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Affiliation |
Advanced Research Center for Geriatric Medicine |
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Laboratory Address |
3F, Research building for Basic Medicine, 1-1-1, Hondo, Akita 010-8543 JAPAN |
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Mail Address |
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Special Affairs |
MAYANAGI Takako |
OHNUMA Takako
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Graduating School 【 display / non-display 】
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1994.04-1998.03
Iwate University Faculty of Agriculture Graduated
Graduate School 【 display / non-display 】
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2000.04-2003.03
Iwate University Graduate School, Division of Agricltural Sciences Doctor's Course Completed
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1998.04-2000.03
Iwate University Graduate School, Division of Agriculture Master's Course Completed
Campus Career 【 display / non-display 】
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2024.07-Now
Akita University Advanced Research Center for Geriatric Medicine Specially-appointed Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Laboratory animal science
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Life Science / Molecular biology
Research Achievements 【 display / non-display 】
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Tatsunori Shimizu, Hidetaka Ota, Ayuto Kodama, Yasuhiro Suzuki, Takako Ohnuma, Rieko Suzuki, Kaoru Sugawara, Yasushi Sato, Hiroyuki Kodama
Biomolecules ( MDPI ) 14 ( 9 ) 2024.08 [Refereed]
Research paper (journal) Domestic Co-author
With aging populations in many countries, including Japan, efforts to mitigate the aging-related decline in physical function have gained importance not only for improving individual quality of life but also for mitigating the effects of this loss of function on society. Impaired glucose tolerance, muscle weakness, and cognitive decline are well-known effects of aging. These interrelated factors can create a vicious cycle because impaired glucose tolerance can accelerate muscle weakness and cognitive decline. Unmodulated 40 Hz (u40Hz) stimulation is imperceptible to the human ear and has been reported to improve cognitive function in humans and mice. However, research on the effects of u40Hz stimulation is still limited. This study aimed to report the effects of u40Hz stimulation on glucose tolerance and muscle strength in senescence-accelerated prone (SAMP)-10 mice, a model of accelerated aging. SAMP-10 mice underwent five weeks of u40Hz stimulation followed by glucose-tolerance tests, cognitive and behavioral assessments, and frailty evaluations. In comparison with the control group, the u40Hz-stimulation group showed mitigation of age-related decline in glucose tolerance, a better frailty index (FI), and notably preserved muscle strength. Microarray analysis of stimulated muscle tissue revealed significant upregulation of β-oxidation genes and genes functioning downstream of peroxisome proliferator-activated receptor gamma, and significant downregulation of clock genes. These findings indicate the beneficial effects of u40Hz stimulation on glucose tolerance, muscle strength, and cognitive function, warranting further research in this area.
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Molecular spectrum of somaclonal variation in regenerated rice revealed by whole-genome sequencing
Akio Miyao, Mario Nakagome, takako Ohnuma, Harumi Ymagata, hiroyuki kanamori, Yuichi Katayose, Akira Takahashi, Takashi Matsumoto, Hirohiko Hirochika
Plant & Cell physiology ( Oxford academic ) 53 ( 1 ) 256 - 264 2012.01 [Refereed]
Research paper (journal) Domestic Co-author
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Association of culture of mouse urogenital complexes in media containing rodent sera with the appearance of primordial germ cell-like cells.
T.Mayanagi, K.Ito, J,Takahashi
Reproduction ( Bioscientifia Ltd ) ( 125 ) 519 - 526 2003.01 [Refereed]
Research paper (journal) Single author
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Purification of mouse primordial germ cells by Nycodenz
T.Mayanagi, R.Kurosawa, K.Ohnuma, K.Ito, J,Takahashi
Reproduction ( Bioscientifia Ltd ) ( 125 ) 667 - 675 2003.01 [Refereed]
Research paper (journal) Single author