|
Affiliation |
Graduate School of Medicine Telemedicine Development and Research Center |
|
Date of Birth |
1969 |
|
Homepage URL |
OKAZAKI Mitsuhiro
|
|
|
Research Interests 【 display / non-display 】
-
地域医療情報学
-
医療制度
-
医薬品情報学
-
医療制度
-
医薬品情報
Graduating School 【 display / non-display 】
-
1992.04-1997.03
Tokyo University of Pharmacy and Life Science Graduate School of Pharmacy Graduated
-
1988.04-1992.03
Tokyo University of Pharmacy and Life Science Faculty of Pharmaceutical Science Graduated
Graduate School 【 display / non-display 】
-
-1997.03
Tokyo University of Pharmacy and Life Science Graduate School, Division of Pharmaceutical Sciences Doctor's Course Completed
Campus Career 【 display / non-display 】
-
2024.07-2027.06
Akita University Graduate School of Medicine Telemedicine Development and Research Center Associate Professor
External Career 【 display / non-display 】
-
2024.07
Akita University Graduate School of Medicine Associate Professor
-
2021.06
Tokyo University of Pharmacy and Life Sciences
-
2017.01-2024.03
The University of Tokyo Graduate School of Pharmaceutical Sciences
-
2014.04
Hokkaido University Faculty of Health Sciences
-
2008.04-2014.03
Hokkaido Pharmaceutical University School of Pharmacy Associate Professor
Academic Society Affiliations 【 display / non-display 】
-
2021.04-Now
Japan
The Japanese Society of Oral Care
-
2019.05-Now
Japan
Japanese association for home care and medicine
-
1997.04-Now
Japan
The Japanese Society of Community Pharmacy
-
2014.04-Now
Japan
Japanese Society for Pharmacoepidemiology
-
1992.04-Now
Japan
The Pharmaceutical Society of Japan
Research Areas 【 display / non-display 】
-
Informatics / Life, health and medical informatics / 医療情報学、医薬品情報学、医療制度
-
Life Science / Clinical pharmacy
-
Humanities & Social Sciences / Library and information science, humanistic and social informatics
-
Life Science / Pharmaceutical hygiene and biochemistry
-
Life Science / Medical management and medical sociology / 医療情報学、医薬品情報学、医療制度
Research Achievements 【 display / non-display 】
-
Patient satisfaction with oral health check-ups at a community pharmacy and their effect on oral self-care habits and dental consultation behavior.
Hiroki Iwata, Koichi Shibano, Mitsuhiro Okazaki, Kotaro Fujimaki, Noriko Kobayashi, Kazuko Fujimoto, Naoko Hayashi, Tomoyuki Goto, Katsunori Yamaura
Drug discoveries & therapeutics 14 ( 6 ) 319 - 324 2021.01
Research paper (journal)
Maintaining good oral health is important because oral diseases are related to systemic diseases, and community pharmacies play a key role in maintaining the health of local residents. This study aimed to examine the effects of oral health check-ups and information provision at community pharmacies on oral health-associated behaviors as well as patient satisfaction. We conducted oral health check-ups and provided information about oral health self-care to 84 patients at a community pharmacy, and then asked them to complete a questionnaire survey. One month later, we sent them a follow-up questionnaire and received responses from 66.7% (56/84) of the participants. The large majority were satisfied with the salivary test (95.2%) and the information (96.4%) we provided. Most of the participants (89.3%) indicated that they wanted to use the oral health check-up service again in the future. Compared with baseline, the ratio of participants restricting their intake of sugar-rich foods and drinks significantly increased 1 month later (p = 0.021). About 60% of those who had not undergone a regular dental examination at baseline reported newly visiting or planning to visit a dental clinic. The results revealed high satisfaction with the oral health check-up and information about oral self-care they received at the community pharmacy. The results suggested that oral health check-ups had the potential to change both oral self-care habits and dental consultation behavior. Our findings indicate that community pharmacies can contribute to the maintenance and promotion of oral health by providing oral health check-ups to local residents.
-
Analysis of spontaneous inquiries about suspected adverse drug reactions posted by the general public on the electronic Japanese bulletin board "Yahoo! Japan Chiebukuro".
