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Affiliation |
Hospital SurgeryⅡ |
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Date of Birth |
1982 |
Graduating School 【 display / non-display 】
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2001.04-2007.03
Akita University Faculty of Medicine Graduated
Graduate School 【 display / non-display 】
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-2014.03
Akita University Graduate School, Division of Medicine Doctor's Course Completed
Campus Career 【 display / non-display 】
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2021.04-Now
Akita University Hospital SurgeryⅡ Lecturer
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2019.04-2021.03
Akita University Graduate School of Medicine Doctorial Course in Medicine Oncoregulatory Medicine Assistant Professor
Research Areas 【 display / non-display 】
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Life Science / Respiratory surgery
Thesis for a degree 【 display / non-display 】
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Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer
Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S, Minamiya Y
Tumor Biology 35 ( 5 ) 4257 - 4265 2014.03 [Refereed]
Domestic Co-author
Research Achievements 【 display / non-display 】
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Tracheal bifurcation repair for blunt thoracic trauma in a patient with COVID-19.
Shoji Kuriyama, Kazuhiro Imai, Kasumi Tozawa, Shinogu Takashima, Ryo Demura, Haruka Suzuki, Yuzu Harata, Tatsuki Fujibayashi, Sumire Shibano, Yoshihiro Minamiya
Surgical case reports 9 ( 1 ) 108 - 108 2023.06
Research paper (journal)
BACKGROUND: Tracheobronchial injury (TBI) is a rare but potentially life-threatening trauma that requires prompt diagnosis and treatment. We present a case in which a patient with COVID-19 infection was successfully treated for a TBI through surgical repair and intensive care with extracorporeal membrane oxygenation (ECMO) support. CASE PRESENTATION: This is the case of a 31-year-old man transported to a peripheral hospital following a car crash. Tracheal intubation was performed for severe hypoxia and subcutaneous emphysema. Chest computed tomography showed bilateral lung contusion, hemopneumothorax, and penetration of the endotracheal tube beyond the tracheal bifurcation. A TBI was suspected; moreover, his COVID-19 polymerase chain reaction screening test was positive. Requiring emergency surgery, the patient was transferred to a private negative pressure room in our intensive care unit. Due to persistent hypoxia and in preparation for repair, the patient was started on veno-venous ECMO. With ECMO support, tracheobronchial injury repair was performed without intraoperative ventilation. In accordance with the surgery manual for COVID-19 patients in our hospital, all medical staff who treated this patient used personal protective equipment. Partial transection of the tracheal bifurcation membranous wall was detected and repaired using 4-0 monofilament absorbable sutures. The patient was discharged on the 29th postoperative day without postoperative complications. CONCLUSIONS: ECMO support for traumatic TBI in this patient with COVID-19 reduced mortality risk while preventing aerosol exposure to the virus.
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Inferior pulmonary ligament division during left upper lobectomy causes pulmonary dysfunction.
Shoji Kuriyama, Kazuhiro Imai, Hajime Saito, Shinogu Takashima, Nobuyasu Kurihara, Ryo Demura, Haruka Suzuki, Yuzu Harata, Yusuke Sato, Katsutoshi Nakayama, Kyoko Nomura, Yoshihiro Minamiya
Interdisciplinary cardiovascular and thoracic surgery 36 ( 5 ) 2023.05
Research paper (journal)
OBJECTIVES: The division of inferior pulmonary ligament (IPL) during upper lobectomy (UL) was believed to be mandatory to dilate the remaining lung sufficiently. However, the benefits, especially postoperative pulmonary function, remain controversial. This study aimed to evaluate whether IPL division leads to pulmonary dysfunction. METHODS: This retrospective study included 213 patients who underwent UL between 2005 and 2018. They were categorized into an IPL division group (D group, n = 106) and a preservation group (P group, n = 107). Postoperative dead space at the lung apex, pulmonary function and complications were assessed using chest X-rays and spirometry. Changes in bronchial angle, cross-sectional area and circumference of the narrowed bronchus on the excised side were measured on three-dimensional computed tomography. RESULTS: There was no significant difference in the postoperative complication rate, the dead space area, forced vital capacity (FVC), or forced expiratory volume in 1 s (FEV1) between the 2 groups after right UL (FVC; P = 0.838, FEV1; P = 0.693). By contrast, after left UL pulmonary function was significantly better in the P than in the D group (FVC; P = 0.038, FEV1; P = 0.027). Changes in bronchial angle did not significantly differ between the 2 groups. The narrowed bronchus's cross-sectional area (P = 0.021) and circumference (P = 0.009) were significantly smaller in the D group than in the P group after left UL. CONCLUSIONS: IPL division during left UL caused postoperative pulmonary dysfunction and airflow limitation due to bronchial kinking. IPL preservation may have a beneficial impact on postoperative pulmonary function.
