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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Thoracis Surgery |
MATSUO Tsubasa
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Graduating School 【 display / non-display 】
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-2011.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2022.09
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2025.09-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Department of Thoracis Surgery Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Respiratory surgery
Thesis for a degree 【 display / non-display 】
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Harmonization across programmed death ligand1(PD-L1) assays for lung cancer by immunohistochemistry using noncontact alternating current electric field mixing
Tsubasa Matsuo, Kazuhiro Imai, Hiroshi Nanjo, Shinogu Takashima, Yuko Hiroshima, Maiko Atari, Shoji Kuriyama, Yoshiaki Ishii, Yuki Wakamatsu, Yusuke Sato, Satoru Motoyama, Yuki Matsumura, Hiroyuki Suzuki, Kyoko Nomura, Yoshihiro Minamiya
Thoracic cancer 12 1187 - 1194 2022.09 [Refereed]
Research Achievements 【 display / non-display 】
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Perioperative strategies and management of giant anterior mediastinal tumors: a narrative review.
Kengo Tani, Daisuke Kimura, Tsubasa Matsuo, Takahiro Sasaki, Shuta Kimura, Chisaki Muto, Masahito Minakawa
Mediastinum (Hong Kong, China) 8 34 - 34 2024
Research paper (journal)
BACKGROUND AND OBJECTIVE: Giant anterior mediastinal tumors sometimes may cause circulatory collapse and respiratory failure, known as mediastinal mass syndrome (MMS). The prediction and prevention of MMS is challenging. The aim of this study is to summarize the evaluation methods for MMS and formulate treatment strategies for giant anterior mediastinal tumors. METHODS: We performed a thorough analysis of recent international literature on giant anterior mediastinal tumors (>10 cm in diameter) and MMS published in the PubMed database. The search spanned the duration of the preceding 10 years from August 19, 2023, and only studies published in English were included. KEY CONTENT AND FINDINGS: Mature teratomas and liposarcomas are the most common giant anterior mediastinal tumors and MMS develops most frequently in case of malignant lymphomas. Here, we propose a new treatment strategy for giant anterior mediastinal tumors. Based on imaging findings, giant anterior mediastinal tumors can be classified as cystic or solid and further blood investigation data are useful for a definitive diagnosis. When malignant lymphoma or malignant germ cell tumor is highly suspected, the first choice of treatment is not surgery but chemotherapy and radiotherapy. Moreover, image-guided drainage may be effective if giant cystic anterior tumors develop into MMS. The risk classification of MMS is important for treating giant anterior mediastinal tumors. If the MMS risk classification is 'unsafe' or 'uncertain', the intraoperative management deserves special attention. The surgical approach should however be based on tumor localization and invasion of surrounding tissues. Multidisciplinary team coordination is indispensable in the treatment of giant anterior mediastinal tumors. CONCLUSIONS: When giant anterior mediastinal tumors are encountered, it is important to follow the appropriate treatment strategy, focusing on the development of MMS based on imaging findings and symptoms.
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Wallenberg syndrome in a patient after pulmonary resection: a case report.
Tsubasa Matsuo, Daisuke Kimura, Kengo Tani, Takahiro Sasaki, Masahito Minakawa
General thoracic and cardiovascular surgery cases 2 ( 1 ) 48 - 48 2023.08
Research paper (journal)
BACKGROUND: Cerebral infarction after pulmonary resection is a minor but critical complication. We report a rare case of postoperative complication of Wallenberg syndrome caused by cerebral infarction in the posterior inferior cerebral artery after the left upper lobectomy. CASE PRESENTATION: A 72-year-old man developed cerebral infarction 2 days after a left upper lobectomy for lung cancer. Magnetic resonance imaging indicated right vertebral artery occlusion following an early ischemic area on the right lateral side of the medulla oblongata and cerebellum. Contrast-enhanced computed tomography revealed no thrombus in the left superior pulmonary vein stump. The patient was diagnosed with Wallenberg syndrome, and prompt anticoagulation therapy was initiated. The patient was discharged and transferred to another hospital for rehabilitation on postoperative day 16. CONCLUSIONS: We present a rare case of Wallenberg syndrome occurring in the posterior inferior cerebral artery area due to vertebral artery occlusion after lobectomy. Because cerebral infarction of the posterior circulation has many similar symptoms due to the side effects of anesthetic drugs, careful physical examination is required to determine Wallenberg syndrome.
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Rescue computed tomography-guided drainage of a giant mediastinal mature teratoma causing airway obstruction prior to surgical resection: a case report.
