研究者詳細 - 小林　敬宏

Kobayashi Takahiro, Honami Sato, Miura Masatomo, Fukushi Yayoi, Kuroki Wataru, Ito Fumiko, Teshima Kazuaki, Watanabe Atsushi, Fujishima Naohito, Kobayashi Isuzu, Kameoka Yoshihiro, Takahashi Naoto

Cancer Chemotherapy and Pharmacology ( Springer Nature ) 2024年

CiNii Research

AMLのVEN/AZA治療におけるベネトクラクスの血中濃度と好中球減少症との関連

小林敬宏, 佐藤保奈実, 三浦昌朋, 福司弥生, 藤田菜々子, 黒木航, 伊藤史子, 手島和暁, 渡部敦, 藤島直仁, 高橋直人

日本血液学会学術集会 ( (一社)日本血液学会 ) 85回 377 - 377 2023年10月

Safe administration and pharmacokinetic monitoring of crushed venetoclax tablets with posaconazole and clarithromycin via percutaneous endoscopic gastrostomy tube in a patient with acute myeloid leukemia

Sato H.

Cancer Chemotherapy and Pharmacology ( Cancer Chemotherapy and Pharmacology ) 90 ( 3 ) 279 - 284 2022年09月

DOI

EMD originates from hyaluronan-induced homophilic interactions of CD44 variant-expressing MM cells under shear stress

Jiro Kikuchi, Nobuyuki Kodama, Masataka Takeshita, Sho Ikeda, Takahiro Kobayashi, Yoshiaki Kuroda, Michihiro Uchiyama, Naoki Osada, Bjarne Bogen, Hiroshi Yasui, Naoto Takahashi, Akiyoshi Miwa, Yusuke Furukawa

Blood Advances ( American Society of Hematology ) 7 ( 4 ) 508 - 524 2022年08月

Extramedullary disease (EMD) is known to be associated with chemoresistance and poor prognosis in multiple myeloma (MM); however, the mechanisms of its development are not fully understood. Elucidating the mechanism of EMD development and its therapeutic targeting would greatly contribute to further improvement of treatment outcome in MM patients. Here, we show that bone marrow stroma cell-derived hyaluronan elicits homophilic interactions of MM cells by binding to surface CD44, especially long-stretch variants, under physiological shear stress and generates cell clusters that might develop into EMD. We recapitulated the development of EMD via administration of hyaluronan in a syngeneic murine MM model in a CD44-dependent manner. Hyaluronan-induced MM cell clusters exhibited the specific resistance to proteasome inhibitors (PIs) in vitro and in murine models via γ-secretase-mediated cleavage of the intracellular domains of CD44, which in turn transactivated PI resistance-inducible genes. Treatment of hyaluronan-injected mice with anti-CD44 antibody or γ-secretase inhibitors readily suppressed the development of EMD from transplanted MM cells and significantly prolonged the survival of recipients by overcoming PI resistance. The hyaluronan-CD44 axis represents a novel pathway to trigger EMD development and could be a target of the prediction, prevention, and treatment of EMD in MM patients.

DOI

髄外病変はヒアルロン酸とCD44バリアントを介した骨髄腫細胞同士の凝集から発症する(Extramedullary diseases originate from hyaluronan-induced homophilic cell-cell interaction of CD44 variant-expressing myeloma cells)

菊池次郎, 小玉信之, 竹下昌孝, 比島智子, 池田翔, 小林敬宏, 黒田芳明, 内山倫宏, 長田直希, ボーゲン・ビヤーネ, 安井寛, 高橋直人, 三輪哲義, 古川雄祐

International Journal of Myeloma ( (一社)日本骨髄腫学会 ) 12 ( 3 ) 111 - 111 2022年05月

[Postmortem diagnosis of intravascular large B-cell lymphoma after atraumatic splenic rupture due to splenic infiltration].

