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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Public Health and Environmental Medicine Department of Environmental health science and Public Health |
IWAKURA Masahiro
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Research Interests 【 display / non-display 】
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Pulmonary Rehabilitation
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Perioperative Rehabilitation
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Cancer Rehabilitation
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COPD
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Frailty・Sarcopenia
Graduating School 【 display / non-display 】
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-2014.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2019.03
Akita University Graduate School, Division of Medicine Doctor's Degree Program Completed
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-2016.03
Akita University Graduate School, Division of Medicine Master's Degree Program Completed
Campus Career 【 display / non-display 】
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2023.09-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Public Health and Environmental Medicine Department of Environmental health science and Public Health Assistant Professor
External Career 【 display / non-display 】
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2022.04
Akita Rehabilitation Core Academy, School Corporation Part-time lecturer
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2019.01
Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
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2014.04-2023.08
Akita City Hospital Department of Physical Therapy Physical Therapist
Research Areas 【 display / non-display 】
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Life Science / Nutrition science and health science
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Life Science / Hygiene and public health (non-laboratory)
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Life Science / Hygiene and public health (non-laboratory)
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Life Science / Nutrition science and health science
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Life Science / Rehabilitation science
Research Achievements 【 display / non-display 】
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Association between parent-child relationships and self-esteem among elementary and junior high school students: Considering household economic status and young carer status
YAMAZAKI Teiichiro, SHOJI Hitoshi, IWAKURA Masahiro, JUNG Songee, NOMURA Kyoko
Nihon Koshu Eisei Zasshi(JAPANESE JOURNAL OF PUBLIC HEALTH) ( Japanese Society of Public Health ) advpub ( 0 ) 2026.01 [Refereed]
Research paper (journal) Domestic Co-author
<p><b>Objective</b> This study investigated whether self-rated parent-child relationships are associated with self-esteem among elementary and junior high school students, after statistically adjusting for family economic status and young carer status.</p><p><b>Methods</b> In 2024, 893 anonymous questionnaires were administered among fifth-grade elementary and second-grade junior high school students in Yurihonjo City, Japan. Exposure—defined as a “poor parent-child relationship"—was determined based on responses indicating “somewhat does not apply" or “does not apply" to one or more of six relevant items. Self-esteem was measured using the total score ranging from 3 to 12 on the Tokyo version of the Self-Esteem Scale. “Financial difficulties" were defined as responses indicating that the household's living conditions were “somewhat difficult" or “very difficult." Young carers were defined as children who provided care to family members in a manner that affected their daily lives. A linear regression model was used to examine the association between parent-child relationships and self-esteem. The total score on the self-esteem scale was treated as the dependent variable, whereas parent-child relationship (reference: good), household economic status (reference: sufficient), young carer status (reference: non-carer), and additional covariates were included as independent variables. Regression coefficients representing differences in self-esteem scores relative to the reference categories were estimated along with their 95% confidence intervals (CIs).</p><p><b>Results</b> Among the participants, 49% were female, 52% were fifth-grade elementary school students, and 17% lived in single-parent households. A total of 23% participants reported poor parent-child relationships, 10% reported economic difficulties, 2% were young carers, and the median self-esteem score was 9.5. Regarding basic characteristics, children who reported poor parent-child relationships when compared to those with good relationships, exhibited the following features: a higher proportion of females, poorer self-rated health, and limited household economic status, while a lower proportion had someone to consult. After adjusting for covariates, the difference in self-esteem scores was −0.98 (95% CI: −1.19 to −0.77) for poor parent-child relationships. In addition, the total self-esteem scale score was −0.21 (95% CI: −0.50 to 0.09) among those experiencing poorer household economic status and 0.25 (95% CI: −0.26 to 0.75) among those identified as young carers.</p><p><b>Conclusion</b> These findings suggest that parent-child relationships may serve as a key factor in fostering self-esteem among elementary and junior high school students.</p>
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Resignation in Working Women With Breast and Gynecologic Cancers
Iwakura M.
