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Affiliation |
Hospital Internal MedicineⅢ |
Graduating School 【 display / non-display 】
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2014.04-2018.09
Akita University Graduate School of Medicine Graduated
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-2010.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2018.09
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2024.09-Now
Akita University Hospital Internal MedicineⅢ Assistant Professor
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2023.04-2024.08
Akita University Hospital Pharmaceutical Management Center Assistant Professor
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2019.10-2023.03
Akita University Hospital Internal MedicineⅢ Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Connective tissue disease and allergy
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Life Science / Nephrology
Thesis for a degree 【 display / non-display 】
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Clinicopathological and long-term prognostic features of membranous nephropathy with crescents: a Japanese single-center experience.
Saito M, Komatsuda A, Sato R, Saito A, Kaga H, Abe F, Sawamura M, Nara M, Togashi M, Okuyama S, Wakui H, Takahashi N.
2018.09
Domestic Co-author
Research Achievements 【 display / non-display 】
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Multiple myeloma-associated non-crystalline proximal tubulopathy and crystalline cast nephropathy: Biochemical and structural features of disease-causing monoclonal kappa light chains.
Toshinori Ezawa, Riku Otomo, Yumi Kariya, Kyoko Nozawa, Sonosuke Kyoya, Chikako Furutani, Keiichi Noguchi, Masafumi Yohda, Masafumi Odaka, Hirotoshi Matsumura, Ayano Saito, Masaya Saito, Fumito Abe, Yuki Fujioka, Akihiro Kitadate, Hideki Wakui, Naoto Takahashi
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 39 ( 1 ) e70296 2025.01
Research paper (journal)
Various tubular diseases in patients with multiple myeloma (MM) are caused by monoclonal immunoglobulin light chains (LCs). However, the physicochemical characteristics of the disease-causing LCs contributing to the onset of MM-associated tubular diseases remain unclear. We herein report a rare case of MM-associated combined tubulopathies: non-crystalline light chain proximal tubulopathy (LCPT) and crystalline light chain cast nephropathy (LCCN). The patient's urinary κ-LC (Bence-Jones proteins, BJP-κ PT-CN) was detected through immunofixation. Renal biopsy revealed cytoplasmic vacuoles in swollen proximal tubular cells and distal tubular casts. Immunohistochemistry showed proximal tubular reabsorption granules and distal tubular casts positively stained with an anti-κ-LC antibody. Electron microscopy identified vacuolation and an increased number of lysosomes in proximal tubular epithelial cells without crystalline structures. Distal tubular casts comprised numerous crystals with both rod-shaped and needle-like configurations and tube-shaped materials. To elucidate the molecular mechanisms underlying tubular toxicity, we performed the following physicochemical analyses of BJP-κ PT-CN: N-terminal amino acid sequencing, cDNA cloning, size-exclusion chromatography, thermal shift assays, and X-ray crystallography. The variable segment of BJP-κ PT-CN was derived from the IGKV1-39 gene. The characteristic features of BJP-κ PT-CN were a positively charged surface patch, concentration-dependent monomer-dimer equilibrium, and the R61G mutation. This is the first biochemical and structural characterization of disease-causing BJPs in MM-associated LCPT and crystalline LCCN. The results obtained suggest that these characteristic features enhance protein binding to negatively charged sites on brush-border membranes in proximal tubules and promote the formation of organized casts in distal tubular lumens.
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Cutaneous Squamous Cell Carcinoma Producing Granulocyte Colony-stimulating Factor and Parathyroid Hormone-related Protein: A Case Report and Literature Review.
Takuya Kumagai, Masaya Saito, Takahiko Sato, Junichi Inoue, Norihisa Ishikawa, Tsuyoshi Ono, Michihiro Kono, Naoto Takahashi
Internal medicine (Tokyo, Japan) 2024.12 [Refereed]
Research paper (journal)
We herein report a case of cutaneous squamous cell carcinoma (SCC) characterized by paraneoplastic hypercalcemia-leukocytosis syndrome. The patient presented with systemic symptoms, including anorexia, a fever, and a tumoral lesion on the upper arm. Laboratory test results revealed hypercalcemia and leukocytosis. A tissue biopsy confirmed SCC, and further investigation revealed elevated parathyroid hormone-related protein (PTHrP) and granulocyte-colony stimulating factor (G-CSF) levels. Immunostaining demonstrated G-CSF production by the tumor cells. Radiation therapy was administered, which improved leukocytosis and decreased G-CSF and PTHrP levels. Through a case report and literature review, we explored the clinical characteristics of tumors that produce G-CSF and PTHrP.
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Successful Treatment of Monoclonal Immunotactoid Glomerulopathy Associated with Chronic Lymphocytic Leukemia Using Ibrutinib.
Ayano Saito, Yoshihiro Kameoka, Kumi Ubukawa, Hiroshi Ohtani, Fumito Abe, Masaya Saito, Mako Hashimoto, Tatsuro Kanazawa, Atsushi Komatsuda, Naoto Takahashi
Internal medicine (Tokyo, Japan) 2024.10 [Refereed]
Research paper (journal)
A 71-year-old woman developed nephrotic syndrome during 10-year follow-up for chronic lymphocytic leukemia. A renal biopsy sample analysis revealed IgG1-lambda-positive monoclonal immunotactoid glomerulopathy (mITG). The patient was treated with ibrutinib, a Bruton tyrosine kinase inhibitor, and complete renal remission was achieved after 24 months. ITG is a rare disease that is characterized by glomerular deposition. In particular, mITG, which presents immune deposits that exhibit light-chain restriction, is often associated with hematologic disorders. Most patients with mITG receive immunosuppressive therapy and/or chemotherapy; however, to our knowledge, there have been no reports of treatment with ibrutinib.
