|
Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Integrative Physiology |
TAGASHIRA Hideaki
|
|
|
Graduating School 【 display / non-display 】
-
2011.04-2014.03
Tohoku University Graduate School of Pharmaceutical Sciences Graduated
-
2009.04-2011.03
Tohoku University Graduate School of Pharmaceutical Sciences Graduated
-
-2009.03
Tokushima Bunri University Faculty of Pharmaceutical Science Graduated
Graduate School 【 display / non-display 】
-
-2014.03
Tohoku University Graduate School, Division of Pharmaceutical Sciences Doctor's Degree Program Completed
-
-2011.03
Tohoku University Graduate School, Division of Pharmaceutical Sciences Master's Degree Program Completed
Campus Career 【 display / non-display 】
-
2022.04-Now
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Integrative Physiology Associate Professor
External Career 【 display / non-display 】
-
2022.04
Akita University Graduate School of Medicine Associate Professor
-
2021.04-2022.03
Fukuoka University Associate Professor
-
2016.04-2021.03
Fukuoka University Lecturer
-
2014.04-2016.03
Fukuoka University Assistant Professor
Research Areas 【 display / non-display 】
-
Life Science / Pharmacology / General Pharmacology
Research Achievements 【 display / non-display 】
-
Cardioprotective effects of Moku-boi-to and its impact on AngII-induced cardiomyocyte hypertrophy
Tagashira H, Abe F, Sato-Numata K, Aizawa K, Hirasawa K, Kure Y, Iwata D, Numata T.
Front Cell Dev Biol. 2023.11 [Refereed]
Research paper (journal) Domestic Co-author
-
Perineural treatment with anti-TNF-α antibody ameliorates persistent allodynia and edema in novel mouse models with complex regional pain syndrome.
Shibata S, Tagashira H, Nemoto T, Kita S, Kita T, Shinoda Y, Akiyoshi K, Yamaura K, Iwamoto T.
J Pharmacol Sci. 153 ( 1 ) 1 - 11 2023.09 [Refereed]
Research paper (journal) Domestic Co-author
-
Functional characteristics and therapeutic potential of SLC41 transporters.
Nemoto T, Tagashira H, Kita T, Kita S, Iwamoto T.
J Pharmacol Sci. 151 ( 2 ) 88 - 92 2023.02 [Refereed]
Research paper (journal) Domestic Co-author
-
Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4
Hideaki Yamada，Naoaki Sakata，Tomoko Tanaka，Hideaki Tagashira，Gumpei Yoshimatsu，Ryo Kawakami，Hideichi Wada，Takahiro Iwamoto，Shohta Kodama
Journal of Pharmacological Sciences 146 ( 4 ) 244 - 248 2021.08 [Refereed]
Research paper (journal) Domestic Co-author
-
Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms
Naohiro Kon，Hsin-Tzu Wang，Yoshiaki S Kato，Kyouhei Uemoto，Naohiro Kawamoto，Koji Kawasaki，Ryosuke Enoki，Gen Kurosawa，Tatsuto Nakane, Yasunori Sugiyama，Hideaki Tagashira，Motomu Endo，Hideo Iwasaki，Takahiro Iwamoto，Kazuhiko Kume，Yoshitaka Fukada
Science Advances 7 ( 18 ) eabe8132 2021.04 [Refereed]
Research paper (journal) Domestic Co-author
-
The regulation mechanisms of mitochondrial Ca<sup>2+</sup> signaling mediated by cardiac Sigma-1 receptor
Tagashira Hideaki, Shinoda Yasuharu, Numata Tomohiro, Fukunaga Kohji
Proceedings for Annual Meeting of The Japanese Pharmacological Society ( Japanese Pharmacological Society ) 96 1-B-P-020 2022
Cardiovascular disease (CVD) is a leading cause of death worldwide. We previously reported that the Sigma-1 receptor (Sigmar1) is down-regulated in mice with cardiac dysfunction. Recent study suggested that Sigmar1 deficient mice display cardiac dysfunction via impairment of mitochondrial function. However, the mechanism of mitochondrial quality control mediated by Sigmar1 has not been investigated in detail. In this study, we investigated the role of Sigmar1 for ER-mitochondrial tethering and mitochondrial Ca<sup>2+</sup> signaling using a Sigmar1-knockdown cardiomyocytes. We found that disruption of ER-mitochondrial tethering and reduction of ER-mitochondrial Ca<sup>2+</sup> transport was induced by Sigmar1 knockdown in cardiomyocytes. We also demonstrated that Endothelin-1-induced cardiomyocyte hypertrophy is aggravated associated with induction of mitophagy in Sigmar1 knockdown cardiomyocytes. These data suggest that reduction of cardiac Sigmar1 is involved in myocyte hypertrophy by maintaining of intracellular Ca<sup>2+</sup> signaling mediated by regulation of ER-mitochondrial tethering.
