|
所属 |
附属病院 第二外科 |
|
生年 |
1982年 |
|
研究室住所 |
秋田市本道1-1-1 |
職務経歴（学内） 【 表示 ／ 非表示 】
-
2021年04月-継続中
秋田大学 附属病院 第二外科 講師
-
2019年04月-2021年03月
秋田大学 大学院医学系研究科（医学専攻等） 医学専攻 腫瘍制御医学系 助教
研究経歴 【 表示 ／ 非表示 】
-
非小細胞肺がん術後補助化学療法としての カルボプラチン+ゲムシタビンの効果と安全性に関しての検討
（選択しない）
研究期間：
2019年04月-継続中研究態様：機関内共同研究
-
Cyclin B2 mRNAの発現と非小細胞肺癌予後との関連性の検討
（選択しない）
研究期間：
2013年04月-2014年03月研究態様：機関内共同研究
学位論文 【 表示 ／ 非表示 】
-
Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S, Minamiya Y
Tumor Biology 35 ( 5 ) 4257 - 4265 2014年03月 [査読有り]
国内共著
研究等業績 【 表示 ／ 非表示 】
-
Prognostic impact of preoperative osteopenia in elderly patients with lung cancer
Kuriyama S.
World Journal of Surgical Oncology ( World Journal of Surgical Oncology ) 24 ( 1 ) 26 - 26 2026年12月
研究論文（学術雑誌）
BACKGROUND: Osteopenia was recently reported to be a factor contributing to a poorer prognosis in various cancers. However, its prognostic impact on non-small cell lung cancer (NSCLC) patients remains unclear. In the present study, we focused on osteopenia in elderly NSCLC patients and investigated survival outcomes. METHODS: This study included 315 NSCLC patients aged 75 years or older who had undergone radical lobectomy or segmentectomy at our institution between 2010 and 2023. Osteopenia was evaluated based on the average pixel density within a circle in the mid-vertebral core at the 11th thoracic vertebra on preoperative computed tomography. RESULTS: Osteopenia was identified in 126 patients (40%). This osteopenia group had significantly poorer overall survival (OS) than the non-osteopenia group (5-year OS: 71.4%vs 81.0%, p = 0.026). Multivariable analysis revealed that Charlson comorbidity index (CCI) ≥ 2 (p = 0.020), Brinkman index (BI) ≥ 400 (p < 0.001), pathological Stage ≥ II (p < 0.001), and osteopenia (p = 0.016) were independent factors affecting OS. The cumulative incidence of non-lung cancer mortality was significantly higher in the osteopenia group than non-osteopenia group (5-year mortality rate: 16.9% vs. 6.4%, p = 0.005). In multivariable analysis, CCI ≥ 2 (p = 0.009), BI ≥ 400 (p < 0.008) and osteopenia (p = 0.001) were independent factors affecting non-lung cancer mortality. CONCLUSIONS: Elderly patients with osteopenia have significantly poorer OS, and osteopenia was closely associated with non-lung cancer mortality. Screening for osteopenia may assist in identifying high-risk patients of non-lung cancer death and developing appropriate treatment strategies.
-
Imai K.
Cancer Imaging ( Cancer Imaging ) 24 ( 1 ) 69 - 69 2024年12月
研究論文（学術雑誌）
BACKGROUND: Accurate clinical staging is crucial for selection of optimal oncological treatment strategies in non-small cell lung cancer (NSCLC). Although brain MRI, bone scintigraphy and whole-body PET/CT play important roles in detecting distant metastases, there is a lack of evidence regarding the indication for metastatic staging in early NSCLCs, especially ground-grass nodules (GGNs). Our aim was to determine whether checking for distant metastasis is required in cases of clinical T1N0 GGN. METHODS: This was a retrospective study of initial staging using imaging tests in patients who had undergone complete surgical R0 resection for clinical T1N0 Stage IA NSCLC. RESULTS: A total of 273 patients with cT1N0 GGNs (n = 183) or cT1N0 solid tumors (STs, n = 90) were deemed eligible. No cases of distant metastasis were detected on initial routine imaging evaluations. Among all cT1N0M0 cases, there were 191 incidental findings on various modalities (128 in the GGN). Most frequently detected on brain MRI was cerebral leukoaraiosis, which was found in 98/273 (35.9%) patients, while cerebral infarction was detected in 12/273 (4.4%) patients. Treatable neoplasms, including brain meningioma and thyroid, gastric, renal and colon cancers were also detected on PET/CT (and/or MRI). Among those, 19 patients were diagnosed with a treatable disease, including other-site cancers curable with surgery. CONCLUSIONS: Extensive staging (MRI, scintigraphy, PET/CT etc.) for distant metastasis is not required for patients diagnosed with clinical T1N0 GGNs, though various imaging modalities revealed the presence of adventitious diseases with the potential to increase surgical risks, lead to separate management, and worsen patient outcomes, especially in elderly patients. If clinically feasible, it could be considered to complement staging with whole-body procedures including PET/CT.
