|
所属 |
大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 胸部外科学講座 |
学位論文 【 表示 ／ 非表示 】
-
Using CT to evaluate mediastinal great vein invasion by thymic epithelial tumors: measurement of the interface between the tumor and neighboring structures
Shoji Kuriyama, Kazuhiro Imai, Koichi Ishiyama, Shinogu Takashima, Maiko Atari, Tsubasa Matsuo, Yoshiaki Ishii, Yuzu Harata, Yusuke Sato, Satoru Motoyama, Kyoko Nomura, Manabu Hashimoto, Yoshihiro Minamiya
European Radiology 2022年09月 [査読有り]
単著
研究等業績 【 表示 ／ 非表示 】
-
Prognostic impact of preoperative osteopenia in elderly patients with lung cancer.
Shoji Kuriyama, Motoko Konno, Naoko Mori, Shinogu Takashima, Tsubasa Matsuo, Hidenobu Iwai, Haruka Suzuki, Tatsuki Fujibayashi, Sumire Shibano, Akiyuki Wakita, Yusuke Sato, Kyoko Nomura, Yoshihiro Minamiya, Kazuhiro Imai
World journal of surgical oncology 2025年12月
研究論文（学術雑誌）
BACKGROUND: Osteopenia was recently reported to be a factor contributing to a poorer prognosis in various cancers. However, its prognostic impact on non-small cell lung cancer (NSCLC) patients remains unclear. In the present study, we focused on osteopenia in elderly NSCLC patients and investigated survival outcomes. METHODS: This study included 315 NSCLC patients aged 75 years or older who had undergone radical lobectomy or segmentectomy at our institution between 2010 and 2023. Osteopenia was evaluated based on the average pixel density within a circle in the mid-vertebral core at the 11th thoracic vertebra on preoperative computed tomography. RESULTS: Osteopenia was identified in 126 patients (40%). This osteopenia group had significantly poorer overall survival (OS) than the non-osteopenia group (5-year OS: 71.4%vs 81.0%, p = 0.026). Multivariable analysis revealed that Charlson comorbidity index (CCI) ≥ 2 (p = 0.020), Brinkman index (BI) ≥ 400 (p < 0.001), pathological Stage ≥ II (p < 0.001), and osteopenia (p = 0.016) were independent factors affecting OS. The cumulative incidence of non-lung cancer mortality was significantly higher in the osteopenia group than non-osteopenia group (5-year mortality rate: 16.9% vs. 6.4%, p = 0.005). In multivariable analysis, CCI ≥ 2 (p = 0.009), BI ≥ 400 (p < 0.008) and osteopenia (p = 0.001) were independent factors affecting non-lung cancer mortality. CONCLUSIONS: Elderly patients with osteopenia have significantly poorer OS, and osteopenia was closely associated with non-lung cancer mortality. Screening for osteopenia may assist in identifying high-risk patients of non-lung cancer death and developing appropriate treatment strategies.
-
Takashima S.
Thoracic Cancer ( Thoracic Cancer ) 16 ( 8 ) e70077 2025年04月
研究論文（学術雑誌）
BACKGROUND: As the population ages, the number of elderly lung cancer patients has been increasing. While surgery is the best treatment for resectable lung cancer, elderly patients often have multiple comorbidities, making accurate preoperative risk assessment crucial when formulating an appropriate treatment plan. This study aims to explore how psoas muscle volume relates to postoperative outcomes in elderly lung cancer patients. METHODS: This single-center, retrospective study included 344 elderly (≥ 75) patients who underwent complete surgical resection for non-small cell cancer between 2010 and 2023. The psoas muscle volume index (PVI, cm3/m3) was measured using a 3-dimensional imaging workstation based on preoperative computed tomography images and grouped based on the median value for each gender. Postoperative complications and survival rates were then compared between the groups. RESULTS: The median PVI was 60.5 cm3/m3 for males and 47.7 cm3/m3 for females. The PVI-high group had significantly fewer complications (15.6%) than the PVI-low group (37.1%) (p < 0.001). The 5-year overall survival (OS) rate was higher in the PVI-high group (80.5%) than in the PVI-low group (66.7%) (p = 0.01). Multivariate analyses showed that PVI-high was an independent predictor of lower complication risk (odds ratio 0.28, p < 0.001) and an independent factor that improved OS (hazard ratio 0.60, p = 0.042). CONCLUSIONS: PVI in elderly lung cancer patients is associated with postoperative complications and survival.
-
Kuriyama S.
