KOIZUMI Yukio

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Biochemistry and Metabolic Science

Graduating School 【 display / non-display

  •  
    -
    1996.03

    Nihon University   Faculty of Science and Engineering   Graduated

Graduate School 【 display / non-display

  •  
    -
    2002.03

    Tokyo University of Agriculture and Technology  Graduate School, Division of Agricltural Sciences  Doctor's Course  Completed

Campus Career 【 display / non-display

  • 2009.04
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Assistant Professor  

 

Published Papers 【 display / non-display

  • Stimulation of the hair growth by α2-blocker SST-VED

    Natsui Miyuki, Kawagoe Masami, Somei Masanori, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  41 ( 1 ) 23 - 33   2014

    The hair follicle was picked from the beard of a C57BL/6J mouse, and the influence on hair follicle extension was measured by hair follicle organ culture under the addition of SST-VED1. Compared with control( solvent of SST-VED1), the hair growth by SST-VED1 addition was observed in dose-dependent manner. When SST-VED1 was compared with SST-VED2, SST-VED1 promotes the hair growth significantly. Moreover, it turned out that growth is large in order of RiUP^<(R)>, SST-VED1, and Glechoma hederacea extract. In this research, it was shown clearly that new molecular chemicals of SST-VED 1 and 2 have a hair growth action. Furthermore, by using it together with the extract obtained from Glechoma hederacea of product-of-nature origin, it turned out that a hair growth action is amplified.

    Repository CiNii

  • Identification of antioxidants derived from Inonotus obliquus

    Kumagai Ayako, Koizumi Yukio, Kawagoe Masami, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  40 ( 2 ) 113 - 119   2013

    The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. In the present study, the lipophilic fraction of Inonotus obliquus were investigated for their antioxidative activity with hydroxyl radical scavenging activity assays. As a result, two acidic materials had higher antioxidative activity than basic or neutral materials. Furthermore, antioxidative acidic materials including organic acids were isolated by silica gel column chromatography and subsequent preparative high-performance liquid chromatography. Two purified antioxidants, designated compound 1 and 2, were identified as vanillic acid and syringic acid, respectively. Vanillic acid and syringic acid were showed the antioxidative activities with IC_50 values of 59.0 and 2.8 μg/ml, respectively.

    Repository CiNii

  • Sitmulation of the hair growth by a natural origin Glechoma hederacea extract

    Natsui Miyuki, Kawagoe Masami, Nagai Shigeharu, Qiao Zhiwei, Sato Yoshiaki, Flores Maria Jolina, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  40 ( 1 ) 1 - 12   2013

    The glechoma hederacea subsp. grandis( G. grandis) is used as an herbal medicine and is supposed that the extract at the time of the bloom shade-drying is effective against a child's convulsion. Moreover, it may be considered as reduction of blood sugar level. In this study, the clinical test of the hair growth facilitatory effect of the G. grandis extract in human during one to three years showed remarkable improvement or a little improvement by evaluation at 95%(41 persons among 43 persons). With the mice, the tendency for hair growth was promoted compared with a control( physiological saline). Furthermore, we used the hair follicle organ culture system for the hair growth promoting substance from G. grandis extract. As a result, G. grandis in the growth phase after the bloom had remarkable growth effect, and found out having the remarkable hair growth effect in a fraction of aqueous phase from the extract especially. This aims at the establishment of the hair regenerative technology which utilizes the natural plant, G. grandis. It is possible to apply to the baldness and the alopecia caused by various factors, and preventive effect for the depilation, trichogenous, and the hair restoration action improve synergistic and it is effective as the external application medicine for the head with high safety compared with the scalp.

    Repository CiNii

Review Papers 【 display / non-display

  • 環状ペプチドマルホルミンが賦活化する細胞性血栓溶解にはRSK1の活性化が関与する

    小泉幸央, 長井賢一郎, GAO Lina, 山口智和, 夏井美幸, 今井由美子, 蓮見惠司, 杉山俊博, 久場敬司

    日本農芸化学会大会講演要旨集(Web)   2018   ROMBUNNO.3A14p01 (WEB ONLY)   2018.03

    Unselected

    J-GLOBAL

  • Stimulation of the hair growth by α2-blocker SST-VED

    Natsui Miyuki, Kawagoe Masami, Somei Masanori, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  41 ( 1 ) 23 - 33   2014

