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Affiliation |
Hospital SurgeryⅡ |
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Date of Birth |
1982 |
Graduating School 【 display / non-display 】
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2001.04-2007.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2014.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2021.04-Now
Akita University Hospital SurgeryⅡ Lecturer
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2019.04-2021.03
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Respiratory surgery
Thesis for a degree 【 display / non-display 】
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Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S, Minamiya Y
Tumor Biology 35 ( 5 ) 4257 - 4265 2014.03 [Refereed]
Domestic Co-author
Research Achievements 【 display / non-display 】
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A case of right middle lobectomy for primary lung cancer in a patient with heterotaxy syndrome.
Ryo Demura, Kazuhiro Imai, Shinogu Takashima, Nobuyasu Kurihara, Shoji Kuriyama, Haruka Suzuki, Yuzu Harata, Yoshihiro Minamiya
General Thoracic and Cardiovascular Surgery Cases 3 ( 1 ) 52 - 52 2024.11
Research paper (journal)
BACKGROUND: Anatomical abnormalities in the pulmonary vessels have long aroused great interest among thoracic surgeons, and numerous variations of pulmonary vessels have been reported. Heterotaxy syndrome is an anatomical abnormality in which typically asymmetrical organs, including the lungs, develop symmetrically. We report the case of a 71-year-old man with heterotaxy syndrome undergoing radical lobectomy in the treatment of non-small cell lung cancer. CASE PRESENTATION: Computed tomography (CT) revealed an irregular nodule 25 mm in diameter in the right middle lobe. Two months later, at his first visit to our University Hospital, CT revealed a rapidly growing tumor 60 mm in diameter. In addition, three-dimensional (3D) CT revealed the upper and middle lobar bronchi forming a common trunk with the mediastinal type of the right pulmonary artery (PA). The patient underwent video-assisted right middle lobectomy + systematic complete hilar and mediastinal lymph node dissection. The interlobar fissure between the right upper and middle lobes was incomplete, and the common trunk formed by the upper-middle bronchus emerged from an area between the right PA (A1+3) and the right superior pulmonary vein. CONCLUSION: The finding of A4+5 branching from the right main PA and descending posterior to the right upper-middle bronchus, which formed a common trunk, resembled a mirror image of the normal left lung. To our knowledge, a common trunk with the mediastinal type of the right PA has never been reported during video-assisted right middle lobectomy. In patients with heterotaxy syndrome, 3D-CT to preoperatively understand their anatomy is essential.
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Tracheal bifurcation repair for blunt thoracic trauma in a patient with COVID-19.
Shoji Kuriyama, Kazuhiro Imai, Kasumi Tozawa, Shinogu Takashima, Ryo Demura, Haruka Suzuki, Yuzu Harata, Tatsuki Fujibayashi, Sumire Shibano, Yoshihiro Minamiya
Surgical case reports 9 ( 1 ) 108 - 108 2023.06
Research paper (journal)
BACKGROUND: Tracheobronchial injury (TBI) is a rare but potentially life-threatening trauma that requires prompt diagnosis and treatment. We present a case in which a patient with COVID-19 infection was successfully treated for a TBI through surgical repair and intensive care with extracorporeal membrane oxygenation (ECMO) support. CASE PRESENTATION: This is the case of a 31-year-old man transported to a peripheral hospital following a car crash. Tracheal intubation was performed for severe hypoxia and subcutaneous emphysema. Chest computed tomography showed bilateral lung contusion, hemopneumothorax, and penetration of the endotracheal tube beyond the tracheal bifurcation. A TBI was suspected; moreover, his COVID-19 polymerase chain reaction screening test was positive. Requiring emergency surgery, the patient was transferred to a private negative pressure room in our intensive care unit. Due to persistent hypoxia and in preparation for repair, the patient was started on veno-venous ECMO. With ECMO support, tracheobronchial injury repair was performed without intraoperative ventilation. In accordance with the surgery manual for COVID-19 patients in our hospital, all medical staff who treated this patient used personal protective equipment. Partial transection of the tracheal bifurcation membranous wall was detected and repaired using 4-0 monofilament absorbable sutures. The patient was discharged on the 29th postoperative day without postoperative complications. CONCLUSIONS: ECMO support for traumatic TBI in this patient with COVID-19 reduced mortality risk while preventing aerosol exposure to the virus.
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Inferior pulmonary ligament division during left upper lobectomy causes pulmonary dysfunction.