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Changes in Serum Trace Element Concentrations before and after Surgery in Resectable Breast Cancer
Takahashi E.
Anticancer Research ( Anticancer Research ) 42 ( 11 ) 5323 - 5334 2022.11 [Refereed]
Research paper (journal) Domestic Co-author
BACKGROUND/AIM: Minerals and trace elements (TEs) play vital roles in normal biological functions and in all cancers. Breast carcinoma is the most commonly occurring cancer in women. The aim of this study was to evaluate changes in TE levels before and after breast cancer surgery and the clinical utility and reliability of TE levels assayed using inductively coupled plasma mass spectrometry (ICP-MS). PATIENTS AND METHODS: Thirteen patients with ductal carcinoma in situ (DCIS) and 34 with invasive ductal carcinoma (IDC) treated with planned surgery were enrolled between August 2017 and February 2019. Blood samples were collected before and the day after resection of the primary tumor. All enrolled patients received mastectomy or quadrantectomy and axillary lymph node dissection/biopsy. Serum TE concentrations were determined using ICP-MS. RESULTS: Changes in boron, titanium, vanadium, chromium, copper, zinc, and selenium levels from before to after surgery differed between IDC and DCIS patients. Boron and copper levels before surgery and changes in titanium, vanadium, and chromium before and after surgery are potential predictors distinguishing DCIS from IDC. Subset analysis showed that chromium is a potential biomarker for luminal subtype, while titanium and chromium are potential biomarkers for pathological staging. CONCLUSION: Changes in serum TEs before and after surgery may help with diagnosis and staging of breast cancer and in establishing TE supplementation protocols.
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Atari M.
Lung Cancer ( Lung Cancer ) 173 75 - 82 2022.11 [Refereed]
Research paper (journal) Domestic Co-author
OBJECTIVES: Locoregional recurrence of non-small cell lung cancer (NSCLC) occurs even among patients with stage I disease, as a result of tumor proliferative activity. The aim of this study was to evaluate the clinical reliability of a new rapid immunohistochemistry (IHC) technique for assessing malignant potential through detection of tumoral Ki-67 expression. MATERIALS AND METHODS: The rapid IHC method uses non-contact alternating current (AC) mixing to achieve more rapid/stable staining within 20 min during surgery. First, to investigate the association between clinical outcomes and tumoral Ki-67 labeling with rapid IHC, 21 pairs of surgical patients treated between 2012 and 2020 for pStage IA1-3 NSCLC with/without recurrence were retrospectively reviewed. Second, 40 frozen section (FS) samples in patients with NSCLC for whom radical surgery was planned between April 2021 and February 2022 were deemed eligible for comparison of the clinical performance of conventional IHC and intraoperative rapid Ki-67 IHC with FS. RESULTS: Detection of tumoral Ki-67 expression using rapid IHC with formalin-fixed, paraffin-embedded (FFPE) blocks was significantly associated with clinical outcomes in R0 pStage IA NSCLC surgical patients, including overall and recurrence-free survival (P = 0.0043 and P < 0.0001, respectively). Levels of Ki-67 expression among resectable NSCLC patients detected using rapid IHC with FS significantly correlated with those detected using conventional FFPE-IHC (p < 0.001). An intraoperative cut-off of > 7.5 % tumor cell Ki-67 positivity accurately predicted pathological stage more advanced than IA3 [P = 0.0185, Odds ratio = 20.477, 95 % confidence interval (CI): 1.660-252.55]. CONCLUSION: Rapid Ki-67 IHC with AC mixing could potentially serve as a clinical tool for intraoperative determination of tumor malignancy status. The present study suggests that segmentectomy for early small NSCLCs is oncologically safe and a reasonable alternative to lobectomy, but only when there is adequate intraoperative selection for primary tumors with low-grade malignancy, which could be verified using intraoperative rapid Ki-67 IHC with FS.