Wataru Kuroki, Takahiro Kobayashi, Michinobu Umakoshi, Akihiro Kitadate, Chihiro Imaizumi, Masaya Saito, Isuzu Kobayashi, Masumi Fujishima, Naohito Fujishima, Tomoko Yoshioka, Akiteru Goto, Naoto Takahashi

[Rinsho ketsueki] The Japanese journal of clinical hematology ( 一般社団法人日本血液学会 ) 63 ( 6 ) 523 - 529 2022年

Atraumatic splenic rupture (ASR) is a rare but fatal complication of malignant lymphoma. However, only one case of intravascular large B-cell lymphoma (IVLBCL)-related ASR (IVLBCL-ASR) has previously been reported, and the mechanism of IVLBCL-ASR is unknown. We present the case of a 78-year-old man who died unexpectedly and was diagnosed with IVLBCL-ASR pathologically by autopsy. A massive intraperitoneal hemorrhage and four lacerations on the splenic surface were discovered during the autopsy. CD20-positive lymphoma cells that infiltrated into small vessels were highly concentrated in the center of the spleen and were only slightly distributed in the lacerations on the splenic surface. Therefore, increased intrasplenic pressure due to lymphoma cell proliferation was identified as the cause of ASR. The patient had undergone 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for tongue cancer evaluation 3 months earlier, and positive uptake was found in the right adrenal gland, where lymphoma cell infiltration was confirmed by the autopsy. Our findings suggest that clinicians should be aware that the advanced stage of IVLBCL can cause fatal ASR via increased intrasplenic pressure. Therefore, early diagnosis and early treatment intervention are desirable to prevent the onset of IVLBCL-ASR, and 18F-FDG PET/CT is useful for the early diagnosis of IVLBCL.

DOI PubMed CiNii Research

IGL/MYC再構成を有し、かつCD138の発現を伴うB細胞性リンパ芽球性白血病(Precursor B-lymphoblastic leukemia with IGL/MYC rearrangement and CD138 expression)

倉橋保奈実, 山下鷹也, 北舘明宏, 道下吉広, 川端良成, 北林淳, 松本奈津美, 齋藤雅也, 小林敬宏, 藤島直仁, 亀岡吉弘, 高橋直人

日本血液学会学術集会 ( (一社)日本血液学会 ) 83回 OS3 - 3 2021年09月

高腫瘍量濾胞性リンパ腫における治療前PET/CTを用いたTLGの予後予測因子としての有用性(Prognostic value of baseline total lesion glycolysis in high-tumor-burden follicular lymphoma)

黒木航, 北舘明宏, 山下鷹也, 小林敬宏, 池田翔, 奈良美保, 鵜生川久美, 藤島直仁, 吉岡智子, 石山公一, 亀岡吉弘, 高橋直人

日本血液学会学術集会 ( (一社)日本血液学会 ) 83回 OS1 - 1 2021年09月

血液形態診断のためのケースカンファレンス Cryptic translocationを認めたPML-RARA陽性微細顆粒型急性前骨髄球性白血病

菊地優子, 山下鷹也, 小林敬宏, 永沼綾子, 齊藤由紀子, 安保綾奈, 荒井杏子, 富谷陽子, 高橋直人, 植木重治

日本検査血液学会雑誌 ( (一社)日本検査血液学会 ) 22 ( 2 ) 263 - 269 2021年07月

症例は50歳代男性。職場の健診にて白血球増多を指摘され当院紹介となった。受診の2日前より発熱、頭痛あり、また最近誘因無く四肢に紫斑が出現することを自覚していた。受診時の血液検査所見として、白血球著増、貧血、血小板減少、線溶亢進型播種性血管内凝固症候群を認めた。末梢血液像は、核網繊細で核形不整が顕著な単球様細胞で占められており、僅かにアズール顆粒が豊富な細胞やファゴット細胞を認めた。骨髄像は末梢血と同様の異常細胞で占められており、細胞表面マーカーでは、CD2、CD13、CD33、CD117、MPOが陽性、CD34、CD56、HLA-DRが陰性であった。染色体検査は正常核型であったが、遺伝子検査ではPML-RARA融合遺伝子を認めたことから、cryptic translocationを認めたPML-RARA陽性微細顆粒型急性前骨髄球性白血病の診断に至った。本症例のように線溶亢進型播種性血管内凝固症候群と白血病細胞の増多を認めるが、典型的な急性前骨髄球性白血病細胞をほとんど認めない場合は、微細顆粒型急性前骨髄球性白血病を鑑別に挙げ、全トランス型レチノイン酸による治療を遅滞なく行うことが重要である。(著者抄録)

