NIYAMA Yukitoshi

写真a

Affiliation

Graduate School of Medicine  Doctorial Course in Medicine  Bioregulatory Medicine  Department of Anesthesia and Intensive Care Medicine
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Research Interests 【 display / non-display 】

  • TRP

  • transient receptor vanilloid subfamily 1

  • カプサイシン

  • 麻酔科

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Graduating School 【 display / non-display 】

  • 　
    -
    1998.03

    Sapporo Medical University   Faculty of Medicine   Graduated

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Graduate School 【 display / non-display 】

  • 　
    -
    2007.03

    Sapporo Medical University  Graduate School,Division of Medicine  Doctor's Course  Completed

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Campus Career 【 display / non-display 】

  • 2020.02
    -
    Now

    Akita University   Graduate School of Medicine   Doctorial Course in Medicine   Bioregulatory Medicine   Professor  

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Research Areas 【 display / non-display 】

  • Life Science / Anesthesiology

  • Life Science / Pathophysiologic neuroscience

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Qualification acquired 【 display / non-display 】

  • Doctor

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Thesis for a degree 【 display / non-display 】

  • The impact of air transport for acute coronary syndrome patients.

    Homma H, Niiyama Y, Sonoda H, Himuro N, Yamakage M 

      2019.03

    Domestic Co-author

  • Propofol target controlled infusion in obese Japanese patients: Evaluation of bias for predicted and measured concentrations. An open-label comparative study.

    Tachibana N, Niiyama Y, Yamakage M 

      2014.03

    Domestic Co-author

  • Suppression of bone marrow-derived microglia in the amygdala improves anxiety-like behavior induced by chronic partial sciatic nerve ligation in mice.

    Sawada A, Niiyama Y, Ataka K, Nagaishi K, Yamakage M, Fujimiya M 

      2014.03

    Domestic Co-author

  • Down-regulation of mu opioid receptor expression within distinct subpopulations of dorsal root ganglion neurons in a murine model of bone cancer pain.

    Yamamoto J, Kawamata T, Niiyama Y, Omote K, Namiki A 

      2014.03

    Domestic Co-author

  • Reduction of bone cancer pain by activation of spinal cannabinoid receptor 1 and its expression in the superficial dorsal horn of the spinal cord in a murine model of bone cancer pain.

    Furuse S, Kawamata T, Yamamoto J, Niiyama Y, Omote K, Watanabe M, Namiki A 

      2009.03

    Domestic Co-author

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Research Achievements 【 display / non-display 】

    ◆Original paper【 display / non-display 】

  • Influence of Different Sevoflurane Concentrations on Postoperative Cognitive Function in Aged Rats.

    Natsuko Yamamoto, Tetsu Kimura, Yukitoshi Niiyama

    Anesthesia and analgesia   136 ( 4 ) 772 - 778   2023.04

    Research paper (journal)  

    BACKGROUND: Postoperative cognitive dysfunction may be associated with neuroinflammation, and sevoflurane suppresses surgery-induced inflammation. We hypothesized that low concentrations of sevoflurane would result in more impaired postoperative cognitive function compared to high concentrations. METHODS: Aged male Sprague-Dawley rats (n = 21, 17-22 months) were randomly assigned to 1 of 3 groups: control (C), sevoflurane 2% (S2), and sevoflurane 4% (S4). Rats in the S2 and S4 groups underwent open femoral fracture and intramedullary fixation of the left hind limb under 2 hours of sevoflurane anesthesia. Neurological outcomes were evaluated using the Morris water maze (MWM) test, and histopathological outcomes were assessed 28 days after surgery. RESULTS: The S2 group showed prolonged swimming latency compared to S4 on day 7 (difference of means, 34.4; 95% confidence interval [CI], 2.57-66.3; P = .031) and compared to the C group on day 9 (difference of means, -33.4; 95% CI, -65.3 to -1.55; P = .037). The intact CA1 cells in the S2 group were significantly less than those in the C and S4 groups (H statistic, 10.87; P = .006 versus C; P = .033 versus S4). CONCLUSIONS: We found that low concentrations of sevoflurane prolonged the swimming latency of the MWM compared to high concentrations and reduced intact CA1 hippocampal neurons in aged rats. These results suggest that low-concentration sevoflurane anesthesia may be more detrimental than high concentration for spatial cognitive function and postoperative impairment of hippocampal CA1 cells in aged rats.

    DOI PubMed

  • Less postoperative sore throat after nasotracheal intubation using a fiberoptic bronchoscope than using a Macintosh laryngoscope: A double-blind, randomized, controlled study.