JAMA Network Open ( JAMA Network Open ) 8 ( 8 ) e2528844 2025.08 [Refereed]
Research paper (journal) Domestic Co-author
IMPORTANCE: Diagnosis of breast and gynecologic cancers may hamper employment; little is known about who is at greater risk of resignation. OBJECTIVE: To examine whether a breast or gynecologic cancer diagnosis is associated with resignation in working women and to identify high-risk subpopulations. DESIGN, SETTING, AND PARTICIPANTS: This matched cohort study included women aged 15 to 58 years insured by the Japan Health Insurance Association. From April 2017 to March 2023, women newly diagnosed with breast, cervical, uterine, or ovarian cancer were identified and matched in a 1:10 ratio to working women without these cancers. EXPOSURE: Cancer diagnosis was based on International Statistical Classification of Diseases and Related Health Problems, Tenth Revision (ICD-10). MAIN OUTCOMES AND MEASURES: The primary outcome was all-cause resignation, and the secondary outcome was a composite of resignation and death, both assessed during a 2-year follow-up. Stratified Cox proportional-hazards models were applied, with multiple imputation and covariate adjustments. Subgroup analyses by prespecified covariates assessed effect size moderation and interactions between exposure and these covariates. RESULTS: The study included 99 964 women with cancer, including 59 452 women with breast cancer (median [IQR] age, 48 [44-53] years), 14 713 women with cervical cancer (median [IQR] age, 46 [39-51] years), 16 933 women with uterine cancer (median [IQR] age, 49 [44-53 years]), and 8866 women with ovarian cancer (median age [IQR] age, 47 [40-52] years), as well as 999 640 matched controls (594 520 for the breast cancer cohort, 147 130 for the cervical cancer cohort, 169 330 for the uterine cancer cohort, and 88 660 for the ovarian cancer cohort). Most women with cancer were working in the medical, health care, or welfare sector (32 123 women [32.1%]). During follow-up, resignation rates were significantly higher for women with cancer vs controls (breast cancer: 10 820 women [18.2%] vs 97 892 women [16.5%]; hazard ratio [HR], 1.18; 95% CI, 1.16-1.20; cervical cancer: 3296 women [22.4%] vs 27 476 women [18.7%]; HR, 1.31; 95% CI, 1.26-1.36; uterine cancer: 3161 women [18.7%] vs 27 786 women [16.4%]; HR, 1.24; 95% CI, 1.19-1.29; ovarian cancer: 2004 women [22.6%] vs 15 847 women [17.9%]; HR, 1.44; 95% CI, 1.37-1.51). Regarding the composite outcome of resignation and death, there was an increased risk for all cohorts, ranging from an HR of 1.25 (95% CI, 1.22-1.27) for breast cancer to 1.81 (95% CI, 1.73-1.89) for ovarian cancer. Among all 4 cancer cohorts, resignation risk was higher among women with older age, lower income, and a history of depression. CONCLUSIONS AND RELEVANCE: In this cohort study using a nationwide health claims database in Japan, breast and gynecologic cancers were associated with a higher resignation risk, especially among those with older age, lower income, and depression history. These findings suggest that developing targeted support interventions may benefit women at high resignation risk after a cancer diagnosis.
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An umbrella review of efficacy of digital health interventions for workers
Iwakura M.
Npj Digital Medicine ( Npj Digital Medicine ) 8 ( 1 ) 2025.04 [Refereed]
Research paper (journal) Domestic Co-author
Efficacy of digital health (d-Health) interventions on workers’ physical activity (PA), sedentary behavior, and physiological outcomes remains unclear. This umbrella review searched PubMed, Cochrane Library, and Google Scholar up to October 25, 2024. We identified 24 systematic reviews (SRs) and selected 130 individual studies from these SRs for analysis. The AMSTAR 2 tool rated the quality of most SRs as critically low. Narrative syntheses suggested that d-Health interventions could potentially improve all outcomes compared with no intervention. However, whether d-Health interventions outperform non-d-Health interventions remains uncertain. Meta-analyses showed a significantly small effect of d-Health interventions on step counts, sedentary/sitting time, and weight compared with no intervention, while d-Health interventions slightly improved only moderate-to-vigorous PA compared with non-d-Health interventions. Subgroup analyses identified potential sources of heterogeneity (e.g., risk of bias, control conditions), which may vary between outcomes. Further high-quality studies are needed to evaluate the efficacy of d-Health interventions.
