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Sato T.
Sensors ( Sensors ) 25 ( 3 ) 2025年02月
研究論文（学術雑誌）
BACKGROUND: Orthostatic hypotension can occur during acute spinal cord injury (SCI) and subsequently persist. We investigated whether a gait rehabilitation robot combined with functional electrical stimulation (FES) stabilizes hemodynamics during orthostatic stress in SCI. METHODS: Six intermediate-phase SCI patients (five males and one female; mean age: 49.5 years; four with quadriplegia and two with paraplegia) participated. The participants underwent robotic training (RT), with a gait rehabilitation robot combined with FES, and tilt table training (TT). Hemodynamics were monitored using a laser Doppler flowmeter for the earlobe blood flow (EBF) and non-invasive blood pressure measurements. The EBF over time and the resting and exercise blood pressures were compared between each session. Adverse events were also evaluated. RESULTS: The EBF change decreased in TT but increased in RT at the 0.5-min slope (p = 0.03). Similarly, the pulse rate change increased in TT but decreased in RT at the 1-min slope (p = 0.03). Systolic and mean blood pressures were slightly higher in RT than in TT but not significantly (p = 0.35; 0.40). No adverse events occurred in RT, but two TT sessions were incomplete due to dizziness. CONCLUSIONS: RT with FES can reduce symptoms during orthostatic stress in intermediate-phase SCI. Future studies require a larger number of cases to generalize this study.
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Kimura R.
Biomimetics ( Biomimetics ) 9 ( 10 ) 2024年10月
研究論文（学術雑誌）
This study aimed to identify whether the combined use of functional electrical stimulation (FES) reduces the motor torque of a gait exercise rehabilitation robot in spinal cord injury (SCI) and to verify the effectiveness of the developed automatic assist level adjustment in people with paraplegia. Acute and chronic SCI patients (1 case each) performed 10 min of gait exercises with and without FES using a rehabilitation robot. Reinforcement learning was used to adjust the assist level automatically. The maximum torque values and assist levels for each of the ten walking cycles when walking became steady were averaged and compared with and without FES. The motor's output torque and the assist level were measured as outcomes. The assist level adjustment allowed both the motor torque and assist level to decrease gradually to a steady state. The motor torque and the assist levels were significantly lower with the FES than without the FES under steady conditions in both cases. No adverse events were reported. The combined use of FES attenuated the motor torque of a gait exercise rehabilitation robot for SCI. Automatic assistive level adjustment is also useful for spinal cord injuries.
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Dural Injury During Spinal Surgery and Postoperative Cerebrospinal Fluid Leakage: A Single-Center Experience.
Hayato Kinoshita, Michio Hongo, Takashi Kobayashi, Yuji Kasukawa, Kazuma Kikuchi, Daisuke Kudo, Ryota Kimura, Yuichi Ono, Fumihito Kasama, Naohisa Miyakoshi
Cureus 16 ( 10 ) e71878 2024年10月
研究論文（学術雑誌）
BACKGROUND: The incidence of dural injury during spinal surgery and postoperative cerebrospinal fluid leakage varies between studies. We examined these rates in our institution. METHODS: Among 4014 patients who underwent a spinal operation between January 2012 and February 2020, 176 experienced an intraoperative dural injury (176 of 4014 cases, 4.3%). Among these, 22 (22 of 176 cases, 12.5%) developed postoperative cerebrospinal fluid leakage. RESULTS: The cause of dural injury was identified in 74 of 176 patients (42%). The rates of dural injury associated with thoracic, cervical, and lumbar operations were 7.8% (25 of 321 cases), 3.2% (19 of 602 cases), and 4.3% (132 of 3091 cases), respectively. Corresponding rates of cerebrospinal fluid leakage were 28% (seven of 25 cases), 5.3% (one of 19 cases), and 11% (14 of 132 cases), respectively. Most patients who experienced cerebrospinal fluid leakage recovered with bed rest; however, cerebral hemorrhage occurred in two patients. CONCLUSIONS: Although it was difficult to identify the cause of dural injury in more than half of patients, suturing the dura and using polyglycolic acid mesh with fibrin glue was effective. No patients required reoperation, even those who developed cerebrospinal fluid leakage.
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Clinical Manifestations and Diagnostic Considerations of C7-T1 Single-Level Myelopathy: A Case Series.
