Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of General Medical Practice and Laboratory Diagnostic Medicine |
MORITOKI Yuki
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Research Interests 【 display / non-display 】
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B lymphocytes
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Primary Biliary Cholangitis
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Autoimmune Liver Diseases
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Simulation-Based Medical Education
Graduating School 【 display / non-display 】
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1993.04-1999.03
Akita University Faculty of Medicine Graduated
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-1992.03
Kobe University Faculty of Science Graduated
Graduate School 【 display / non-display 】
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2002.04-2006.03
Tohoku University Graduate School, Division of Medicine Doctor's Course Completed
Studying abroad experiences 【 display / non-display 】
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2004.07-2009.03
Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis Postgraduate research scholar, Postdoctoral research scholar
Campus Career 【 display / non-display 】
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2022.04-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Department of General Medical Practice and Laboratory Diagnostic Medicine Associate Professor
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2019.07-2022.03
Akita University Hospital Center for Medical Education and Training Specially-appointed Associate Professor
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2014.10-2019.06
Akita University Hospital Center for Medical Education and Training Specially-appointed Lecturer
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2013.04-2014.09
Akita University Hospital Medical Doctor Support Center Specially-appointed Lecturer
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2011.04-2013.03
Akita University Hospital Career Development Center Specially-appointed Lecturer
Qualification acquired 【 display / non-display 】
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Doctor
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Certified Healthcare Simulation Educator (CHSE) of SSH
Research Achievements 【 display / non-display 】
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Improving performance and self-efficacy of novice nurses using hybrid simulation-based mastery learning
Takashiki, R. Komatsu, J. Nowicki, M. Moritoki, Y. Okazaki, M. Ohshima, S. Hasegawa, H. Nomura, K. Ouchi, G. Berg, B. W. Shirakawa, H. Nakayama, K. Takahashi, N.
Japan Journal of Nursing Science 2022.10 [Refereed]
Research paper (journal) International Co-author
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Clonal hematopoiesis in adult pure red cell aplasia
Fujishima, N. Kohmaru, J. Koyota, S. Kuba, K. Saga, T. Omokawa, A. Moritoki, Y. Ueki, S. Ishida, F. Nakao, S. Matsuda, A. Ohta, A. Tohyama, K. Yamasaki, H. Usuki, K. Nakashima, Y. Sato, S. Miyazaki, Y. Nannya, Y. Ogawa, S. Sawada, K. Mitani, K. Hirokawa, M.
Scientific Reports ( Scientific Reports ) 11 ( 1 ) 2021.12 [Refereed]
Research paper (journal) Domestic Co-author
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Eosinophil-mediated inflammation in the absence of eosinophilia
Miyabe, Y. Kobayashi, Y. Fukuchi, M. Saga, A. Moritoki, Y. Saga, T. Akuthota, P. Ueki, S.
Asia Pacific Allergy ( Asia Pacific Allergy ) 11 2021.07 [Refereed]
Research paper (journal) International Co-author
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The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells
MaruYama, T. Kobayashi, S. Nakatsukasa, H. Moritoki, Y. Taguchi, D. Sunagawa, Y. Morimoto, T. Asao, A. Jin, W. Owada, Y. Ishii, N. Iwabuchi, Y. Yoshimura, A. Chen, W. Shibata, H.
Frontiers in Immunology ( Frontiers in Immunology ) 12 2021.06 [Refereed]
Research paper (journal) International Co-author
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Osaki, S. Kikuchi, K. Moritoki, Y. Motegi, C. Ohyatsu, S. Nariyama, T. Matsumoto, K. Tsunashima, H. Kikuyama, T. Kubota, J. Nagumo, K. Fujioka, H. Kato, R. Murakawa, Y.
Journal of Infection and Chemotherapy ( Journal of Infection and Chemotherapy ) 26 ( 7 ) 672 - 675 2020.07 [Refereed]
Research paper (journal) Domestic Co-author
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Pathological features of new animal models for primary biliary cirrhosis
Tsuneyama K, Moritoki Y, Kikuchi K, Nakanuma Y.
Int J Hepatol ( Hindawi ) 2011.04
Introduction and explanation (scientific journal) Domestic Co-author
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Murine models of autoimmune cholangitis.
Ueno Y, Ambrosini YM, Moritoki Y, Ridgway WM, Gershwin ME.
Curr Opin Gastroenterol. ( Wolters Kluwel ) 2010.05
Introduction and explanation (scientific journal) Domestic Co-author
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B cells and autoimmune liver diseases
Moritoki Y, Lian ZX, Ohsugi Y, Ueno Y, Gershwin ME.
Autoimmun Rev ( Elsevier ) 2006.08
Introduction and explanation (scientific journal) Domestic Co-author
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Proliferation and differentiation of cholangiocytes
Moritoki Y., Ueno Y.
KANTANSUI 2003.05
Introduction and explanation (commerce magazine) Domestic Co-author
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How to detect eosinophil ETosis (EETosis) and extracellular traps
Fukuchi, M. Miyabe, Y. Furutani, C. Saga, T. Moritoki, Y. Yamada, T. Weller, P. F. Ueki, S.
Allergology International ( Allergology International ) 70 ( 1 ) 19 - 29 2021.01 [Refereed]
International Co-author
<p>Eosinophils are short-lived and comprise only a small population of circulating leukocytes; however, they play surprisingly multifunctional roles in homeostasis and various diseases including allergy and infection. Recent research has shed light on active cytolytic eosinophil cell death that releases eosinophil extracellular traps (EETs) and total cellular contents, namely eosinophil extracellular trap cell death (EETosis). The pathological contribution of EETosis was made more cogent by recent findings that a classical pathological finding of eosinophilic inflammation, that of Charcot-Leyden crystals, is closely associated with EETosis. Currently no gold standard methods to identify EETosis exist, but "an active eosinophil lysis that releases cell-free granules and net-like chromatin structure" appears to be a common feature of EETosis. In this review, we describe several approaches that visualize EETs/EETosis in clinical samples and <i>in vitro</i> studies using isolated human eosinophils. EETs/EETosis can be observed using simple chemical or fluorescence staining, immunostaining, and electron microscopy, although it is noteworthy that visualization of EETs is greatly changed by sample preparation including the extracellular space of EETotic cells and shear flow. Considering the multiple aspects of biological significance, further study into EETs/EETosis is warranted to give a detailed understanding of the roles played in homeostasis and disease pathogenesis.</p>
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Matsumoto, K. Ichimura, M. Tsuneyama, K. Moritoki, Y. Tsunashima, H. Omagari, K. Hara, M. Yasuda, I. Miyakawa, H. Kikuchi, K.
PLoS ONE ( PLoS ONE ) 12 ( 6 ) 2017.06 [Refereed]
Domestic Co-author