所属 |
大学院医学系研究科(医学専攻等) 医学専攻 病態制御医学系 薬物動態学講座 |
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2021年12月-継続中
秋田大学 大学院医学系研究科(医学専攻等) 医学専攻 病態制御医学系 薬物動態学講座 教授
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2013年04月-2021年11月
秋田大学 附属病院 薬剤部 教授
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Influence of UGT1A7 and UGT1A9 intronic I399 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients
Masatomo,Miura
Ther Drug Monit 29 ( 299 ) 304 2007年01月
研究論文(学術雑誌) 単著
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Influence of UGT1A8 and UGT2B7 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients
Masatomo,Miura
Eur J Clin Pharmacol 63 ( 279 ) 288 2007年01月 [査読有り]
研究論文(学術雑誌) 単著
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Determination of fexofenadine enantiomers in human plasma with high-performance liquid chromatography
Masatomo,Miura
J Pharm Biomed Anal 43 ( 741 ) 745 2007年01月
研究論文(学術雑誌) 単著
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Pharmacokinetics of fexofenadine enantiomers in healthy subjects
Masatomo,Miura
Chirality 19 ( 223 ) 227 2007年01月
研究論文(学術雑誌) 単著
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Fujita K.
Cancer Chemotherapy and Pharmacology ( Cancer Chemotherapy and Pharmacology ) 95 ( 1 ) 2025年12月
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Yokota H.
Cancer Chemotherapy and Pharmacology ( Cancer Chemotherapy and Pharmacology ) 95 ( 1 ) 2025年12月
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Terasawa A.
World Journal of Experimental Medicine ( World Journal of Experimental Medicine ) 15 ( 2 ) 2025年06月
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LM1010高速液体クロマトグラフィ法と化学発光免疫測定法によるバンコマイシン血中濃度測定値の比較
赤嶺 由美子, 松下 美由紀, 森川 悟, 三浦 昌朋
医療薬学 ( 一般社団法人日本医療薬学会 ) 51 ( 4 ) 187 - 195 2025年04月
<p>Many immunoassay methods have been developed for quantifying vancomycin levels in biological fluids. Recently, the LM1010, a high-performance liquid chromatography-based medical diagnostic device was approved. This study compared the results obtained with LM1010 with those obtained using ARCHITECT plus chemiluminescent immunoassay (CLIA) to measure vancomycin levels in patient serum samples. The retention times measured with LM1010 for vancomycin and its major and minor crystalline degradation products (CDP-1) were 2.50, 2.38, and 1.91 min, respectively, and the separation was satisfactory. When five CLIA calibrator samples (5.0 – 100 μg/mL) were analyzed using LM1010, the concentrations were lower than expected, with an average of −12.96% (range: −7.07% to −17.53%). In addition, in a Japanese external quality control survey examination, LM1010 demonstrated high accuracy (0.33% to −6.68%). A strong correlation was observed between the results obtained using LM1010 (calculated by peak height) and CLIA (<i>r</i> = 0.9682). The slope of the Deming regression comparing LM1010 to CLIA was 0.831, and a Bland–Altman plot for LM1010 relative to CLIA showed a mean negative bias (±1.96 standard deviation) of −2.356 (−6.108 – 1.396) μg/mL. Thus, the results obtained with CLIA were higher than those obtained with LM1010. If the calibrators for CLIA are adjusted by considering cross-reactivities with CDP-1 or other metabolites, the vancomycin concentrations in patient samples determined using CLIA may be higher than those determined using LM1010. Overall, vancomycin concentrations should be analyzed using an assay with higher accuracy, such as LM1010.</p>
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Abumiya M.
International Journal of Hematology ( International Journal of Hematology ) 2025年
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科研費(文科省・学振)獲得実績 【 表示 / 非表示 】
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重篤な副作用回避に向けた分子標的抗がん剤治療法の開発
基盤研究(C)
研究期間: 2020年04月 - 2022年03月