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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Molecular Medicine and Biochemistry |
Kuriyama sei
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Research Interests 【 display / non-display 】
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Oncobiology
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metastasis
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collective cell migration
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morphology
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neural crest cells
Graduating School 【 display / non-display 】
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-2001
Kwansei Gakuin University Graduated
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-2001
Kwansei Gakuin University Graduated
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-1998
Kwansei Gakuin University Faculty of Science Graduated
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1992.04-1996.03
Kwansei Gakuin University Faculty of Science Graduated
Graduate School 【 display / non-display 】
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1998.04-2001.03
Kwansei Gakuin University Graduate School, Division of Science Doctor's Course Accomplished credits for doctoral program
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1996.04-1998.03
Kwansei Gakuin University Graduate School, Division of Science Master's Course Completed
Studying abroad experiences 【 display / non-display 】
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2006.10-2009.07
University College London BBSRC postdoctoral fellow
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2005.10-2006.10
University College London Honorary Postdoctoral fellow
Campus Career 【 display / non-display 】
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2009.08-Now
Akita University Associate Professor
External Career 【 display / non-display 】
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2009.08
Akita University Grad. Sch. Med. Dept. Molecular Medicine & Biochemistry Associate Professor
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2005.08-2009.07
University College London Dept. Anatomy Postdoc
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2005.04-2005.07
Kumamoto University Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Developmental biology
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Life Science / Cell biology
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Life Science / Tumor biology
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Life Science / Tumor biology
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Life Science / Developmental biology
Research Achievements 【 display / non-display 】
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LPP inhibits collective cell migration during lung caner dissemination
Sei Kuriyama et al.
Oncogene 35 ( 8 ) 952 - 964 2016.06
Research paper (journal) Domestic Co-author
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In vivo collective cell migration requires an LPAR2-dependent increase in tissue fluidity.
Sei Kuriyama
Jornal Cell Biology ( 206 ) 113 - 127 2014.07 [Refereed]
Research paper (journal) Domestic Co-author
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Sei Kuriyama, Kuboki Thasaneeya, Go Itoh, Satoru Kidoaki, Masamitsu Tanaka
Histochemistry and Cell Biology ( Histochemistry and Cell Biology ) 162 ( 4 ) 337 - 347 2024.10 [Refereed]
Research paper (journal)
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Misato Horie, Kurara Takagane, Go Itoh, Sei Kuriyama, Kazuyoshi Yanagihara, Masakazu Yashiro, Michinobu Umakoshi, Akiteru Goto, Junichi Arita, Masamitsu Tanaka
Molecular oncology ( Molecular Oncology ) 18 ( 1 ) 21 - 43 2023.09
Research paper (journal)
Peritoneal dissemination of cancer affects patient survival. The behavior of peritoneal mesothelial cells (PMCs) and immune cells influences the establishment of a microenvironment that promotes cancer cell metastasis in the peritoneum. Here, we investigated the roles of lactosylceramide alpha-2,3-sialyltransferase (ST3G5; also known as ST3GAL5 and GM3 synthase) in the exosome-mediated pre-metastatic niche in peritoneal milky spots (MSs). Exosomes secreted from ST3G5high cancer cells (ST3G5high -cExos) were found to contain high levels of hypoxia-inducible factor 1-alpha (HIF1α) and accumulated in MSs via uptake in macrophages (MΦs) owing to increased expression of sialic acid binding Ig like lectin 1 (CD169; also known as SIGLEC1). ST3G5high -cExos induced pro-inflammatory cytokines and glucose metabolic changes in MΦs, and the interaction of these MΦs with PMCs promoted mesothelial-mesenchymal transition (MMT) in PMCs, thereby generating αSMA+ myofibroblasts. ST3G5high -cExos also increased the expression of immune checkpoint molecules and T cell exhaustion in MSs, which accelerated metastasis to the omentum. These events were prevented following ST3G5 depletion in cancer cells. Mechanistically, ST3G5high -cExos upregulated chemokines, including CC-chemokine ligand 5 (CCL5), in recipient MΦs and dendritic cells (DCs), which induced MMT and immunosuppression via activation of signal transducer and activator of transcription 3 (STAT3). Maraviroc, a C-C chemokine receptor type 5 (CCR5) antagonist, prevented ST3G5high -cExo-mediated MMT, T cell suppression and metastasis in MSs. Our results suggest ST3G5 as a suitable therapeutic target for preventing cExo-mediated peritoneal dissemination.
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Sei Kuriyama, Masamitsu Tanaka
Development, growth & differentiation ( Development Growth and Differentiation ) 65 ( 2 ) 109 - 119 2023.01 [Refereed]
Research paper (journal)
Tetraspanins (Tspans) are a four-pass transmembrane domain cell surface protein family. Tspans have been found on the plasma membrane and exosomes of various organelles. Reports on the function of tetraspanins during the early development of Xenopus have mainly focused on the expression of uroplakins in gametes. Although the roles of extracellular vesicles (EVs) including exosomes have been actively analyzed in cancer research, the contribution of EVs to early development is not well understood. This is because the diffusible property of EVs is not compatible with a very strict developmental process. In this study, we analyzed members of the tetraspanins in early development of Xenopus. The expression pattern was prominent in specific organs such as the notochord, eye, cranial neural crest cells (CNCs), trunk neural crest cells, placodes, and somites. We tested overexpressions of several different combination of Tspans expressing in CNC in vitro, and in vivo. Changing the partner changed the distribution of fluorescent-labeled Tspans. Therefore, it suggested that multiple Tspan expressions in particular tissue might produce heterogeneity of intercellular communication, which has not yet been recognized.
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Exosomes of ST3G5<sup>high</sup> cancer cells promote pre-metastatic niche of peritoneal dissemination
田中正光, 堀江美里, 高金くらら, 伊藤剛, 栗山正, 柳原五吉, 八代正和
日本癌学会学術総会抄録集(Web) 82nd 2023
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Study of tumor progression systems by fibroblasts
伊藤剛, 高金くらら, 福士由真, 栗山正, 田中正光
月刊Precision Medicine 4 ( 14 ) 1347 - 1350 2022.01
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PEDF is required for extravasation and mesenchymal to epithelial-like transition of osteosarcoma
栗山正, 田中正光
日本癌学会学術総会抄録集(Web) 79th 2020
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PEDF overexpression in osteosarcoma cell line increases the endothelial permeability and promotes metastasis
栗山正, 田中正光
日本癌学会学術総会抄録集(Web) 78th 2019
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Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors.
Shimazu K, Inoue M, Sugiyama S, Fukuda K, Yoshida T, Taguchi D, Uehara Y, Kuriyama S, Tanaka M, Miura M, Nanjyo H, Iwabuchi Y, Shibata H
Cancer science 109 ( 10 ) 3285 - 3293 2018.10
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2015.04 - 2018.03
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Research for the trial of cancer cell removal from fibrotic tissues by disturbing mechanosensitizer
Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(B)
Project Year： 2022.04 - 2025.03
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Macrophage-mediated transfer of cancer-derived components to stromal cells creates a pro-tumor microenvironment
Grant-in-Aid for Scientific Research(B)
Project Year： 2019.04 - 2022.03 Investigator(s): Tanaka Masamitsu
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Neo-Seed&Soil: Can Organ-specific mesenchymal cells modify the organ tropism?
Grant-in-Aid for Scientific Research(C)
Project Year： 2018.04 - 2021.03 Investigator(s): Kuriyama Sei