|
所属 |
大学院医学系研究科（医学専攻等） 医学専攻 社会環境医学系 衛生学・公衆衛生学講座 |
出身大学 【 表示 ／ 非表示 】
-
2019年10月-2024年09月
静岡県立大学 薬学研究科 卒業
-
2017年04月-2019年03月
京都大学 大学院薬学研究科 医薬創成情報科学専攻 卒業
-
-2017年03月
静岡県立大学 薬学部 卒業
-
2013年04月-2017年03月
静岡県立大学 薬学部 薬学科 卒業
研究等業績 【 表示 ／ 非表示 】
-
An Exploratory Randomized Controlled Study to Investigate Concentration-Dependence of Green Tea Catechin Gargling on Acute Upper Respiratory Tract Infections
Takeichiro Tominaga, Takatsugu Ikukawa, Daisuke Furushima, Takahiro J. Nakamura, Hiroshi Yamada
Biological and Pharmaceutical Bulletin 47 ( 7 ) 1331 - 1337 2024年07月 [査読有り]
研究論文（学術雑誌）
-
An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.
Yoshiaki Yamaguchi, Yota Maekawa, Kyohei Kabashima, Takanobu Mizuno, Motomi Tainaka, Toru Suzuki, Kumiko Dojo, Takeichiro Tominaga, Sayaka Kuroiwa, Satoru Masubuchi, Masao Doi, Keiko Tominaga, Kazuto Kobayashi, Satoshi Yamagata, Keiichi Itoi, Manabu Abe, William J Schwartz, Kenji Sakimura, Hitoshi Okamura
Proceedings of the National Academy of Sciences of the United States of America 120 ( 43 ) e2308489120 2023年10月 [査読有り]
研究論文（学術雑誌）
The circadian clock is a biological timekeeping system that oscillates with a circa-24-h period, reset by environmental timing cues, especially light, to the 24-h day-night cycle. In mammals, a "central" clock in the hypothalamic suprachiasmatic nucleus (SCN) synchronizes "peripheral" clocks throughout the body to regulate behavior, metabolism, and physiology. A key feature of the clock's oscillation is resistance to abrupt perturbations, but the mechanisms underlying such robustness are not well understood. Here, we probe clock robustness to unexpected photic perturbation by measuring the speed of reentrainment of the murine locomotor rhythm after an abrupt advance of the light-dark cycle. Using an intersectional genetic approach, we implicate a critical role for arginine vasopressin pathways, both central within the SCN and peripheral from the anterior pituitary.
-
Improvement of Depressed Mood with Green Tea Intake.
Keiko Unno, Daisuke Furushima, Yuya Tanaka, Takeichiro Tominaga, Hirotomo Nakamura, Hiroshi Yamada, Kyoko Taguchi, Toshinao Goda, Yoriyuki Nakamura
Nutrients 14 ( 14 ) 2949 - 2949 2022年07月 [査読有り]
研究論文（学術雑誌）
Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4-5 is beneficial to improving depressed mood.
-
An Exploratory Evaluation of a Low Dose Theanine Consumption on Improving Sleep in Middle-Aged and Older Males
Takeichiro Tominaga, Daisuke Furushima, Keiko Unno, Ibuki Sugiyama, Makoto Ozeki, Yoriyuki Nakamura, Hiroshi Yamada
Food Science & Nutrition Research ( {SciVision} Publishers {LLC} ) 5 ( 1 ) 1 - 7 2022年06月 [査読有り]
研究論文（学術雑誌）
<jats:p>L-theanine (theanine), one of the ingredients of green tea, had been proven to have anti-anxiety, anti-stress, memory, cognitive, and sleep improvement effects in most clinical trials. However, these effects have shown efficacy at a dose of 200–400 mg of theanine a day. In this study, we explored the sleep-improving effects of a lower dose (100 mg/day) of theanine. A double-blind, randomized crossover study was conducted on 25 middle-aged and older males. Participants were randomly assigned to Groups A and B. Group A took theanine first, and Group B took theanine later in the intervention period. The participants took theanine/placebo for one week. Electroencephalogram (EEG) parameters were measured with a monitoring device during sleep, and subjective sleep quality after waking up was evaluated using a questionnaire. Following the statistical analysis between interventions, subgroup analyses according to the participants’ background information were conducted on the representative sleep parameters of non-REM sleep, REM sleep, and wakefulness. Of the 25 participants, three withdrew from this study. In the sleep analysis, there was no significant difference in all sleep parameters between the theanine and placebo periods. In particular, the difference in the percentage of nonREM sleep in stage 2 per sleep duration was not significant (p = 0.053). However, subgroup analysis of the results showed that the percentage of non-REM sleep in stage 2 in groups aged <50 years was higher in theanine than that of the placebo, and in groups with green tea consumption habit of <3 to 4 days per week (p = 0.018, 0.048). The intake of 100 mg/day of theanine does not have an effect on sleep improvement. However, subgroup analyses showed that theanine had an improved effect in stage 2 non-REM sleep according to age and green tea consumption habit.</jats:p>
-
Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis.
