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大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 胸部外科学講座 |
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Harmonization across programmed death ligand1(PD-L1) assays for lung cancer by immunohistochemistry using noncontact alternating current electric field mixing
Tsubasa Matsuo, Kazuhiro Imai, Hiroshi Nanjo, Shinogu Takashima, Yuko Hiroshima, Maiko Atari, Shoji Kuriyama, Yoshiaki Ishii, Yuki Wakamatsu, Yusuke Sato, Satoru Motoyama, Yuki Matsumura, Hiroyuki Suzuki, Kyoko Nomura, Yoshihiro Minamiya
Thoracic cancer 12 1187 - 1194 2022年09月 [査読有り]
研究等業績 【 表示 ／ 非表示 】
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Perioperative strategies and management of giant anterior mediastinal tumors: a narrative review.
Kengo Tani, Daisuke Kimura, Tsubasa Matsuo, Takahiro Sasaki, Shuta Kimura, Chisaki Muto, Masahito Minakawa
Mediastinum (Hong Kong, China) 8 34 - 34 2024年
研究論文（学術雑誌）
BACKGROUND AND OBJECTIVE: Giant anterior mediastinal tumors sometimes may cause circulatory collapse and respiratory failure, known as mediastinal mass syndrome (MMS). The prediction and prevention of MMS is challenging. The aim of this study is to summarize the evaluation methods for MMS and formulate treatment strategies for giant anterior mediastinal tumors. METHODS: We performed a thorough analysis of recent international literature on giant anterior mediastinal tumors (>10 cm in diameter) and MMS published in the PubMed database. The search spanned the duration of the preceding 10 years from August 19, 2023, and only studies published in English were included. KEY CONTENT AND FINDINGS: Mature teratomas and liposarcomas are the most common giant anterior mediastinal tumors and MMS develops most frequently in case of malignant lymphomas. Here, we propose a new treatment strategy for giant anterior mediastinal tumors. Based on imaging findings, giant anterior mediastinal tumors can be classified as cystic or solid and further blood investigation data are useful for a definitive diagnosis. When malignant lymphoma or malignant germ cell tumor is highly suspected, the first choice of treatment is not surgery but chemotherapy and radiotherapy. Moreover, image-guided drainage may be effective if giant cystic anterior tumors develop into MMS. The risk classification of MMS is important for treating giant anterior mediastinal tumors. If the MMS risk classification is 'unsafe' or 'uncertain', the intraoperative management deserves special attention. The surgical approach should however be based on tumor localization and invasion of surrounding tissues. Multidisciplinary team coordination is indispensable in the treatment of giant anterior mediastinal tumors. CONCLUSIONS: When giant anterior mediastinal tumors are encountered, it is important to follow the appropriate treatment strategy, focusing on the development of MMS based on imaging findings and symptoms.
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Wallenberg syndrome in a patient after pulmonary resection: a case report.
Tsubasa Matsuo, Daisuke Kimura, Kengo Tani, Takahiro Sasaki, Masahito Minakawa
General thoracic and cardiovascular surgery cases 2 ( 1 ) 48 - 48 2023年08月
研究論文（学術雑誌）
BACKGROUND: Cerebral infarction after pulmonary resection is a minor but critical complication. We report a rare case of postoperative complication of Wallenberg syndrome caused by cerebral infarction in the posterior inferior cerebral artery after the left upper lobectomy. CASE PRESENTATION: A 72-year-old man developed cerebral infarction 2 days after a left upper lobectomy for lung cancer. Magnetic resonance imaging indicated right vertebral artery occlusion following an early ischemic area on the right lateral side of the medulla oblongata and cerebellum. Contrast-enhanced computed tomography revealed no thrombus in the left superior pulmonary vein stump. The patient was diagnosed with Wallenberg syndrome, and prompt anticoagulation therapy was initiated. The patient was discharged and transferred to another hospital for rehabilitation on postoperative day 16. CONCLUSIONS: We present a rare case of Wallenberg syndrome occurring in the posterior inferior cerebral artery area due to vertebral artery occlusion after lobectomy. Because cerebral infarction of the posterior circulation has many similar symptoms due to the side effects of anesthetic drugs, careful physical examination is required to determine Wallenberg syndrome.
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Rescue computed tomography-guided drainage of a giant mediastinal mature teratoma causing airway obstruction prior to surgical resection: a case report.
Kengo Tani, Daisuke Kimura, Tsubasa Matsuo, Yoshiaki Saito, Kageaki Taima, Shinya Kakehata, Akira Kurose, Masahito Minakawa
Surgical case reports 9 ( 1 ) 59 - 59 2023年04月
研究論文（学術雑誌）
BACKGROUND: Giant mediastinal mature teratomas may cause airway obstruction or decreased venous return due to the mass effect. Preoperative stabilization of the respiratory and circulatory systems is important for perioperative management to safely perform surgery, including general anesthesia. However, to the best of our knowledge, there are only a few reports regarding the preoperative computed tomography (CT)-guided drainage of mediastinal tumors. CASE PRESENTATION: A 30-year-old woman was admitted to the emergency room with sudden dyspnea. CT findings revealed a giant cystic mass in the anterior mediastinum compressing the trachea and the right main bronchus. The patient was intubated and CT-guided drainage of the fluid content of the cyst was performed to decompress the airway obstruction. Thereafter, the mediastinal tumor was resected during elective surgery and pathologically diagnosed as a mature teratoma. CONCLUSIONS: Rescue preoperative CT-guided drainage of a giant mediastinal mature teratoma allowed safe general anesthesia and surgery by releasing the airway obstruction.