Kento Okamoto, Ryota Kimura, Yuji Kasukawa, Michio Hongo, Daisuke Kudo, Hayato Kinoshita, Yuichi Ono, Naohisa Miyakoshi
Cureus 16 ( 5 ) e60306 2024年05月
研究論文（学術雑誌）
Cervical myelopathy is caused by compression of the cervical spinal cord for any reason. Cervical myelopathy most commonly affects the C5-6 level. However, C7-T1 single-level myelopathy is rare, and neurological findings may be atypical, making diagnosis difficult. We report three cases and discuss their clinical manifestations. Unlike other levels of cervical myelopathy, C7-T1 single-level myelopathy may present with gait disturbance without neurological deficits in the upper extremities. In addition, all three of our cases had different levels of spinal cord compression and locations of sensory deficits; at the C7-T1 level, the spinal cord compression may not correspond to the site of the sensory deficit. These features may help clinicians in the diagnosing of myelopathy.
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Comparison of Postoperative Results With Prognostic Nutritional Index for Lumbar Disc Herniation.
Hayato Kinoshita, Michio Hongo, Eiji Abe, Takashi Kobayashi, Yuji Kasukawa, Kazuma Kikuchi, Daisuke Kudo, Ryota Kimura, Yuichi Ono, Naohisa Miyakoshi
Cureus 16 ( 5 ) e60584 2024年05月
研究論文（学術雑誌）
INTRODUCTION: The prognostic nutritional index (PNI) is an immune-nutritional index simply provided by a blood test. We retrospectively compared the postoperative outcomes of patients with lumbar disc herniation divided into two groups according to the PNI. MATERIALS AND METHODS: Seventy-three patients who underwent surgery at our hospital were included in the study. All patients had herniation between one of the L3/4, L4/5, or L5/S intervertebral discs and underwent one posterior lumbar interbody fusion. These patients were divided into two groups: patients with a PNI of <50 (poorly nourished (PN) group) and patients with a PNI of ≥50 (well-nourished (WN) group). Evaluation items included patient background characteristics, operative time, blood loss, postoperative complications, and length of hospital stay. RESULTS: The results showed that the body mass index was significantly higher in the WN group than in the PN group (p=0.0221). The rates of collagen disease, steroid use, and postoperative complications were significantly higher (p=0.0475, p=0.0073, and p=0.0211, respectively) and the length of hospital stay was significantly longer (p=0.021) in the PN group than in the WN group. CONCLUSION: In conclusion, this study indicates that postoperative complications and the length of hospital stay are significantly worse in PN patients than in WN patients.
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Kotaki Y.
Sensors ( Sensors ) 25 ( 21 ) 2025年11月
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特集 脊髄再生を用いない脊髄損傷治療の現実と到達点 日本における脊髄損傷の発生率の変遷-脊髄再生時代の幕開けに向けて
須田 浩太, 宮腰 尚久, 工藤 大輔
脊椎脊髄ジャーナル ( 三輪書店 ) 38 ( 8 ) 464 - 468 2025年08月
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Effect of Zoledronic Acid Administration Timing on Metastatic Bone Tumors
Watanabe M.
In Vivo ( In Vivo ) 39 ( 4 ) 1984 - 1991 2025年07月
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Okamoto K.
Applied Sciences (Switzerland) ( Applied Sciences (Switzerland) ) 14 ( 19 ) 2024年10月
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Effect of Acridine Orange and Zoledronic Acid on Bone Metastasis in Renal Cell Carcinoma
Oya K.
Anticancer Research ( Anticancer Research ) 44 ( 6 ) 2487 - 2495 2024年06月
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傍脊柱筋におけるIL-6，TNFα，PGC-1αの発現と腰椎後弯、背筋運動の関連
基盤研究(C)
研究期間: 2019年04月 - 2023年03月 代表者: 工藤 大輔, 宮腰 尚久, 本郷 道生, 粕川 雄司
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傍脊柱筋におけるIL-6，TNFα，PGC-1αの発現と腰椎後弯、背筋運動の関連
基盤研究(C)
研究期間: 2019年04月 - 2023年03月 代表者: 工藤 大輔, 宮腰 尚久, 本郷 道生, 粕川 雄司