KUBOTA Hitoshi

写真a

Affiliation

Graduate School of Engineering Science  Department of Life Science  Life Science Course 

To the head of this page.▲

Research Interests 【 display / non-display 】

  • protein aggregation

  • molecular chaperone

  • neurodegenerative disease

To the head of this page.▲

Graduating School 【 display / non-display 】

  • 　
    -
    1985.03

    Shizuoka University   Faculty of Science   Graduated

To the head of this page.▲

Graduate School 【 display / non-display 】

  • 　
    -
    1992.03

    Osaka University  Graduate School,Division of Medicine  Doctor's Course  Completed

  • 　
    -
    1987.03

    Shizuoka University  Graduate School, Division of Natural Science  Master's Course  Completed

To the head of this page.▲

Campus Career 【 display / non-display 】

  • 2016.04
    -
    Now

    Akita University   Graduate School of Engineering Science   Department of Life Science   Life Science Course   Professor  

  • 2010.11
    -
    2016.03

    Akita University   Graduate School of Engineering and Resource Science   Department of Life Science   Professor  

  • 2008.04
    -
    2010.10

    Akita University   Graduate School of Engineering and Resource Science   Associate Professor  

To the head of this page.▲

External Career 【 display / non-display 】

  • 1992.04
    -
    1995.08

    Institute of Cancer Research   postdoctoral fellow  

To the head of this page.▲

Research Areas 【 display / non-display 】

  • Life Science / Molecular biology

  • Life Science / Cell biology

To the head of this page.▲
 

Thesis for a degree 【 display / non-display 】

  • Nucleotide sequence of mouse Tcp-1a cDNA.

    Kubota, H., Morita, T., Nagata, T., Takemoto, Y., Nozaki, M., Gachelin, G., and Matsushiro, A. 

    Gene  105   269 - 273   1992.03

    Domestic Co-author

To the head of this page.▲

Research Achievements 【 display / non-display 】

    ◆Original paper【 display / non-display 】

  • Chondroitin sulfate promotes the proliferation of keloid fibroblasts through activation of the integrin and protein kinase B pathways.

    Katayama Y, Naitoh M, Kubota H, Yamawaki S, Aya R, Ishiko T, Morimoto N.

    Int. J. Mol. Sci.   21   E1955   2020.03  [Refereed]

    Research paper (journal)   Domestic Co-author

  • HtrA1 is specifically up-regulated in active keloid lesions and stimulates keloid development.

    Yamawaki, S., Naitoh, M., Kubota, H., Aya, R., Katayama, Y., Ishiko, T., Tamura, T., Yoshikawa, K., Enoshiri, T., Ikeda, M., and Suzuki, S.

    Int. J. Mol. Sci.   19   E1275   2018.04  [Refereed]

    Research paper (journal)   Domestic Co-author

  • Physicochemical properties of the mammalian molecular chaperone HSP60.

    Ishida, R., Okamoto, T., Motojima, F., Kubota, H., Takahashi, H., Tanabe, M., Oka, T., Kitamura, A., Kinjo, M., Yoshida, M., Otaka, M., Grave, E., and Itoh, H.

    Int. J. Mol. Sci.   19   E489   2018.02  [Refereed]

    Research paper (journal)   Domestic Co-author

  • Detection of substrate binding of a collagen-specific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy.

    Kitamura, A., Ishida, Y., Kubota, H., Pack, C. G., Homma, T., Ito, S., Araki, K., Kinjo, M., and Nagata, K.

    Biochem. Biophys. Res. Commun.   497   279 - 284   2018.02  [Refereed]

    Research paper (journal)   Domestic Co-author

  • ATPase activity and ATP-dependent conformational change in the co-chaperone HOP.

    Yamamoto, S., Subedi, G.P., Hanashima, S., Satoh, T., Otaka, M., Wakui, H., Sawada, K., Yokota, S., Yamaguchi, Y., Kubota, H., and Itoh, H.

    J. Biol. Chem.   289   9880 - 9886   2014.04  [Refereed]

    Research paper (journal)   Domestic Co-author

    • display all >>

    To the head of this page.▲

    ◆Introduction and explanation【 display / non-display 】

  • Analyzing the aggregation of polyglutamine-expansion proteins and its modulation by molecular chaperones.

    Kubota, H., Kitamura, A. and Nagata, K.

    Methods ( Elsevier )  53   267 - 274   2011.03

    Introduction and explanation (scientific journal)   Domestic Co-author

  • Amyloid oligomers: dynamics and toxicity in the cytosol and nucleus.

    Kitamura, A. and Kubota, H.

    FEBS J. ( Wiley-Blackwell )  277   1369 - 1379   2010.03

    Introduction and explanation (scientific journal)   Domestic Co-author

  • Quality control against misfolded proteins in the cytosol: a network for cell survival.

    Kubota, H.

    J. Biochem. ( Oxford University Press )  146   609 - 616   2009.11

    Introduction and explanation (scientific journal)   Single author

    • To the head of this page.▲

    ◆Other【 display / non-display 】

  • Physicochemical Properties of the Mammalian Molecular Chaperone HSP60.

    Ishida R, Okamoto T, Motojima F, Kubota H, Takahashi H, Tanabe M, Oka T, Kitamura A, Kinjo M, Yoshida M, Otaka M, Grave E, Itoh H

    International journal of molecular sciences   19 ( 2 )   2018.02

    DOI PubMed

  • Detection of substrate binding of a collagen-specific molecular chaperone HSP47 in solution using fluorescence correlation spectroscopy.

    Kitamura A, Ishida Y, Kubota H, Pack CG, Homma T, Ito S, Araki K, Kinjo M, Nagata K

    Biochemical and biophysical research communications   497 ( 1 ) 279 - 284   2018.02

    DOI PubMed

To the head of this page.▲

Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2014.04  -  2017.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2011.04  -  2014.03 

  • Grant-in-Aid for Scientific Research on Priority Areas

    Project Year： 2010.04  -  2012.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2008.04  -  2011.03 

  • Grant-in-Aid for Scientific Research on Priority Areas

    Project Year： 2008.04  -  2010.03 

To the head of this page.▲