Surgery Today ( Surgery Today ) 2025年
研究論文（学術雑誌）
PURPOSE: Predicting perioperative complications in high-risk elderly patients with lung cancer has become increasingly important as the population ages. This study investigated the relationship between preoperative diaphragmatic thickness (DT) and perioperative complications. METHODS: We enrolled 101 patients ≥ 75 years old who had undergone radical resection for primary lung cancer between 2013 and 2018. Bilateral DT was measured on axial and coronal computed tomography, and the mean DT (MDT) was calculated based on these measurements. Outcomes were assessed based on postoperative complications, defined as Clavien-Dindo classification ≥ 2. RESULTS: The MDT was 3.51 ± 1.00 mm. Thirteen patients who experienced postoperative respiratory complications had a significantly lower MDT than a higher MDT (p = 0.0390). Multivariate logistic regression analyses revealed that an MDT ≤ 3.63 mm was an independent factor associated with postoperative complications (odds ratio, 5.559). CONCLUSIONS: Patients with a low MDT are at an increased risk of postoperative complications. Therefore, these patients require careful perioperative management.
-
Multiple Pulmonary Cavernous Hemangioma: A Case Report
Takashima Shinogu, Nanjo Hiroshi, Matsuo Tsubasa, Kuriyama Shoji, Iwai Hidenobu, Suzuki Haruka, Kobayashi Mirai, Fujibayashi Tatsuki, Shibano Sumire, Minamiya Yoshihiro, Imai Kazuhiro
Surgical Case Reports ( 一般社団法人 日本外科学会 ) 11 ( 1 ) n/a 2025年
研究論文（学術雑誌）
<p><b>INTRODUCTION:</b> Pulmonary cavernous hemangioma (PCH) is extremely rare and, due to the lack of specific radiological characteristics, is often misdiagnosed as other pulmonary diseases, including metastatic tumors. Here, we report a case of multiple PCH lesions with concomitant hepatic cavernous hemangioma (HCH), emphasizing the diagnostic implications of imaging findings.</p><p><b>CASE PRESENTATION:</b> A 57-year-old man presented with fever. CT revealed numerous well-circumscribed pulmonary nodules and multiple low-density hepatic lesions. Dynamic contrast-enhanced CT demonstrated mild, nonspecific enhancement of the pulmonary nodules, whereas the hepatic lesions showed enhancement from the center to the periphery. Serum tumor markers were within normal limits, and PET-CT revealed no abnormal fluorodeoxyglucose uptake in any of the lesions. Although the hepatic lesions appeared suggestive of hemangioma on imaging, the possibility of malignancy, such as hepatic angiosarcoma and its pulmonary metastases, could not be completely ruled out. Therefore, both hepatic and pulmonary biopsies were performed, and histopathological examination confirmed cavernous hemangioma in both organs.</p><p><b>CONCLUSIONS:</b> PCH is a rare benign tumor lacking distinctive imaging characteristics; therefore, differentiation from metastatic pulmonary tumors is often challenging and represents a key diagnostic issue. Although definitive diagnosis currently relies on surgical biopsy, combining suggestive imaging findings—such as the presence of microcalcifications within nodules and the absence of fluorodeoxyglucose uptake on PET-CT—may help avoid unnecessary invasive procedures.</p>
-
A case of right middle lobectomy for primary lung cancer in a patient with heterotaxy syndrome.
Ryo Demura, Kazuhiro Imai, Shinogu Takashima, Nobuyasu Kurihara, Shoji Kuriyama, Haruka Suzuki, Yuzu Harata, Yoshihiro Minamiya
General Thoracic and Cardiovascular Surgery Cases ( General Thoracic and Cardiovascular Surgery Cases ) 3 ( 1 ) 52 - 52 2024年11月
研究論文（学術雑誌）
BACKGROUND: Anatomical abnormalities in the pulmonary vessels have long aroused great interest among thoracic surgeons, and numerous variations of pulmonary vessels have been reported. Heterotaxy syndrome is an anatomical abnormality in which typically asymmetrical organs, including the lungs, develop symmetrically. We report the case of a 71-year-old man with heterotaxy syndrome undergoing radical lobectomy in the treatment of non-small cell lung cancer. CASE PRESENTATION: Computed tomography (CT) revealed an irregular nodule 25 mm in diameter in the right middle lobe. Two months later, at his first visit to our University Hospital, CT revealed a rapidly growing tumor 60 mm in diameter. In addition, three-dimensional (3D) CT revealed the upper and middle lobar bronchi forming a common trunk with the mediastinal type of the right pulmonary artery (PA). The patient underwent video-assisted right middle lobectomy + systematic complete hilar and mediastinal lymph node dissection. The interlobar fissure between the right upper and middle lobes was incomplete, and the common trunk formed by the upper-middle bronchus emerged from an area between the right PA (A1+3) and the right superior pulmonary vein. CONCLUSION: The finding of A4+5 branching from the right main PA and descending posterior to the right upper-middle bronchus, which formed a common trunk, resembled a mirror image of the normal left lung. To our knowledge, a common trunk with the mediastinal type of the right PA has never been reported during video-assisted right middle lobectomy. In patients with heterotaxy syndrome, 3D-CT to preoperatively understand their anatomy is essential.
