KOYOTA Souichi

写真a

Affiliation

Bioscience Education and Research Support Center 

Research Interests 【 display / non-display

  • Glycobiology

  • Glycobiology

  • Molecular Biology

  • Biochemistry

  • Regenarative Medicine

Graduating School 【 display / non-display

  • 1988.04
    -
    1992.03

    University of Shizuoka   Faculty of Pharmaceutical Science   Graduated

Graduate School 【 display / non-display

  • 1994.04
    -
    1997.03

    Tokyo Institute of Technology  Graduate School, Division of Life Science and Engineering  Doctor's Course  Accomplished credits for doctoral program

  • 1992.04
    -
    1994.03

    University of Shizuoka  Graduate School, Division of Pharmaceutical Sciences  Master's Course  Completed

Campus Career 【 display / non-display

  • 2016.04
    -
    Now

    Akita University   Bioscience Education and Research Support Center   Associate Professor  

  • 2013.12
    -
    2016.03

    Akita University   Bioscience Education and Research Center   Associate Professor  

  • 2009.04
    -
    2013.11

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Lecturer  

  • 2005.06
    -
    2009.03

    Akita University   School of Medicine   School of Medicine   Lecturer  

Research Areas 【 display / non-display

  • Life Science / Medical biochemistry  / 糖鎖、糖転移酵素、糖鎖生物学

  • Life Science / Medical biochemistry  / 糖鎖、糖転移酵素、糖鎖生物学

 

Thesis for a degree 【 display / non-display

Research Achievements 【 display / non-display

    ◆Original paper【 display / non-display

  • Cell-cell contact-dependent secretion of large-extracellular vesicles from EFNB<sup>high</sup> cancer cells accelerates peritoneal dissemination

    Hayashi K.

    British Journal of Cancer ( British Journal of Cancer )  131 ( 6 ) 982 - 995   2024.10  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Oncofetal IGF2BP3-mediated control of microRNA structural diversity in the malignancy of early-stage lung adenocarcinoma

    Fujiwara Y.

    Proceedings of the National Academy of Sciences of the United States of America ( Proceedings of the National Academy of Sciences of the United States of America )  121 ( 36 )   2024.09  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

  • Peritumoral CD16b positive-neutrophil accumulation strongly correlates with regional lymph node metastasis in thoracic esophageal squamous cell cancer

    Fujita H., Motoyama S., An J., Nagakai Y., Yamaguchi T., Koyota S., Sato Y., Wakita A., Imai K., Kuba K., Minamiya Y.

    Surgery (United States) ( Surgery (United States) )  171 ( 6 ) 1535 - 1542   2022.06  [Refereed]

    Research paper (journal)   Domestic Co-author

    BACKGROUND: The mechanism underlying cancer cell metastasis from the tumor to regional lymph nodes is not yet fully understood. We hypothesized that peritumoral neutrophil accumulation promotes regional lymph node metastasis in thoracic esophageal squamous cell cancer. METHODS: Between 2010 and 2019, 126 thoracic esophageal squamous cell cancer patients received curative (R0) esophagectomy without preoperative treatment in our hospital. Using paraffin-embedded resected tumors, we performed immunohistochemical analysis of CD16b-positive neutrophil accumulation in the peritumoral area, which was defined as a 1-mm region centered on the border separating the malignant cell nests from the host tissue. The relationship between the density of peritumoral CD16b staining and pathological lymph node metastasis or 5-year overall survival was evaluated. RESULTS: Although the clinicopathological characteristics of CD16b-high and CD16b-low patients did not differ, greater pathological lymph node metastasis (P < .001) and lymphatic invasion by the tumor (P = .024) and a poorer 5-year survival (P = .010) were seen in CD16b-high patients. Moreover, CD16b-positive neutrophil density was generally higher in the peritumoral area than within the tumor itself. Univariate and multivariate analyses showed that CD16b-positive neutrophil accumulation was an independent factor for lymph node metastasis with an odds ratio >25 (P < .001). On the other hand, blood neutrophil counts did not correlate with lymph node metastasis. CONCLUSION: Peritumoral accumulation of CD16b-positive neutrophils is an independent factor strongly correlated with lymph node metastasis in thoracic esophageal squamous cell cancer.