    Tachibana N, Niiyama Y, Yamakage M

    J Clin Anesth     2017.06

    Research paper (journal)   Domestic Co-author

  • Continuous wound infiltration with 0.2% ropivacaine versus a single intercostal nerve block with 0.75% ropivacaine for postoperative pain management after reconstructive surgery for microtia.

    Niiyama Y, Yotsuyanagi T, Yamakage M

    J Plast Reconstr Aesthet Surg     2016.10

    Research paper (journal)   Domestic Co-author

  • Incidence of cannot intubate-cannot ventilate (CICV): results of a 3-year retrospective multicenter clinical study in a network of university hospitals.

    Tachibana N, Niiyama Y, Yamakage M

    J Anesth     2015.06

    Research paper (journal)   Domestic Co-author

  • Involvement of transient receptor potential vanilloid subfamily 1 in endothelin-1-induced pain-like behavior.

    Kawamata T, Ji W, Yamamoto J, Niiyama Y, Furuse S, Omote K, Namiki A

    Neuroreport     2009.02

    Research paper (journal)   Domestic Co-author

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    ◆Other【 display / non-display 】

  • Combined spinal and epidural anesthesia for emergency cesarean section in a woman with congenital absence of the pericardium

    Saga Takashi, Kodama Sahoko, Ishino Hirokazu, Horikoshi Yuta, Goyagi Toru, Niiyama Yukitoshi

    Cardiovascular Anesthesia ( Japanese Society of Cardiovascular Anesthesiologists )  28 ( 1 ) 147 - 152   2024.09

    <p> A woman in her twenties (height: 166 cm, weight: 64 kg) underwent inpatient management for congenital absence of the pericardium, which complicated her pregnancy. However, she developed chest pain, and emergency cesarean section was performed at 34 weeks and 4 days of gestation. An antecedent MRI revealed an approximately 3 cm defect in the left ventricular apex epicardium with ECG changes dependent on positioning. Preoperatively, the patient experienced chest pain in the left lateral decubitus position, while being asymptomatic in the supine position. Combined spinal and epidural anesthesia (CSEA) was selected, with the puncture performed in the right lateral decubitus position. There was no subsequent conversion to the supine position perioperatively. Intraoperatively, the patient did not report chest pain and palpitations, and the hemodynamic status remained stable. The pericardial defect at the left ventricular apex may have deviated due to the left lateral decubitus position, resulting in thoracic symptoms. Contributing factors to exacerbating symptoms may include physical factors associated with uterine enlargement throughout the pregnancy and increased pre-load due to augmented circulatory blood volume. Considering the uncertainty surrounding the impact of positive pressure ventilation on the mother and fetus, general anesthesia was avoided, and CSEA, which our institution is most proficient in, was selected for perioperative management for pericardial defect complicating pregnancy. While there is no definitive consensus regarding the selection of anesthetic techniques for cesarean sections in cases of congenital absence of the pericardium during pregnancy, this case demonstrated the feasibility of stable anesthetic management with CSEA.</p>

    DOI CiNii Research

  • A Case of Tracheobronchopathia Osteochondroplastica Discovered Accidentally by Difficult Intubation

    KONNO Toshihiro, KODAMA Sahoko, KIMURA Tetsu, NIIYAMA Yukitoshi

    THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA ( THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA )  41 ( 2 ) 152 - 155   2021

    <p>We experienced a case of Tracheobronchopathia Osteochondroplastica(TO)discovered by difficult tracheal intubation during general anesthesia. A 66 year-old woman was diagnosed with acute appendicitis, and underwent emergency surgery under general anesthesia. Mask ventilation was easily performed after induction of anesthesia. Despite Cormack-Lehane grade I with direct laryngoscopy, the end-tracheal tube with an internal diameter(ID)of 7.0 mm could not pass through the glottis because of friction beneath the glottis. After confirming mask ventilation, we re-assessed the airway with computed tomography images. Several protrusions from the anterior part of the tracheal wall seemed to disrupt tracheal intubation. Finally, the trachea was successfully intubated with the thinner tube(ID 6.0 mm), rotating the bevel toward the posterior wall of the trachea after passing the glottis.</p><p>Because TO often progresses asymptomatically, patients with TO may undergo general anesthesia without a diagnosis. Although TO is one cause of difficult intubation, patients can be managed safely.</p>

    DOI

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Grant-in-Aid for Scientific Research 【 display / non-display 】

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2023.04  -  2027.03 

  • Grant-in-Aid for Scientific Research(C)

    Project Year： 2021.04  -  2024.03 

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Presentations 【 display / non-display 】

  • Effects of gender, age, and body mass undex on sedation level during infusion of propofol by target-controlled infusion.

    Niiyama Y, Omote K, Kawamata T, Namiki A

    米国麻酔科学会  2002.10  -  2002.10 

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