植木 重治 (ウエキ シゲハル)

UEKI Shigeharu

写真a

所属

大学院医学系研究科(医学専攻等)  医学専攻  病態制御医学系  総合診療・検査診断学講座

研究室住所

秋田市本道1-1-1 臨床南棟4F

研究室電話

018-884-6209

ホームページ

http://www.med.akita-u.ac.jp/~gimclm/

研究分野・キーワード

呼吸器アレルギー学、臨床検査、感染制御、好酸球

出身大学 【 表示 / 非表示

  •  
    -
    1999年03月

    秋田大学   医学部   卒業

出身大学院 【 表示 / 非表示

  •  
    -
    2003年03月

    秋田大学  医学研究科  博士課程  修了

取得学位 【 表示 / 非表示

  • 秋田大学 -  医学博士

職務経歴(学内) 【 表示 / 非表示

  • 2021年10月
    -
    継続中

    秋田大学   大学院医学系研究科(医学専攻等)   医学専攻   病態制御医学系   総合診療・検査診断学講座   教授  

  • 2014年04月
    -
    2021年09月

    秋田大学   大学院医学系研究科(医学専攻等)   医学専攻   病態制御医学系   総合診療・検査診断学講座   准教授  

 

論文 【 表示 / 非表示

  • Case Report: Eosinophilic Bronchiolitis With Eosinophil ETosis in Mucus Plugs Successfully Treated With Benralizumab

    Sasaki H.

    Frontiers in Pharmacology ( Frontiers in Pharmacology )  12   2022年01月

    DOI

  • Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis

    Imoto Y.

    Frontiers in Pharmacology ( Frontiers in Pharmacology )  12   793607 - 793607   2022年01月

    Background: Eosinophilic chronic sinusitis (ECRS) is a subtype of CRS with nasal polyps (CRSwNP) that is frequently comorbid with asthma. Notably, ECRS patients often show a high recurrence of NPs after surgical resection. Leptin is a hormone produced by adipocytes that has been implicated in airway inflammatory diseases. However, to date, the role of leptin in ECRS has not been investigated. Objective: To determine whether the serum levels of leptin are altered in patients with ECRS. Methods: In total, 40 patients with ECRS, 15 patients with non-eosinophilic CRS (non-ECRS), and 12 individuals without CRS (control) were included in this study. Patient's serum leptin levels were assessed, and the number of eosinophils in their NPs were measured through a histological evaluation of the three densest areas with cellular infiltrate beneath the epithelial surface. Finally, nasal fibroblast cultures established from NPs were stimulated with varying concentrations of recombinant leptin in vitro to determine whether leptin affects eotaxin-3 (Chemokine (C-C motif) ligand 26 :26: CCL26) expression. Results: The serum leptin levels in both the ECRS and non-ECRS groups were significantly higher than those in the control subjects (p < 0.0001 vs. ECRS; p < 0.05 vs. non-ECRS). Furthermore, ECRS patients displayed significantly elevated serum leptin levels compared to non-ECRS patients (p < 0.001), although there was no difference in body mass index between the groups. Notably, serum leptin levels were correlated with the proportion of eosinophils in peripheral blood (r = 0.3575, p < 0.01) and the number of eosinophils in NPs (r = 0.5109, p < 0.0001). Serum leptin levels were also correlated with eotaxin-3 mRNA expression in NPs (r = 0.5374, p < 0.01). Finally, leptin significantly augmented eotaxin-3 expression in nasal fibroblasts established in vitro from NPs in a leptin receptor-dependent manner (p < 0.05). Conclusion: Leptin levels are elevated in ECRS patients and may both promote and indicate the severity of ECRS as well as systemic type 2-biased inflammatory responses. Combined, these data indicate that circulating leptin may play a significant role in the development of eosinophilic inflammation in NPs.

    DOI PubMed

  • Clonal hematopoiesis in adult pure red cell aplasia

    Fujishima N.

    Scientific Reports ( Scientific Reports )  11 ( 1 )   2021年12月

    DOI

  • Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide- co-glycolide)-Poly(1,5-dioxepan-2-one) Multiblock Copolymer

    Jikei M.

    ACS Omega ( ACS Omega )  6 ( 42 ) 27968 - 27975   2021年10月

    Platelet adhesion and denaturation on artificial medical implants induce thrombus formation. In this study, bioabsorbable copolymers composed of poly(l-lactide-co-glycolide) (PLGA) and poly(1,5-dioxepan-2-one) (PDXO) were synthesized and evaluated for their antiplatelet adhesive properties. The PLGA-PXO multiblock copolymer (PLGA-PDXO MBC) and its random copolymer (PLGA-PDXO RC) showed effective antiplatelet adhesive properties, and the number of adhered platelets was similar to those adhered on poly(2-methoxyethylacrylate), a known antiplatelet adhesive polymer, although a large number of denatured platelets were observed on a PLGA-poly(ε-caprolactone) multiblock copolymer (PLGA-PCL MBC). Using monoclonal antifibrinogen IgG antibodies, we also found that both αC and γ-chains, the binding sites of fibrinogen for platelets, were less exposed on the PLGA-PDXO MBC surface compared to PLGA-PCL MBC. Furthermore, free-standing films of PLGA-PDXO MBC were prepared by casting the polymer solution on glass plates and showed good tensile properties and slow hydrolytic degradation in phosphate-buffered saline (pH = 7.4). We expect that the unique properties of PLGA-PDXO MBC, i.e., antiplatelet adhesive behavior, good tensile strength, and hydrolytic degradation, will pave the way for the development of new bioabsorbable implanting materials suitable for application at blood-contacting sites.

    DOI PubMed

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MISC(査読の無い研究業績) 【 表示 / 非表示

  • 慢性肉芽腫症における好中球と好酸球のETosis

    有馬 実咲, 古谷 千香子, 山本 梨絵, 守時 由起, 富谷 陽子, 嵯峨 知生, 植木 重治

    日本臨床検査医学会誌 ( (一社)日本臨床検査医学会 )  69 ( 補冊 ) 123 - 123   2021年10月

    未設定

  • 【好酸球関連疾患】生体内における好酸球の動態

    富澤 宏基, 植木 重治

    臨床免疫・アレルギー科 ( (有)科学評論社 )  76 ( 4 ) 386 - 391   2021年10月

    未設定

  • 好酸球性多発血管炎性肉芽腫症における細胞外DNAの意義 好酸球細胞外トラップと免疫血栓症の検討

    橋本 哲平, 植木 重治, 上出 庸介, 福地 峰世, 宮部 結, 古川 哲也, 東 直人, 松井 聖

    日本臨床免疫学会総会プログラム・抄録集 ( (一社)日本臨床免疫学会 )  49回   104 - 104   2021年10月

    未設定

  • ETosis誘導刺激による末梢血白血球の反応の差異

    古谷 千香子, 有馬 実咲, 山本 梨絵, 守時 由起, 富谷 陽子, 嵯峨 知生, 涌井 秀樹, 植木 重治

    日本臨床検査医学会誌 ( (一社)日本臨床検査医学会 )  69 ( 補冊 ) 122 - 122   2021年10月

    未設定

  • インフルエンザ関連鋳型気管支炎における粘液栓の形成と好酸球活性化

    植木 重治, 有馬 実咲, 古谷 千香子, 山本 梨絵, 守時 由起, 富谷 陽子, 嵯峨 知生

    日本臨床検査医学会誌 ( (一社)日本臨床検査医学会 )  69 ( 補冊 ) 115 - 115   2021年10月

    未設定

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