    Unselected

    The hair follicle was picked from the beard of a C57BL/6J mouse, and the influence on hair follicle extension was measured by hair follicle organ culture under the addition of SST-VED1. Compared with control( solvent of SST-VED1), the hair growth by SST-VED1 addition was observed in dose-dependent manner. When SST-VED1 was compared with SST-VED2, SST-VED1 promotes the hair growth significantly. Moreover, it turned out that growth is large in order of RiUP^<(R)>, SST-VED1, and Glechoma hederacea extract. In this research, it was shown clearly that new molecular chemicals of SST-VED 1 and 2 have a hair growth action. Furthermore, by using it together with the extract obtained from Glechoma hederacea of product-of-nature origin, it turned out that a hair growth action is amplified.

    CiNii

  • Sitmulation of the hair growth by a natural origin Glechoma hederacea extract

    Natsui Miyuki, Kawagoe Masami, Nagai Shigeharu, Qiao Zhiwei, Sato Yoshiaki, Flores Maria Jolina, Koizumi Yukio, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  40 ( 1 ) 1 - 12   2013

    Unselected

    The glechoma hederacea subsp. grandis( G. grandis) is used as an herbal medicine and is supposed that the extract at the time of the bloom shade-drying is effective against a child's convulsion. Moreover, it may be considered as reduction of blood sugar level. In this study, the clinical test of the hair growth facilitatory effect of the G. grandis extract in human during one to three years showed remarkable improvement or a little improvement by evaluation at 95%(41 persons among 43 persons). With the mice, the tendency for hair growth was promoted compared with a control( physiological saline). Furthermore, we used the hair follicle organ culture system for the hair growth promoting substance from G. grandis extract. As a result, G. grandis in the growth phase after the bloom had remarkable growth effect, and found out having the remarkable hair growth effect in a fraction of aqueous phase from the extract especially. This aims at the establishment of the hair regenerative technology which utilizes the natural plant, G. grandis. It is possible to apply to the baldness and the alopecia caused by various factors, and preventive effect for the depilation, trichogenous, and the hair restoration action improve synergistic and it is effective as the external application medicine for the head with high safety compared with the scalp.

    CiNii

  • Identification of antioxidants derived from Inonotus obliquus

    Kumagai Ayako, Koizumi Yukio, Kawagoe Masami, Koyota Souichi, Sugiyama Toshihiro

    Akita journal of medicine ( Akita University )  40 ( 2 ) 113 - 119   2013

    Unselected

    The medicinal mushroom Inonotus obliquus is a traditional and widely used multi-functional fungus. In the present study, the lipophilic fraction of Inonotus obliquus were investigated for their antioxidative activity with hydroxyl radical scavenging activity assays. As a result, two acidic materials had higher antioxidative activity than basic or neutral materials. Furthermore, antioxidative acidic materials including organic acids were isolated by silica gel column chromatography and subsequent preparative high-performance liquid chromatography. Two purified antioxidants, designated compound 1 and 2, were identified as vanillic acid and syringic acid, respectively. Vanillic acid and syringic acid were showed the antioxidative activities with IC_50 values of 59.0 and 2.8 μg/ml, respectively.

    CiNii

  • The preventive effect of high blood pressure and hyperlipidemia by MCM water intake

    Akita journal of medicine ( Akita University )  36 ( 3 ) 165 - 170   2009

    Unselected

    Spontaneous hypertensive rat(SHR)which is the model animal of human essential hypertension was given free drinking water of the 0.5%MCM(Marina Crystal Minerals)from the time of immature before hypertension development of symptoms(five-week)to adult age(24-week), and the preventive effect of hypertension and hyperlipidemia were examined by blood pressure and the biochemistry laboratory data of blood. As a result, it was observed the significant suppression of blood pressure by about 15 mmHg compared with control group at adult age (20~24-week). Furthermore, the neutral fat was significantly lower by 25% and HDL-cholesterol was significantly higher by 8% compared with the control. On the other hand, LDL-cholesterol of the 0.5%MCM group was low by 12 %. However the significant difference was not seen intensely for the LDL-cholesterol and total cholesterol. The above result showed that the anti-hyperlipidemic effect in addition to anti-hypertension effect were seen under the conditions those still were moderately elevated. There was possibility of the preventive effect of arteriosclerosis if MCM will be taken in from the young ages.

    CiNii