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Affiliation |
Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Integrative Physiology |
SATO-NUMATA Kaori
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Research Interests 【 display / non-display 】
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cell physiology
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osmotic-sensor
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cell volume regulation
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arginine-vasopressin
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漢方薬
Graduating School 【 display / non-display 】
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2002.04-2006.03
Tokyo Gakugei University Graduated
Graduate School 【 display / non-display 】
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2006.04-2011.03
The Graduate University for Advanced Studies Doctor's Course Completed
Degree 【 display / non-display 】
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The Graduate University for Advanced Studies - Doctor (Science)
Campus Career 【 display / non-display 】
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2022.01-2024.11
Akita University Graduate School of Medicine Doctorial Course in Medicine Organ Function-Oriented Medicine Department of Integrative Physiology Assistant Professor
External Career 【 display / non-display 】
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2014.08-2015.03
National Institutes of Natural Sciences Researcher
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2011.04-2014.07
National Institutes of Natural Sciences
Research Areas 【 display / non-display 】
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Life Science / Physiology
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Life Science / Clinical pharmacy
Research Achievements 【 display / non-display 】
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Role of Piezo2 in Schwann Cell Volume Regulation and its Impact on Neurotrophic Release Regulation
Chawapun Suttinont, Katsuyuki Maeno, Mamiko Yano, Kaori Sato-Numata, Tomohiro Numata, Moe Tsutsumi
Cellular Physiology and Biochemistry 2024.07 [Refereed]
Research paper (journal) Single author
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Cardioprotective effects of Moku-boi-to and its impact on AngII-induced cardiomyocyte hypertrophy.
Hideaki Tagashira, Fumiha Abe, Kaori Sato-Numata, Karen Aizawa, Kei Hirasawa, Yoshinobu Kure, Daiki Iwata, Tomohiro Numata
Frontiers in cell and developmental biology 11 1264076 - 1264076 2023.11 [Refereed]
Research paper (journal) Domestic Co-author
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Cell death induction and protection by activation of ubiquitously expressed anion/cation channels. Part 3: the roles and properties of TRPM2 and TRPM7.
Yasunobu Okada, Tomohiro Numata, Ravshan Z Sabirov, Makiko Kashio, Peter G Merzlyak, Kaori Sato-Numata
Frontiers in cell and developmental biology 11 1246955 - 1246955 2023.09 [Refereed]
Research paper (journal) International Co-author
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Intermediate conductance Ca2+ -activated potassium channels are activated by functional coupling with stretch-activated nonselective cation channels in cricket myocytes
Tomohiro Numata, Kaori Sato-Numata, Masami Yoshino
Frontiers in Insect Science 2023.01 [Refereed]
Research paper (journal) Domestic Co-author
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TRPM7 is an essential regulator for volume-sensitive outwardly rectifying anion channel
Tomohiro Numata, Kaori Sato-Numata, Meredith C. Hermosura, Yasuo Mori, Yasunobu Okada
Communications Biology ( Springer Science and Business Media LLC ) 4 ( 1 ) 599 - 599 2021.12 [Refereed]
Research paper (journal) International Co-author
<title>Abstract</title>Animal cells can regulate their volume after swelling by the regulatory volume decrease (RVD) mechanism. In epithelial cells, RVD is attained through KCl release mediated via volume-sensitive outwardly rectifying Cl<sup>−</sup> channels (VSOR) and Ca<sup>2+</sup>-activated K<sup>+</sup> channels. Swelling-induced activation of TRPM7 cation channels leads to Ca<sup>2+</sup> influx, thereby stimulating the K<sup>+</sup> channels. Here, we examined whether TRPM7 plays any role in VSOR activation. When TRPM7 was knocked down in human HeLa cells or knocked out in chicken DT40 cells, not only TRPM7 activity and RVD efficacy but also VSOR activity were suppressed. Heterologous expression of TRPM7 in TRPM7-deficient DT40 cells rescued both VSOR activity and RVD, accompanied by an increase in the expression of LRRC8A, a core molecule of VSOR. TRPM7 exerts the facilitating action on VSOR activity first by enhancing molecular expression of LRRC8A mRNA through the mediation of steady-state Ca<sup>2+</sup> influx and second by stabilizing the plasmalemmal expression of LRRC8A protein through the interaction between LRRC8A and the <italic>C</italic>-terminal domain of TRPM7. Therefore, TRPM7 functions as an essential regulator of VSOR activity and LRRC8A expression.
◆Original paper【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for JSPS Fellows
Project Year： 2018.10 - 2022.03
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Grant-in-Aid for Scientific Research(C)
Project Year： 2017.04 - 2020.03
Presentations 【 display / non-display 】
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Differences in functional properties between acid-sensitive chloride channels and volume-sensitive chloride channels
Kaori Sato-Numata [Invited]
ICMS (Ion Channel Modulation Symposium) 2024 Japan (東京大学 弥生講堂 一条ホール) 2024.05 - 2024.05 ソフィオン バイオサイエンス株式会社
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LRRC8Dのヒト上皮細胞における調節性容積減少への役割
佐藤（沼田）かお理, 鈴木太郎, 酒井彩子, 森俊太郎, 岡田泰伸, 沼田朋大
日本生理学会 第100回記念大会 (国立京都国際会館) 2023.03 - 2023.03 日本生理学会第100回記念大会
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バソプレシンニューロンは高浸透圧刺激に対して分泌性容積減少（SVD）と調節性容積増加（RVI）という相反性容積応答をする
佐藤（沼田）かお理，沼田朋大，上田陽一，岡田泰伸
第126回 日本解剖学会総会・全国学術集会, 第98回 日本生理学会大会 2021.03 - 2021.03
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Sensitivity of voltage-dependent Ca2+ channels in rat AVP neurons to an anthranilic acid derivative
Kaori Sato-Numata，Tomohiro Numata，Yoichi Ueta，Yasunobu Okada
The 9th Federation of Asian and Oceanian Physiological Societies (FAOPS) Congress 2019.03 - 2019.03
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Ionic mechanisms of cell volume regulation under hypo/hyperosmotic conditions in AVP neurons and effects of AVP secretion thereon
[Invited]
2018.07 - 2018.07