研究者詳細 - 尾野　祐一

Objectives: The extent to which locomotive syndrome is associated with low back pain (LBP), health-related quality of life (HRQOL), and impairment of activities of daily living among elderly men and women remains poorly documented. This study evaluated associations between locomotive syndrome and both HRQOL and LBP as assessed using a questionnaire completed by elderly individuals, including some >80 years old.Methods: We conducted a survey assessing locomotive syndrome using the loco-check, HRQOL using the Short-Form 36 questionnaire (SF-36), and LBP using the Roland-Morris Disability Questionnaire (RDQ) among individuals >60 years old. SF-36 and RDQ scores were compared between 253 subjects with and without locomotive syndrome.Results: Fifty-seven men (48%) and 71 women (53%) were diagnosed with locomotive syndrome. Subjects of both sexes with locomotive syndrome scored significantly lower for eight items from SF-36. Physical and mental component summary scores were significantly worse in women with locomotive syndrome in their 60s and 70s. RDQ scores were significantly higher in participants with locomotive syndrome for men in their 60s and for both men and women in their 70s.Conclusions: Locomotive syndrome was associated with impaired HRQOL and worse LBP among men and women >60 years old. Differences in HRQOL and LBP between subjects with and without locomotive syndrome were significant for both men and women in their 60s and 70s, but not in their 80s. Locomotive syndrome should be prevented to maintain HRQOL, particularly for men and women in their 60s and 70s.

DOI PubMed CiNii Research

Micro-CT imaging analysis for the effects of ibandronate and eldecalcitol osecondary osteoporosis and arthritis in adjuvant-induced arthritis rats

Ono Y.

Biomedical Research (Japan) ( Biomedical Research (Japan) ) 40 ( 5 ) 197 - 205 2019年

We investigated the effects of ibandronate, a bisphosphonate; eldecalcitol, an active vitamin D3 analogue; and combination treatment with both agents on secondary osteoporosis and arthritis using rats with adjuvant-induced arthritis. Arthritis was induced in 8-week-old male Lewis rats. Rats were randomized into four treatment groups and an untreated normal control group: ibandronate, eldecalcitol, ibandronate + eldecalcitol, vehicle, and control. Paw thickness was measured to evaluate arthritis. Joint destruction was evaluated histomorphometrically by the ankle joint stained with Fast Green and safranin O. The femur and lumbar spine were scanned using dual-energy X-ray absorptiometry, and the distal femur was scanned using micro-computed tomography for bone mineral density (BMD) and trabecular microstructural evaluations. Ibandronate and/or eldecalcitol increased BMD in both the lumbar vertebrae and femur and improved several microstructural parameters (bone volume/total volume, structure model index, trabecular number, and trabecular separation of the distal femur). In addition, there was an additive effect of combination treatment compared with single treatments for most trabecular parameters, including BMD and bone volume. However, ibandronate and/or eldecalcitol did not inhibit arthritis and joint destruction. Combination treatment with ibandronate and eldecalcitol may be effective for secondary osteoporosis associated with arthritis.

DOI PubMed CiNii Research

Lumbar spinal stenosis associated with progression of locomotive syndrome and lower extremity muscle weakness

Kasukawa Y.

Clinical Interventions in Aging ( Clinical Interventions in Aging ) 14 1399 - 1405 2019年

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Surgical results of patients with myelopathy due to ossification of the ligamentum flavum with ossification of the posterior longitudinal ligament or a vertebral fracture at the same level of the thoracic spine: A retrospective comparative study

Kasukawa Y.

Asian Spine Journal ( Asian Spine Journal ) 13 ( 5 ) 832 - 841 2019年

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Effects of activated Vitamin D, alfacalcidol, and low-intensity aerobic exercise on osteopenia and muscle atrophy in type 2 diabetes mellitus model rats

Akagawa M.

PLoS ONE ( PLoS ONE ) 13 ( 10 ) 2018年10月

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Limaprost or Pregabalin: Preoperative and Postoperative Medication for Pain due to Lumbar Spinal Stenosis

Kasukawa Y.

Pain Practice ( Pain Practice ) 18 ( 5 ) 625 - 630 2018年06月

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Analgesic effects of minodronate in a rat chronic pain model

Kasukawa Y.

Biomedical Research (Japan) ( Biomedical Research (Japan) ) 39 ( 5 ) 261 - 268 2018年

We evaluated the analgesic effects of minodronate, alendronate and pregabalin on mechanical and thermal allodynia, as well as changes in bone mineral density and skeletal muscle volume caused by chronic constriction injury (CCI) in an ovariectomized rat. Ovariectomy was performed on four-week-old female Wistar rats. Thereafter, at 8-weeks of age, the left sciatic nerve was ligated to create the chronic pain model (CCI limb), and sham surgery was performed on the right hindlimb. In all rats, either minodronate (0.15 mg/kg/week), alendronate (0.15 mg/kg/week), pregabalin (10 mg/kg/week), or their vehicle was administered for 2 weeks starting on the 0th day of CCI. Behavioral evaluations, with von Frey testing and the hot plate test, were performed on days 0, 7 and 14. After 2 weeks, bilateral femurs and tibialis anterior muscles were harvested for bone mineral density and cross sectional area measurements, respectively. Two weeks treatment with minodronate significantly improved mechanical and thermal allodynia evaluated by the von Frey and hot plate tests in the CCI limb (P < 0.05). Minodronate and alendronate treatment for 2 weeks significantly increased total femoral bone mineral density in the CCI limb compared with pregabalin or vehicle treatment (P < 0.01). Cross sectional area of the CCI limb in the minodronate group was significantly larger than that of the alendronate group (P < 0.05) and pregabalin group (P < 0.05). Two-week treatment with minodronate, but not alendronate or pregabalin, improved mechanical and thermal allodynia caused by CCI in ovariectomized rats.

DOI PubMed CiNii Research

経験と考察痙縮に対するボツリヌス毒素治療後の小児足部変形の手術成績

尾野祐一, 坂本仁, 三澤晶子, 石原芳人, 遠藤博之, 島田洋一

整形外科 ( 南江堂 ) 68 ( 12 ) 1259 - 1262 2017年11月

DOI CiNii Research

Kasukawa Y.

Clinical Interventions in Aging ( Clinical Interventions in Aging ) 12 413 - 420 2017年02月

DOI

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<尾野　祐一>

研究等業績 - その他 - 尾野　祐一