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KAWAGOSHI Atsuyoshi, IWAKURA Masahiro, FURUKAWA Yutaka, KERA Takeshi, KAWAI Hisashi, OBUCHI Shuichi, SUGAWARA Keiyu, SHIOYA Takanobu
Physical Therapy Research ( 一般社団法人日本理学療法学会連合 ) advpub ( 0 ) 145 - 149 2025.04 [Refereed]
Research paper (journal) Domestic Co-author
<p>Objectives: The effect of the co-occurrence of whole-body muscle wasting and respiratory muscle weakness on the clinical characteristics of patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated this association in patients with chronic respiratory diseases. Methods: 47 outpatients with mild to very severe COPD were classified into four groups according to their fat-free mass index and respiratory muscle strength: 19 without muscle wasting and respiratory muscle weakness (normal), 6 with muscle wasting only (MW), 11 with respiratory weakness only (RW), and 11 with muscle wasting and respiratory weakness (MW + RW). We measured their body composition, pulmonary function, lower muscle strength, submaximal exercise capacity, physical activity in daily life, nutritional status, frailty status, and health-related quality of life (QOL). Multiple linear regression analyses examined the association of muscle wasting and/or respiratory muscle weakness with participant characteristics, using each participant’s characteristics as an explained variable adjusted for confounding variables (Normal as the reference). Results: The regression analysis revealed that the percentage of vital capacity, lower muscle strength, submaximal exercise capacity, nutritional status, and frailty status were worse in the MW + RW group than in the Normal group. The MR + RW group had the largest number of variables with significant differences compared to the Normal group. Conclusions: These data suggest that the co-occurrence of whole-body muscle wasting and respiratory muscle weakness was significantly associated with deteriorating clinical characteristics in patients with COPD.</p>
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Takenoshita Shinichi, Iwakura Masahiro, Nagasawa Toru, Nomura Kyoko
The Tohoku Journal of Experimental Medicine ( 東北ジャーナル刊行会 ) advpub ( 0 ) 51 - 62 2023.12 [Refereed]
Research paper (journal) Domestic Co-author
<p>Fostering the research skills of young physician scientists is essential to increase the level of medical research in Japan. We aimed to clarify the mentor characteristics associated with a decreased risk of mentees’ psychological burnout. A task team comprising medical doctors, researchers, nurses, and other healthcare professionals developed 35 items related to the characteristics of research mentors. In 2015, we recruited 258 physician researchers who were awarded a new Grant-in-Aid for Young Scientists between 2014-2015 and asked them to score 35 items on a five-point Likert scale. We developed a large research mentor scale using factor analysis and investigated which characteristics (i.e., domains) of the developed scale would be associated with a decreased level of psychological burnout measured by the Copenhagen Burnout Inventory. Maximum likelihood factor analysis with varimax rotation found three domains with 16 items. The three domains were labeled “Building a good trust relationship” (6 items, Cronbach’s alpha = 0.889), “Mentorship in research” (6 items, alpha = 0.853), and “Established and authorized mentor” (3 items, alpha = 0.882). Multivariate linear regression models demonstrated that “Mentorship in research” was inversely associated with personal burnout (PBO) (beta = −6.25, p = 0.014) and work-related burnout (WBO) (beta = −4.76, p = 0.029); and “Building a good trust relationship” was inversely associated with client-related burnout (CBO) (beta = −4.91, p = 0.014). A great research mentor may be encouraged to have mentorship in research and a trusting relationship with mentees for mental health support.</p>
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Gait-related Self-efficacy is Low in Older Adults with Knee Osteoarthritis: A Preliminary Study
OKURA Kazuki, SHIBATA Kazuyuki, SUDA Tomohiro, IWAKURA Masahiro, WAKASA Masahiko, KIMURA Yoshiaki, OKADA Kyoji
Physical Therapy Research ( 一般社団法人日本理学療法学会連合 ) 25 ( 1 ) 31 - 34 2022.04 [Refereed]
