研究等業績 - 原著論文 - 三島 和夫
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Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: a meta-analysis.
Kishi T, Ikuta T, Matsui Y, Inada K, Matsuda Y, Mishima K, Iwata N.
Psychol Med. 18 1 - 8 2018年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep-wake disorders.
Hida A, Kitamura S, Kadotani H, Uchiyama M, Ebisawa T, Inoue Y, Kamei Y, Mishima K.
Hum Genome Var. 5 17 2018年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Effectiveness of cognitive behavioral therapy for pharmacotherapy-resistant chronic insomnia: a multi-center randomized controlled trial in Japan.
Ayabe N, Okajima I, Nakajima S, Inoue Y, Watanabe N, Yamadera W, Uchimura N, Tachimori H, Kamei Y, Mishima K.
Sleep Med. 50 105 - 112 2018年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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Effect of discontinuation v. maintenance of antipsychotic medication on relapse rates in patients with remitted/stable first-episode psychosis: a meta-analysis.
Kishi T, Ikuta T, Matsui Y, Inada K, Matsuda Y, Mishima K, Iwata N
Psychol Med. 18 1 - 8 2018年06月 [査読有り]
研究論文（学術雑誌） 国内共著
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都留 あゆみ, 亀井 雄一, 木村 綾乃, 三島 和夫
不眠研究 ( メディカルフロントインターナショナル(有) ) 2017 72 - 74 2017年10月
研究論文（学術雑誌） 国内共著
過眠症における終夜睡眠ポリグラフ検査(PSG)の所見として、ナルコレプシー(NA)では覚醒反応が多いことや、筋活動抑制を伴わないREM睡眠(RWA)を認めること、特発性過眠症(IH)では睡眠効率が良いことなどが知られている。また、NA患者では健常対照群に比べて睡眠中の周期性四肢運動が多いという報告があるが、IHとの比較はあまり検討されていない。そこで今回、当院のNA患者68例(うちカタプレキシーを伴う者20例)とIH患者60例を対象とし、「PSGにおける覚醒反応指数(Arousal index)」「覚醒を伴う周期性四肢運動となる脚動指数(PLM arousal index)」「周期性四肢運動指数(PLMI)」の群間比較を行った。結果、Arousal indexはNA群とIH群の間で有意差はみられなかったが、NA群のうちカタプレキシー(CA)を伴う群ではIH群に比べて高い傾向にあった。PLM arousal indexもNA群とIH群の間で有意差はなかったが、CAを伴う群ではIH群に比べて有意に高かった。PLMIはNA群がIH群に比べて有意に高かった。
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Two Days' Sleep Debt Causes Mood Decline During Resting State Via Diminished Amygdala-Prefrontal Connectivity.
Motomura Y, Katsunuma R, Yoshimura M, Mishima K.
Sleep 40 ( 10 ) pii: zsx133 2017年10月 [査読有り]
研究論文（学術雑誌） 国内共著
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Unrecognized Sleep Loss Accumulated in Daily Life Can Promote Brain Hyperreactivity to Food Cue
Ruri Katsunuma, Kentaro Oba, Shingo Kitamura, Yuki Motomura, Yuri Terasawa, Kyoko Nakazaki, Akiko Hida, Yoshiya Moriguchi, Kazuo Mishima
SLEEP ( OXFORD UNIV PRESS INC ) 40 ( 10 ) 2017年10月 [査読有り]
研究論文（学術雑誌） 国内共著
Epidemiological studies have shown that sleep debt increases the risk of obesity. Experimental total sleep deprivation (TSD) has been reported to activate the reward system in response to food stimuli, but food-related responses in everyday sleep habits, which could lead to obesity, have not been addressed. Here, we report that habitual sleep time at home among volunteers without any sleep concerns was shorter than their optimal sleep time estimated by the 9-day extended sleep intervention, which indicates that participants had already been in sleep debt in their usual sleep habits. The amygdala and anterior insula, which are responsible for both affective responses and reward prediction, were found to exhibit significantly lowered activity in the optimal sleep condition. Additionally, a subsequent one-night period of TSD reactivated the right anterior insula in response to food images; however, the activity level of amygdala remained lowered. These findings indicate that (1) our brain is at risk of hyperactivation to food triggers in everyday life, which could be a risk factor for obesity and lifestyle diseases, and (2) optimal sleep appears to reduce this hypersensitivity to food stimuli.
