研究等業績 - 原著論文 - 渡邊 健太
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Iijima K.
Tohoku Journal of Experimental Medicine ( Tohoku Journal of Experimental Medicine ) 257 ( 1 ) 65 - 71 2022年05月 [査読有り]
研究論文（学術雑誌）
<p>Disruption of cancer screening programs and diagnoses of gastrointestinal cancers by the COVID-19 pandemic has been reported; however, little attention has been paid to the situation in depopulated areas with low infection rates. Akita Prefecture is one of the most depopulated areas of Japan and has the lowest COVID-19 infection rate per capita; at the same time, the prefecture has been top-ranked for mortality due to gastrointestinal cancer for years. In this population-based study in Akita Prefecture, we investigated the occurrence of gastrointestinal cancers and the number of cancer screening procedures over the five-year period of 2016-2020, employing a database from the collaborative Akita Prefecture hospital-based registration system of cancers. The occurrence of gastrointestinal cancers, especially esophago-gastric cancers, declined by 11.0% in 2020, when the COVID-19 pandemic affected the overall healthcare system, compared with the average of 2016-2019. Nonetheless, the occurrence of advanced-stage (stage IV) esophago-gastric cancers increased by 7.2% in 2020. The decrease in the gastrointestinal cancer diagnosis rate in 2020 coincided with a 30% decline in the total number of regular population-based screening programs. Under the ongoing COVID-19 pandemic, cancer screening was uniformly suspended throughout Japan. Accordingly, the COVID-19 pandemic has substantially disrupted the cancer screening system, leading to delays in diagnoses of gastrointestinal cancer, even in depopulated areas (Akita Prefecture) of Japan with a low prevalence of infection. Suspension of cancer screening procedures during an infectious disease pandemic should be thoroughly considered for each region based on the cancer incidence and infection status in that area.</p>
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Fukuda S.
Digestive Endoscopy ( Digestive Endoscopy ) 34 ( 4 ) 757 - 765 2022年05月 [査読有り]
研究論文（学術雑誌）
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Watanabe K.
Scandinavian Journal of Gastroenterology ( Scandinavian Journal of Gastroenterology ) 57 ( 12 ) 1463 - 1469 2022年 [査読有り]
研究論文（学術雑誌）
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Shimodaira Y.
Scandinavian Journal of Gastroenterology ( Scandinavian Journal of Gastroenterology ) 57 ( 2 ) 165 - 168 2022年 [査読有り]
研究論文（学術雑誌）
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Takahashi S.
Digestive Diseases and Sciences ( Digestive Diseases and Sciences ) 68 ( 5 ) 2050 - 2060 2022年 [査読有り]
研究論文（学術雑誌）
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Norita K.
Digestive Endoscopy ( Digestive Endoscopy ) 33 ( 7 ) 1085 - 1092 2021年11月 [査読有り]
研究論文（学術雑誌）
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Kikuchi H.
Esophagus ( Esophagus ) 18 ( 2 ) 380 - 387 2021年04月 [査読有り]
研究論文（学術雑誌）
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Shimodaira Y.
Intestinal Research ( Intestinal Research ) 19 ( 2 ) 225 - 231 2021年04月 [査読有り]
研究論文（学術雑誌）
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Shimodaira Y.
Tohoku Journal of Experimental Medicine ( Tohoku Journal of Experimental Medicine ) 255 ( 1 ) 33 - 39 2021年 [査読有り]
研究論文（学術雑誌）
<p>The onset age of ulcerative colitis has been increasing in several countries. Furthermore, the number of elderly patients with ulcerative colitis has been increasing in an aging society. We investigated the incidence of ulcerative colitis patients in Japan using a large-scale health insurance claims database to survey the ulcerative colitis incidence ratio and the clinical characteristics in late-onset ulcerative colitis patients. Newly diagnosed 2,791 ulcerative colitis between 2015 and 2018 was investigated. Medical treatment within 12 months of diagnosis was analyzed among 0-19, 20-39, 40-59 and 60-75 age groups. The mean age at diagnosis was 40.3 years (SD: 12.9), and the incidence ratio peaked in the 40’s. Most of patients received 5-aminocylitic acid (91.7%), a subset of patients received prednisolone (20.1%), and a small number of patients took immunomodulator (6.8%), cytapheresis (3.3%), anti-TNF<i>α</i> therapy (4.3%), and colectomy (1.0%) within 12 months after diagnosis. All treatments except colectomy were most frequent in the 0-19 age group; however, colectomy was most frequent in 60-75 age group.<b> </b>The clinical course of ulcerative colitis that developed in adults did not differ significantly in terms of medical treatment within 12 months from the onset; meanwhile, the surgery rate was high in elderly patients. It is necessary to pay close attention to future trends regarding the aging of the onset age and the treatment, especially for late-onset ulcerative colitis patients.</p>
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Fukuda S.
Digestion ( Digestion ) 101 ( 1 ) 31 - 37 2020年01月 [査読有り]
研究論文（学術雑誌）