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Affiliation |
Future Cooperative Research Organization Bioscience Education and Research Support Center |
KOYOTA Souichi
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Research Interests 【 display / non-display 】
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Glycobiology
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Glycobiology
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Molecular Biology
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Biochemistry
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Regenarative Medicine
Graduating School 【 display / non-display 】
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1988.04-1992.03
University of Shizuoka Faculty of Pharmaceutical Science Graduated
Graduate School 【 display / non-display 】
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1994.04-1997.03
Tokyo Institute of Technology Graduate School, Division of Life Science and Engineering Doctor's Course Accomplished credits for doctoral program
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1992.04-1994.03
University of Shizuoka Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
Campus Career 【 display / non-display 】
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2025.04-Now
Akita University Future Cooperative Research Organization Bioscience Education and Research Support Center Associate Professor
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2016.04-2025.03
Akita University Bioscience Education and Research Support Center Associate Professor
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2013.12-2016.03
Akita University Bioscience Education and Research Center Associate Professor
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2009.04-2013.11
Akita University Graduate School of Medicine Doctorial Course in Medicine Bioregulatory Medicine Lecturer
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2005.06-2009.03
Akita University School of Medicine School of Medicine Lecturer
Research Areas 【 display / non-display 】
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Life Science / Medical biochemistry / 糖鎖、糖転移酵素、糖鎖生物学
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Life Science / Medical biochemistry / 糖鎖、糖転移酵素、糖鎖生物学
Thesis for a degree 【 display / non-display 】
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Souichi Koyota, K. M. Swarna Wimalasiri and Motonori Hoshi
The Journal of Biological Chemistry 272 ( 16 ) 10372 - 10376 1997.06
Domestic Co-author
精子先体反応誘起物質の活性を担う糖鎖の構造
Research Achievements 【 display / non-display 】
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Hayashi K.
British Journal of Cancer ( British Journal of Cancer ) 131 ( 6 ) 982 - 995 2024.10 [Refereed]
Research paper (journal) Domestic Co-author
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Fujiwara Y.
Proceedings of the National Academy of Sciences of the United States of America ( Proceedings of the National Academy of Sciences of the United States of America ) 121 ( 36 ) 2024.09 [Refereed]
Research paper (journal) Domestic Co-author
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Fujita H., Motoyama S., An J., Nagakai Y., Yamaguchi T., Koyota S., Sato Y., Wakita A., Imai K., Kuba K., Minamiya Y.
Surgery (United States) ( Surgery (United States) ) 171 ( 6 ) 1535 - 1542 2022.06 [Refereed]
Research paper (journal) Domestic Co-author
BACKGROUND: The mechanism underlying cancer cell metastasis from the tumor to regional lymph nodes is not yet fully understood. We hypothesized that peritumoral neutrophil accumulation promotes regional lymph node metastasis in thoracic esophageal squamous cell cancer. METHODS: Between 2010 and 2019, 126 thoracic esophageal squamous cell cancer patients received curative (R0) esophagectomy without preoperative treatment in our hospital. Using paraffin-embedded resected tumors, we performed immunohistochemical analysis of CD16b-positive neutrophil accumulation in the peritumoral area, which was defined as a 1-mm region centered on the border separating the malignant cell nests from the host tissue. The relationship between the density of peritumoral CD16b staining and pathological lymph node metastasis or 5-year overall survival was evaluated. RESULTS: Although the clinicopathological characteristics of CD16b-high and CD16b-low patients did not differ, greater pathological lymph node metastasis (P < .001) and lymphatic invasion by the tumor (P = .024) and a poorer 5-year survival (P = .010) were seen in CD16b-high patients. Moreover, CD16b-positive neutrophil density was generally higher in the peritumoral area than within the tumor itself. Univariate and multivariate analyses showed that CD16b-positive neutrophil accumulation was an independent factor for lymph node metastasis with an odds ratio >25 (P < .001). On the other hand, blood neutrophil counts did not correlate with lymph node metastasis. CONCLUSION: Peritumoral accumulation of CD16b-positive neutrophils is an independent factor strongly correlated with lymph node metastasis in thoracic esophageal squamous cell cancer.
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Clonal hematopoiesis in adult pure red cell aplasia
Fujishima N, Kohmaru J, Koyota S, Kuba K, Saga T, Omokawa A, Moritoki Y, Ueki S, Ishida F, Nakao S, Matsuda A, Ohta A, Tohyama K, Yamasaki H, Usuki K, Nakashima Y, Sato S, Miyazaki Y, Nannya Y, Ogawa S, Sawada K, Mitani K, Hirokawa M.
Scientific Reports ( Scientific Reports ) 11 ( 1 ) 2253 - 2253 2021.12 [Refereed]
Research paper (journal)
Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse were associated with death. PRCA may represent the prodrome to MDS. Thus, clonal hematopoiesis may be responsible for treatment failure. We investigated gene mutations in myeloid neoplasm-associated genes in acquired PRCA. We identified 21 mutations affecting amino acid sequences in 11 of the 38 adult PRCA patients (28.9%) using stringent filtering of the error-prone sequences and SNPs. Four PRCA patients showed 7 driver mutations in TET2, DNMT3A and KDM6A, and 2 PRCA patients carried multiple mutations in TET2. Five PRCA patients had mutations with high VAFs exceeding 0.3. These results suggest that clonal hematopoiesis by stem/progenitor cells might be related to the pathophysiology of chronic PRCA in certain adult patients.
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B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.
Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K.
Nature Communications 11 ( 1 ) 1058 2020.02 [Refereed]
Research paper (journal) Domestic Co-author
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Microstructure and antibacterial property of dissimilar overlay welds of Cu alloy on stainless steel
KADOI Kota, MIYANO Yasuyuki, KAWABAATA Shunta, KOYOTA Souichi, INOUE Hiroshige
Preprints of the National Meeting of JWS ( JAPAN WELDING SOCIETY ) 2022f ( 0 ) 214 - 215 2022
Research paper (research society, symposium materials, etc.) Domestic Co-author
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Influence of Soybean on the Intestinal Mucosa
TAKAHASHI Ayuki, HOSAKA Chiruna, SAITO Yuki, MIURA Ayaka, SUTO Saki, MATSUDA Ritsuko, KOYOTA Soichi, SUMA Asako, ASANO Jumpei
Bulletin of Seirei Women's Junior College ( Seirei Women's Junior College ) 51 ( 0 ) 73 - 80 2023
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Influence of Soybean on the Visceral Adipose Tissue
TAKAHASHI Ayuki, ISHIKAWA Kei, SUTO Saki, MATSUDA Ritsuko, KOYOTA Soichi, SUMA Asako, ASANO Jumpei
Bulletin of Seirei Women's Junior College ( Seirei Women's Junior College ) 51 ( 0 ) 66 - 72 2023
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Somatic Mutations of Myeloid Malignancy-Associated Genes in Acquired Pure Red Cell Aplasia in Adults
Makoto Hirokawa, Junki Kohmaru, Souichi Koyota, Keiji Kuba, Naohito Fujishima, Tomoo Saga, Ayumi Omokawa, Shigeharu Ueki, Fumihiro Ishida, Shinji Nakao, Akira Matsuda, Akiko Ohta, Kaoru Tohyama, Ryuji Suzuki, Kinuko Mitani
BLOOD ( AMER SOC HEMATOLOGY ) 132 2018.11
Summary of the papers read (international conference)
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◆Original paper【 display / non-display 】
◆Research society, Symposium materials, etc.【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03