Shoji Kuriyama, Kazuhiro Imai, Hajime Saito, Shinogu Takashima, Nobuyasu Kurihara, Ryo Demura, Haruka Suzuki, Yuzu Harata, Yusuke Sato, Katsutoshi Nakayama, Kyoko Nomura, Yoshihiro Minamiya
Interdisciplinary cardiovascular and thoracic surgery ( Interdisciplinary Cardiovascular and Thoracic Surgery ) 36 ( 5 ) 2023.05
Research paper (journal)
OBJECTIVES: The division of inferior pulmonary ligament (IPL) during upper lobectomy (UL) was believed to be mandatory to dilate the remaining lung sufficiently. However, the benefits, especially postoperative pulmonary function, remain controversial. This study aimed to evaluate whether IPL division leads to pulmonary dysfunction. METHODS: This retrospective study included 213 patients who underwent UL between 2005 and 2018. They were categorized into an IPL division group (D group, n = 106) and a preservation group (P group, n = 107). Postoperative dead space at the lung apex, pulmonary function and complications were assessed using chest X-rays and spirometry. Changes in bronchial angle, cross-sectional area and circumference of the narrowed bronchus on the excised side were measured on three-dimensional computed tomography. RESULTS: There was no significant difference in the postoperative complication rate, the dead space area, forced vital capacity (FVC), or forced expiratory volume in 1 s (FEV1) between the 2 groups after right UL (FVC; P = 0.838, FEV1; P = 0.693). By contrast, after left UL pulmonary function was significantly better in the P than in the D group (FVC; P = 0.038, FEV1; P = 0.027). Changes in bronchial angle did not significantly differ between the 2 groups. The narrowed bronchus's cross-sectional area (P = 0.021) and circumference (P = 0.009) were significantly smaller in the D group than in the P group after left UL. CONCLUSIONS: IPL division during left UL caused postoperative pulmonary dysfunction and airflow limitation due to bronchial kinking. IPL preservation may have a beneficial impact on postoperative pulmonary function.
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Changes in Serum Trace Element Concentrations before and after Surgery in Resectable Breast Cancer
Takahashi E.
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5323 - 5334 2022.11 [Refereed]
Research paper (journal) Domestic Co-author
BACKGROUND/AIM: Minerals and trace elements (TEs) play vital roles in normal biological functions and in all cancers. Breast carcinoma is the most commonly occurring cancer in women. The aim of this study was to evaluate changes in TE levels before and after breast cancer surgery and the clinical utility and reliability of TE levels assayed using inductively coupled plasma mass spectrometry (ICP-MS). PATIENTS AND METHODS: Thirteen patients with ductal carcinoma in situ (DCIS) and 34 with invasive ductal carcinoma (IDC) treated with planned surgery were enrolled between August 2017 and February 2019. Blood samples were collected before and the day after resection of the primary tumor. All enrolled patients received mastectomy or quadrantectomy and axillary lymph node dissection/biopsy. Serum TE concentrations were determined using ICP-MS. RESULTS: Changes in boron, titanium, vanadium, chromium, copper, zinc, and selenium levels from before to after surgery differed between IDC and DCIS patients. Boron and copper levels before surgery and changes in titanium, vanadium, and chromium before and after surgery are potential predictors distinguishing DCIS from IDC. Subset analysis showed that chromium is a potential biomarker for luminal subtype, while titanium and chromium are potential biomarkers for pathological staging. CONCLUSION: Changes in serum TEs before and after surgery may help with diagnosis and staging of breast cancer and in establishing TE supplementation protocols.
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Atari M.
Lung Cancer ( Lung Cancer ) 173 75 - 82 2022.11 [Refereed]
Research paper (journal) Domestic Co-author
OBJECTIVES: Locoregional recurrence of non-small cell lung cancer (NSCLC) occurs even among patients with stage I disease, as a result of tumor proliferative activity. The aim of this study was to evaluate the clinical reliability of a new rapid immunohistochemistry (IHC) technique for assessing malignant potential through detection of tumoral Ki-67 expression. MATERIALS AND METHODS: The rapid IHC method uses non-contact alternating current (AC) mixing to achieve more rapid/stable staining within 20 min during surgery. First, to investigate the association between clinical outcomes and tumoral Ki-67 labeling with rapid IHC, 21 pairs of surgical patients treated between 2012 and 2020 for pStage IA1-3 NSCLC with/without recurrence were retrospectively reviewed. Second, 40 frozen section (FS) samples in patients with NSCLC for whom radical surgery was planned between April 2021 and February 2022 were deemed eligible for comparison of the clinical performance of conventional IHC and intraoperative rapid Ki-67 IHC with FS. RESULTS: Detection of tumoral Ki-67 expression using rapid IHC with formalin-fixed, paraffin-embedded (FFPE) blocks was significantly associated with clinical outcomes in R0 pStage IA NSCLC surgical patients, including overall and recurrence-free survival (P = 0.0043 and P < 0.0001, respectively). Levels of Ki-67 expression among resectable NSCLC patients detected using rapid IHC with FS significantly correlated with those detected using conventional FFPE-IHC (p < 0.001). An intraoperative cut-off of > 7.5 % tumor cell Ki-67 positivity accurately predicted pathological stage more advanced than IA3 [P = 0.0185, Odds ratio = 20.477, 95 % confidence interval (CI): 1.660-252.55]. CONCLUSION: Rapid Ki-67 IHC with AC mixing could potentially serve as a clinical tool for intraoperative determination of tumor malignancy status. The present study suggests that segmentectomy for early small NSCLCs is oncologically safe and a reasonable alternative to lobectomy, but only when there is adequate intraoperative selection for primary tumors with low-grade malignancy, which could be verified using intraoperative rapid Ki-67 IHC with FS.
