Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of General Medical Practice and Laboratory Diagnostic Medicine

Research Interests 【 display / non-display

  • Primary Biliary Cholangitis

  • Autoimmune Liver Diseases

  • B lymphocytes

  • Simulation-Based Medical Education

Graduating School 【 display / non-display

  • 1993.04

    Akita University   Faculty of Medicine   Graduated


    Kobe University   Faculty of Science   Graduated

Graduate School 【 display / non-display

  • 2002.04

    Tohoku University  Graduate School, Division of Medicine  Doctor's Course  Completed

Studying abroad experiences 【 display / non-display

  • 2004.07

    Division of Rheumatology, Allergy and Clinical Immunology, University of California Davis   Postgraduate research scholar, Postdoctoral research scholar

Campus Career 【 display / non-display

  • 2022.04

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Department of General Medical Practice and Laboratory Diagnostic Medicine   Associate Professor  

  • 2019.07

    Akita University   Hospital   Center for Medical Education and Training   Specially-appointed Associate Professor  

  • 2014.10

    Akita University   Hospital   Center for Medical Education and Training   Specially-appointed Lecturer  

  • 2013.04

    Akita University   Hospital   Medical Doctor Support Center   Specially-appointed Lecturer  

  • 2011.04

    Akita University   Hospital   Career Development Center   Specially-appointed Lecturer  

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Qualification acquired 【 display / non-display

  • Doctor

  • Certified Healthcare Simulation Educator (CHSE) of SSH


Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • Improving performance and self-efficacy of novice nurses using hybrid simulation-based mastery learning

    Takashiki, R. Komatsu, J. Nowicki, M. Moritoki, Y. Okazaki, M. Ohshima, S. Hasegawa, H. Nomura, K. Ouchi, G. Berg, B. W. Shirakawa, H. Nakayama, K. Takahashi, N.

    Japan Journal of Nursing Science     2022.10  [Refereed]

    Research paper (journal)   International Co-author

  • Clonal hematopoiesis in adult pure red cell aplasia

    Fujishima, N. Kohmaru, J. Koyota, S. Kuba, K. Saga, T. Omokawa, A. Moritoki, Y. Ueki, S. Ishida, F. Nakao, S. Matsuda, A. Ohta, A. Tohyama, K. Yamasaki, H. Usuki, K. Nakashima, Y. Sato, S. Miyazaki, Y. Nannya, Y. Ogawa, S. Sawada, K. Mitani, K. Hirokawa, M.

    Scientific Reports ( Scientific Reports )  11 ( 1 )   2021.12  [Refereed]

    Research paper (journal)   Domestic Co-author


  • Eosinophil-mediated inflammation in the absence of eosinophilia

    Miyabe, Y. Kobayashi, Y. Fukuchi, M. Saga, A. Moritoki, Y. Saga, T. Akuthota, P. Ueki, S.

    Asia Pacific Allergy ( Asia Pacific Allergy )  11   2021.07  [Refereed]

    Research paper (journal)   International Co-author


  • The Curcumin Analog GO-Y030 Controls the Generation and Stability of Regulatory T Cells

    MaruYama, T. Kobayashi, S. Nakatsukasa, H. Moritoki, Y. Taguchi, D. Sunagawa, Y. Morimoto, T. Asao, A. Jin, W. Owada, Y. Ishii, N. Iwabuchi, Y. Yoshimura, A. Chen, W. Shibata, H.

    Frontiers in Immunology ( Frontiers in Immunology )  12   2021.06  [Refereed]

    Research paper (journal)   International Co-author


  • Distinguishing coagulase-negative Staphylococcus bacteremia from contamination using blood-culture positive bottle detection pattern and time to positivity

    Osaki, S. Kikuchi, K. Moritoki, Y. Motegi, C. Ohyatsu, S. Nariyama, T. Matsumoto, K. Tsunashima, H. Kikuyama, T. Kubota, J. Nagumo, K. Fujioka, H. Kato, R. Murakawa, Y.

    Journal of Infection and Chemotherapy ( Journal of Infection and Chemotherapy )  26 ( 7 ) 672 - 675   2020.07  [Refereed]

    Research paper (journal)   Domestic Co-author


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    ◆Introduction and explanation【 display / non-display

  • Pathological features of new animal models for primary biliary cirrhosis

    Tsuneyama K, Moritoki Y, Kikuchi K, Nakanuma Y.

    Int J Hepatol ( Hindawi )    2011.04

    Introduction and explanation (scientific journal)   Domestic Co-author


  • Murine models of autoimmune cholangitis.

    Ueno Y, Ambrosini YM, Moritoki Y, Ridgway WM, Gershwin ME.

    Curr Opin Gastroenterol. ( Wolters Kluwel )    2010.05

    Introduction and explanation (scientific journal)   Domestic Co-author


  • B cells and autoimmune liver diseases

    Moritoki Y, Lian ZX, Ohsugi Y, Ueno Y, Gershwin ME.

    Autoimmun Rev ( Elsevier )    2006.08

    Introduction and explanation (scientific journal)   Domestic Co-author


  • Proliferation and differentiation of cholangiocytes

    Moritoki Y., Ueno Y.

    KANTANSUI     2003.05

    Introduction and explanation (commerce magazine)   Domestic Co-author

  • ◆Other【 display / non-display

  • How to detect eosinophil ETosis (EETosis) and extracellular traps

    Fukuchi, M. Miyabe, Y. Furutani, C. Saga, T. Moritoki, Y. Yamada, T. Weller, P. F. Ueki, S.

    Allergology International ( Allergology International )  70 ( 1 ) 19 - 29   2021.01  [Refereed]

    International Co-author

    <p>Eosinophils are short-lived and comprise only a small population of circulating leukocytes; however, they play surprisingly multifunctional roles in homeostasis and various diseases including allergy and infection. Recent research has shed light on active cytolytic eosinophil cell death that releases eosinophil extracellular traps (EETs) and total cellular contents, namely eosinophil extracellular trap cell death (EETosis). The pathological contribution of EETosis was made more cogent by recent findings that a classical pathological finding of eosinophilic inflammation, that of Charcot-Leyden crystals, is closely associated with EETosis. Currently no gold standard methods to identify EETosis exist, but "an active eosinophil lysis that releases cell-free granules and net-like chromatin structure" appears to be a common feature of EETosis. In this review, we describe several approaches that visualize EETs/EETosis in clinical samples and <i>in vitro</i> studies using isolated human eosinophils. EETs/EETosis can be observed using simple chemical or fluorescence staining, immunostaining, and electron microscopy, although it is noteworthy that visualization of EETs is greatly changed by sample preparation including the extracellular space of EETotic cells and shear flow. Considering the multiple aspects of biological significance, further study into EETs/EETosis is warranted to give a detailed understanding of the roles played in homeostasis and disease pathogenesis.</p>


  • Fructo-oligosaccharides and intestinal barrier function in a methionine–choline-deficient mouse model of nonalcoholic steatohepatitis

    Matsumoto, K. Ichimura, M. Tsuneyama, K. Moritoki, Y. Tsunashima, H. Omagari, K. Hara, M. Yasuda, I. Miyakawa, H. Kikuchi, K.

    PLoS ONE ( PLoS ONE )  12 ( 6 )   2017.06  [Refereed]

    Domestic Co-author



Academic Activity 【 display / non-display

  • 2013.01

  • 2011.02