-
当院における胸腺上皮性腫瘍手術の変遷と成績
松尾 翼, 今井 一博, 高嶋 祉之具, 栗山 章司, 岩井 英頌, 鈴木 陽香, 藤林 立吉, 柴野 菫, 南谷 佳弘
日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 39 ( 3 ) DP5 - 7 2025年04月
-
殺細胞性抗癌剤と免疫チェックポイント阻害剤の併用療法における至適投与条件の検討
鈴木 陽香, 山口 歩子, 高嶋 祉之具, 松尾 翼, 栗山 章司, 岩井 英頌, 藤林 立吉, 柴野 菫, 南谷 佳弘, 今井 一博, 海老原 敬
日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 39 ( 3 ) O53 - 2 2025年04月
-
胸腺上皮腫瘍における3D-CTを用いた腫瘍倍加時間と組織型との関連についての検討
栗山 章司, 高嶋 祉之具, 松尾 翼, 岩井 英頌, 鈴木 陽香, 藤林 立吉, 柴野 菫, 南谷 佳弘, 今井 一博
日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 39 ( 3 ) O35 - 4 2025年04月
-
胸腺原発神経内分泌腫瘍の手術経験
柴野 菫, 高嶋 祉之具, 今井 一博, 松尾 翼, 栗山 章司, 岩井 英頌, 鈴木 陽香, 藤林 立吉, 南谷 佳弘
日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 39 ( 3 ) P19 - 7 2025年04月
-
高齢早期非小細胞肺癌患者に対する区域切除と肺葉切除の比較
高嶋 祉之具, 松尾 翼, 栗山 章司, 岩井 英頌, 鈴木 陽香, 藤林 立吉, 柴野 菫, 今井 一博
日本呼吸器外科学会雑誌 ( (一社)日本呼吸器外科学会 ) 39 ( 3 ) DP2 - 1 2025年04月
◆原著論文【 表示 ／ 非表示 】
◆その他【 表示 ／ 非表示 】
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
-
血液製剤を使用しない確実な肺瘻閉鎖を実現するガロール基高強度水中接着シートの開発
基盤研究(C)
研究期間: 2025年04月 - 2028年03月 代表者: 高嶋 祉之具, 江島 広貴, 松尾 翼, 佐藤 雄亮, 栗山 章司, 今井 一博
-
呼吸サルコペニアが肺癌周術期に与える影響の検討
若手研究
研究期間: 2024年04月 - 2027年03月 代表者: 栗山 章司
その他競争的資金獲得実績 【 表示 ／ 非表示 】
-
呼吸サルコペニアが肺癌周術期に与える影響についての検討
提供機関: 秋田大学 秋田大学若手研究者支援事業
研究期間： 2023年08月 - 継続中
資金支給機関区分：その他
学会等発表 【 表示 ／ 非表示 】
-
COVID-19感染を伴う外傷性気管分岐部損傷に対してECMO下に修復術を施行した1例
栗山章司, 今井一博, 髙嶋祉之具, 栗原伸泰, 鈴木陽香, 出村遼, 原田柚子, 南谷佳弘
日本呼吸器外科学会総会 2023年05月 - 2023年05月
-
The Postoperative Impacts of Inferior Pulmonary Ligament Division During Upper Lobectomy
Shoji Kuriyama, Kazuhiro Imai, Shinogu Takashima, Nobuyasu Kurihara, Ryo Demura, Haruka Suzuki, Yuzu Harata, Yoshihiro Minamiya
日本胸部外科学会定期学術集会 2022年11月 - 2022年11月
-
マルチプレックス免疫染色法の術中迅速診断への応用
栗山章司, 今井一博, 髙嶋祉之具, 中麻衣子, 石井良明, 小林昭仁, 小林未来, 原田柚子, 南谷佳弘
日本呼吸器外科学会総会 2022年05月 - 2022年05月
-
過剰気管気管支を有する右上葉に発生した肺癌の1切除例
栗山章司, 木村大輔, 今井一博, 髙嶋祉之具, 中麻衣子, 石井良明, 小林昭仁, 髙橋秀悟, 原田柚子, 皆川正仁, 南谷佳弘
日本肺癌学会学術集会 2021年11月 - 2021年11月
-
Using CT to evaluate organ invasion by thymic epithelial tumors: measurement of the interface between the tumor and neighboring structures
Shoji Kuriyama, Kazuhiro Imai, Shinogu Takashima, Maiko Atari, Yoshiaki Ishii, Akihito Kobayashi, Shugo Takahashi, Yuzu Harata, Yoshihiro Minamiya
日本胸部外科学会定期学術集会 2021年10月 - 2021年11月