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Validation of Brain-Derived Signals in Near-Infrared Spectroscopy Through Multivoxel Analysis of Concurrent Functional Magnetic Resonance Imaging
Yoshiya Moriguchi, Takamasa Noda, Kosei Nakayashiki, Yohei Takata, Shiori Setoyama, Shingo Kawasaki, Yoshihiko Kunisato, Kazuo Mishima, Kazuyuki Nakagome, Takashi Hanakawa
HUMAN BRAIN MAPPING ( WILEY ) 38 ( 10 ) 5274 - 5291 2017年10月 [査読有り]
研究論文（学術雑誌） 国内共著
Near-infrared spectroscopy (NIRS) is a convenient and safe brain-mapping tool. However, its inevitable confounding with hemodynamic responses outside the brain, especially in the frontotemporal head, has questioned its validity. Some researchers attempted to validate NIRS signals through concurrent measurements with functional magnetic resonance imaging (fMRI), but, counterintuitively, NIRS signals rarely correlate with local fMRI signals in NIRS channels, although both mapping techniques should measure the same hemoglobin concentration. Here, we tested a novel hypothesis that different voxels within the scalp and the brain tissues might have substantially different hemoglobin absorption rates of near-infrared light, which might differentially contribute to NIRS signals across channels. Therefore, we newly applied a multivariate approach, a partial least squares regression, to explain NIRS signals with multivoxel information from fMRI within the brain and soft tissues in the head. We concurrently obtained fMRI and NIRS signals in 9 healthy human subjects engaging in an n-back task. The multivariate fMRI model was quite successfully able to predict the NIRS signals by cross-validation (interclass correlation coefficient = similar to 0.85). This result confirmed that fMRI and NIRS surely measure the same hemoglobin concentration. Additional application of Monte-Carlo permutation tests confirmed that the model surely reflects temporal and spatial hemodynamic information, not random noise. After this thorough validation, we calculated the ratios of the contributions of the brain and soft-tissue hemodynamics to the NIRS signals, and found that the contribution ratios were quite different across different NIRS channels in reality, presumably because of the structural complexity of the frontotemporal regions. (C) 2017 Wiley Periodicals, Inc.
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Reliability and validity of a brief sleep questionnaire for children in Japan.
Okada M, Kitamura S, Iwadare Y, Tachimori H, Kamei Y, Higuchi S, Mishima K.
J Physiol Anthropol. 36 ( 1 ) 35 2017年09月 [査読有り]
研究論文（学術雑誌） 国内共著
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Pathophysiology and strategic treatment of sighted non-24-h sleep–wake rhythm disorders.
Mishima K.
Sleep and Biological Rhythms 15 11 - 20 2017年09月 [査読有り]
研究論文（学術雑誌） 単著
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Recovery from Unrecognized Sleep Loss Accumulated in Daily Life Improved Mood Regulation via Prefrontal Suppression of Amygdala Activity.
Motomura Y, Kitamura S, Nakazaki K, Oba K, Katsunuma R, Terasawa Y, Hida A, Moriguchi Y, Mishima K.
Front Neurol. 8 306 2017年07月 [査読有り]
研究論文（学術雑誌） 国内共著
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Validation of brain-derived signals in near-infrared spectroscopy through multivoxel analysis of concurrent functional magnetic resonance imaging.
Moriguchi Y, Noda T, Nakayashiki K, Takata Y, Setoyama S, Kawasaki S, Kunisato Y, Mishima K, Nakagome K, Hanakawa T.
Hum Brain Mapp. 38 ( 10 ) 5274 - 5291 2017年07月 [査読有り]
研究論文（学術雑誌） 国内共著
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ASSOCIATION BETWEEN MINDFULNESS TENDENCY ASSESSED BY FIVE FACET MINDFULNESS QUESTIONNAIRE AND REGIONAL GRAY MATTER VOLUME IN A JAPANESE POPULATION
Hiroki Murakami, Ruri Katsunuma, Kentaro Oba, Kazuo Mishima, Yoshiya Moriguchi
PSYCHOSOMATIC MEDICINE ( LIPPINCOTT WILLIAMS & WILKINS ) 79 ( 4 ) A61 - A61 2017年05月 [査読有り]
研究論文（学術雑誌） 国内共著
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Personal lifestyle as a resource for work engagement.
Nishi D, Suzuki Y, Nishida J, Mishima K, Yamanouchi Y.
J Occup Health. 59 ( 1 ) 17 - 23 2017年01月 [査読有り]
研究論文（学術雑誌） 国内共著
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Hida A.
Translational Psychiatry ( Translational Psychiatry ) 7 ( 4 ) 2017年 [査読有り]
研究論文（学術雑誌） 国内共著