血液形態診断のためのケースカンファレンス Cryptic translocationを認めたPML-RARA陽性微細顆粒型急性前骨髄球性白血病

菊地優子, 山下鷹也, 小林敬宏, 永沼綾子, 齊藤由紀子, 安保綾奈, 荒井杏子, 富谷陽子, 高橋直人, 植木重治

日本検査血液学会雑誌 ( (一社)日本検査血液学会 ) 22 ( 2 ) 263 - 269 2021年07月

Correlation between increased immune checkpoint molecule expression and refractoriness to blinatumomab evaluated by longitudinal T cell analysis

Kobayashi T.

International Journal of Hematology ( International Journal of Hematology ) 2021年

DOI

Successful salvage therapy of D-PACE combined with pomalidomide in a patient with triple-class refractory secondary plasma cell leukemia

KOBAYASHI Takahiro, KUROKI Jun, KOBAYASHI Isuzu, SAITO Masaya, FUJISHIMA Masumi, UBUKAWA Kumi, FUJISHIMA Naohito, KAMEOKA Yoshihiro, NANJO Hiroshi, TAKAHASHI Naoto

International Journal of Myeloma ( 一般社団法人日本骨髄腫学会 ) 11 ( 4 ) 27 - 31 2021年

<p>Novel agents have dramatically improved the prognosis of multiple myeloma (MM). However, the prognosis of MM resistant to several classes of novel agents and secondary plasma cell leukemia (sPCL) is poor. In such cases, cisplatin, doxorubicin, cyclophosphamide, and etoposide (PACE)-based regimens are considered in combination with dexamethasone, thalidomide, and bortezomib. Herein, we report the case of a 47-year-old patient with Bence Jones Protein (BJP)-λ-type MM, primary refractory to bortezomib, lenalidomide, and dexamethasone (VRd) therapy, which subsequently progressed to sPCL accompanied with the acquired 17p deletion. Although the patient was also refractory to daratumumab-based therapy (triple-class refractory MM), he was successfully treated with dexamethasone and pomalidomide with PACE (DP-PACE) therapy, and after three cycles, he achieved complete remission (CR) and bridged to allogeneic stem cell transplantation (SCT). To the best of our knowledge, this is the first report of DP-PACE regimen, which may be considered for patients with relapsed refractory MM as a bridge to SCT.</p>

DOI CiNii Research

Successful salvage therapy of D-PACE combined with pomalidomide in a patient with triple-class refractory secondary plasma cell leukemia(和訳中)

Kobayashi Takahiro, Kuroki Jun, Kobayashi Isuzu, Saito Masaya, Fujishima Masumi, Ubukawa Kumi, Fujishima Naohito, Kameoka Yoshihiro, Nanjo Hiroshi, Takahashi Naoto

International Journal of Myeloma ( (一社)日本骨髄腫学会 ) 11 ( 4 ) 27 - 31 2021年

有毛細胞白血病を疑うリンパ球増多症で発症し,細胞表面解析から診断に至った慢性NK細胞増多症の一例

齊藤由紀子, 小林敬宏, 小林敬宏, 鎌田幸子, 亀岡吉弘, 菊地優子, 永沼綾子, 富谷陽子, 高橋直人, 嵯峨知生, 嵯峨知生, 植木重治, 植木重治

日本検査血液学会雑誌 22 2021年

J-GLOBAL

髄外疾患はヒアルロナン誘導同種親和性骨髄腫細胞-細胞相互作用に由来する【JST・京大機械翻訳】|||

菊池次郎, 小玉信之, 小玉信之, 竹下昌孝, 竹下昌孝, 比島智子, 比島智子, 池田翔, 小林敬宏, 黒田芳明, 内山倫宏, 長田直希, 小山大輔, BOGEN Bjarne, 安井寛, 高橋直人, 三輪哲義, 三輪哲義

日本血液学会学術集会抄録(Web) ( (一社)日本血液学会 ) 83rd ( 2 ) OS2 - 1 2021年

J-GLOBAL

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