<p>Objective: To investigate the differences in self-efficacy (SE) for walking tasks between older patients with knee osteoarthritis (OA) and older adults without knee OA. Methods: A cross-sectional design was employed. Older patients with radiographic knee OA and community-dwelling older adults without knee OA as controls were enrolled in the study. SE for the walking task was assessed using the modified gait efficacy scale (mGES). A Wilcoxon rank-sum test was used to compare the mGES between the groups of participants. A Tobit regression model was used to estimate the difference in mGES. The presence of radiographic knee OA was used as an independent variable. Sex (women), age, and body mass index were used as potential confounding variables in the model. Results: After exclusion, 78 participants (n=40 with knee OA, n=38 controls) were included. The mGES was lower in patients with knee OA than in controls. In the Tobit regression model adjusted for confounding factors, mGES in patients with knee OA was estimated to be 26.8 (95% confidence interval [CI]: 15.8-37.8) points lower than in controls. Conclusion: This study demonstrated that mGES was lower in older patients with knee OA than in older adults without knee OA.</p>
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Recent Advances in Inspiratory Muscle Training:
SHIOYA Takanobu, KAGAYA Yuki, TERUI Yoshino, OKURA Kazuki, IWAKURA Masahiro, KAWAGOSHI Atsuyoshi
Journal of Clinical Physiology ( Japanese Society of Clinical Physiology ) 52 ( 1 ) 11 - 17 2022.02
<p> Inspiratory Muscle Training (IMT) can be defined as a technique that aims to improve the function of the respiratory muscles through specific devices. IMT has been shown to improve respiratory muscle strength and exercise endurance, and health related QOL and IMT also has been shown to reduce dyspnea on exertion. Recently, the benefits of IMT have been demonstrated in patients with heart failure (HF), respiratory management in ICU, preoperative period, and cerebrovascular disease.</p><p> The pathologic changes that occur in the lung as a consequence of chronic pulmonar y venous hypertension, pulmonary function test abnormalities, and potential mechanisms for dyspnea including airflow obstruction and/or respiratory muscle dysfunction are discussed. It is worth noting that muscle weakness appears first in the respiratory muscles and then in the musculature of the limbs, which may be considered one of the main causes of exercise intolerance. IMT seems to be a useful intervention to reduce inspiratory muscle metaboreflex in order to increase patients' exercise tolerance under HF condition.</p><p> A systematic review was necessary to review the effects of IMT on inspiratory muscle weakness. For people with heart failure, IMT by itself, without being combined with other exercise, can improve ease of breathing, increase the amount of distance that they can walk, and improve quality of life. Inspirator y training with higher loads might be helpful for those with respiratory muscle weakness who are unable to do conventional exercise. In this review, new devices for IMT those recently developed and the working mechanism are shown. Further research should be warranted for IMT in the patients with HF and other disease than respiratory diseases.</p>
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Kawagoshi Atsuyoshi, Furukawa Yutaka, Iwakura Masahiro, Okura Kazuki, Sugawara Keiyu, Takahashi Hitomi, Shioya Takanobu
The Journal of the Japan Society for Respiratory Care and Rehabilitation ( The Japan Society for Respiratory Care and Rehabilitation ) 30 ( 1 ) 59 - 64 2021.12
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How to Interpret Muscle Weakness: an Example of Quadriceps Femoris Muscle Strength Assessment in a Patient with Chronic Obstructive Pulmonary Disease
岩倉正浩
秋田理学療法 28 ( 1 ) 33 - 36 2021
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Efficacy of a interval training for inspiratory muscle in healthy young people
Kubota Mika, Satake Masahiro, Iwakura Masaharu, Furukawa Yutaka, Sugawara Keiyu, Takahashi Hitomi, Shioya Takanobu
The Journal of the Japan Society for Respiratory Care and Rehabilitation ( The Japan Society for Respiratory Care and Rehabilitation ) 29 ( 2 ) 292 - 298 2020.12
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Clinically important difference in muscle strength and physical function in patients with abdominal tumors undergoing surgery
Grant-in-Aid for Early-Career Scientists
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Research Activity start-up
Project Year： 2019.08 - 2023.03
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Grant-in-Aid for Research Activity start-up
Project Year： 2019.08 - 2023.03
Academic Activity 【 display / non-display 】
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2023.04-Now
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2022.07-Now
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2022.06-Now
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2021.04-Now
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2020-2021