Kengo Tani, Daisuke Kimura, Tsubasa Matsuo, Yoshiaki Saito, Kageaki Taima, Shinya Kakehata, Akira Kurose, Masahito Minakawa
Surgical case reports 9 ( 1 ) 59 - 59 2023.04
Research paper (journal)
BACKGROUND: Giant mediastinal mature teratomas may cause airway obstruction or decreased venous return due to the mass effect. Preoperative stabilization of the respiratory and circulatory systems is important for perioperative management to safely perform surgery, including general anesthesia. However, to the best of our knowledge, there are only a few reports regarding the preoperative computed tomography (CT)-guided drainage of mediastinal tumors. CASE PRESENTATION: A 30-year-old woman was admitted to the emergency room with sudden dyspnea. CT findings revealed a giant cystic mass in the anterior mediastinum compressing the trachea and the right main bronchus. The patient was intubated and CT-guided drainage of the fluid content of the cyst was performed to decompress the airway obstruction. Thereafter, the mediastinal tumor was resected during elective surgery and pathologically diagnosed as a mature teratoma. CONCLUSIONS: Rescue preoperative CT-guided drainage of a giant mediastinal mature teratoma allowed safe general anesthesia and surgery by releasing the airway obstruction.
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Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Matsuo Tsubasa, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 36 ( 6 ) 621 - 626 2022.09
<p>Segmentectomy is a standard surgical treatment option for stage IA non-small cell lung cancer (NSCLC). However, segmentectomy is only an oncologically safe and reasonable alternative to lobectomy when the intraoperative lymph node staging and surgical margin are adequate. The aim of the present study was to compare the outcomes (frequency, reasons, and prognosis) of patients converted from segmentectomy to lobectomy at the intraoperative direction of the surgical team. This retrospective study analyzed the outcomes of 121 patients who were scheduled to undergo segmentectomy for clinical stage IA NSCLC between January 2014 and August 2020. Eight of the 121 patients were converted from segmentectomy to lobectomy based on the intraoperative diagnosis and surgeon's judgment. Among the 8 converted cases, 4 were diagnosed with lymph nodes metastasis based on analysis of frozen sections and 4 had a problem related to the surgical technique (e.g., surgical margin or uncontrollable bleeding). Diagnosis of the 3 node malignant-positive patients was guided by rapid-immunohistochemistry using noncontact alternating current electric field mixing. There was no significant difference in overall survival between patients with completed segmentectomy (n=113) and those converted to lobectomy (n=8) (P=0.5828). In clinical stage IA NSCLC patients, lobectomy can be selected instead of segmentectomy, if appropriate judgement/diagnosis is intraoperatively achieved.</p>
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Outcomes of clinical Stage I non-small cell lung cancer patients whose treatment was converted from segmentectomy to lobectomy
原田柚子, 今井一博, 高嶋祉之具, 中麻衣子, 松尾翼, 南谷佳弘
日本呼吸器外科学会雑誌(Web) 36 ( 6 ) 2022
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Matsuo Tsubasa, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Watanabe Shin-nosuke, Minamiya Yoshihiro
Haigan ( The Japan Lung Cancer Society ) 59 ( 7 ) 1184 - 1189 2019.12
<p><b><i>Introduction. </i></b>Osimertinib, a third-generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), has shown significant efficacy and prolongation of the overall survival in patients with EGFR mutation-positive non-small cell lung cancer. However, drug-induced lung injury is recognized as one of the most severe adverse events. <b><i>Case. </i></b>A 58-year-old woman was diagnosed with pulmonary adenocarcinoma harboring an EGFR exon 19 deletion. After receiving her informed consent, left upper lobectomy and systemic lymph node dissection were performed. Three years after the surgery, the patient received gefitinib for multiple pulmonary metastases, and she experienced a partial response (PR); however, the disease progressed further. A computed tomography (CT)-guided percutaneous needle biopsy for pulmonary metastasis revealed an EGFR T790M mutation. The patient received osimertinib. A light cough without sputum appeared a year after osimertinib initiation, and CT showed a ground-glass shadow localized in the right middle lobe. Based on these findings, we diagnosed the patient with drug-induced lung injury. The patient discontinued osimertinib and started treatment with prednisolone immediately, but her pulmonary metastasis was re-enhanced. Although the patient switched to platinum-doublet chemotherapy, she was unable to maintain a PR. Eventually, we attempted rechallenge with osimertinib with 5 mg prednisolone daily. The patient is now receiving osimertinib treatment without disease progression or recurrence of drug-induced lung injury. <b><i>Conclusion. </i></b>This is a successful osimertinib rechallenge in a case with a history of steroid therapy osimertinib-induced lung injury.</p>
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Successful Osimertinib Rechallenge After Osimertinib-induced Interstitial Lung Disease in a Patient with Postoperative Recurrence of Lung Cancer
松尾翼, 今井一博, 高嶋祉之具, 中麻衣子, 渡邉伸之助, 南谷佳弘
肺癌(Web) 59 ( 7 ) 2019
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A case of thymic basaloid carcinoma with lung and mediastinal lymph node metastases that developed three years after a resection of primary tumor
細野由希子, 松尾翼, 松尾翼, 藤嶋悟志, 三井匡史, 南谷佳弘
秋田医学 46 ( 2 ) 2019