Akira Dobashi, Kaori Kurata, Mitsuhiro Okazaki, Mari Nishizawa
Patient preference and adherence 10 511 - 21 2016 [Refereed]
Research paper (journal)
PURPOSE: Spontaneous inquiries about the development of adverse drug reactions (ADRs) to medicines can be extracted based on the questions posted by the general public on the electronic Japanese bulletin board "Yahoo! Japan Chiebukuro". Our aim was to clarify the characteristics related to people's descriptions of suspected ADRs and determine the reasons for submitting a spontaneous inquiry. METHODS: Fifty brand names of medicines used for inquiry extraction were chosen by selecting 35 pharmaceutical products, based on the generic names that had the highest sales in Japan. Questions containing both the brand name of one of these medicines and the term "Fukusayō" (ADR in Japanese) that were posted from July 2004 to June 2009 were extracted from the site. RESULTS: Among 1,419 questions extracted, 614 questions had at least one identifiable brand name of a suspected medicine, an ADR description, and the extent to which the ADR appeared to be caused by the suspected medicine(s). Among these 614 questions, 589 described in detail the symptoms/signs that the inquirers themselves or their families had experienced as ADRs. The highest number of questions was found for Paxil (525). Posts asking whether the symptoms being experienced were due to an ADR accounted for the highest number of questions. In most cases, the inquirer suspected that a single medicine led to an ADR and was seeking advice from others taking the same medicine. CONCLUSION: Our examination of spontaneous inquiries showed that people have sufficient knowledge to adequately report potential ADRs in terms of their symptoms, suspected medicines, and the disease for which the medicine was used. However, they often did not describe the start time when the ADR appeared or when the suspected medicine was started.
-
Patients views and experiences in online reporting adverse drug reactions: findings of a national pilot study in Japan.
Michiko Yamamoto, Kiyoshi Kubota, Mitsuhiro Okazaki, Akira Dobashi, Masayuki Hashiguchi, Hirohisa Doi, Machi Suka, Mayumi Mochizuki
Patient preference and adherence 9 173 - 84 2015
Research paper (journal)
BACKGROUND: Patients have been allowed to report adverse drug reactions (ADRs) directly to the government in some countries, which would contribute to pharmacovigilance. OBJECTIVE: We started a pilot study to determine whether web-based patient ADR reporting would work in Japan. This article aims to describe the characteristics of the patient reporters, and to clarify patient views and experiences of reporting. METHODS: Patients who submitted online ADR reports were contacted to respond to an ADR reporting questionnaire; only consenting reporters were included. Subjects with multiple responses were excluded from analysis. The questionnaire consisted of both closed and open questions. Questionnaire responses were examined using Pearson's chi-squared test. RESULTS: A total of 220 web-based ADR reports were collected from January to December 2011; questionnaires were sent to 190 reporters, excluding those who gave multiple reports and those that refused to be contacted. Responses were obtained from 94 individuals (effective response rate: 49.5%). The median respondent age was 46.0 years. Sixty-three respondents found out about this pilot study on the Internet (67.0%). The numbers of respondents claiming that they had difficulty recalling the time/date of ADR occurrence were 16 patient reporters and three non-patient reporters. The number of reporters who found it difficult to complete the online reporting form was 22 patients (26.2%) and one non-patient (10%). Fifty-seven respondents (60.6%) expected feedback after reporting and many respondents wanted to know the process of ADR data collection and related information. Seventy-three respondents (77.7%) stated that they would report ADRs again in future. CONCLUSION: Throughout the entire questionnaire, online patient ADR reporting was received with a forward-looking, positive approach. To facilitate smoother web-based reporting experiences in future, some improvements may be required in online ADR reporting forms, particularly with regard to respondent feedback.
-
Overexpressed mitochondrial hinge protein, a cytochrome c-binding protein, accelerates apoptosis by enhancing the release of cytochrome c from mitochondria
M Okazaki, Y Ishibashi, S Asoh, S Ohta
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ( ACADEMIC PRESS INC ) 243 ( 1 ) 131 - 136 1998.02
Research paper (journal)
Holocytochrome c released from mitochondria has been revealed to be one of the contributors of apoptosis. To investigate how the cytochrome c protein is released from mitochondria, we examined the effects of overexpression of the hinge protein, a cytochrome c-binding protein, or cytochrome c on apoptosis by introducing their cDNAs under a constitutive promoter. Overexpression of the cytochrome c and hinge protein mRNAs was confirmed by Northern blotting, although marked accumulation of the cytochrome c protein was not observed. In transfectants of the hinge protein gene as well as cytochrome c gene, apoptosis was accelerated as judged by FITC-conjugated Annexin V binding to the cell surface and DNA fragmentation. In addition, enhancement of the release of cytochrome c into cytosol was demonstrated in these transfectants by a subcellular fractionation experiment, followed by Western blotting. These findings suggest that the release of the cytochrome c protein from mitochondria is regulated by the hinge protein involved in the respiratory chain in the apoptotic process. (C) 1998 Academic Press.