-
A case of right middle lobectomy for primary lung cancer in a patient with heterotaxy syndrome.
Ryo Demura, Kazuhiro Imai, Shinogu Takashima, Nobuyasu Kurihara, Shoji Kuriyama, Haruka Suzuki, Yuzu Harata, Yoshihiro Minamiya
General Thoracic and Cardiovascular Surgery Cases ( General Thoracic and Cardiovascular Surgery Cases ) 3 ( 1 ) 52 - 52 2024年11月
研究論文（学術雑誌）
BACKGROUND: Anatomical abnormalities in the pulmonary vessels have long aroused great interest among thoracic surgeons, and numerous variations of pulmonary vessels have been reported. Heterotaxy syndrome is an anatomical abnormality in which typically asymmetrical organs, including the lungs, develop symmetrically. We report the case of a 71-year-old man with heterotaxy syndrome undergoing radical lobectomy in the treatment of non-small cell lung cancer. CASE PRESENTATION: Computed tomography (CT) revealed an irregular nodule 25 mm in diameter in the right middle lobe. Two months later, at his first visit to our University Hospital, CT revealed a rapidly growing tumor 60 mm in diameter. In addition, three-dimensional (3D) CT revealed the upper and middle lobar bronchi forming a common trunk with the mediastinal type of the right pulmonary artery (PA). The patient underwent video-assisted right middle lobectomy + systematic complete hilar and mediastinal lymph node dissection. The interlobar fissure between the right upper and middle lobes was incomplete, and the common trunk formed by the upper-middle bronchus emerged from an area between the right PA (A1+3) and the right superior pulmonary vein. CONCLUSION: The finding of A4+5 branching from the right main PA and descending posterior to the right upper-middle bronchus, which formed a common trunk, resembled a mirror image of the normal left lung. To our knowledge, a common trunk with the mediastinal type of the right PA has never been reported during video-assisted right middle lobectomy. In patients with heterotaxy syndrome, 3D-CT to preoperatively understand their anatomy is essential.
-
Kuriyama S.
Thoracic Cancer ( Thoracic Cancer ) 15 ( 21 ) 1681 - 1684 2024年07月
研究論文（学術雑誌）
When a mass occurs at the staple line following lung resection, it can be difficult to distinguish between local cancer recurrence and granuloma. We present a case of a staple-line granuloma with 18F-fluorodeoxyglucose-positron emission tomography uptake and elevated serum carbohydrate antigen 19-9 (CA19-9) in a patient with ovarian cancer lung metastasis. After granuloma resection, serum CA19-9 levels normalized, and CA19-9 positive cells were identified in the resected tumor. Therefore, serum CA19-9 elevation does not rule out a staple-line granuloma. Whereas granulomas on computed tomography (CT) scans tend to show smooth shadows along the staple line unilaterally, detailed CT evaluation may help diagnostic differentiation. Differentiation based on imaging and tumor markers has limitations. However, core needle biopsy has the risk of misdiagnosis and tumor cell dissemination, therefore surgical resection should be considered when comprehensive findings indicate a potential recurrence.
-
Tracheal bifurcation repair for blunt thoracic trauma in a patient with COVID-19.