-
Lymphangiogenesis and angiogenesis rescue murine ischemic hindlimb via transient receptor potential vanilloid 4.
Yamada H, Sakata N, Tanaka T, Tagashira H, Yoshimatsu G, Kawakami R, Wada H, Iwamoto T, Kodama S
J Pharmacol Sci. ( Elsevier BV ) 146 ( 4 ) 244 - 248 2021.08 [Refereed]
-
Na+/Ca2+ exchanger mediates cold Ca2+ signaling conserved for temperature-compensated circadian rhythms.
Kon N, Wang HT, Kato YS, Uemoto K, Kawamoto N, Kawasaki K, Enoki R, Kurosawa G, Nakane T, Sugiyama Y, Tagashira H, Endo M, Iwasaki H, Iwamoto T, Kume K, Fukada Y
Sci Adv. 7 ( 18 ) eabe8132 2021.04 [Refereed]
Circadian rhythms are based on biochemical oscillations generated by clock genes/proteins, which independently evolved in animals, fungi, plants, and cyanobacteria. Temperature compensation of the oscillation speed is a common feature of the circadian clocks, but the evolutionary-conserved mechanism has been unclear. Here, we show that Na+/Ca2+ exchanger (NCX) mediates cold-responsive Ca2+ signaling important for the temperature-compensated oscillation in mammalian cells. In response to temperature decrease, NCX elevates intracellular Ca2+, which activates Ca2+/calmodulin-dependent protein kinase II and accelerates transcriptional oscillations of clock genes. The cold-responsive Ca2+ signaling is conserved among mice, Drosophila, and Arabidopsis The mammalian cellular rhythms and Drosophila behavioral rhythms were severely attenuated by NCX inhibition, indicating essential roles of NCX in both temperature compensation and autonomous oscillation. NCX also contributes to the temperature-compensated transcriptional rhythms in cyanobacterial clock. Our results suggest that NCX-mediated Ca2+ signaling is a common mechanism underlying temperature-compensated circadian rhythms both in eukaryotes and prokaryotes.
-
Genetic knockout and pharmacologic inhibition of NCX1 attenuate hypoxia-induced pulmonary arterial hypertension.
Nagata A, Tagashira H, Kita S, Kita T, Nakajima N, Abe K, Iwasaki A, Iwamoto T
Biochem Biophys Res Commun. 529 ( 3 ) 793 - 798 2020.08 [Refereed]
-
Pharmacological exercise using a computer simulation of isolated preparation of guinea-pig ileum
根本 隆行, 田頭 秀章, 喜多 知, 柴田 志保, 岩本 隆宏
福岡大学医学紀要 47 ( 1 ) 93 - 99 2020.03 [Refereed]
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Presentations 【 display / non-display 】
-
Characteristics of sudden death in cardiac-specific conditional NCX1 knockout mice
Hideaki Tagashira, Satomi Kita, Takahiro Iwamoto
第94回日本薬理学会年会 (札幌) 2021.03 - 2021.03
-
Vascular smooth muscle NCX1 as a potential drug target for pulmonary arterial hypertension
Hideaki Tagashira, Asahi Nagata, Satomi Kita, Kohtaro Abe, Takahiro Iwamoto
第85回日本循環器学会学術集会 (横浜) 2021.03 - 2021.03
-
The pathophysiological role of vascular smooth muscle NCX1 for pulmonary arterial hypertension
Hideaki Tagashira, Asahi Nagata, Tomo Kita, Satomi Kita, Takahiro Iwamoto
65th Biophysical Society Annual Meeting (Boston, USA) 2021.02 - 2021.02
-
Development of a new model mouse for Mg metabolism disorder targeted for functional suppressing TRPM7.
Hideaki Tagashira, Tomo Kita, Tomohiro Numata, Satomi Kita, Takahiro Iwamoto
第93回日本薬理学会年会 (横浜) 2020.03 - 2020.03
-
血管平滑筋NCX1を介したCa2+シグナル異常は低酸素誘発性肺高血圧の発症に関与する
田頭秀章, 永田旭, 喜多知, 阿部弘太郎, 岩本隆宏
第49回日本心脈管作動物質学会年会 (久留米) 2020.02 - 2020.02