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Prognostic impact of preoperative osteopenia in elderly patients with lung cancer
Kuriyama S.
World Journal of Surgical Oncology ( World Journal of Surgical Oncology ) 24 ( 1 ) 26 - 26 2026年12月
BACKGROUND: Osteopenia was recently reported to be a factor contributing to a poorer prognosis in various cancers. However, its prognostic impact on non-small cell lung cancer (NSCLC) patients remains unclear. In the present study, we focused on osteopenia in elderly NSCLC patients and investigated survival outcomes. METHODS: This study included 315 NSCLC patients aged 75 years or older who had undergone radical lobectomy or segmentectomy at our institution between 2010 and 2023. Osteopenia was evaluated based on the average pixel density within a circle in the mid-vertebral core at the 11th thoracic vertebra on preoperative computed tomography. RESULTS: Osteopenia was identified in 126 patients (40%). This osteopenia group had significantly poorer overall survival (OS) than the non-osteopenia group (5-year OS: 71.4%vs 81.0%, p = 0.026). Multivariable analysis revealed that Charlson comorbidity index (CCI) ≥ 2 (p = 0.020), Brinkman index (BI) ≥ 400 (p < 0.001), pathological Stage ≥ II (p < 0.001), and osteopenia (p = 0.016) were independent factors affecting OS. The cumulative incidence of non-lung cancer mortality was significantly higher in the osteopenia group than non-osteopenia group (5-year mortality rate: 16.9% vs. 6.4%, p = 0.005). In multivariable analysis, CCI ≥ 2 (p = 0.009), BI ≥ 400 (p < 0.008) and osteopenia (p = 0.001) were independent factors affecting non-lung cancer mortality. CONCLUSIONS: Elderly patients with osteopenia have significantly poorer OS, and osteopenia was closely associated with non-lung cancer mortality. Screening for osteopenia may assist in identifying high-risk patients of non-lung cancer death and developing appropriate treatment strategies.
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Ichinohe Chisaki, Tani Kengo, Kimura Daisuke, Matsuo Tsubasa, Sasaki Takahiro, Kimura Shuta, Minakawa Masahito
Surgical Case Reports ( 一般社団法人 日本外科学会 ) 12 ( 1 ) n/a 2026年
<p><b>INTRODUCTION:</b> Empyema associated with parapneumonic pleural effusion can cause respiratory failure requiring surgical intervention. However, some cases remain difficult to manage even after surgery. Patients with Down syndrome are particularly susceptible to respiratory infections and tend to develop more severe symptoms. Few studies have addressed the management of postoperative respiratory failure in acute empyema.</p><p><b>CASE PRESENTATION:</b> A 12-year-old girl with Down syndrome developed acute empyema following right-sided parapneumonic pleural effusion and underwent thoracoscopic empyema cavity debridement. Surgical intervention alone was not sufficient to resolve postoperative respiratory failure. She was managed with adjunctive therapies including inhaled nitric oxide (iNO), intrapulmonary percussive ventilation (IPV), and prone positioning therapy. These therapies resulted in marked improvements in postoperative atelectasis and respiratory failure, enabling successful weaning from mechanical ventilation.</p><p><b>CONCLUSIONS:</b> The combined use of iNO, IPV, and prone positioning therapy may be an effective management strategy for severe respiratory failure after acute empyema surgery in patients with Down syndrome. These adjunctive therapies could contribute to recovery of respiratory function in patients with postoperative atelectasis.</p>
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手術の工夫 クラムシェル開胸および胸骨下部部分切開で切除した巨大縦隔脂肪肉腫
谷 建吾, 木村 大輔, 松尾 翼, 佐々木 嵩洋, 山口谷 健, 木村 脩太, 一戸 千咲, 加藤 翼, 皆川 正仁
胸部外科 ( 南江堂 ) 78 ( 12 ) 1007 - 1012 2025年11月
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ロボット支援下に摘出した後縦隔ミュラー管嚢胞の1例
土井 孝太, 高嶋 祉之具, 松尾 翼, 栗山 章司, 今井 一博
肺癌 ( (NPO)日本肺癌学会 ) 65 ( 6 ) 986 - 986 2025年10月
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男性に発症した不完全型Carney's triadの1例
石井 良明, 高嶋 祉之具, 松尾 翼, 栗山 章司, 岩井 英頌, 鈴木 陽香, 加藤 佳亮, 今井 一博
肺癌 ( (NPO)日本肺癌学会 ) 65 ( 6 ) 985 - 985 2025年10月
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科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
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血液製剤を使用しない確実な肺瘻閉鎖を実現するガロール基高強度水中接着シートの開発
基盤研究(C)
研究期間: 2025年04月 - 2028年03月 代表者: 高嶋 祉之具, 江島 広貴, 松尾 翼, 佐藤 雄亮, 栗山 章司, 今井 一博