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IGL/MYC再構成を有し、かつCD138の発現を伴うB細胞性リンパ芽球性白血病(Precursor B-lymphoblastic leukemia with IGL/MYC rearrangement and CD138 expression)
倉橋 保奈実, 山下 鷹也, 北舘 明宏, 道下 吉広, 川端 良成, 北林 淳, 松本 奈津美, 齋藤 雅也, 小林 敬宏, 藤島 直仁, 亀岡 吉弘, 高橋 直人
日本血液学会学術集会 ( (一社)日本血液学会 ) 83回 OS3 - 3 2021.09
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Kobayashi Takahiro, Kuroki Jun, Kobayashi Isuzu, Saito Masaya, Fujishima Masumi, Ubukawa Kumi, Fujishima Naohito, Kameoka Yoshihiro, Nanjo Hiroshi, Takahashi Naoto
International Journal of Myeloma ( (一社)日本骨髄腫学会 ) 11 ( 4 ) 27 - 31 2021
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MALTリンパ腫に発症した膜性増殖性糸球体腎炎
阿部 史人, 齋藤 綾乃, 齋藤 雅也, 澤村 昌人, 奈良 瑞穂, 佐藤 隆太, 奥山 慎, 小松田 敦, 涌井 秀樹
日本腎臓学会誌 ( (一社)日本腎臓学会 ) 60 ( 6 ) 922 - 922 2018.08
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腸炎を契機に発症した横紋筋融解に伴う急性腎障害
齋藤 雅也, 渡邊 春佳, 阿部 史人, 池田 翔, 奈良 瑞穂, 鵜生川 久美, 佐藤 隆太, 奥山 慎, 亀岡 吉弘, 小松田 敦, 高橋 直人
日本腎臓学会誌 ( (一社)日本腎臓学会 ) 60 ( 6 ) 902 - 902 2018.08
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特発性膜性腎症における抗PLA2R抗体の経時的推移の検討
阿部 史人, 澤村 昌人, 齋藤 綾乃, 齋藤 雅也, 加賀 一, 小澤 政豊, 大谷 浩, 奥山 慎, 小松田 敦, 涌井 秀樹, 高橋 直人
日本腎臓学会誌 ( (一社)日本腎臓学会 ) 60 ( 3 ) 370 - 370 2018.04
◆Original paper【 display / non-display 】
◆Other【 display / non-display 】
Grant-in-Aid for Scientific Research 【 display / non-display 】
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Grant-in-Aid for Scientific Research(C)
Project Year： 2024.04 - 2027.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
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Grant-in-Aid for Early-Career Scientists
Project Year： 2021.04 - 2024.03
Presentations 【 display / non-display 】
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腸炎を契機に発症した横紋筋融解に伴う急性腎障害
齋藤 雅也, 渡邊 春佳, 阿部 史人, 池田 翔, 奈良 瑞穂, 鵜生川 久美, 佐藤 隆太, 奥山 慎, 亀岡 吉弘, 小松田 敦, 高橋 直人
日本腎臓学会誌 2018.08 - 2018.08 (一社)日本腎臓学会
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半月体形成糸球体を伴う膜性腎症の臨床病理学的検討
齋藤 雅也, 小松田 敦, 佐藤 隆太, 齋藤 綾乃, 阿部 史人, 加賀 一, 澤村 昌人, 涌井 秀樹, 高橋 直人
日本腎臓学会誌 2017.04 - 2017.04 (一社)日本腎臓学会
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Distribution pattern of glomerular IgG subclass deposits in membranous nephropathy patients with crescent formation and positive MPO-ANCA
Masaya Saito
The 18th International Vasculitis & ANCA Workshop 2017.03 - 2017.03
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腎浸潤と膜性腎症を合併したマントル細胞リンパ腫
齋藤 雅也, 今泉 ちひろ, 加賀 一, 阿部 史人, 齋藤 綾乃, 奈良 瑞穂, 面川 歩, 富樫 賢, 奥山 慎, 涌井 秀樹, 三田 亜紀子, 茂木 睦仁, 仁村 隆, 小松田 敦, 高橋 直人
日本腎臓学会誌 2016.08 - 2016.08 (一社)日本腎臓学会
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ステロイド依存性微小変化型ネフローゼ症候群のリツキシマブ治療における尿中リツキシマブ濃度の検討
齋藤 雅也, 小原 綾乃, 加賀 一, 阿部 史人, 奈良 瑞穂, 面川 歩, 富樫 賢, 奥山 慎, 涌井 秀樹, 小松田 敦, 高橋 直人
日本腎臓学会誌 2016.05 - 2016.05 (一社)日本腎臓学会
Academic Activity 【 display / non-display 】
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2024.04-Now
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2020.10-Now
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2020.04-Now