研究等業績 - その他 - 尾野　祐一

Analgesic effects of minodronate in a rat chronic pain model

Kasukawa Y.

Biomedical Research (Japan) ( Biomedical Research (Japan) )  39 ( 5 ) 261 - 268   2018年

<p>We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0.15 mg/kg/week), alendronate (0.15 mg/kg/week), pregabalin (10 mg/kg/week), or their vehicle was administered for 2 weeks starting on the 0th day of CCI. Behavioral evaluations, with von Frey testing and the hot plate test, were performed on days 0, 7 and 14. After 2 weeks, bilateral femurs and tibialis anterior muscles were harvested for bone mineral density and cross sectional area measurements, respectively. Two weeks treatment with minodronate significantly improved mechanical and thermal allodynia evaluated by the von Frey and hot plate tests in the CCI limb (<i>P</i> < 0.05). Minodronate and alendronate treatment for 2 weeks significantly increased total femoral bone mineral density in the CCI limb compared with pregabalin or vehicle treatment (<i>P</i> < 0.01). Cross sectional area of the CCI limb in the minodronate group was significantly larger than that of the alendronate group (<i>P</i> < 0.05) and pregabalin group (<i>P</i> < 0.05). Two-week treatment with minodronate, but not alendronate or pregabalin, improved mechanical and thermal allodynia caused by CCI in ovariectomized rats.</p>

DOI PubMed CiNii Research

経験と考察 痙縮に対するボツリヌス毒素治療後の小児足部変形の手術成績

尾野 祐一, 坂本 仁, 三澤 晶子, 石原 芳人, 遠藤 博之, 島田 洋一

整形外科 ( 南江堂 )  68 ( 12 ) 1259 - 1262   2017年11月

DOI CiNii Research

Age-related changes in muscle strength and spinal kyphosis angles in an elderly Japanese population

Kasukawa Y.

Clinical Interventions in Aging ( Clinical Interventions in Aging )  12   413 - 420   2017年02月

DOI