-
Leukocyte activation by (1→3)-beta-D-glucans
Yoshiyuki ADACHI, Mitsuhiro OKAZAKI, Naohito OHNO, Toshiro YADOMAE
MEDIATORS OF INFLAMMATION ( CARFAX PUBL CO ) 6 ( 4 ) 251 - 256 1997.11 [Refereed]
Research paper (journal)
We studied the activities of several kinds of P-glucans, including sonifilan, grifolan, Sclerotinia sclerotiorum glucan, laminarin and zymosan, on macrophages, Preculture of macrophages with inactive beta-glucans rendered the cells unresponsive to subsequent stimulation with grifolan, suggesting a specific pathway in the beta-glucan structure, The importance of protein C and phosphorylation of mitogen-activated protein kinase was demonstrated in the activation with grifolan or zymosan, Immunoprecipitation of complement receptor (CR3), coprecipitated other proteins carrying phosphotyrosine residues in stimulation with grifolan, These data suggest that protein kinase C and tyrosine kinases are essential for signal transduction, and that CR3 might participate in the activation through interaction with other intracellular proteins.
-
患者向け医薬品情報及び患者向医薬品ガイドに関する実態調査
山本 健, 宮田 滉平, 鈴木 榛華, 黒澤 光, 岡崎 光洋, 浅田 和弘, 須賀 万智, 佐藤 嗣道, 中村 敏明, 古川 綾, 折井 孝男, 高橋 英孝, 杉森 裕樹, 中山 健夫, 山本 美智子
日本薬学会年会要旨集 ( (公社)日本薬学会 ) 136年会 ( 4 ) 110 - 110 2016.03
-
薬学共用試験OSCEの結果解析
入江 徹美, 木内 祐二, 橋詰 勉, 野田 幸裕, 岡村 昇, 岡崎 光洋, 吉富 博則, 木津 純子, 宮崎 智, 奥 直人, 山元 弘
日本薬学会年会要旨集 ( (公社)日本薬学会 ) 134年会 ( 4 ) 238 - 238 2014.03
-
Temporal relationship between multiple drugs and multiple events in patient reports on adverse drug reactions: findings in a pilot study in Japan.
Kiyoshi Kubota, Mitsuhiro Okazaki, Akira Dobashi, Michiko Yamamoto, Masayuki Hashiguchi, Arisa Horie, Ataru Inagaki, Toshiaki Kikuchi, Mayumi Mochizuki
Pharmacoepidemiology and drug safety 22 ( 10 ) 1134 - 7 2013.10 [Refereed]
-
BI-6-2 Tele-health Consultation System Connected Between Drugstore and University
Ogasawara Katsuhiko, Abe Tamotsu, Okazaki Mitsuhiro, Goto Teruaki, Yoshimachi Masako, Iwamaru Hiroaki, Tamura Shingo, Shimoda Tomoko, Yoshimura Sadako
Proceedings of the Society Conference of IEICE ( The Institute of Electronics, Information and Communication Engineers ) 2011 ( 1 ) "SS - 47"-"SS-48" 2011.08
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Academic Awards Received 【 display / non-display 】
-
Good Design Award
2018.10
Grant-in-Aid for Scientific Research 【 display / non-display 】
-
Development of polypharmacy patient extraction algorithm and construction of intervention program by clinical pharmacy practice.
Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
-
Development of remote health consultation in cooperation with non-working nurses in their home
Grant-in-Aid for Scientific Research(B)
Project Year： 2012.04 - 2015.03 Investigator(s): YOSHIMURA Sadako, SHIMODA Tomoko, OGASAWARA Katsuhiko, OKAZAKI Mitsuhiro
-
Consideration on the state of the separation of the dispensing function and the prescribing function by the empirical analysis of the various factors which affect pharmacy management.
Grant-in-Aid for Scientific Research(C)
Project Year： 2004 - 2006 Investigator(s): SAKURAI Hidehiko, HAYASE Yukitoshi, OKAZAKI Mitsuhiro
-
Grant-in-Aid for Young Scientists(B)
Project Year： 2004 - 2005
Presentations 【 display / non-display 】
-
患者向け医薬品情報及び患者向医薬品ガイドに関する実態調査
山本 健, 宮田 滉平, 鈴木 榛華, 黒澤 光, 岡崎 光洋, 浅田 和弘, 須賀 万智, 佐藤 嗣道, 中村 敏明, 古川 綾, 折井 孝男, 高橋 英孝, 杉森 裕樹, 中山 健夫, 山本 美智子
日本薬学会年会要旨集 2016.03 - 2016.03 (公社)日本薬学会
Academic Activity 【 display / non-display 】
-
The Japanese Society of Oral Care
2021.04-NowCouncilor
-
2019.08-Now
-
2016.01-Now
-
Smart HealthCare Association
2015.03-NowBoard Chairman
-
2024.04-Now