    DOI PubMed

  • Clonal hematopoiesis in adult pure red cell aplasia

    Fujishima N, Kohmaru J, Koyota S, Kuba K, Saga T, Omokawa A, Moritoki Y, Ueki S, Ishida F, Nakao S, Matsuda A, Ohta A, Tohyama K, Yamasaki H, Usuki K, Nakashima Y, Sato S, Miyazaki Y, Nannya Y, Ogawa S, Sawada K, Mitani K, Hirokawa M.

    Scientific Reports ( Scientific Reports )  11 ( 1 ) 2253 - 2253   2021.12  [Refereed]

    Research paper (journal)  

    Idiopathic pure red cell aplasia (PRCA) and secondary PRCA associated with thymoma and large granular lymphocyte leukemia are generally considered to be immune-mediated. The PRCA2004/2006 study showed that poor responses to immunosuppression and anemia relapse were associated with death. PRCA may represent the prodrome to MDS. Thus, clonal hematopoiesis may be responsible for treatment failure. We investigated gene mutations in myeloid neoplasm-associated genes in acquired PRCA. We identified 21 mutations affecting amino acid sequences in 11 of the 38 adult PRCA patients (28.9%) using stringent filtering of the error-prone sequences and SNPs. Four PRCA patients showed 7 driver mutations in TET2, DNMT3A and KDM6A, and 2 PRCA patients carried multiple mutations in TET2. Five PRCA patients had mutations with high VAFs exceeding 0.3. These results suggest that clonal hematopoiesis by stem/progenitor cells might be related to the pathophysiology of chronic PRCA in certain adult patients.

    DOI PubMed

  • B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction.

    Minato T, Nirasawa S, Sato T, Yamaguchi T, Hoshizaki M, Inagaki T, Nakahara K, Yoshihashi T, Ozawa R, Yokota S, Natsui M, Koyota S, Yoshiya T, Yoshizawa-Kumagaye K, Motoyama S, Gotoh T, Nakaoka Y, Penninger JM, Watanabe H, Imai Y, Takahashi S, Kuba K.

    Nature Communications   11 ( 1 ) 1058   2020.02  [Refereed]

    Research paper (journal)   Domestic Co-author

    DOI

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    ◆Research society, Symposium materials, etc.【 display / non-display

  • Microstructure and antibacterial property of dissimilar overlay welds of Cu alloy on stainless steel

    KADOI Kota, MIYANO Yasuyuki, KAWABAATA Shunta, KOYOTA Souichi, INOUE Hiroshige

    Preprints of the National Meeting of JWS ( JAPAN WELDING SOCIETY )  2022f ( 0 ) 214 - 215   2022

    Research paper (research society, symposium materials, etc.)   Domestic Co-author

    DOI CiNii Research

  • ◆Other【 display / non-display

  • Influence of Soybean on the Intestinal Mucosa

    TAKAHASHI Ayuki, HOSAKA Chiruna, SAITO Yuki, MIURA Ayaka, SUTO Saki, MATSUDA Ritsuko, KOYOTA Soichi, SUMA Asako, ASANO Jumpei

    Bulletin of Seirei Women's Junior College ( Seirei Women's Junior College )  51 ( 0 ) 73 - 80   2023

    DOI CiNii Research

  • Influence of Soybean on the Visceral Adipose Tissue

    TAKAHASHI Ayuki, ISHIKAWA Kei, SUTO Saki, MATSUDA Ritsuko, KOYOTA Soichi, SUMA Asako, ASANO Jumpei

    Bulletin of Seirei Women's Junior College ( Seirei Women's Junior College )  51 ( 0 ) 66 - 72   2023

    DOI CiNii Research

  • Somatic Mutations of Myeloid Malignancy-Associated Genes in Acquired Pure Red Cell Aplasia in Adults

    Makoto Hirokawa, Junki Kohmaru, Souichi Koyota, Keiji Kuba, Naohito Fujishima, Tomoo Saga, Ayumi Omokawa, Shigeharu Ueki, Fumihiro Ishida, Shinji Nakao, Akira Matsuda, Akiko Ohta, Kaoru Tohyama, Ryuji Suzuki, Kinuko Mitani

    BLOOD ( AMER SOC HEMATOLOGY )  132   2018.11

    Summary of the papers read (international conference)  

    0

    DOI

Grant-in-Aid for Scientific Research 【 display / non-display

  • Grant-in-Aid for Scientific Research(C)

    Project Year: 2024.04  -  2027.03