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Extracorporeal Membrane Oxygenation-Assisted Thoracic Surgery: A Series of 10 Cases
Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Kuriyama Shoji, Iwai Hidenobu, Suzuki Haruka, Demura Ryo, Shibano Sumire, Minamiya Yoshihiro
Surgical Case Reports ( 一般社団法人 日本外科学会 ) 11 ( 1 ) n/a 2025
<p><b>INTRODUCTION:</b> Extracorporeal membrane oxygenation (ECMO) is a type of extracorporeal circulation used to divert blood from and deliver blood to peripheral blood vessels. Recently, the use of ECMO has been reported in various non-transplant surgeries. Particularly in tracheal surgeries, ECMO provides an unobstructed surgical field and enables safe induction of general anesthesia in difficult intubation cases. Here, we report on 10 cases of thoracic surgery in which ECMO was employed at our institution.</p><p><b>CASE PRESENTATION:</b> These 10 cases comprise 4 tracheal cancer surgeries, 2 lung cancer surgeries, and 1 case each of surgery for thyroid cancer, mediastinal cancer, tracheomalacia, and tracheobronchial injury. Veno-venous (VV)-ECMO is most often selected, but veno-arterial (VA)-ECMO is chosen when recirculation with VV-ECMO is unacceptable, when pulmonary artery bleeding needs to be controlled, or when cardiac support is necessary. Among the 10 presented cases, VV-ECMO was used in 8, while VA-ECMO was employed in 2. Three of these cases involved ECMO bailout due to dyspnea caused by airway stenosis. Six of the patients did not receive heparin maintenance. Of those, 1 was maintained on nafamostat mesilate, 2 were maintained on nafamostat mesilate after receiving a single dose of heparin, and 3 received only a single dose of heparin. In none of those cases did ECMO fail to maintain flow due to thrombus formation. A postoperative hemothorax occurred as one of the ECMO-related complications in Case 4. There were no perioperative cardiopulmonary complications, in-hospital deaths, or deaths within 30 days after surgery. One patient died from metastatic recurrence of non-small cell lung cancer 5 months after surgery, another from progression of disease in mediastinal anaplastic cancer 4 months after surgery, and the 3rd from upper gastrointestinal bleeding 2 years after surgery. The other 7 patients remain alive.</p><p><b>CONCLUSIONS:</b> ECMO is useful in tracheal surgery and in cases where intubation is difficult or dangerous, because it facilitates safe and accurate surgery. We also believe that individualized anticoagulant strategies can be safely implemented.</p>
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Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Kurihara Nobuyasu, Kuriyama Shoji, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 38 ( 2 ) 99 - 105 2024.03
<p>The patient was a 74-year-old female diagnosed with primary hyperparathyroidism, due to elevated serum levels of calcium and intact parathyroid hormone. CT and <sup>99m</sup>Tc-MIBI SPECT indicated the presence of an ectopic mediastinal parathyroid adenoma, which prompted her referral to our department for its surgical resection. Based on CT, the nodule was buried within the mediastinal fat and would be difficult to identify during surgery. Therefore, radio-guidance with <sup>99m</sup>Tc-MIBI and monitoring of intact-PTH were used as intraoperative guides. The operation was performed by hybrid video-assisted thoracic surgery with a 6-cm incision in the 3<sup>rd</sup> intercostal space, and we resected the nodule buried in the superior mediastinal fat. The nodule showed high <sup>99m</sup>Tc accumulation, and the intact-PTH level decreased after 10 minutes following resection. This led us to conclude that complete resection had been achieved. The final pathological diagnosis was ectopic mediastinal parathyroid adenoma, and there has been no recurrence to date. This outcome suggests that intraoperative guidance using a radioisotope technique along with intact-PTH monitoring may enable more precise excision of mediastinal ectopic parathyroid adenoma, and that accurate identification of the position of the nodule may reduce the rate of recurrence.</p>
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A case of emergency carinal reconstruction with ECMO support
Atari Maiko, Kawai Hideki, Ishii Yoshiaki, Takashima Shinogu, Imai Kazuhiro, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 37 ( 5 ) 493 - 499 2023.07
<p>Among respiratory surgeries, carinal reconstruction is a rare surgical procedure. In addition, it requires advanced techniques; thus, it is often performed after repeated preoperative simulations, especially in collaboration with the anesthesiology department. Here, we report a case of tracheal cancer that required emergency surgery with carinal reconstruction.</p><p>The patient was a 76-year-old man who was transferred to our department following the diagnosis of tracheal cancer. After transfer to our hospital, complete atelectasis of the left lung was confirmed during the preoperative examination; therefore, emergency surgery was decided for life-saving purposes. The surgery was performed under extracorporeal membrane oxygenation (ECMO). Carinal resection was conducted via right-sided thoracotomy, and double-barrelled reconstruction was performed. After the surgery, postoperative complications, such as aspiration pneumonia, interstitial pneumonia, and anastomotic dehiscence of the carina, were noted, and perioperative management was challenging. Nonetheless, the patient was safely transferred approximately 4 months after the surgery. It is rare to have an emergency operation that requires carinal reconstruction; thus, we present this case along with a review of the literature.</p>