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Harata Yuzu, Imai Kazuhiro, Takashima Shinogu, Atari Maiko, Matsuo Tsubasa, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 36 ( 6 ) 621 - 626 2022.09 [Refereed]
Research paper (journal) Domestic Co-author
<p>Segmentectomy is a standard surgical treatment option for stage IA non-small cell lung cancer (NSCLC). However, segmentectomy is only an oncologically safe and reasonable alternative to lobectomy when the intraoperative lymph node staging and surgical margin are adequate. The aim of the present study was to compare the outcomes (frequency, reasons, and prognosis) of patients converted from segmentectomy to lobectomy at the intraoperative direction of the surgical team. This retrospective study analyzed the outcomes of 121 patients who were scheduled to undergo segmentectomy for clinical stage IA NSCLC between January 2014 and August 2020. Eight of the 121 patients were converted from segmentectomy to lobectomy based on the intraoperative diagnosis and surgeon's judgment. Among the 8 converted cases, 4 were diagnosed with lymph nodes metastasis based on analysis of frozen sections and 4 had a problem related to the surgical technique (e.g., surgical margin or uncontrollable bleeding). Diagnosis of the 3 node malignant-positive patients was guided by rapid-immunohistochemistry using noncontact alternating current electric field mixing. There was no significant difference in overall survival between patients with completed segmentectomy (n=113) and those converted to lobectomy (n=8) (P=0.5828). In clinical stage IA NSCLC patients, lobectomy can be selected instead of segmentectomy, if appropriate judgement/diagnosis is intraoperatively achieved.</p>
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A case of emergency carinal reconstruction with ECMO support
Atari Maiko, Kawai Hideki, Ishii Yoshiaki, Takashima Shinogu, Imai Kazuhiro, Minamiya Yoshihiro
The Journal of the Japanese Association for Chest Surgery ( The Japanese Association for Chest Surgery ) 37 ( 5 ) 493 - 499 2023.07
<p>Among respiratory surgeries, carinal reconstruction is a rare surgical procedure. In addition, it requires advanced techniques; thus, it is often performed after repeated preoperative simulations, especially in collaboration with the anesthesiology department. Here, we report a case of tracheal cancer that required emergency surgery with carinal reconstruction.</p><p>The patient was a 76-year-old man who was transferred to our department following the diagnosis of tracheal cancer. After transfer to our hospital, complete atelectasis of the left lung was confirmed during the preoperative examination; therefore, emergency surgery was decided for life-saving purposes. The surgery was performed under extracorporeal membrane oxygenation (ECMO). Carinal resection was conducted via right-sided thoracotomy, and double-barrelled reconstruction was performed. After the surgery, postoperative complications, such as aspiration pneumonia, interstitial pneumonia, and anastomotic dehiscence of the carina, were noted, and perioperative management was challenging. Nonetheless, the patient was safely transferred approximately 4 months after the surgery. It is rare to have an emergency operation that requires carinal reconstruction; thus, we present this case along with a review of the literature.</p>