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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Public Health and Environmental Medicine Department of Environmental health science and Public Health |
TOMINAGA Takeichiro
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Graduating School 【 display / non-display 】
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2019.10-2024.09
University of Shizuoka Graduate School of Pharmaceutical Sciences Graduated
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2017.04-2019.03
Kyoto University Graduate School of Pharmaceutical Sciences Division of Bioinformatics and Chemical Genomics Graduated
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-2017.03
University of Shizuoka Faculty of Pharmaceutical Science Graduated
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2013.04-2017.03
University of Shizuoka Faculty of Pharmaceutical Science Division of Pharmaceutical Science Graduated
Graduate School 【 display / non-display 】
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-2024.09
University of Shizuoka Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
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-2019.03
Kyoto University Graduate School, Division of Pharmaceutical Sciences Master's Course Completed
Campus Career 【 display / non-display 】
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2025.06-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Public Health and Environmental Medicine Department of Environmental health science and Public Health Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Hygiene and public health (laboratory)
Research Achievements 【 display / non-display 】
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An Exploratory Randomized Controlled Study to Investigate Concentration-Dependence of Green Tea Catechin Gargling on Acute Upper Respiratory Tract Infections
Takeichiro Tominaga, Takatsugu Ikukawa, Daisuke Furushima, Takahiro J. Nakamura, Hiroshi Yamada
Biological and Pharmaceutical Bulletin 47 ( 7 ) 1331 - 1337 2024.07 [Refereed]
Research paper (journal)
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An intact pituitary vasopressin system is critical for building a robust circadian clock in the suprachiasmatic nucleus.
Yoshiaki Yamaguchi, Yota Maekawa, Kyohei Kabashima, Takanobu Mizuno, Motomi Tainaka, Toru Suzuki, Kumiko Dojo, Takeichiro Tominaga, Sayaka Kuroiwa, Satoru Masubuchi, Masao Doi, Keiko Tominaga, Kazuto Kobayashi, Satoshi Yamagata, Keiichi Itoi, Manabu Abe, William J Schwartz, Kenji Sakimura, Hitoshi Okamura
Proceedings of the National Academy of Sciences of the United States of America 120 ( 43 ) e2308489120 2023.10 [Refereed]
Research paper (journal)
The circadian clock is a biological timekeeping system that oscillates with a circa-24-h period, reset by environmental timing cues, especially light, to the 24-h day-night cycle. In mammals, a "central" clock in the hypothalamic suprachiasmatic nucleus (SCN) synchronizes "peripheral" clocks throughout the body to regulate behavior, metabolism, and physiology. A key feature of the clock's oscillation is resistance to abrupt perturbations, but the mechanisms underlying such robustness are not well understood. Here, we probe clock robustness to unexpected photic perturbation by measuring the speed of reentrainment of the murine locomotor rhythm after an abrupt advance of the light-dark cycle. Using an intersectional genetic approach, we implicate a critical role for arginine vasopressin pathways, both central within the SCN and peripheral from the anterior pituitary.
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Improvement of Depressed Mood with Green Tea Intake.
Keiko Unno, Daisuke Furushima, Yuya Tanaka, Takeichiro Tominaga, Hirotomo Nakamura, Hiroshi Yamada, Kyoko Taguchi, Toshinao Goda, Yoriyuki Nakamura
Nutrients 14 ( 14 ) 2949 - 2949 2022.07 [Refereed]
Research paper (journal)
Being in a prolonged depressed state increases the risk of developing depression. To investigate whether green tea intake is effective in improving depression-like moods, we used an experimental animal model of depression with lipopolysaccharide (LPS) and clarified the effects of green tea on the biological stress response and inflammation in the brain. Regarding the stress reduction effect of green tea, we found that the sum of caffeine (C) and epigallocatechin gallate (E) relative to the sum of theanine (T) and arginine (A), the major components of green tea, or the CE/TA ratio, is important. The results showed that depression-like behavior, adrenal hypertrophy as a typical stress response, and brain inflammation were suppressed in mice fed green tea components with CE/TA ratios of 2 to 8. In addition, the expression of Npas4, which is reduced in anxiety and depression, was maintained at the same level as controls in mice that consumed green tea with a CE/TA ratio of 4. In clinical human trials, the consumption of green tea with CE/TA ratios of 3.9 and 4.7 reduced susceptibility to subjective depression. These results suggest that the daily consumption of green tea with a CE/TA ratio of 4-5 is beneficial to improving depressed mood.
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Preventive effects of tea and tea catechins against influenza and acute upper respiratory tract infections: a systematic review and meta-analysis.
Mai Umeda, Takeichiro Tominaga, Kazuya Kozuma, Hidefumi Kitazawa, Daisuke Furushima, Masanobu Hibi, Hiroshi Yamada
European journal of nutrition 60 ( 8 ) 4189 - 4202 2021.12 [Refereed]
Research paper (journal)
PURPOSE: Gargling with tea has protective effects against influenza infection and upper respiratory tract infection (URTI). To evaluate if tea and tea catechin consumption has the same protective effects as gargling with tea, we performed a systematic review and meta-analysis. METHODS: We performed a comprehensive literature search using the PubMed, Cochrane Library, Web of Science, and Ichu-shi Web databases. The search provided six randomized controlled trials (RCTs) and four prospective cohort studies (n = 3748). The quality of each trial or study was evaluated according to the Cochrane risk-of-bias tool or Newcastle-Ottawa Scale. We collected data from publications meeting the search criteria and conducted a meta-analysis of the effect of tea gargling and tea catechin consumption for preventing URTI using a random effects model. RESULTS: Tea gargling and tea catechin consumption had significant preventive effects against URTI (risk ratio [RR] = 0.74, 95% confidence interval [CI] 0.64-0.87). In sub-analyses, a significant preventive effect was observed by study type (prospective cohort study: RR = 0.67, 95% CI 0.50-0.91; RCT: RR = 0.79, 95% CI 0.66-0.94) and disease type (influenza: RR = 0.69, 95% CI 0.58-0.84; acute URTI: RR = 0.78, 95% CI 0.62-0.98). Both gargling with tea and consuming tea catechins effectively protected against URTI (tea and tea catechins consumption: RR = 0.68, 95% CI 0.52-0.87; tea gargling: RR = 0.83, 95% CI 0.72-0.96). CONCLUSION: Our findings suggest that tea gargling and tea catechin consumption may have preventive effects against influenza infection and URTI. The potential effectiveness of these actions as non-pharmaceutical interventions, however, requires further investigation.
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NAKAMURA Hirotomo, AKAZAWA Sota, SAKURAI Mamoru, FURUSHIMA Daisuke, MAKINOSE Shohei, TOMINAGA Takeichiro, AMANO Shingo, YAMADA Hiroshi
Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics ( The Japanese Society of Clinical Pharmacology and Therapeutics ) 54 ( 6 ) 239 - 244 2023.11 [Refereed]
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Books 【 display / non-display 】
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Tea as a Food Ingredient Properties, Processing, and Health Aspects
Takeichiro Tominaga, Daisuke Furushima, Hiroshi Yamada
CRC press 2022.07 ISBN: 9781003152828