroyuki Tsuchie, Hiroyuki Nagasawa, Toshihito Ebina, Naohisa Miyakoshi
Cureus 16 ( 11 ) e73933 2024.11 [Refereed]
Research paper (journal) Domestic Co-author
Subungual exostosis is a relatively rare benign bone tumor that occurs near the distal phalanges of the fingers and toes. Though it is similar to osteochondroma, it can be distinguished by its specific location and lack of communication with the medullary cavity. Although recurrence after surgical excision has been reported, no studies have examined the timing or progression of recurrence, nor have there been reports detailing the chronological imaging findings of recurrent cases. A case of subungual exostosis that recurred rapidly with significant growth shortly after surgical excision is reported. The patient was a 13-year-old boy with subungual exostosis of the fourth toe. Tumor recurrence was observed four weeks after the initial excision, and it gradually enlarged, growing to several times the size of the original tumor three months after surgery. A second procedure was performed approximately four months after the initial procedure, and no recurrence has been observed since. This case represents the first report of the chronological radiographic progression of recurrent subungual exostosis, highlighting the importance of careful follow-up and consideration of early recurrence after excision.
-
Michinobu Umakoshi, Yukitsugu Kudo-Asabe, Hiroyuki Tsuchie, Zhuo Li, Kei Koyama, Ken Miyabe, Makoto Yoshida, Hiroyuki Nagasawa, Hiroshi Nanjo, Kyoji Okada, Daichi Maeda, Naohisa Miyakoshi, Masamitsu Tanaka, Akiteru Goto
Pathobiology : journal of immunopathology, molecular and cellular biology ( Pathobiology ) 92 ( 1 ) 2024.07 [Refereed]
Research paper (journal) Domestic Co-author
INTRODUCTION: The tumor microenvironment of sarcomas has not been studied in detail; in particular, little is known about cancer-associated fibroblasts (CAFs). Sarcoma cells are difficult to distinguish from CAFs, either histomorphologically or immunohistochemically. METHODS: We scored expression of individual CAF markers (fibroblast activating protein (FAP), CD10, and podoplanin) in the intratumoral and marginal areas of 133 sarcomas. We also examined the association between these markers, as well as the number of CD163-positive macrophages (i.e., tumor-associated macrophages), and clinical outcome. RESULTS: In all cases, the log-rank test revealed that those with high marker scores and macrophage counts (except for marginal CD10+ CAFs) showed significantly worse disease-free survival (DFS). Grade 2/3 cases with high CAF scores (excluding the marginal FAP and CD10 scores) showed significantly worse DFS, whereas those with high intratumoral FAP/CD10 and marginal podoplanin scores showed significantly worse metastasis-free survival (MFS), and those with a high intratumoral CD10 score showed significantly worse local recurrence-free survival (LFS). Multivariate analysis identified intratumoral CD10/podoplanin scores and marginal FAP/podoplanin scores as independent prognostic factors for DFS, intratumoral FAP/CD10 and marginal FAP/podoplanin/CD163-positive macrophage scores as independent prognostic factors for MFS, and the intratumoral podoplanin score as an independent prognostic factor for LFS. There was a weak-to-moderate correlation between each score and CD163-positive macrophage counts. CONCLUSION: Patients with high CAF marker expression in the intratumoral and marginal areas have a poorer outcome.
-
70 ( 1 ) 1 - 3 2019.01 [Refereed]
Introduction and explanation (commerce magazine) Domestic Co-author
-
Yuasa Y, Miyakoshi N, Kasukawa Y, Nagahata I, Akagawa M, Ono Y, Sato C, Tsuchie H, Nozaka K, Nagasawa H, Hongo M, Shimada Y
Journal of bone and mineral metabolism 38 ( 2 ) 179 - 187 2020.03
-
Treatment outcome of chest wall soft tissue sarcomas: Analysis of prognostic factors.
Nakahashi N, Emori M, Tsuchie H, Nagasawa H, Sonoda T, Takada K, Miyajima M, Watanabe A, Shimada Y, Yamashita T
Journal of surgical oncology 120 ( 7 ) 1235 - 1240 2019.12
-
Tsuchie H, Emori M, Nagasawa H, Miyakoshi N, Murahashi Y, Shimizu J, Mizushima E, Yamashita T, Shimada Y
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 28 ( 5 ) 425 - 431 2019.09
-
Costal osteomyelitis as a side reaction of Bacillus Calmette-Guérin vaccination: A case report
WAKABAYASHI Rena, MIYAKOSHI Naohisa, TSUCHIE Hiroyuki, NAGASAWA Hiroyuki, SHIMADA Yoichi
Journal of the Eastern Japan Association of Orthopaedics and Traumatology ( The Eastern Japan Association of Orthopaedics and Traumatology ) 31 ( 4 ) 483 - 486 2019
-
Impact of Acridine Orange in Patients With Soft Tissue Sarcoma Treated With Marginal Resection.
Tsuchie H, Emori M, Miyakoshi N, Nagasawa H, Okada K, Murahashi Y, Mizushima E, Shimizu J, Yamashita T, Shimada Y
Anticancer research 39 ( 11 ) 6365 - 6372 2019
◆Original paper【 display / non-display 】
◆Introduction and explanation【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki
-
The effect of intravascular administration of acridine orange on multiple metastases of carcinoma
Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
-
Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki
-
Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki
-
Effects of intravascular administration of acridine orange and bisphosphonate in a local bone metastasis of breast cancer model
Grant-in-Aid for Scientific Research(C)
Project Year： 2019.04 - 2022.03 Investigator(s): Tsuchie Hiroyuki