Shoji Kuriyama, Kazuhiro Imai, Kasumi Tozawa, Shinogu Takashima, Ryo Demura, Haruka Suzuki, Yuzu Harata, Tatsuki Fujibayashi, Sumire Shibano, Yoshihiro Minamiya
Surgical case reports 9 ( 1 ) 108 - 108 2023年06月
研究論文（学術雑誌）
BACKGROUND: Tracheobronchial injury (TBI) is a rare but potentially life-threatening trauma that requires prompt diagnosis and treatment. We present a case in which a patient with COVID-19 infection was successfully treated for a TBI through surgical repair and intensive care with extracorporeal membrane oxygenation (ECMO) support. CASE PRESENTATION: This is the case of a 31-year-old man transported to a peripheral hospital following a car crash. Tracheal intubation was performed for severe hypoxia and subcutaneous emphysema. Chest computed tomography showed bilateral lung contusion, hemopneumothorax, and penetration of the endotracheal tube beyond the tracheal bifurcation. A TBI was suspected; moreover, his COVID-19 polymerase chain reaction screening test was positive. Requiring emergency surgery, the patient was transferred to a private negative pressure room in our intensive care unit. Due to persistent hypoxia and in preparation for repair, the patient was started on veno-venous ECMO. With ECMO support, tracheobronchial injury repair was performed without intraoperative ventilation. In accordance with the surgery manual for COVID-19 patients in our hospital, all medical staff who treated this patient used personal protective equipment. Partial transection of the tracheal bifurcation membranous wall was detected and repaired using 4-0 monofilament absorbable sutures. The patient was discharged on the 29th postoperative day without postoperative complications. CONCLUSIONS: ECMO support for traumatic TBI in this patient with COVID-19 reduced mortality risk while preventing aerosol exposure to the virus.
-
Advantage of Sleeve Right Lower Lobectomy for Lung Cancer in COPD Patients: A Case Series
Harata Y.
Thoracic Cancer ( Thoracic Cancer ) 17 ( 3 ) 2026年02月
-
転移性肺腫瘍との鑑別を要した多発肺海綿状血管腫の1例
湯川 涼介, 高嶋 祉之具, 松尾 翼, 栗山 章司, 今井 一博
肺癌 ( (NPO)日本肺癌学会 ) 65 ( 6 ) 986 - 986 2025年10月
-
ロボット支援下に摘出した後縦隔ミュラー管嚢胞の1例
土井 孝太, 高嶋 祉之具, 松尾 翼, 栗山 章司, 今井 一博
肺癌 ( (NPO)日本肺癌学会 ) 65 ( 6 ) 986 - 986 2025年10月
-
男性に発症した不完全型Carney's triadの1例
石井 良明, 高嶋 祉之具, 松尾 翼, 栗山 章司, 岩井 英頌, 鈴木 陽香, 加藤 佳亮, 今井 一博
肺癌 ( (NPO)日本肺癌学会 ) 65 ( 6 ) 985 - 985 2025年10月
-
Takashima S.
Thoracic Cancer ( Thoracic Cancer ) 16 ( 8 ) e70077 2025年04月
BACKGROUND: As the population ages, the number of elderly lung cancer patients has been increasing. While surgery is the best treatment for resectable lung cancer, elderly patients often have multiple comorbidities, making accurate preoperative risk assessment crucial when formulating an appropriate treatment plan. This study aims to explore how psoas muscle volume relates to postoperative outcomes in elderly lung cancer patients. METHODS: This single-center, retrospective study included 344 elderly (≥ 75) patients who underwent complete surgical resection for non-small cell cancer between 2010 and 2023. The psoas muscle volume index (PVI, cm3/m3) was measured using a 3-dimensional imaging workstation based on preoperative computed tomography images and grouped based on the median value for each gender. Postoperative complications and survival rates were then compared between the groups. RESULTS: The median PVI was 60.5 cm3/m3 for males and 47.7 cm3/m3 for females. The PVI-high group had significantly fewer complications (15.6%) than the PVI-low group (37.1%) (p < 0.001). The 5-year overall survival (OS) rate was higher in the PVI-high group (80.5%) than in the PVI-low group (66.7%) (p = 0.01). Multivariate analyses showed that PVI-high was an independent predictor of lower complication risk (odds ratio 0.28, p < 0.001) and an independent factor that improved OS (hazard ratio 0.60, p = 0.042). CONCLUSIONS: PVI in elderly lung cancer patients is associated with postoperative complications and survival.
◆原著論文【 表示 ／ 非表示 】
◆その他【 表示 ／ 非表示 】
科研費（文科省・学振）獲得実績 【 表示 ／ 非表示 】
-
血液製剤を使用しない確実な肺瘻閉鎖を実現するガロール基高強度水中接着シートの開発
基盤研究(C)
研究期間: 2025年04月 - 2028年03月 代表者: 高嶋 祉之具, 江島 広貴, 松尾 翼, 佐藤 雄亮, 栗山 章司, 今井 一博