Mai Umeda, Takeichiro Tominaga, Kazuya Kozuma, Hidefumi Kitazawa, Daisuke Furushima, Masanobu Hibi, Hiroshi Yamada
European journal of nutrition 60 ( 8 ) 4189 - 4202 2021年12月 [査読有り]
研究論文（学術雑誌）
PURPOSE: Gargling with tea has protective effects against influenza infection and upper respiratory tract infection (URTI). To evaluate if tea and tea catechin consumption has the same protective effects as gargling with tea, we performed a systematic review and meta-analysis. METHODS: We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases. The search provided six randomized controlled trials (RCTs) and four prospective cohort studies (n = 3748). The quality of each trial or study was evaluated according to the Cochrane risk-of-bias tool or Newcastle-Ottawa Scale. We collected data from publications meeting the search criteria and conducted a meta-analysis of the effect of tea gargling and tea catechin consumption for preventing URTI using a random effects model. RESULTS: Tea gargling and tea catechin consumption had significant preventive effects against URTI (risk ratio [RR] = 0.74, 95% confidence interval [CI] 0.64-0.87). In sub-analyses, a significant preventive effect was observed by study type (prospective cohort study: RR = 0.67, 95% CI 0.50-0.91; RCT: RR = 0.79, 95% CI 0.66-0.94) and disease type (influenza: RR = 0.69, 95% CI 0.58-0.84; acute URTI: RR = 0.78, 95% CI 0.62-0.98). Both gargling with tea and consuming tea catechins effectively protected against URTI (tea and tea catechins consumption: RR = 0.68, 95% CI 0.52-0.87; tea gargling: RR = 0.83, 95% CI 0.72-0.96). CONCLUSION: Our findings suggest that tea gargling and tea catechin consumption may have preventive effects against influenza infection and URTI. The potential effectiveness of these actions as non-pharmaceutical interventions, however, requires further investigation.
-
健康食品利用者からの安全性情報に関わる相談に対する情報ツールを用いた対応：保険薬局における探索的実態調査
中村 洸友, 赤澤 壮太, 櫻井 護, 古島 大資, 牧之瀬 翔平, 富永 健一郎, 天野 進吾, 山田 浩
臨床薬理 ( 一般社団法人 日本臨床薬理学会 ) 54 ( 6 ) 239 - 244 2023年11月 [査読有り]
-
緑茶うがいによる急性上気道炎予防 ランダム化比較試験による濃度依存性の検討
生川 誉紹, 富永 健一郎, 中村 孝博, 古島 大資, 山田 浩
日本臨床薬理学会学術総会抄録集 ( (一社)日本臨床薬理学会 ) 43回 2 - 1 2022年12月
-
緑茶および緑茶成分のうがいによるインフルエンザ罹患への影響 メタ解析による検討
富永 健一郎, 古島 大資, 山田 浩
臨床薬理 ( (一社)日本臨床薬理学会 ) 51 ( Suppl. ) S344 - S344 2020年10月
◆原著論文【 表示 ／ 非表示 】
◆その他【 表示 ／ 非表示 】
Book（書籍） 【 表示 ／ 非表示 】
-
Tea as a Food Ingredient Properties, Processing, and Health Aspects
Takeichiro Tominaga, Daisuke Furushima, Hiroshi Yamada ( 担当： 共著 )
CRC press 2022年07月 ISBN: 9781003152828
学術書
学会等発表 【 表示 ／ 非表示 】
-
健康的な食品選択に向けたナッジを探る：スコーピングレビュー
富永健一郎, 種村菜奈枝, 樫野いく子
D＆I科学研究会第10回学術集会 2024年07月 - 2024年07月
-
すべての人に届く、自然に続けられる健康でおいしい食生活の実現に向けて
樫野いく子, 森渚, 種村菜奈枝, 富永健一郎
第94回日本衛生学会学術総会 (鹿児島) 2024年03月 - 2024年03月 日本衛生学会
自由集会
-
緑茶うがいによる急性上気道炎予防：介入試験を対象としたメタアナリシス．
生川誉紹, 富永健一郎, 田中雄也, 蒔田篤則, 中村洸友, 古島大資, 山田浩
日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会 2023 (名古屋) 2023年11月 - 2023年11月 日本病院薬剤師会東海ブロック・日本薬学会東海支部
-
新型コロナウイルス感染症罹患状況の地域差と緑茶関連情報に関する生態学的検討．
田中雄也, 富永健一郎, 生川誉紹, 蒔田篤則, 中村洸友, 古島大資, 山田浩
日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会 2023 (名古屋) 2023年11月 - 2023年11月 日本病院薬剤師会東海ブロック・日本薬学会東海支部
-
緑茶成分の心理的ストレス及び睡眠に与える影響：ランダム化比較試験による検討．
田中雄也, 海野けい子, 古島大資, 中村洸友, 富永健一郎, 中村順行, 山田浩
第 38 回茶学術研究会講演会 (静岡) 2023年02月 - 2023年02月 茶学術研究会